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Projectile vomiting

MedGen UID:
67442
Concept ID:
C0221151
Sign or Symptom
Synonym: Projectile Vomiting
SNOMED CT: Projectile vomiting (8579004)
 
HPO: HP:0002587

Definition

Vomiting that ejects the gastric contents with great force. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProjectile vomiting

Conditions with this feature

Hypomyelinating leukodystrophy 3
MedGen UID:
342403
Concept ID:
C1850053
Disease or Syndrome
Autosomal recessive hypomyelinating leukodystrophy-3 (HLD3) is a severe neurologic disorder characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system (summary by Feinstein et al., 2010). The disorder is phenotypically similar to X-linked Pelizaeus-Merzbacher disease (PMD; 312080), which is caused by mutation in the PLP1 gene (300401). For a general phenotypic description and a discussion of genetic heterogeneity of HLD, see 312080.
Pyloric stenosis, infantile hypertrophic, 1
MedGen UID:
357978
Concept ID:
C1867403
Disease or Syndrome
Infantile pyloric stenosis is the most common condition requiring surgical intervention in the first year of life. It typically presents in infants 2 to 6 weeks after birth. Clinically the disorder is characterized by projectile vomiting, visible gastric peristalsis, and a palpable pyloric tumor (summary by Everett et al., 2008). Mortality was high until successful treatment by pyloromyotomy was developed by Ramstedt (1912). Genetic Heterogeneity of Infantile Hypertrophic Pyloric Stenosis Multiple susceptibility loci have been implicated in IHPS including IHPS1 on chromosome 12q, IHPS2 (610260) on chromosome 16p13-p12, IHPS3 (612017) on chromosome 11q14-q22, IHPS4 (300711) on chromosome Xq23, and IHPS5 (612525) on chromosome 16q24.
Combined oxidative phosphorylation deficiency 43
MedGen UID:
1718250
Concept ID:
C5394284
Disease or Syndrome
Congenital short bowel syndrome
MedGen UID:
1784105
Concept ID:
C5441717
Disease or Syndrome
A rare intestinal disorder of neonates of unknown etiology. Patients are born with a short small bowel (less than 75 cm in length) that compromises proper intestinal absorption and leads chronic diarrhea, vomiting and failure to thrive.
Intestinal dysmotility syndrome
MedGen UID:
1823992
Concept ID:
C5774219
Disease or Syndrome
Intestinal dysmotility syndrome (IDMTS) is an autosomal recessive disorder characterized by impaired intestinal motility resulting in episodes of diarrhea and distention of intestinal loops. Intestinal and hepatic portal venous gas, similar to findings seen in necrotizing enterocolitis, may be present. Dysmorphic features and developmental delay may also be present (Park et al., 2021).

Professional guidelines

PubMed

Leonard SA, Nowak-Wegrzyn A
Pediatr Ann 2013 Jul;42(7):135-40. doi: 10.3928/00904481-20130619-11. PMID: 23805961
Kumar KP, Kumar SP, Nair GA
J Environ Biol 2009 May;30(3):319-25. PMID: 20120452
Blumer SL, Zucconi WB, Cohen HL, Scriven RJ, Lee TK
Ultrasound Q 2004 Sep;20(3):79-89. doi: 10.1097/00013644-200409000-00002. PMID: 15322385

Recent clinical studies

Etiology

Dewangan A, Singh J, Kumar D, Kumar N, Kumar K, Dinkar A
Infect Disord Drug Targets 2023;23(1):e210622206242. doi: 10.2174/1871526522666220621110723. PMID: 35726810
Lin CM, Wang AY, Chen CC, Wu YM, Liu CH, Tsay PK, Chang CH
Biomed J 2019 Oct;42(5):352-357. Epub 2019 Nov 1 doi: 10.1016/j.bj.2019.04.006. PMID: 31783996Free PMC Article
Galea R, Said E
Neonatal Netw 2018 Jul;37(4):197-204. Epub 2018 Jul 1 doi: 10.1891/0730-0832.37.4.197. PMID: 30567916
Leonard SA, Nowak-Wegrzyn A
Pediatr Ann 2013 Jul;42(7):135-40. doi: 10.3928/00904481-20130619-11. PMID: 23805961
Kumar KP, Kumar SP, Nair GA
J Environ Biol 2009 May;30(3):319-25. PMID: 20120452

