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Red eye

MedGen UID:
68614
Concept ID:
C0235267
Sign or Symptom
Synonyms: Red Eye; Red eyes
SNOMED CT: Red eye (703630003)
 
HPO: HP:0025337

Definition

A reddish appearance over the white part (sclera) of the eye ranging from a few enlarged blood vessels appearing as wiggly lines over the sclera to a bright red color completely covering to sclera. [from HPO]

Conditions with this feature

Hereditary benign intraepithelial dyskeratosis
MedGen UID:
75588
Concept ID:
C0265966
Disease or Syndrome
Hereditary benign intraepithelial dyskeratosis (HBID) is a rare inherited disease characterized by elevated plaques on the ocular and oral mucous membranes. The bulbar conjunctiva is involved, especially in the nasal and temporal perilimbal region. Dilated superficial vessels in association with the conjunctival plaques give the eye an overall red appearance, which accounts for the disease's nickname of 'red eye.' Morphologically, the lesions consist of a dyskeratotic hyperplastic epithelium. The oral lesions, which are typically asymptomatic and may go unrecognized, usually appear as thick, soft, white papules and plaques of various sizes, involving any part of the oral cavity. The ocular manifestations in this condition vary in severity from asymptomatic plaques on the bulbar conjunctiva to complete involvement of the cornea with severe vision loss. Patients commonly complain of symptoms of irritation, such as erythema, itching, excessive lacrimation, and photophobia. Periods of acute intensification of symptoms are common, especially in the spring. The lesions may become apparent in early infancy and may date from birth. The plaques persist throughout life and sometimes progress, but may wax and wane (summary by Witkop et al., 1960; Reed et al., 1979; and Baroni et al., 2009).
RECON progeroid syndrome
MedGen UID:
1841140
Concept ID:
C5830504
Disease or Syndrome
RECON progeroid syndrome (RECON) is a chromosomal instability disorder characterized by postnatal growth retardation, progeroid facial appearance, hypoplastic nose, prominent premaxilla, skin photosensitivity and xeroderma, muscle wasting with reduced subcutaneous fat, and slender elongated thumbs (Abu-Libdeh et al., 2022).

Professional guidelines

PubMed

Dunlop AL, Wells JR
Prim Care 2015 Sep;42(3):267-84. Epub 2015 Jul 26 doi: 10.1016/j.pop.2015.05.002. PMID: 26319338
Cronau H, Kankanala RR, Mauger T
Am Fam Physician 2010 Jan 15;81(2):137-44. PMID: 20082509
Mahmood AR, Narang AT
Emerg Med Clin North Am 2008 Feb;26(1):35-55, vi. doi: 10.1016/j.emc.2007.10.002. PMID: 18249256

Recent clinical studies

Etiology

Mueller A
Handb Exp Pharmacol 2022;268:95-99. doi: 10.1007/164_2021_491. PMID: 34136960
Bradford CA, Melson AT
Med Clin North Am 2021 May;105(3):409-423. Epub 2021 Apr 2 doi: 10.1016/j.mcna.2021.02.002. PMID: 33926638
Barnett BP, Afshari NA
Transl Vis Sci Technol 2020 Feb 25;9(3):29. doi: 10.1167/tvst.9.3.29. PMID: 32742759Free PMC Article
Flores-Sánchez BC, Tatham AJ
Br J Hosp Med (Lond) 2019 Dec 2;80(12):C174-C179. doi: 10.12968/hmed.2019.80.12.C174. PMID: 31822188
Mantelli F, Tranchina L, Lambiase A, Bonini S
Curr Opin Allergy Clin Immunol 2011 Oct;11(5):464-70. doi: 10.1097/ACI.0b013e32834a95c9. PMID: 21822131

