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Infection by human herpesvirus 6

MedGen UID:
678532
Concept ID:
C0854530
Disease or Syndrome
Synonyms: HHV-6 Infection; HHV6 Infection; Human Herpes Virus-6 Infection; Human Herpesvirus-6 Infection; Infection caused by human herpesvirus 6
SNOMED CT: Infection by human herpesvirus 6 (442177008); Infection caused by human herpesvirus 6 (442177008)

Definition

An infection that is caused by human herpesvirus-6. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfection by human herpesvirus 6

Professional guidelines

PubMed

Mehrmal S, Mojica R, Guo AM, Missall TA
Clin Geriatr Med 2024 Feb;40(1):147-175. Epub 2023 Oct 8 doi: 10.1016/j.cger.2023.09.003. PMID: 38000858
Costa BKD, Sato DK
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):12-19. Epub 2019 Sep 9 doi: 10.1016/j.jped.2019.07.006. PMID: 31513761Free PMC Article
Ward KN, Hill JA, Hubacek P, de la Camara R, Crocchiolo R, Einsele H, Navarro D, Robin C, Cordonnier C, Ljungman P; 2017 European Conference on Infections in Leukaemia (ECIL)
Haematologica 2019 Nov;104(11):2155-2163. Epub 2019 Aug 29 doi: 10.3324/haematol.2019.223073. PMID: 31467131Free PMC Article

Recent clinical studies

Etiology

Lareau CA, Yin Y, Maurer K, Sandor KD, Daniel B, Yagnik G, Peña J, Crawford JC, Spanjaart AM, Gutierrez JC, Haradhvala NJ, Riberdy JM, Abay T, Stickels RR, Verboon JM, Liu V, Buquicchio FA, Wang F, Southard J, Song R, Li W, Shrestha A, Parida L, Getz G, Maus MV, Li S, Moore A, Roberts ZJ, Ludwig LS, Talleur AC, Thomas PG, Dehghani H, Pertel T, Kundaje A, Gottschalk S, Roth TL, Kersten MJ, Wu CJ, Majzner RG, Satpathy AT
Nature 2023 Nov;623(7987):608-615. Epub 2023 Nov 8 doi: 10.1038/s41586-023-06704-2. PMID: 37938768Free PMC Article
Servellita V, Sotomayor Gonzalez A, Lamson DM, Foresythe A, Huh HJ, Bazinet AL, Bergman NH, Bull RL, Garcia KY, Goodrich JS, Lovett SP, Parker K, Radune D, Hatada A, Pan CY, Rizzo K, Bertumen JB, Morales C, Oluniyi PE, Nguyen J, Tan J, Stryke D, Jaber R, Leslie MT, Lyons Z, Hedman HD, Parashar U, Sullivan M, Wroblewski K, Oberste MS, Tate JE, Baker JM, Sugerman D, Potts C, Lu X, Chhabra P; Pediatric Hepatitis of Unknown Etiology Working Group, Ingram LA, Shiau H, Britt W, Gutierrez Sanchez LH, Ciric C, Rostad CA, Vinjé J, Kirking HL, Wadford DA, Raborn RT, St George K, Chiu CY
Nature 2023 May;617(7961):574-580. Epub 2023 Mar 30 doi: 10.1038/s41586-023-05949-1. PMID: 36996871Free PMC Article
Berzero G, Campanini G, Vegezzi E, Paoletti M, Pichiecchio A, Simoncelli AM, Colombo AA, Bernasconi P, Borsani O, Di Matteo A, Rossi V, Foiadelli T, Savasta S, Compagno F, Zecca M, Baldanti F, Marchioni E
Neurol Neuroimmunol Neuroinflamm 2021 Mar;8(2) Epub 2021 Jan 12 doi: 10.1212/NXI.0000000000000942. PMID: 33587722Free PMC Article
Clark DA
Rev Med Virol 2000 May-Jun;10(3):155-73. doi: 10.1002/(sici)1099-1654(200005/06)10:3<155::aid-rmv277>3.0.co;2-6. PMID: 10815027
Dockrell DH, Smith TF, Paya CV
Mayo Clin Proc 1999 Feb;74(2):163-70. doi: 10.4065/74.2.163. PMID: 10069356

