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Crimean-Congo hemorrhagic fever

MedGen UID:
6800
Concept ID:
C0019099
Disease or Syndrome
Synonyms: Congo Crimean Hemorrhagic Fever; Congo Virus Infection; Congo-Crimean Hemorrhagic Fever; Crimean Congo Haemorrhagic Fever; Crimean Congo Hemorrhagic Fever; Crimean Hemorrhagic Fever; Crimean-Congo Haemorrhagic Fever; Crimean-Congo Hemorrhagic Fever; Fever, Congo-Crimean Hemorrhagic; Fever, Crimean Hemorrhagic; Fever, Crimean-Congo Haemorrhagic; Fever, Crimean-Congo Hemorrhagic; Haemorrhagic Fever, Crimean-Congo; Hemorrhagic Fever, Congo-Crimean; Hemorrhagic Fever, Crimean; Hemorrhagic Fever, Crimean-Congo; Infection, Congo Virus
SNOMED CT: CHF - Crimean hemorrhagic fever (43489008); Crimean-Congo hemorrhagic fever (43489008); CCHF - Crimean-Congo hemorrhagic fever (43489008); Congo fever (43489008); Viral hemorrhagic fever, Crimean-Congo (43489008); Congo-Crimean hemorrhagic fever (43489008); Crimean hemorrhagic fever (43489008); Central Asian hemorrhagic fever (43489008)
 
Monarch Initiative: MONDO:0020501
Orphanet: ORPHA99827

Definition

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by CCHF virus and characterized by initial fever, headache, and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock, and multi-organ system failure. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCrimean-Congo hemorrhagic fever

Professional guidelines

PubMed

Gholizadeh O, Jafari MM, Zoobinparan R, Yasamineh S, Tabatabaie R, Akbarzadeh S, Amini P, Eslami M, Yousefi B, Dadashpour M
Microb Pathog 2022 Aug;169:105657. Epub 2022 Jun 24 doi: 10.1016/j.micpath.2022.105657. PMID: 35753597
Sağmak Tartar A, Akbulut A, Demirdağ K, Balin ŞÖ
Turkiye Parazitol Derg 2022 Mar 1;46(1):50-53. doi: 10.4274/tpd.galenos.2021.32042. PMID: 35232706
Ergonul O
Antiviral Res 2008 Apr;78(1):125-31. Epub 2007 Dec 3 doi: 10.1016/j.antiviral.2007.11.002. PMID: 18096251

Recent clinical studies

Etiology

Hawman DW, Feldmann H
Nat Rev Microbiol 2023 Jul;21(7):463-477. Epub 2023 Mar 14 doi: 10.1038/s41579-023-00871-9. PMID: 36918725Free PMC Article
Madison-Antenucci S, Kramer LD, Gebhardt LL, Kauffman E
Clin Microbiol Rev 2020 Mar 18;33(2) Epub 2020 Jan 2 doi: 10.1128/CMR.00083-18. PMID: 31896541Free PMC Article
Fillâtre P, Revest M, Tattevin P
Med Mal Infect 2019 Nov;49(8):574-585. Epub 2019 Oct 10 doi: 10.1016/j.medmal.2019.09.005. PMID: 31607406
Leblebicioglu H, Ozaras R, Fletcher TE, Beeching NJ; ESCMID Study Group for Infections in Travellers and Migrants (ESGITM)
Travel Med Infect Dis 2016 Mar-Apr;14(2):73-80. Epub 2016 Mar 10 doi: 10.1016/j.tmaid.2016.03.002. PMID: 26970396Free PMC Article
Whitehouse CA
Antiviral Res 2004 Dec;64(3):145-60. doi: 10.1016/j.antiviral.2004.08.001. PMID: 15550268

Diagnosis

Lorenzo Juanes HM, Carbonell C, Sendra BF, López-Bernus A, Bahamonde A, Orfao A, Lista CV, Ledesma MS, Negredo AI, Rodríguez-Alonso B, Bua BR, Sánchez-Seco MP, Muñoz Bellido JL, Muro A, Belhassen-García M
Emerg Infect Dis 2023 Feb;29(2):252-259. doi: 10.3201/eid2902.220677. PMID: 36692301Free PMC Article
Raabe VN
J Clin Microbiol 2020 Mar 25;58(4) doi: 10.1128/JCM.01580-19. PMID: 32024724Free PMC Article
Madison-Antenucci S, Kramer LD, Gebhardt LL, Kauffman E
Clin Microbiol Rev 2020 Mar 18;33(2) Epub 2020 Jan 2 doi: 10.1128/CMR.00083-18. PMID: 31896541Free PMC Article
Shayan S, Bokaean M, Shahrivar MR, Chinikar S
Lab Med 2015 Summer;46(3):180-9. doi: 10.1309/LMN1P2FRZ7BKZSCO. PMID: 26199256
Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M
Antiviral Res 2013 Oct;100(1):159-89. Epub 2013 Jul 29 doi: 10.1016/j.antiviral.2013.07.006. PMID: 23906741

