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Crimean-Congo hemorrhagic fever

MedGen UID:
6800
•Concept ID:
C0019099
•
Disease or Syndrome
Synonyms: Congo Crimean Hemorrhagic Fever; Congo Virus Infection; Congo-Crimean Hemorrhagic Fever; Crimean Congo Haemorrhagic Fever; Crimean Congo Hemorrhagic Fever; Crimean Hemorrhagic Fever; Crimean-Congo Haemorrhagic Fever; Crimean-Congo Hemorrhagic Fever; Fever, Congo-Crimean Hemorrhagic; Fever, Crimean Hemorrhagic; Fever, Crimean-Congo Haemorrhagic; Fever, Crimean-Congo Hemorrhagic; Haemorrhagic Fever, Crimean-Congo; Hemorrhagic Fever, Congo-Crimean; Hemorrhagic Fever, Crimean; Hemorrhagic Fever, Crimean-Congo; Infection, Congo Virus
SNOMED CT: CHF - Crimean hemorrhagic fever (43489008); Crimean-Congo hemorrhagic fever (43489008); CCHF - Crimean-Congo hemorrhagic fever (43489008); Congo fever (43489008); Viral hemorrhagic fever, Crimean-Congo (43489008); Congo-Crimean hemorrhagic fever (43489008); Crimean hemorrhagic fever (43489008); Central Asian hemorrhagic fever (43489008)
 
Monarch Initiative: MONDO:0020501
Orphanet: ORPHA99827

Definition

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by CCHF virus and characterized by initial fever, headache, and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock, and multi-organ system failure. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCrimean-Congo hemorrhagic fever

Professional guidelines

PubMed

Crimean-Congo Hemorrhagic Fever Virus for Clinicians-Diagnosis, Clinical Management, and Therapeutics.
Frank MG, Weaver G, Raabe V; State of the Clinical Science Working Group of the National Emerging Pathogens Training; Education Center’s Special Pathogens Research Network2; State of the Clinical Science Working Group of the National Emerging Pathogens Training Education Center’s Special Pathogens Research Network
Emerg Infect Dis 2024 May;30(5):864-873. doi: 10.3201/eid3005.231648. PMID: 38666553Free PMC Article
Recent advances in treatment Crimean-Congo hemorrhagic fever virus: A concise overview.
Gholizadeh O, Jafari MM, Zoobinparan R, Yasamineh S, Tabatabaie R, Akbarzadeh S, Amini P, Eslami M, Yousefi B, Dadashpour M
Microb Pathog 2022 Aug;169:105657. Epub 2022 Jun 24 doi: 10.1016/j.micpath.2022.105657. PMID: 35753597
Treatment of Crimean-Congo hemorrhagic fever.
Ergonul O
Antiviral Res 2008 Apr;78(1):125-31. Epub 2007 Dec 3 doi: 10.1016/j.antiviral.2007.11.002. PMID: 18096251

Recent clinical studies

Etiology

Third International Conference on Crimean-Congo Hemorrhagic Fever in Thessaloniki, Greece, September 19-21, 2023.
Welch SR, Garrison AR, Bente DA, Burt F, D'Addiego J, Devignot S, Dowall S, Fischer K, Hawman DW, Hewson R, Mirazimi A, Oestereich L, Vatansever Z, Spengler JR, Papa A
Antiviral Res 2024 May;225:105844. Epub 2024 Feb 29 doi: 10.1016/j.antiviral.2024.105844. PMID: 38428749
Crimean-Congo haemorrhagic fever virus.
Hawman DW, Feldmann H
Nat Rev Microbiol 2023 Jul;21(7):463-477. Epub 2023 Mar 14 doi: 10.1038/s41579-023-00871-9. PMID: 36918725Free PMC Article
Crimean-Congo hemorrhagic fever: Immunopathogenesis and recent advances in the development of vaccines.
Munir F, Shakoor A, Sindhu ZUD, Aleem MT
Microb Pathog 2023 Apr;177:106054. Epub 2023 Mar 5 doi: 10.1016/j.micpath.2023.106054. PMID: 36882130
Crimean-Congo hemorrhagic fever virus in Central, Eastern, and South-eastern Asia.
Fereidouni M, Apanaskevich DA, Pecor DB, Pshenichnaya NY, Abuova GN, Tishkova FH, Bumburidi Y, Zeng X, Kuhn JH, Keshtkar-Jahromi M
Virol Sin 2023 Apr;38(2):171-183. Epub 2023 Jan 18 doi: 10.1016/j.virs.2023.01.001. PMID: 36669701Free PMC Article
Emerging Tick-Borne Diseases.
Madison-Antenucci S, Kramer LD, Gebhardt LL, Kauffman E
Clin Microbiol Rev 2020 Mar 18;33(2) Epub 2020 Jan 2 doi: 10.1128/CMR.00083-18. PMID: 31896541Free PMC Article