Diagnosis

Vojdani A, Vojdani E, Saidara E, Maes M
Viruses 2023 Jan 31;15(2) doi: 10.3390/v15020400. PMID: 36851614Free PMC Article
Berzero G, Campanini G, Vegezzi E, Paoletti M, Pichiecchio A, Simoncelli AM, Colombo AA, Bernasconi P, Borsani O, Di Matteo A, Rossi V, Foiadelli T, Savasta S, Compagno F, Zecca M, Baldanti F, Marchioni E
Neurol Neuroimmunol Neuroinflamm 2021 Mar;8(2) Epub 2021 Jan 12 doi: 10.1212/NXI.0000000000000942. PMID: 33587722Free PMC Article
Green DA, Pereira M, Miko B, Radmard S, Whittier S, Thakur K
Clin Infect Dis 2018 Sep 14;67(7):1125-1128. doi: 10.1093/cid/ciy288. PMID: 29635334Free PMC Article
Agut H, Bonnafous P, Gautheret-Dejean A
Microbiol Spectr 2016 Jun;4(3) doi: 10.1128/microbiolspec.DMIH2-0007-2015. PMID: 27337451
Agut H, Bonnafous P, Gautheret-Dejean A
Clin Microbiol Rev 2015 Apr;28(2):313-35. doi: 10.1128/CMR.00122-14. PMID: 25762531Free PMC Article

Therapy

Lareau CA, Yin Y, Maurer K, Sandor KD, Daniel B, Yagnik G, Peña J, Crawford JC, Spanjaart AM, Gutierrez JC, Haradhvala NJ, Riberdy JM, Abay T, Stickels RR, Verboon JM, Liu V, Buquicchio FA, Wang F, Southard J, Song R, Li W, Shrestha A, Parida L, Getz G, Maus MV, Li S, Moore A, Roberts ZJ, Ludwig LS, Talleur AC, Thomas PG, Dehghani H, Pertel T, Kundaje A, Gottschalk S, Roth TL, Kersten MJ, Wu CJ, Majzner RG, Satpathy AT
Nature 2023 Nov;623(7987):608-615. Epub 2023 Nov 8 doi: 10.1038/s41586-023-06704-2. PMID: 37938768Free PMC Article
Ward KN, Hill JA, Hubacek P, de la Camara R, Crocchiolo R, Einsele H, Navarro D, Robin C, Cordonnier C, Ljungman P; 2017 European Conference on Infections in Leukaemia (ECIL)
Haematologica 2019 Nov;104(11):2155-2163. Epub 2019 Aug 29 doi: 10.3324/haematol.2019.223073. PMID: 31467131Free PMC Article
Agut H, Bonnafous P, Gautheret-Dejean A
Microbiol Spectr 2016 Jun;4(3) doi: 10.1128/microbiolspec.DMIH2-0007-2015. PMID: 27337451
Agut H, Bonnafous P, Gautheret-Dejean A
Clin Microbiol Rev 2015 Apr;28(2):313-35. doi: 10.1128/CMR.00122-14. PMID: 25762531Free PMC Article
Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, Roujeau JC
Am J Med 2011 Jul;124(7):588-97. Epub 2011 May 17 doi: 10.1016/j.amjmed.2011.01.017. PMID: 21592453

Prognosis

Kampouri E, Zamora D, Kiem ES, Liu W, Ibrahimi S, Blazevic RL, Lovas EA, Kimball LE, Huang ML, Jerome KR, Ueda Oshima M, Mielcarek M, Zerr DM, Boeckh MJ, Krantz EM, Hill JA
Clin Microbiol Infect 2023 Nov;29(11):1450.e1-1450.e7. Epub 2023 Jul 31 doi: 10.1016/j.cmi.2023.07.026. PMID: 37532126Free PMC Article
Noviello M, Lorentino F, Xue E, Racca S, Furnari G, Valtolina V, Campodonico E, Dvir R, Lupo-Stanghellini MT, Giglio F, Piemontese S, Clerici D, Oltolini C, Tassi E, Beretta V, Farina F, Mannina D, Ardemagni A, Vago L, Bernardi M, Corti C, Peccatori J, Clementi M, Ciceri F, Bonini C, Greco R
Blood Adv 2023 Sep 26;7(18):5446-5457. doi: 10.1182/bloodadvances.2022009274. PMID: 37067947Free PMC Article
Jubelt B, Mihai C, Li TM, Veerapaneni P
Curr Neurol Neurosci Rep 2011 Dec;11(6):543-52. doi: 10.1007/s11910-011-0228-5. PMID: 21956758
Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, Roujeau JC
Am J Med 2011 Jul;124(7):588-97. Epub 2011 May 17 doi: 10.1016/j.amjmed.2011.01.017. PMID: 21592453
Abdel-Haq NM, Asmar BI
Indian J Pediatr 2004 Jan;71(1):89-96. doi: 10.1007/BF02725664. PMID: 14979393