Diagnosis

Dewangan A, Singh J, Kumar D, Kumar N, Kumar K, Dinkar A
Infect Disord Drug Targets 2023;23(1):e210622206242. doi: 10.2174/1871526522666220621110723. PMID: 35726810
Lin CM, Wang AY, Chen CC, Wu YM, Liu CH, Tsay PK, Chang CH
Biomed J 2019 Oct;42(5):352-357. Epub 2019 Nov 1 doi: 10.1016/j.bj.2019.04.006. PMID: 31783996Free PMC Article
Galea R, Said E
Neonatal Netw 2018 Jul;37(4):197-204. Epub 2018 Jul 1 doi: 10.1891/0730-0832.37.4.197. PMID: 30567916
Leonard SA, Nowak-Wegrzyn A
Pediatr Ann 2013 Jul;42(7):135-40. doi: 10.3928/00904481-20130619-11. PMID: 23805961
Deluca SA
Am Fam Physician 1993 Jun;47(8):1771-3. PMID: 8498286

Therapy

Eid TJ, Horton M, Hendrix C, Yu JM, Browning EA, Malhotra A
J Pharm Pract 2023 Jun;36(3):679-684. Epub 2021 Oct 20 doi: 10.1177/08971900211052829. PMID: 34670427
Ono S, Takenouchi A, Terui K, Yoshida H, Terui E
Pediatr Int 2019 Nov;61(11):1151-1154. Epub 2019 Nov 12 doi: 10.1111/ped.14009. PMID: 31520503
Thapa A, Mittal N, Kayastha G, Basnyat B
BMJ Case Rep 2018 Sep 4;2018 doi: 10.1136/bcr-2018-225746. PMID: 30181402Free PMC Article
Luo H, Peng L, Wang N, Zhang J, Zheng X, Sun Y, Fan C, Ge H
Cancer Biol Ther 2018;19(10):875-878. Epub 2018 Apr 30 doi: 10.1080/15384047.2018.1456600. PMID: 29580147Free PMC Article
Goldstein LH, Berlin M, Tsur L, Bortnik O, Binyamini L, Berkovitch M
Breastfeed Med 2009 Dec;4(4):197-200. doi: 10.1089/bfm.2008.0135. PMID: 19366316

Prognosis

Dewangan A, Singh J, Kumar D, Kumar N, Kumar K, Dinkar A
Infect Disord Drug Targets 2023;23(1):e210622206242. doi: 10.2174/1871526522666220621110723. PMID: 35726810
Lin CM, Wang AY, Chen CC, Wu YM, Liu CH, Tsay PK, Chang CH
Biomed J 2019 Oct;42(5):352-357. Epub 2019 Nov 1 doi: 10.1016/j.bj.2019.04.006. PMID: 31783996Free PMC Article
Ono S, Takenouchi A, Terui K, Yoshida H, Terui E
Pediatr Int 2019 Nov;61(11):1151-1154. Epub 2019 Nov 12 doi: 10.1111/ped.14009. PMID: 31520503
Gaur K, Batra VV, Gupta R, Sharma MC, Narang P, Pandey PN
Brain Tumor Pathol 2016 Jul;33(3):209-15. Epub 2016 Mar 4 doi: 10.1007/s10014-016-0253-9. PMID: 26942599
Leonard SA, Nowak-Wegrzyn A
Pediatr Ann 2013 Jul;42(7):135-40. doi: 10.3928/00904481-20130619-11. PMID: 23805961

Clinical prediction guides

Lin CM, Wang AY, Chen CC, Wu YM, Liu CH, Tsay PK, Chang CH
Biomed J 2019 Oct;42(5):352-357. Epub 2019 Nov 1 doi: 10.1016/j.bj.2019.04.006. PMID: 31783996Free PMC Article
Carlson ML, Driscoll CL, Link MJ, Inwards CY, Neff BA, Beatty CW
Laryngoscope 2010;120 Suppl 4:S204. doi: 10.1002/lary.21671. PMID: 21225802
Kumar KP, Kumar SP, Nair GA
J Environ Biol 2009 May;30(3):319-25. PMID: 20120452
Goldstein LH, Berlin M, Tsur L, Bortnik O, Binyamini L, Berkovitch M
Breastfeed Med 2009 Dec;4(4):197-200. doi: 10.1089/bfm.2008.0135. PMID: 19366316
Fieguth A, Günther D, Kleemann WJ, Tröger HD
Forensic Sci Int 2002 Nov 5;130(1):8-12. doi: 10.1016/s0379-0738(02)00270-0. PMID: 12427444

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