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Exsanguination

MedGen UID:
68550
Concept ID:
C0232100
Pathologic Function
Synonyms: Exsanguinating Hemorrhage; Exsanguinating Hemorrhages; Hemorrhage, Exsanguinating; Hemorrhages, Exsanguinating
SNOMED CT: Exsanguination (48149007); Total blood loss (48149007)

Definition

Extensive loss of blood due to internal or external hemorrhage. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Patch DA, Hess MC, Spitler CA, Johnson JP
J Am Acad Orthop Surg 2022 Sep 15;30(18):888-895. Epub 2022 May 24 doi: 10.5435/JAAOS-D-21-01018. PMID: 36166384
Lord JM, Midwinter MJ, Chen YF, Belli A, Brohi K, Kovacs EJ, Koenderman L, Kubes P, Lilford RJ
Lancet 2014 Oct 18;384(9952):1455-65. Epub 2014 Oct 17 doi: 10.1016/S0140-6736(14)60687-5. PMID: 25390327Free PMC Article
Saers SJ, Scheltinga MR
Br J Surg 2005 Feb;92(2):143-52. doi: 10.1002/bjs.4928. PMID: 15685700

Recent clinical studies

Etiology

Jansen JO, Hudson J, Cochran C, MacLennan G, Lendrum R, Sadek S, Gillies K, Cotton S, Kennedy C, Boyers D, Ferry G, Lawrie L, Nath M, Wileman S, Forrest M, Brohi K, Harris T, Lecky F, Moran C, Morrison JJ, Norrie J, Paterson A, Tai N, Welch N, Campbell MK; UK-REBOA Study Group, Aylwin C, Bew D, Brooks A, Chinery J, Cowlam T, Frith D, George A, Hudson A, Johnstone P, Mahmood A, Novak A, O'Meara M, Reid S, Sattout A, Smith C, Stansfield T, Thompson J
JAMA 2023 Nov 21;330(19):1862-1871. doi: 10.1001/jama.2023.20850. PMID: 37824132Free PMC Article
Oyelese Y, Javinani A, Shamshirsaz AA
Obstet Gynecol 2023 Sep 1;142(3):503-518. Epub 2023 Aug 3 doi: 10.1097/AOG.0000000000005287. PMID: 37590981Free PMC Article
Integrate (The National ENT Trainee Research Network)
J Laryngol Otol 2018 Dec;132(12):1061-1066. Epub 2018 Nov 20 doi: 10.1017/S0022215118002013. PMID: 30457066
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article
Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, Cook L, Kawahara T, Perel P, Prieto-Merino D, Ramos M, Cairns J, Guerriero C
Health Technol Assess 2013 Mar;17(10):1-79. doi: 10.3310/hta17100. PMID: 23477634Free PMC Article

Diagnosis

Oyelese Y, Javinani A, Shamshirsaz AA
Obstet Gynecol 2023 Sep 1;142(3):503-518. Epub 2023 Aug 3 doi: 10.1097/AOG.0000000000005287. PMID: 37590981Free PMC Article
Panther EJ, Reintgen CD, Cueto RJ, Hao KA, Chim H, King JJ
J Shoulder Elbow Surg 2022 Nov;31(11):e545-e561. Epub 2022 Aug 10 doi: 10.1016/j.jse.2022.06.026. PMID: 35963513
Deshwal H, Sinha A, Mehta AC
Semin Respir Crit Care Med 2021 Feb;42(1):145-159. Epub 2020 Aug 30 doi: 10.1055/s-0040-1714386. PMID: 32862418
Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, Cook L, Kawahara T, Perel P, Prieto-Merino D, Ramos M, Cairns J, Guerriero C
Health Technol Assess 2013 Mar;17(10):1-79. doi: 10.3310/hta17100. PMID: 23477634Free PMC Article
Carter R, Mulder GA, Snyder EN Jr, Brewer LA 3rd
Am J Surg 1978 Jul;136(1):26-30. doi: 10.1016/0002-9610(78)90195-2. PMID: 677387