Clinical prediction guides

Lareau CA, Yin Y, Maurer K, Sandor KD, Daniel B, Yagnik G, Peña J, Crawford JC, Spanjaart AM, Gutierrez JC, Haradhvala NJ, Riberdy JM, Abay T, Stickels RR, Verboon JM, Liu V, Buquicchio FA, Wang F, Southard J, Song R, Li W, Shrestha A, Parida L, Getz G, Maus MV, Li S, Moore A, Roberts ZJ, Ludwig LS, Talleur AC, Thomas PG, Dehghani H, Pertel T, Kundaje A, Gottschalk S, Roth TL, Kersten MJ, Wu CJ, Majzner RG, Satpathy AT
Nature 2023 Nov;623(7987):608-615. Epub 2023 Nov 8 doi: 10.1038/s41586-023-06704-2. PMID: 37938768Free PMC Article
Servellita V, Sotomayor Gonzalez A, Lamson DM, Foresythe A, Huh HJ, Bazinet AL, Bergman NH, Bull RL, Garcia KY, Goodrich JS, Lovett SP, Parker K, Radune D, Hatada A, Pan CY, Rizzo K, Bertumen JB, Morales C, Oluniyi PE, Nguyen J, Tan J, Stryke D, Jaber R, Leslie MT, Lyons Z, Hedman HD, Parashar U, Sullivan M, Wroblewski K, Oberste MS, Tate JE, Baker JM, Sugerman D, Potts C, Lu X, Chhabra P; Pediatric Hepatitis of Unknown Etiology Working Group, Ingram LA, Shiau H, Britt W, Gutierrez Sanchez LH, Ciric C, Rostad CA, Vinjé J, Kirking HL, Wadford DA, Raborn RT, St George K, Chiu CY
Nature 2023 May;617(7961):574-580. Epub 2023 Mar 30 doi: 10.1038/s41586-023-05949-1. PMID: 36996871Free PMC Article
Tzannou I, Papadopoulou A, Naik S, Leung K, Martinez CA, Ramos CA, Carrum G, Sasa G, Lulla P, Watanabe A, Kuvalekar M, Gee AP, Wu MF, Liu H, Grilley BJ, Krance RA, Gottschalk S, Brenner MK, Rooney CM, Heslop HE, Leen AM, Omer B
J Clin Oncol 2017 Nov 1;35(31):3547-3557. Epub 2017 Aug 7 doi: 10.1200/JCO.2017.73.0655. PMID: 28783452Free PMC Article
Leber AL, Everhart K, Balada-Llasat JM, Cullison J, Daly J, Holt S, Lephart P, Salimnia H, Schreckenberger PC, DesJarlais S, Reed SL, Chapin KC, LeBlanc L, Johnson JK, Soliven NL, Carroll KC, Miller JA, Dien Bard J, Mestas J, Bankowski M, Enomoto T, Hemmert AC, Bourzac KM
J Clin Microbiol 2016 Sep;54(9):2251-61. Epub 2016 Jun 22 doi: 10.1128/JCM.00730-16. PMID: 27335149Free PMC Article
Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, Roujeau JC
Am J Med 2011 Jul;124(7):588-97. Epub 2011 May 17 doi: 10.1016/j.amjmed.2011.01.017. PMID: 21592453

Recent systematic reviews

Shafiee A, Teymouri Athar MM, Amini MJ, Hajishah H, Siahvoshi S, Jalali M, Jahanbakhshi B, Mozhgani SH
Rev Med Virol 2023 May;33(3):e2437. Epub 2023 Mar 7 doi: 10.1002/rmv.2437. PMID: 36880642
Mozhgani SH, Rajabi F, Qurbani M, Erfani Y, Yaslianifard S, Moosavi A, Pourrostami K, Baradaran Bagheri A, Soleimani A, Behzadian F, Safavi M, Rezaei F
Intervirology 2022;65(1):49-57. Epub 2021 Jun 23 doi: 10.1159/000517930. PMID: 34348314Free PMC Article
Pormohammad A, Azimi T, Falah F, Faghihloo E
J Cell Physiol 2018 Apr;233(4):2850-2862. Epub 2017 Oct 9 doi: 10.1002/jcp.26000. PMID: 28631829
Mohammadpour Touserkani F, Gaínza-Lein M, Jafarpour S, Brinegar K, Kapur K, Loddenkemper T
J Med Virol 2017 Jan;89(1):161-169. Epub 2016 Aug 9 doi: 10.1002/jmv.24594. PMID: 27272972
Scheurer ME, Pritchett JC, Amirian ES, Zemke NR, Lusso P, Ljungman P
Bone Marrow Transplant 2013 Apr;48(4):574-80. Epub 2012 Sep 24 doi: 10.1038/bmt.2012.180. PMID: 23000642

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