U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Emotional blunting

MedGen UID:
68571
Concept ID:
C0233469
Mental or Behavioral Dysfunction
Synonyms: Blunted Affect; Blunted affect; Blunting of mood; Restricted Range of Emotion
SNOMED CT: Blunted affect (6140007); Emotional blunting (6140007); Blunting of mood (6140007)
 
HPO: HP:0030213

Definition

Inability to feel positive or negative emotions, feelings of detachment, or reduced emotional responsiveness. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEmotional blunting

Conditions with this feature

Pick disease
MedGen UID:
116020
Concept ID:
C0236642
Disease or Syndrome
Pick disease refers to the neuropathologic finding of 'Pick bodies,' which are argyrophilic, intraneuronal inclusions, and 'Pick cells,' which are enlarged neurons. The clinical correlates of Pick disease of brain include those of frontotemporal dementia, which encompass the behavioral variant of FTD, semantic dementia, and progressive nonfluent aphasia (summary by Piguet et al., 2011). Kertesz (2003) suggested the term 'Pick complex' to represent the overlapping syndromes of FTD, primary progressive aphasia (PPA), corticobasal degeneration (CBD), progressive supranuclear palsy (601104), and FTD with motor neuron disease. He noted that frontotemporal dementia may also be referred to as 'clinical Pick disease,' and that the term 'Pick disease' should be restricted to the pathologic finding of Pick bodies.

Professional guidelines

PubMed

Healy D, Bahrick A, Bak M, Barbato A, Calabrò RS, Chubak BM, Cosci F, Csoka AB, D'Avanzo B, Diviccaro S, Giatti S, Goldstein I, Graf H, Hellstrom WJG, Irwig MS, Jannini EA, Janssen PKC, Khera M, Kumar MT, Le Noury J, Lew-Starowicz M, Linden DEJ, Lüning C, Mangin D, Melcangi RC, Rodríguez OWMAAS, Panicker JN, Patacchini A, Pearlman AM, Pukall CF, Raj S, Reisman Y, Rubin RS, Schreiber R, Shipko S, Vašečková B, Waraich A
Int J Risk Saf Med 2022;33(1):65-76. doi: 10.3233/JRS-210023. PMID: 34719438Free PMC Article
Fagiolini A, Florea I, Loft H, Christensen MC
J Affect Disord 2021 Mar 15;283:472-479. Epub 2020 Nov 19 doi: 10.1016/j.jad.2020.11.106. PMID: 33516560
Pringle A, McCabe C, Cowen PJ, Harmer CJ
J Psychopharmacol 2013 Aug;27(8):719-31. Epub 2013 Feb 7 doi: 10.1177/0269881112474523. PMID: 23392757

Recent clinical studies

Etiology

Montano CB, Jackson WC, Vanacore D, Weisler R
Postgrad Med 2023 Jun;135(5):449-465. Epub 2023 Apr 5 doi: 10.1080/00325481.2023.2189868. PMID: 36912037
Peters EM, Balbuena L, Lodhi RJ
J Affect Disord 2022 Dec 1;318:29-32. Epub 2022 Aug 24 doi: 10.1016/j.jad.2022.08.066. PMID: 36029876
Zangrandi L, Schwarzer C
Handb Exp Pharmacol 2022;271:379-400. doi: 10.1007/164_2021_444. PMID: 33712941
Raimo S, Santangelo G, Trojano L
Handb Clin Neurol 2021;183:197-220. doi: 10.1016/B978-0-12-822290-4.00009-8. PMID: 34389118
Quang H, Wong S, Husain M, Piguet O, Hodges JR, Irish M, Kumfor F
Cortex 2021 Jun;139:73-85. Epub 2021 Mar 16 doi: 10.1016/j.cortex.2021.02.028. PMID: 33836304

Diagnosis

Jawad MY, Fatima M, Hassan U, Zaheer Z, Ayyan M, Ehsan M, Khan MHA, Qadeer A, Gull AR, Asif MT, Shad MU
Hum Psychopharmacol 2023 Jul;38(4):e2871. Epub 2023 May 15 doi: 10.1002/hup.2871. PMID: 37184083
Chen J, Chen W, Zhang H, Hong W, Zhang L, Mi W, Qin J, He Y
J Affect Disord 2022 Sep 15;313:278-282. Epub 2022 Jun 30 doi: 10.1016/j.jad.2022.06.044. PMID: 35779672
Barker MS, Cosentino SA, Fremont R, Devanand DP, Huey ED
J Geriatr Psychiatry Neurol 2022 Nov;35(6):751-762. Epub 2022 Apr 5 doi: 10.1177/08919887221090213. PMID: 35380884
Healy D, Bahrick A, Bak M, Barbato A, Calabrò RS, Chubak BM, Cosci F, Csoka AB, D'Avanzo B, Diviccaro S, Giatti S, Goldstein I, Graf H, Hellstrom WJG, Irwig MS, Jannini EA, Janssen PKC, Khera M, Kumar MT, Le Noury J, Lew-Starowicz M, Linden DEJ, Lüning C, Mangin D, Melcangi RC, Rodríguez OWMAAS, Panicker JN, Patacchini A, Pearlman AM, Pukall CF, Raj S, Reisman Y, Rubin RS, Schreiber R, Shipko S, Vašečková B, Waraich A
Int J Risk Saf Med 2022;33(1):65-76. doi: 10.3233/JRS-210023. PMID: 34719438Free PMC Article
Raimo S, Santangelo G, Trojano L
Handb Clin Neurol 2021;183:197-220. doi: 10.1016/B978-0-12-822290-4.00009-8. PMID: 34389118