Therapy

Hawman DW, Feldmann H
Nat Rev Microbiol 2023 Jul;21(7):463-477. Epub 2023 Mar 14 doi: 10.1038/s41579-023-00871-9. PMID: 36918725Free PMC Article
Aslam M, Abbas RZ, Alsayeqh A
Front Public Health 2023;11:1093817. Epub 2023 Jan 26 doi: 10.3389/fpubh.2023.1093817. PMID: 36778537Free PMC Article
Hawman DW, Feldmann H
F1000Res 2018;7 Epub 2018 Oct 29 doi: 10.12688/f1000research.16189.1. PMID: 30416710Free PMC Article
Peyrefitte C, Marianneau P, Tordo N, Bouloy M
Rev Sci Tech 2015 Aug;34(2):391-401. PMID: 26601443
Vorou R, Pierroutsakos IN, Maltezou HC
Curr Opin Infect Dis 2007 Oct;20(5):495-500. doi: 10.1097/QCO.0b013e3282a56a0a. PMID: 17762783

Prognosis

Oygar PD, Gürlevik SL, Sağ E, İlbay S, Aksu T, Demir OO, Coşgun Y, Eyüpoğlu SA, Karakaya J, Cangül ŞÜ, Cengiz AB, Özsürekci Y
Emerg Infect Dis 2023 Feb;29(2):268-277. doi: 10.3201/eid2902.220976. PMID: 36692327Free PMC Article
Mendoza EJ, Warner B, Safronetz D, Ranadheera C
Zoonoses Public Health 2018 Aug;65(5):465-480. Epub 2018 Apr 20 doi: 10.1111/zph.12469. PMID: 29676526Free PMC Article
Burnett MW
J Spec Oper Med 2015 Winter;15(4):96-98. doi: 10.55460/LEK6-UBAB. PMID: 26630102
Mardani M, Keshtkar-Jahromi M
Arch Iran Med 2007 Apr;10(2):204-14. PMID: 17367225
Flick R, Whitehouse CA
Curr Mol Med 2005 Dec;5(8):753-60. doi: 10.2174/156652405774962335. PMID: 16375710

Clinical prediction guides

Oygar PD, Gürlevik SL, Sağ E, İlbay S, Aksu T, Demir OO, Coşgun Y, Eyüpoğlu SA, Karakaya J, Cangül ŞÜ, Cengiz AB, Özsürekci Y
Emerg Infect Dis 2023 Feb;29(2):268-277. doi: 10.3201/eid2902.220976. PMID: 36692327Free PMC Article
Bratuleanu B, Anita A, Temmam S, Dascalu A, Crivei L, Cozma A, Pourquier P, Savuta G, Eloit M, Anita D
Vector Borne Zoonotic Dis 2022 Jul;22(7):397-401. Epub 2022 Jun 30 doi: 10.1089/vbz.2021.0091. PMID: 35772004
Ak Ç, Ergönül Ö, Gönen M
Clin Microbiol Infect 2020 Jan;26(1):123.e1-123.e7. Epub 2019 May 24 doi: 10.1016/j.cmi.2019.05.006. PMID: 31129282Free PMC Article
Akinci E, Bodur H, Sunbul M, Leblebicioglu H
Antiviral Res 2016 Aug;132:233-43. Epub 2016 Jul 1 doi: 10.1016/j.antiviral.2016.06.011. PMID: 27378224
Messina JP, Pigott DM, Golding N, Duda KA, Brownstein JS, Weiss DJ, Gibson H, Robinson TP, Gilbert M, William Wint GR, Nuttall PA, Gething PW, Myers MF, George DB, Hay SI
Trans R Soc Trop Med Hyg 2015 Aug;109(8):503-13. Epub 2015 Jul 4 doi: 10.1093/trstmh/trv050. PMID: 26142451Free PMC Article

Recent systematic reviews

Sadeghi H, Nikkhahi F, Maleki MR, Simiari A, Bakht M, Gholamzadeh Khoei S
Microb Pathog 2023 Aug;181:106153. Epub 2023 Jun 7 doi: 10.1016/j.micpath.2023.106153. PMID: 37295483
Monsalve-Arteaga L, Alonso-Sardón M, Muñoz Bellido JL, Vicente Santiago MB, Vieira Lista MC, López Abán J, Muro A, Belhassen-García M
PLoS Negl Trop Dis 2020 Mar;14(3):e0008094. Epub 2020 Mar 2 doi: 10.1371/journal.pntd.0008094. PMID: 32119682Free PMC Article
Pshenichnaya NY, Leblebicioglu H, Bozkurt I, Sannikova IV, Abuova GN, Zhuravlev AS, Barut S, Shermetova MB, Fletcher TE
Int J Infect Dis 2017 May;58:58-64. Epub 2017 Feb 27 doi: 10.1016/j.ijid.2017.02.019. PMID: 28249811Free PMC Article
Leblebicioglu H, Ozaras R, Fletcher TE, Beeching NJ; ESCMID Study Group for Infections in Travellers and Migrants (ESGITM)
Travel Med Infect Dis 2016 Mar-Apr;14(2):73-80. Epub 2016 Mar 10 doi: 10.1016/j.tmaid.2016.03.002. PMID: 26970396Free PMC Article
Soares-Weiser K, Thomas S, Thomson G, Garner P
BMC Infect Dis 2010 Jul 13;10:207. doi: 10.1186/1471-2334-10-207. PMID: 20626907Free PMC Article

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