U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Addictive amphetamine use

MedGen UID:
68634
•Concept ID:
C0236804
•
Mental or Behavioral Dysfunction
Synonyms: Addiction, Amphetamine; Amphetamine Addiction; Amphetamine Dependence; Dependence, Amphetamine
SNOMED CT: Amfetamine dependence (21647008); Amphetamine dependence (21647008)
 
HPO: HP:0033514

Definition

Addiction to amphetamine or dextroamphetamine is a serious concern. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAddictive amphetamine use

Professional guidelines

PubMed

Clinical management of psychostimulant withdrawal: review of the evidence.
Li MJ, Shoptaw SJ
Addiction 2023 Apr;118(4):750-762. Epub 2022 Dec 12 doi: 10.1111/add.16093. PMID: 36401591Free PMC Article
The treatment of cocaine use disorder.
Kampman KM
Sci Adv 2019 Oct;5(10):eaax1532. Epub 2019 Oct 16 doi: 10.1126/sciadv.aax1532. PMID: 31663022Free PMC Article
Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature.
Courtney KE, Ray LA
Drug Alcohol Depend 2014 Oct 1;143:11-21. Epub 2014 Aug 17 doi: 10.1016/j.drugalcdep.2014.08.003. PMID: 25176528Free PMC Article

Recent clinical studies

Etiology

Risk of Incident Psychosis and Mania With Prescription Amphetamines.
Moran LV, Skinner JP, Shinn AK, Nielsen K, Rao V, Taylor ST, Cohen TR, Erkol C, Merchant J, Mujica CA, Perlis RH, Ongur D
Am J Psychiatry 2024 Oct 1;181(10):901-909. Epub 2024 Sep 12 doi: 10.1176/appi.ajp.20230329. PMID: 39262211
Prescription psychostimulants for the treatment of amphetamine-type stimulant use disorder: A systematic review and meta-analysis of randomized placebo-controlled trials.
Sharafi H, Bakouni H, McAnulty C, Drouin S, Coronado-Montoya S, Bahremand A, Bach P, Ezard N, Le Foll B, Schütz CG, Siefried KJ, Tardelli VS, Ziegler D, Jutras-Aswad D
Addiction 2024 Feb;119(2):211-224. Epub 2023 Oct 25 doi: 10.1111/add.16347. PMID: 37880829
Pharmacological Treatment of Methamphetamine/Amphetamine Dependence: A Systematic Review.
Siefried KJ, Acheson LS, Lintzeris N, Ezard N
CNS Drugs 2020 Apr;34(4):337-365. doi: 10.1007/s40263-020-00711-x. PMID: 32185696Free PMC Article
Responding to global stimulant use: challenges and opportunities.
Farrell M, Martin NK, Stockings E, Bórquez A, Cepeda JA, Degenhardt L, Ali R, Tran LT, Rehm J, Torrens M, Shoptaw S, McKetin R
Lancet 2019 Nov 2;394(10209):1652-1667. Epub 2019 Oct 23 doi: 10.1016/S0140-6736(19)32230-5. PMID: 31668409Free PMC Article
Psychosis induced by amphetamines.
Bramness JG, Rognli EB
Curr Opin Psychiatry 2016 Jul;29(4):236-41. doi: 10.1097/YCO.0000000000000254. PMID: 27175554

Diagnosis

Risk of Incident Psychosis and Mania With Prescription Amphetamines.
Moran LV, Skinner JP, Shinn AK, Nielsen K, Rao V, Taylor ST, Cohen TR, Erkol C, Merchant J, Mujica CA, Perlis RH, Ongur D
Am J Psychiatry 2024 Oct 1;181(10):901-909. Epub 2024 Sep 12 doi: 10.1176/appi.ajp.20230329. PMID: 39262211
Prescription psychostimulants for the treatment of amphetamine-type stimulant use disorder: A systematic review and meta-analysis of randomized placebo-controlled trials.
Sharafi H, Bakouni H, McAnulty C, Drouin S, Coronado-Montoya S, Bahremand A, Bach P, Ezard N, Le Foll B, Schütz CG, Siefried KJ, Tardelli VS, Ziegler D, Jutras-Aswad D
Addiction 2024 Feb;119(2):211-224. Epub 2023 Oct 25 doi: 10.1111/add.16347. PMID: 37880829
Bipolar Disorder and Comorbid Use of Illicit Substances.
Preuss UW, Schaefer M, Born C, Grunze H
Medicina (Kaunas) 2021 Nov 17;57(11) doi: 10.3390/medicina57111256. PMID: 34833474Free PMC Article
International Consensus Statement on Screening, Diagnosis and Treatment of Substance Use Disorder Patients with Comorbid Attention Deficit/Hyperactivity Disorder.
Crunelle CL, van den Brink W, Moggi F, Konstenius M, Franck J, Levin FR, van de Glind G, Demetrovics Z, Coetzee C, Luderer M, Schellekens A; ICASA consensus group, Matthys F
Eur Addict Res 2018;24(1):43-51. Epub 2018 Mar 6 doi: 10.1159/000487767. PMID: 29510390Free PMC Article
Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature.
Courtney KE, Ray LA
Drug Alcohol Depend 2014 Oct 1;143:11-21. Epub 2014 Aug 17 doi: 10.1016/j.drugalcdep.2014.08.003. PMID: 25176528Free PMC Article