Therapy

Cuomo A, Barillà G, Cattolico M, Pardossi S, Mariantoni E, Koukouna D, Carmellini P, Fagiolini A
Expert Rev Neurother 2024 May;24(5):465-476. Epub 2024 Mar 27 doi: 10.1080/14737175.2024.2333394. PMID: 38536761
Camino S, Strejilevich SA, Godoy A, Smith J, Szmulewicz A
Psychol Med 2023 Jul;53(9):4004-4011. Epub 2022 Mar 29 doi: 10.1017/S0033291722000678. PMID: 35346413
Peters EM, Balbuena L, Lodhi RJ
J Affect Disord 2022 Dec 1;318:29-32. Epub 2022 Aug 24 doi: 10.1016/j.jad.2022.08.066. PMID: 36029876
Healy D, Bahrick A, Bak M, Barbato A, Calabrò RS, Chubak BM, Cosci F, Csoka AB, D'Avanzo B, Diviccaro S, Giatti S, Goldstein I, Graf H, Hellstrom WJG, Irwig MS, Jannini EA, Janssen PKC, Khera M, Kumar MT, Le Noury J, Lew-Starowicz M, Linden DEJ, Lüning C, Mangin D, Melcangi RC, Rodríguez OWMAAS, Panicker JN, Patacchini A, Pearlman AM, Pukall CF, Raj S, Reisman Y, Rubin RS, Schreiber R, Shipko S, Vašečková B, Waraich A
Int J Risk Saf Med 2022;33(1):65-76. doi: 10.3233/JRS-210023. PMID: 34719438Free PMC Article
Fagiolini A, Florea I, Loft H, Christensen MC
J Affect Disord 2021 Mar 15;283:472-479. Epub 2020 Nov 19 doi: 10.1016/j.jad.2020.11.106. PMID: 33516560

Prognosis

Ouallet JC, Radat F, Creange A, Abdellaoui M, Heinzlef O, Giannesini C, Hautecoeur P, Lamargue Hamel D, Deloire M, Brochet B, Jean Deleglise AS, Lehert P
J Neurol Sci 2020 Jun 15;413:116739. Epub 2020 Feb 19 doi: 10.1016/j.jns.2020.116739. PMID: 32151852
Unglik J, Bungener C, Delgadillo D, Salachas F, Pradat PF, Bruneteau G, Lenglet T, Le Forestier N, Couratier P, Vacher Y, Lacomblez L
Geriatr Psychol Neuropsychiatr Vieil 2018 Dec 1;16(4):414-422. doi: 10.1684/pnv.2018.0762. PMID: 30355543
Dudley M, Hadzi-Pavlovic D, Andrews D, Perich T
Aust N Z J Psychiatry 2008 Jun;42(6):456-66. doi: 10.1080/00048670802050538. PMID: 18465372
Bodini B, Iacoboni M, Lenzi GL
Curr Opin Neurol 2004 Feb;17(1):55-60. doi: 10.1097/00019052-200402000-00010. PMID: 15090878
Toller SV
Chem Senses 1999 Dec;24(6):705-12. doi: 10.1093/chemse/24.6.705. PMID: 10587505

Clinical prediction guides

Sampson E, Kavakbasi E, Mills NT, Hori H, Schubert KO, Fourrier C, Baune BT
Int J Neuropsychopharmacol 2024 Mar 1;27(3) doi: 10.1093/ijnp/pyad066. PMID: 38441216Free PMC Article
Zorn A, Linn S, Jenkinson M, Neher JO, Safranek S, Kelsberg G
J Fam Pract 2021 Apr;70(3):E1-E3. doi: 10.12788/jfp.0176. PMID: 34314342
Quang H, Wong S, Husain M, Piguet O, Hodges JR, Irish M, Kumfor F
Cortex 2021 Jun;139:73-85. Epub 2021 Mar 16 doi: 10.1016/j.cortex.2021.02.028. PMID: 33836304
Fagiolini A, Florea I, Loft H, Christensen MC
J Affect Disord 2021 Mar 15;283:472-479. Epub 2020 Nov 19 doi: 10.1016/j.jad.2020.11.106. PMID: 33516560
Lee GJ, Lu PH, Mather MJ, Shapira J, Jimenez E, Leow AD, Thompson PM, Mendez MF
J Alzheimers Dis 2014;41(3):793-800. doi: 10.3233/JAD-132219. PMID: 24685626Free PMC Article

Recent systematic reviews

Thompson J, Stansfeld JL, Cooper RE, Morant N, Crellin NE, Moncrieff J
Soc Psychiatry Psychiatr Epidemiol 2020 Feb;55(2):151-164. Epub 2019 Dec 24 doi: 10.1007/s00127-019-01819-2. PMID: 31875238
Caddy C, Amit BH, McCloud TL, Rendell JM, Furukawa TA, McShane R, Hawton K, Cipriani A
Cochrane Database Syst Rev 2015 Sep 23;(9):CD011612. doi: 10.1002/14651858.CD011612.pub2. PMID: 26395901
Kilian S, Asmal L, Goosen A, Chiliza B, Phahladira L, Emsley R
PLoS One 2015;10(6):e0127740. Epub 2015 Jun 2 doi: 10.1371/journal.pone.0127740. PMID: 26035179Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...