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No reflow vascular flow

MedGen UID:
68561
Concept ID:
C0232347
Finding
Synonyms: No Reflow Phenomenon; No-Reflow Phenomenon
SNOMED CT: No reflow vascular flow (67326007); No reflow phenomenon (67326007)

Definition

Markedly reduced or absent REPERFUSION in an infarct zone following the removal of an obstruction or constriction of an artery. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNo reflow vascular flow

Professional guidelines

PubMed

Xenogiannis I, Zenati M, Bhatt DL, Rao SV, Rodés-Cabau J, Goldman S, Shunk KA, Mavromatis K, Banerjee S, Alaswad K, Nikolakopoulos I, Vemmou E, Karacsonyi J, Alexopoulos D, Burke MN, Bapat VN, Brilakis ES
Circulation 2021 Aug 31;144(9):728-745. Epub 2021 Aug 30 doi: 10.1161/CIRCULATIONAHA.120.052163. PMID: 34460327
Allencherril J, Jneid H, Atar D, Alam M, Levine G, Kloner RA, Birnbaum Y
Cardiovasc Drugs Ther 2019 Oct;33(5):589-597. doi: 10.1007/s10557-019-06901-0. PMID: 31418141
Muller O, Trana C, Eeckhout E
Curr Vasc Pharmacol 2013 Mar 1;11(2):278-85. PMID: 23506504

Recent clinical studies

Etiology

Caiazzo G, Musci RL, Frediani L, Umińska J, Wanha W, Filipiak KJ, Kubica J, Navarese EP
Cardiol Clin 2020 Nov;38(4):563-573. Epub 2020 Sep 17 doi: 10.1016/j.ccl.2020.07.001. PMID: 33036718
Sucato V, Novo G, Saladino A, Evola S, Galassi AR
Minerva Cardioangiol 2020 Apr;68(2):153-163. Epub 2020 Feb 20 doi: 10.23736/S0026-4725.20.05070-7. PMID: 32083426
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Allencherril J, Jneid H, Atar D, Alam M, Levine G, Kloner RA, Birnbaum Y
Cardiovasc Drugs Ther 2019 Oct;33(5):589-597. doi: 10.1007/s10557-019-06901-0. PMID: 31418141
Magro M, Springeling T, van Geuns RJ, Zijlstra F
Curr Vasc Pharmacol 2013 Mar 1;11(2):263-77. PMID: 23506503

Diagnosis

Zhang Y, Jiang M, Gao Y, Zhao W, Wu C, Li C, Li M, Wu D, Wang W, Ji X
J Cereb Blood Flow Metab 2024 Jan;44(1):19-37. Epub 2023 Oct 19 doi: 10.1177/0271678X231208476. PMID: 37855115Free PMC Article
Xenogiannis I, Zenati M, Bhatt DL, Rao SV, Rodés-Cabau J, Goldman S, Shunk KA, Mavromatis K, Banerjee S, Alaswad K, Nikolakopoulos I, Vemmou E, Karacsonyi J, Alexopoulos D, Burke MN, Bapat VN, Brilakis ES
Circulation 2021 Aug 31;144(9):728-745. Epub 2021 Aug 30 doi: 10.1161/CIRCULATIONAHA.120.052163. PMID: 34460327
Sucato V, Novo G, Saladino A, Evola S, Galassi AR
Minerva Cardioangiol 2020 Apr;68(2):153-163. Epub 2020 Feb 20 doi: 10.23736/S0026-4725.20.05070-7. PMID: 32083426
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G
Cardiovasc Res 2019 Jun 1;115(7):1143-1155. doi: 10.1093/cvr/cvy286. PMID: 30428011Free PMC Article

