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Heartwater Disease

MedGen UID:
6758
•Concept ID:
C0018835
•
Disease or Syndrome
Synonym: Disease, Heartwater

Definition

A tick-borne septicemic disease of domestic and wild ruminants caused by EHRLICHIA RUMINANTIUM. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeartwater Disease

Recent clinical studies

Etiology

Ethnoknowledge of Bukusu community on livestock tick prevention and control in Bungoma district, western Kenya.
Wanzala W, Takken W, Mukabana WR, Pala AO, Hassanali A
J Ethnopharmacol 2012 Mar 27;140(2):298-324. Epub 2012 Jan 24 doi: 10.1016/j.jep.2012.01.021. PMID: 22306288
Intracellular pathogens go extreme: genome evolution in the Rickettsiales.
Darby AC, Cho NH, Fuxelius HH, Westberg J, Andersson SG
Trends Genet 2007 Oct;23(10):511-20. Epub 2007 Sep 5 doi: 10.1016/j.tig.2007.08.002. PMID: 17822801

Diagnosis

Persistence mechanisms in tick-borne diseases.
Barbet AF
Onderstepoort J Vet Res 2009 Mar;76(1):53-8. doi: 10.4102/ojvr.v76i1.65. PMID: 19967928
Development of a polyclonal competitive enzyme-linked immunosorbent assay for detection of antibodies to Ehrlichia ruminantium.
Sumption KJ, Paxton EA, Bell-Sakyi L
Clin Diagn Lab Immunol 2003 Sep;10(5):910-6. doi: 10.1128/cdli.10.5.910-916.2003. PMID: 12965926Free PMC Article
Uncharacterized Ehrlichia spp. may contribute to clinical heartwater.
Allsopp BA, Allsopp MT, Du Plessis JH, Visser ES
Ann N Y Acad Sci 1996 Jul 23;791:17-23. doi: 10.1111/j.1749-6632.1996.tb53507.x. PMID: 8784482

Therapy

Ethnoknowledge of Bukusu community on livestock tick prevention and control in Bungoma district, western Kenya.
Wanzala W, Takken W, Mukabana WR, Pala AO, Hassanali A
J Ethnopharmacol 2012 Mar 27;140(2):298-324. Epub 2012 Jan 24 doi: 10.1016/j.jep.2012.01.021. PMID: 22306288
Uptake of recombinant myeloperoxidase, free or fused to Fc gamma, by macrophages enhances killing activity toward micro-organisms.
Tournay C, Courtoy PJ, Marodi L, Totté P, Werenne J, Jacquet A, Garcia-Quintana L, Bollen A, Moguilevsky N
DNA Cell Biol 1996 Aug;15(8):617-24. doi: 10.1089/dna.1996.15.617. PMID: 8769563

Clinical prediction guides

Economic Game Theory to Model the Attenuation of Virulence of an Obligate Intracellular Bacterium.
Tago D, Meyer DF
Front Cell Infect Microbiol 2016;6:86. Epub 2016 Aug 25 doi: 10.3389/fcimb.2016.00086. PMID: 27610355Free PMC Article
Coinfection of tick cell lines has variable effects on replication of intracellular bacterial and viral pathogens.
Moniuszko A, Rückert C, Alberdi MP, Barry G, Stevenson B, Fazakerley JK, Kohl A, Bell-Sakyi L
Ticks Tick Borne Dis 2014 Jun;5(4):415-22. Epub 2014 Mar 29 doi: 10.1016/j.ttbdis.2014.01.010. PMID: 24685441Free PMC Article
Development of a polyclonal competitive enzyme-linked immunosorbent assay for detection of antibodies to Ehrlichia ruminantium.
Sumption KJ, Paxton EA, Bell-Sakyi L
Clin Diagn Lab Immunol 2003 Sep;10(5):910-6. doi: 10.1128/cdli.10.5.910-916.2003. PMID: 12965926Free PMC Article

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