Diagnosis

Crimean-Congo Hemorrhagic Fever, Spain, 2013-2021.
Lorenzo Juanes HM, Carbonell C, Sendra BF, López-Bernus A, Bahamonde A, Orfao A, Lista CV, Ledesma MS, Negredo AI, Rodríguez-Alonso B, Bua BR, Sánchez-Seco MP, Muñoz Bellido JL, Muro A, Belhassen-García M
Emerg Infect Dis 2023 Feb;29(2):252-259. doi: 10.3201/eid2902.220677. PMID: 36692301Free PMC Article
Emerging Tick-Borne Diseases.
Madison-Antenucci S, Kramer LD, Gebhardt LL, Kauffman E
Clin Microbiol Rev 2020 Mar 18;33(2) Epub 2020 Jan 2 doi: 10.1128/CMR.00083-18. PMID: 31896541Free PMC Article
Crimean-Congo hemorrhagic fever: An update.
Fillâtre P, Revest M, Tattevin P
Med Mal Infect 2019 Nov;49(8):574-585. Epub 2019 Oct 10 doi: 10.1016/j.medmal.2019.09.005. PMID: 31607406
Crimean-Congo Hemorrhagic Fever.
Shayan S, Bokaean M, Shahrivar MR, Chinikar S
Lab Med 2015 Summer;46(3):180-9. doi: 10.1309/LMN1P2FRZ7BKZSCO. PMID: 26199256
Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity.
Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M
Antiviral Res 2013 Oct;100(1):159-89. Epub 2013 Jul 29 doi: 10.1016/j.antiviral.2013.07.006. PMID: 23906741

Therapy

Favipiravir and Ribavirin protect immunocompetent mice from lethal CCHFV infection.
Tipih T, Meade-White K, Rao D, Bushmaker T, Lewis M, Shaia C, Feldmann H, Hawman DW
Antiviral Res 2023 Oct;218:105703. Epub 2023 Aug 21 doi: 10.1016/j.antiviral.2023.105703. PMID: 37611878
Crimean-Congo haemorrhagic fever virus.
Hawman DW, Feldmann H
Nat Rev Microbiol 2023 Jul;21(7):463-477. Epub 2023 Mar 14 doi: 10.1038/s41579-023-00871-9. PMID: 36918725Free PMC Article
Crimean-Congo haemorrhagic fever.
Peyrefitte C, Marianneau P, Tordo N, Bouloy M
Rev Sci Tech 2015 Aug;34(2):391-401. PMID: 26601443
Crimean-Congo hemorrhagic fever.
Vorou R, Pierroutsakos IN, Maltezou HC
Curr Opin Infect Dis 2007 Oct;20(5):495-500. doi: 10.1097/QCO.0b013e3282a56a0a. PMID: 17762783
Crimean-Congo hemorrhagic fever.
Mardani M, Keshtkar-Jahromi M
Arch Iran Med 2007 Apr;10(2):204-14. PMID: 17367225

Prognosis

Seroepidemiological investigation of Crimean Congo hemorrhagic fever virus in livestock in Uganda, 2017.
Nyakarahuka L, Kyondo J, Telford C, Whitesell A, Tumusiime A, Mulei S, Baluku J, Cossaboom CM, Cannon DL, Montgomery JM, Lutwama JJ, Nichol ST, Balinandi SK, Klena JD, Shoemaker TR
PLoS One 2023;18(11):e0288587. Epub 2023 Nov 9 doi: 10.1371/journal.pone.0288587. PMID: 37943886Free PMC Article
Changing Disease Course of Crimean-Congo Hemorrhagic Fever in Children, Turkey.
Oygar PD, Gürlevik SL, Sağ E, İlbay S, Aksu T, Demir OO, Coşgun Y, Eyüpoğlu SA, Karakaya J, Cangül ŞÜ, Cengiz AB, Özsürekci Y
Emerg Infect Dis 2023 Feb;29(2):268-277. doi: 10.3201/eid2902.220976. PMID: 36692327Free PMC Article
Crimean-Congo Hemorrhagic Fever.
Burnett MW
J Spec Oper Med 2015 Winter;15(4):96-98. doi: 10.55460/LEK6-UBAB. PMID: 26630102
Crimean-Congo hemorrhagic fever.
Mardani M, Keshtkar-Jahromi M
Arch Iran Med 2007 Apr;10(2):204-14. PMID: 17367225
Crimean-Congo hemorrhagic fever virus.
Flick R, Whitehouse CA
Curr Mol Med 2005 Dec;5(8):753-60. doi: 10.2174/156652405774962335. PMID: 16375710

