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No reflow vascular flow

MedGen UID:
68561
•Concept ID:
C0232347
•
Finding
Synonyms: No Reflow Phenomenon; No-Reflow Phenomenon
SNOMED CT: No reflow vascular flow (67326007); No reflow phenomenon (67326007)

Definition

Markedly reduced or absent REPERFUSION in an infarct zone following the removal of an obstruction or constriction of an artery. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNo reflow vascular flow

Professional guidelines

PubMed

Saphenous Vein Graft Failure: From Pathophysiology to Prevention and Treatment Strategies.
Xenogiannis I, Zenati M, Bhatt DL, Rao SV, Rodés-Cabau J, Goldman S, Shunk KA, Mavromatis K, Banerjee S, Alaswad K, Nikolakopoulos I, Vemmou E, Karacsonyi J, Alexopoulos D, Burke MN, Bapat VN, Brilakis ES
Circulation 2021 Aug 31;144(9):728-745. Epub 2021 Aug 30 doi: 10.1161/CIRCULATIONAHA.120.052163. PMID: 34460327
Slow Coronary Flow: Pathophysiology, Clinical Implications, and Therapeutic Management.
Chalikias G, Tziakas D
Angiology 2021 Oct;72(9):808-818. Epub 2021 Mar 29 doi: 10.1177/00033197211004390. PMID: 33779300
Myocardial no-reflow treatment.
Muller O, Trana C, Eeckhout E
Curr Vasc Pharmacol 2013 Mar 1;11(2):278-85. PMID: 23506504

Recent clinical studies

Etiology

Slow Coronary Flow: Pathophysiology, Clinical Implications, and Therapeutic Management.
Chalikias G, Tziakas D
Angiology 2021 Oct;72(9):808-818. Epub 2021 Mar 29 doi: 10.1177/00033197211004390. PMID: 33779300
State of the Art: No-Reflow Phenomenon.
Caiazzo G, Musci RL, Frediani L, Umińska J, Wanha W, Filipiak KJ, Kubica J, Navarese EP
Cardiol Clin 2020 Nov;38(4):563-573. Epub 2020 Sep 17 doi: 10.1016/j.ccl.2020.07.001. PMID: 33036718
Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction.
Su Q, Nyi TS, Li L
Cochrane Database Syst Rev 2015 May 18;2015(5):CD009503. doi: 10.1002/14651858.CD009503.pub3. PMID: 25985145Free PMC Article
Myocardial 'no-reflow' prevention.
Magro M, Springeling T, van Geuns RJ, Zijlstra F
Curr Vasc Pharmacol 2013 Mar 1;11(2):263-77. PMID: 23506503

Diagnosis

Saphenous Vein Graft Failure: From Pathophysiology to Prevention and Treatment Strategies.
Xenogiannis I, Zenati M, Bhatt DL, Rao SV, Rodés-Cabau J, Goldman S, Shunk KA, Mavromatis K, Banerjee S, Alaswad K, Nikolakopoulos I, Vemmou E, Karacsonyi J, Alexopoulos D, Burke MN, Bapat VN, Brilakis ES
Circulation 2021 Aug 31;144(9):728-745. Epub 2021 Aug 30 doi: 10.1161/CIRCULATIONAHA.120.052163. PMID: 34460327
Slow Coronary Flow: Pathophysiology, Clinical Implications, and Therapeutic Management.
Chalikias G, Tziakas D
Angiology 2021 Oct;72(9):808-818. Epub 2021 Mar 29 doi: 10.1177/00033197211004390. PMID: 33779300
State of the Art: No-Reflow Phenomenon.
Caiazzo G, Musci RL, Frediani L, Umińska J, Wanha W, Filipiak KJ, Kubica J, Navarese EP
Cardiol Clin 2020 Nov;38(4):563-573. Epub 2020 Sep 17 doi: 10.1016/j.ccl.2020.07.001. PMID: 33036718
Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection.
Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G
Cardiovasc Res 2019 Jun 1;115(7):1143-1155. doi: 10.1093/cvr/cvy286. PMID: 30428011Free PMC Article