Diagnosis

Mueller A
Handb Exp Pharmacol 2022;268:95-99. doi: 10.1007/164_2021_491. PMID: 34136960
Flores-Sánchez BC, Tatham AJ
Br J Hosp Med (Lond) 2019 Dec 2;80(12):C174-C179. doi: 10.12968/hmed.2019.80.12.C174. PMID: 31822188
Tarff A, Behrens A
Med Clin North Am 2017 May;101(3):615-639. Epub 2017 Mar 8 doi: 10.1016/j.mcna.2016.12.013. PMID: 28372717
Alfonso SA, Fawley JD, Alexa Lu X
Prim Care 2015 Sep;42(3):325-45. Epub 2015 Jul 29 doi: 10.1016/j.pop.2015.05.001. PMID: 26319341
Cronau H, Kankanala RR, Mauger T
Am Fam Physician 2010 Jan 15;81(2):137-44. PMID: 20082509

Therapy

McGinley TC Jr
FP Essent 2022 Aug;519:11-18. PMID: 35947131
Rodgin SG
Optom Vis Sci 2017 Jul;94(7):775-780. doi: 10.1097/OPX.0000000000001088. PMID: 28604572
Alfonso SA, Fawley JD, Alexa Lu X
Prim Care 2015 Sep;42(3):325-45. Epub 2015 Jul 29 doi: 10.1016/j.pop.2015.05.001. PMID: 26319341
Cronau H, Kankanala RR, Mauger T
Am Fam Physician 2010 Jan 15;81(2):137-44. PMID: 20082509
Li J, Tripathi RC, Tripathi BJ
Drug Saf 2008;31(2):127-41. doi: 10.2165/00002018-200831020-00003. PMID: 18217789

Prognosis

Shorter ES, Whiteside MM, Harthan JS, Morettin CE, Perera CD, Johnson SD, Migneco MK, Huecker JB, Hartwick ATE, Than TP, Gordon MO
Clin Exp Optom 2022 Sep;105(7):702-707. Epub 2021 Nov 9 doi: 10.1080/08164622.2021.1984180. PMID: 34751088Free PMC Article
Lakhani BK, Thajudeen B, Jawaid I, Attzs MS, Maharajan VS
Cornea 2021 Jun 1;40(6):769-773. doi: 10.1097/ICO.0000000000002491. PMID: 32833843
Juniat V, Andrew N
BMJ Case Rep 2014 Apr 3;2014 doi: 10.1136/bcr-2013-203363. PMID: 24700045Free PMC Article
Jackson WB
Can J Ophthalmol 2009 Aug;44(4):385-94. doi: 10.3129/i09-015. PMID: 19606158
Granet D
Allergy Asthma Proc 2008 Nov-Dec;29(6):565-74. doi: 10.2500/aap.2008.29.3170. PMID: 19173783

Clinical prediction guides

Hersi RM, Naaman NK, Alghamdi AM, Alnahdi WA, Bukhari ZM, Almarzouki HS
BMC Ophthalmol 2023 Mar 7;23(1):90. doi: 10.1186/s12886-023-02832-5. PMID: 36882722Free PMC Article
Mitchell GL, Richdale K, Lam D, Wagner H, Kinoshita BT, Zimmerman AB, Sorbara L, Rosner B
Cont Lens Anterior Eye 2021 Oct;44(5):101383. Epub 2020 Dec 3 doi: 10.1016/j.clae.2020.11.003. PMID: 33281075
Rodgin SG
Optom Vis Sci 2017 Jul;94(7):775-780. doi: 10.1097/OPX.0000000000001088. PMID: 28604572
Narayana S, McGee S
Am J Med 2015 Nov;128(11):1220-1224.e1. Epub 2015 Jul 11 doi: 10.1016/j.amjmed.2015.06.026. PMID: 26169885
Vichyanond P, Pacharn P, Pleyer U, Leonardi A
Pediatr Allergy Immunol 2014 Jun;25(4):314-22. Epub 2014 Jan 20 doi: 10.1111/pai.12197. PMID: 24438133

Recent systematic reviews

Johnson D, Liu D, Simel D
JAMA 2022 Jun 14;327(22):2231-2237. doi: 10.1001/jama.2022.7687. PMID: 35699701
Narayana S, McGee S
Am J Med 2015 Nov;128(11):1220-1224.e1. Epub 2015 Jul 11 doi: 10.1016/j.amjmed.2015.06.026. PMID: 26169885

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