Clinical prediction guides

Predictive epidemiological, clinical and laboratory parameters in the diagnosis of Crimean-Congo hemorrhagic fever.
Kaygusuz TÖ, Tartar AS, Balin ŞÖ, Akbulut A, Demirdağ K
Biomark Med 2023 Jun;17(11):533-540. Epub 2023 Oct 4 doi: 10.2217/bmm-2023-0330. PMID: 37791843
Changing Disease Course of Crimean-Congo Hemorrhagic Fever in Children, Turkey.
Oygar PD, Gürlevik SL, Sağ E, İlbay S, Aksu T, Demir OO, Coşgun Y, Eyüpoğlu SA, Karakaya J, Cangül ŞÜ, Cengiz AB, Özsürekci Y
Emerg Infect Dis 2023 Feb;29(2):268-277. doi: 10.3201/eid2902.220976. PMID: 36692327Free PMC Article
Clinical and Molecular Epidemiology of Crimean-Congo Hemorrhagic Fever in Humans in Uganda, 2013-2019.
Balinandi S, Whitmer S, Mulei S, Nyakarahuka L, Tumusiime A, Kyondo J, Baluku J, Mutyaba J, Mugisha L, Malmberg M, Lutwama J, Shoemaker TR, Klena JD
Am J Trop Med Hyg 2021 Oct 18;106(1):88-98. doi: 10.4269/ajtmh.21-0685. PMID: 34662872Free PMC Article
Prognostic factors, pathophysiology and novel biomarkers in Crimean-Congo hemorrhagic fever.
Akinci E, Bodur H, Sunbul M, Leblebicioglu H
Antiviral Res 2016 Aug;132:233-43. Epub 2016 Jul 1 doi: 10.1016/j.antiviral.2016.06.011. PMID: 27378224
The global distribution of Crimean-Congo hemorrhagic fever.
Messina JP, Pigott DM, Golding N, Duda KA, Brownstein JS, Weiss DJ, Gibson H, Robinson TP, Gilbert M, William Wint GR, Nuttall PA, Gething PW, Myers MF, George DB, Hay SI
Trans R Soc Trop Med Hyg 2015 Aug;109(8):503-13. Epub 2015 Jul 4 doi: 10.1093/trstmh/trv050. PMID: 26142451Free PMC Article

Recent systematic reviews

Status of Crimean-Congo haemorrhagic fever virus in ticks in Iran: A systematic review with meta-analysis.
Sadeghi H, Nikkhahi F, Maleki MR, Simiari A, Bakht M, Gholamzadeh Khoei S
Microb Pathog 2023 Aug;181:106153. Epub 2023 Jun 7 doi: 10.1016/j.micpath.2023.106153. PMID: 37295483
Crimean-Congo hemorrhagic fever (CCHF) seroprevalence: A systematic review and meta-analysis.
Nasirian H
Acta Trop 2019 Aug;196:102-120. Epub 2019 May 18 doi: 10.1016/j.actatropica.2019.05.019. PMID: 31108083
Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey.
Pshenichnaya NY, Leblebicioglu H, Bozkurt I, Sannikova IV, Abuova GN, Zhuravlev AS, Barut S, Shermetova MB, Fletcher TE
Int J Infect Dis 2017 May;58:58-64. Epub 2017 Feb 27 doi: 10.1016/j.ijid.2017.02.019. PMID: 28249811Free PMC Article
Crimean-Congo haemorrhagic fever in travellers: A systematic review.
Leblebicioglu H, Ozaras R, Fletcher TE, Beeching NJ; ESCMID Study Group for Infections in Travellers and Migrants (ESGITM)
Travel Med Infect Dis 2016 Mar-Apr;14(2):73-80. Epub 2016 Mar 10 doi: 10.1016/j.tmaid.2016.03.002. PMID: 26970396Free PMC Article
Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and meta-analysis.
Soares-Weiser K, Thomas S, Thomson G, Garner P
BMC Infect Dis 2010 Jul 13;10:207. doi: 10.1186/1471-2334-10-207. PMID: 20626907Free PMC Article

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