Therapy

Clinically Ineffective Reperfusion After Endovascular Therapy in Acute Ischemic Stroke.
Nie X, Leng X, Miao Z, Fisher M, Liu L
Stroke 2023 Mar;54(3):873-881. Epub 2022 Dec 7 doi: 10.1161/STROKEAHA.122.038466. PMID: 36475464
Prevalence and Significance of Impaired Microvascular Tissue Reperfusion Despite Macrovascular Angiographic Reperfusion (No-Reflow).
Ng FC, Churilov L, Yassi N, Kleinig TJ, Thijs V, Wu T, Shah D, Dewey H, Sharma G, Desmond P, Yan B, Parsons M, Donnan G, Davis S, Mitchell P, Campbell B
Neurology 2022 Feb 22;98(8):e790-e801. Epub 2021 Dec 14 doi: 10.1212/WNL.0000000000013210. PMID: 34906976
State of the Art: No-Reflow Phenomenon.
Caiazzo G, Musci RL, Frediani L, Umińska J, Wanha W, Filipiak KJ, Kubica J, Navarese EP
Cardiol Clin 2020 Nov;38(4):563-573. Epub 2020 Sep 17 doi: 10.1016/j.ccl.2020.07.001. PMID: 33036718
Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection.
Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G
Cardiovasc Res 2019 Jun 1;115(7):1143-1155. doi: 10.1093/cvr/cvy286. PMID: 30428011Free PMC Article

Prognosis

Slow Coronary Flow: Pathophysiology, Clinical Implications, and Therapeutic Management.
Chalikias G, Tziakas D
Angiology 2021 Oct;72(9):808-818. Epub 2021 Mar 29 doi: 10.1177/00033197211004390. PMID: 33779300
State of the Art: No-Reflow Phenomenon.
Caiazzo G, Musci RL, Frediani L, Umińska J, Wanha W, Filipiak KJ, Kubica J, Navarese EP
Cardiol Clin 2020 Nov;38(4):563-573. Epub 2020 Sep 17 doi: 10.1016/j.ccl.2020.07.001. PMID: 33036718
Coronary microvascular dysfunction.
Sucato V, Novo G, Saladino A, Evola S, Galassi AR
Minerva Cardioangiol 2020 Apr;68(2):153-163. Epub 2020 Feb 20 doi: 10.23736/S0026-4725.20.05070-7. PMID: 32083426
Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection.
Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G
Cardiovasc Res 2019 Jun 1;115(7):1143-1155. doi: 10.1093/cvr/cvy286. PMID: 30428011Free PMC Article

Clinical prediction guides

Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
No-reflow phenomenon in the heart and brain.
Kloner RA, King KS, Harrington MG
Am J Physiol Heart Circ Physiol 2018 Sep 1;315(3):H550-H562. Epub 2018 Jun 8 doi: 10.1152/ajpheart.00183.2018. PMID: 29882685
Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction.
Su Q, Nyi TS, Li L
Cochrane Database Syst Rev 2015 May 18;2015(5):CD009503. doi: 10.1002/14651858.CD009503.pub3. PMID: 25985145Free PMC Article
Myocardial 'no-reflow' prevention.
Magro M, Springeling T, van Geuns RJ, Zijlstra F
Curr Vasc Pharmacol 2013 Mar 1;11(2):263-77. PMID: 23506503
Peri-interventional coronary vasomotion.
Gregorini L, Marco J, Heusch G
J Mol Cell Cardiol 2012 Apr;52(4):883-9. Epub 2011 Sep 24 doi: 10.1016/j.yjmcc.2011.09.017. PMID: 21971073

Recent systematic reviews

Advances in Coronary No-Reflow Phenomenon-a Contemporary Review.
Karimianpour A, Maran A
Curr Atheroscler Rep 2018 Jul 5;20(9):44. doi: 10.1007/s11883-018-0747-5. PMID: 29974260
Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction.
Su Q, Nyi TS, Li L
Cochrane Database Syst Rev 2015 May 18;2015(5):CD009503. doi: 10.1002/14651858.CD009503.pub3. PMID: 25985145Free PMC Article
Safety and effectiveness of nitroprusside in preventing no-reflow during percutaneous coronary intervention: a systematic review.
Su Q, Li L, Naing KA, Sun Y
Cell Biochem Biophys 2014 Jan;68(1):201-6. doi: 10.1007/s12013-013-9690-9. PMID: 23749494
Short-term effect of verapamil on coronary no-reflow associated with percutaneous coronary intervention in patients with acute coronary syndrome: a systematic review and meta-analysis of randomized controlled trials.
Su Q, Li L, Liu Y
Clin Cardiol 2013 Aug;36(8):E11-6. Epub 2013 Jun 7 doi: 10.1002/clc.22143. PMID: 23749333Free PMC Article
Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction.
Aung Naing K, Li L, Su Q, Wu T
Cochrane Database Syst Rev 2013 Jun 4;(6):CD009503. doi: 10.1002/14651858.CD009503.pub2. PMID: 23736949

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