Therapy

Jansen JO, Hudson J, Cochran C, MacLennan G, Lendrum R, Sadek S, Gillies K, Cotton S, Kennedy C, Boyers D, Ferry G, Lawrie L, Nath M, Wileman S, Forrest M, Brohi K, Harris T, Lecky F, Moran C, Morrison JJ, Norrie J, Paterson A, Tai N, Welch N, Campbell MK; UK-REBOA Study Group, Aylwin C, Bew D, Brooks A, Chinery J, Cowlam T, Frith D, George A, Hudson A, Johnstone P, Mahmood A, Novak A, O'Meara M, Reid S, Sattout A, Smith C, Stansfield T, Thompson J
JAMA 2023 Nov 21;330(19):1862-1871. doi: 10.1001/jama.2023.20850. PMID: 37824132Free PMC Article
Oyelese Y, Javinani A, Shamshirsaz AA
Obstet Gynecol 2023 Sep 1;142(3):503-518. Epub 2023 Aug 3 doi: 10.1097/AOG.0000000000005287. PMID: 37590981Free PMC Article
Ganuza M, McKinney-Freeman S
Curr Opin Hematol 2017 Jul;24(4):314-321. doi: 10.1097/MOH.0000000000000347. PMID: 28375987Free PMC Article
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article
Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, Cook L, Kawahara T, Perel P, Prieto-Merino D, Ramos M, Cairns J, Guerriero C
Health Technol Assess 2013 Mar;17(10):1-79. doi: 10.3310/hta17100. PMID: 23477634Free PMC Article

Prognosis

Integrate (The National ENT Trainee Research Network)
J Laryngol Otol 2018 Dec;132(12):1061-1066. Epub 2018 Nov 20 doi: 10.1017/S0022215118002013. PMID: 30457066
Goforth CW, Tranberg JW, Boyer P, Silvestri PJ
Crit Care Nurse 2016 Jun;36(3):50-7. doi: 10.4037/ccn2016780. PMID: 27252101
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article
Schöchl H, Grassetto A, Schlimp CJ
J Cardiothorac Vasc Anesth 2013 Aug;27(4 Suppl):S35-43. doi: 10.1053/j.jvca.2013.05.015. PMID: 23910535
Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, Cook L, Kawahara T, Perel P, Prieto-Merino D, Ramos M, Cairns J, Guerriero C
Health Technol Assess 2013 Mar;17(10):1-79. doi: 10.3310/hta17100. PMID: 23477634Free PMC Article

Clinical prediction guides

Jansen JO, Hudson J, Cochran C, MacLennan G, Lendrum R, Sadek S, Gillies K, Cotton S, Kennedy C, Boyers D, Ferry G, Lawrie L, Nath M, Wileman S, Forrest M, Brohi K, Harris T, Lecky F, Moran C, Morrison JJ, Norrie J, Paterson A, Tai N, Welch N, Campbell MK; UK-REBOA Study Group, Aylwin C, Bew D, Brooks A, Chinery J, Cowlam T, Frith D, George A, Hudson A, Johnstone P, Mahmood A, Novak A, O'Meara M, Reid S, Sattout A, Smith C, Stansfield T, Thompson J
JAMA 2023 Nov 21;330(19):1862-1871. doi: 10.1001/jama.2023.20850. PMID: 37824132Free PMC Article
Eleti S, Roshen M, Griffiths M, Cross S
Clin Radiol 2021 Oct;76(10):787.e15-787.e25. Epub 2021 Jun 6 doi: 10.1016/j.crad.2021.05.012. PMID: 34108097
Integrate (The National ENT Trainee Research Network)
J Laryngol Otol 2018 Dec;132(12):1061-1066. Epub 2018 Nov 20 doi: 10.1017/S0022215118002013. PMID: 30457066
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article
Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, Cook L, Kawahara T, Perel P, Prieto-Merino D, Ramos M, Cairns J, Guerriero C
Health Technol Assess 2013 Mar;17(10):1-79. doi: 10.3310/hta17100. PMID: 23477634Free PMC Article

Recent systematic reviews

Granieri S, Frassini S, Cimbanassi S, Bonomi A, Paleino S, Lomaglio L, Chierici A, Bruno F, Biondi R, Di Saverio S, Khan M, Cotsoglou C
Eur J Trauma Emerg Surg 2022 Oct;48(5):3561-3574. Epub 2022 Mar 20 doi: 10.1007/s00068-022-01955-6. PMID: 35307763
Borger van der Burg BLS, van Dongen TTCF, Morrison JJ, Hedeman Joosten PPA, DuBose JJ, Hörer TM, Hoencamp R
Eur J Trauma Emerg Surg 2018 Aug;44(4):535-550. Epub 2018 May 21 doi: 10.1007/s00068-018-0959-y. PMID: 29785654Free PMC Article
Cattaneo C, Maderna E, Rendinelli A, Gibelli D
Forensic Sci Int 2015 Sep;254:e29-35. Epub 2015 Jul 15 doi: 10.1016/j.forsciint.2015.06.024. PMID: 26216717
Rowland SP, Dharmarajah B, Moore HM, Dharmarajah K, Davies AH
J Trauma Acute Care Surg 2014 Aug;77(2):356-63. doi: 10.1097/TA.0000000000000312. PMID: 25058265
Granville-Chapman J, Jacobs N, Midwinter MJ
Injury 2011 May;42(5):447-59. doi: 10.1016/j.injury.2010.09.037. PMID: 21035118

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