Therapy

Bashtawi Y, Almuwaqqat Z
Cardiovasc Revasc Med 2021 Aug;29:77-84. Epub 2020 Aug 7 doi: 10.1016/j.carrev.2020.08.004. PMID: 32807668
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G
Cardiovasc Res 2019 Jun 1;115(7):1143-1155. doi: 10.1093/cvr/cvy286. PMID: 30428011Free PMC Article
Muller O, Trana C, Eeckhout E
Curr Vasc Pharmacol 2013 Mar 1;11(2):278-85. PMID: 23506504
Magro M, Springeling T, van Geuns RJ, Zijlstra F
Curr Vasc Pharmacol 2013 Mar 1;11(2):263-77. PMID: 23506503

Prognosis

Zhang Y, Jiang M, Gao Y, Zhao W, Wu C, Li C, Li M, Wu D, Wang W, Ji X
J Cereb Blood Flow Metab 2024 Jan;44(1):19-37. Epub 2023 Oct 19 doi: 10.1177/0271678X231208476. PMID: 37855115Free PMC Article
Sucato V, Novo G, Saladino A, Evola S, Galassi AR
Minerva Cardioangiol 2020 Apr;68(2):153-163. Epub 2020 Feb 20 doi: 10.23736/S0026-4725.20.05070-7. PMID: 32083426
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G
Cardiovasc Res 2019 Jun 1;115(7):1143-1155. doi: 10.1093/cvr/cvy286. PMID: 30428011Free PMC Article
Schwartz BG, Kloner RA
J Mol Cell Cardiol 2012 Apr;52(4):873-82. Epub 2011 Jun 21 doi: 10.1016/j.yjmcc.2011.06.009. PMID: 21712046

Clinical prediction guides

Hu J, Nan D, Lu Y, Niu Z, Ren Y, Qu X, Huang Y, Jin H
Eur Neurol 2023;86(2):85-94. Epub 2023 Jan 6 doi: 10.1159/000528250. PMID: 36617418
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Kloner RA, King KS, Harrington MG
Am J Physiol Heart Circ Physiol 2018 Sep 1;315(3):H550-H562. Epub 2018 Jun 8 doi: 10.1152/ajpheart.00183.2018. PMID: 29882685
Magro M, Springeling T, van Geuns RJ, Zijlstra F
Curr Vasc Pharmacol 2013 Mar 1;11(2):263-77. PMID: 23506503
Gregorini L, Marco J, Heusch G
J Mol Cell Cardiol 2012 Apr;52(4):883-9. Epub 2011 Sep 24 doi: 10.1016/j.yjmcc.2011.09.017. PMID: 21971073

Recent systematic reviews

Mujanovic A, Ng F, Meinel TR, Dobrocky T, Piechowiak EI, Kurmann CC, Seiffge DJ, Wegener S, Wiest R, Meyer L, Fiehler J, Olivot JM, Ribo M, Nguyen TN, Gralla J, Campbell BC, Fischer U, Kaesmacher J
Int J Stroke 2024 Jan;19(1):58-67. Epub 2023 Jun 8 doi: 10.1177/17474930231180434. PMID: 37231702
Vakhshoori M, Nemati S, Sabouhi S, Shakarami M, Yavari B, Emami SA, Bondariyan N, Shafie D
J Int Med Res 2023 Oct;51(10):3000605231204469. doi: 10.1177/03000605231204469. PMID: 37848392Free PMC Article
Rehan ST, Imran L, Salim A, Javed SO, Sohail A, Hussain HU, Ahmed J, Yasmin F, Islam MS, Asghar MS
Future Cardiol 2023 Mar;19(3):163-174. Epub 2023 Jun 2 doi: 10.2217/fca-2022-0085. PMID: 37264944
Su Q, Nyi TS, Li L
Cochrane Database Syst Rev 2015 May 18;2015(5):CD009503. doi: 10.1002/14651858.CD009503.pub3. PMID: 25985145Free PMC Article
Aung Naing K, Li L, Su Q, Wu T
Cochrane Database Syst Rev 2013 Jun 4;(6):CD009503. doi: 10.1002/14651858.CD009503.pub2. PMID: 23736949

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