Therapy

Pharmacological Treatment of Methamphetamine/Amphetamine Dependence: A Systematic Review.
Siefried KJ, Acheson LS, Lintzeris N, Ezard N
CNS Drugs 2020 Apr;34(4):337-365. doi: 10.1007/s40263-020-00711-x. PMID: 32185696Free PMC Article
Psychostimulant use and the brain.
Lappin JM, Sara GE
Addiction 2019 Nov;114(11):2065-2077. Epub 2019 Jul 19 doi: 10.1111/add.14708. PMID: 31321819
Psychedelics as anti-inflammatory agents.
Flanagan TW, Nichols CD
Int Rev Psychiatry 2018 Aug;30(4):363-375. Epub 2018 Aug 13 doi: 10.1080/09540261.2018.1481827. PMID: 30102081
Methamphetamine: Effects on the brain, gut and immune system.
Prakash MD, Tangalakis K, Antonipillai J, Stojanovska L, Nurgali K, Apostolopoulos V
Pharmacol Res 2017 Jun;120:60-67. Epub 2017 Mar 14 doi: 10.1016/j.phrs.2017.03.009. PMID: 28302577
Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature.
Courtney KE, Ray LA
Drug Alcohol Depend 2014 Oct 1;143:11-21. Epub 2014 Aug 17 doi: 10.1016/j.drugalcdep.2014.08.003. PMID: 25176528Free PMC Article

Prognosis

Bidirectional causality between addiction and cognitive deficits.
Melugin PR, Nolan SO, Siciliano CA
Int Rev Neurobiol 2021;157:371-407. Epub 2020 Dec 30 doi: 10.1016/bs.irn.2020.11.001. PMID: 33648674Free PMC Article
Cocaine and methamphetamine: Pharmacology and dental implications.
Nassar P, Ouanounou A
Can J Dent Hyg 2020 Jun 1;54(2):75-82. PMID: 33240367Free PMC Article
Responding to global stimulant use: challenges and opportunities.
Farrell M, Martin NK, Stockings E, Bórquez A, Cepeda JA, Degenhardt L, Ali R, Tran LT, Rehm J, Torrens M, Shoptaw S, McKetin R
Lancet 2019 Nov 2;394(10209):1652-1667. Epub 2019 Oct 23 doi: 10.1016/S0140-6736(19)32230-5. PMID: 31668409Free PMC Article
Global statistics on alcohol, tobacco and illicit drug use: 2017 status report.
Peacock A, Leung J, Larney S, Colledge S, Hickman M, Rehm J, Giovino GA, West R, Hall W, Griffiths P, Ali R, Gowing L, Marsden J, Ferrari AJ, Grebely J, Farrell M, Degenhardt L
Addiction 2018 Oct;113(10):1905-1926. Epub 2018 Jun 4 doi: 10.1111/add.14234. PMID: 29749059
Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules.
Wingo T, Nesil T, Choi JS, Li MD
J Neuroimmune Pharmacol 2016 Sep;11(3):456-70. Epub 2015 Oct 19 doi: 10.1007/s11481-015-9636-7. PMID: 26481371Free PMC Article

Clinical prediction guides

Risk of Incident Psychosis and Mania With Prescription Amphetamines.
Moran LV, Skinner JP, Shinn AK, Nielsen K, Rao V, Taylor ST, Cohen TR, Erkol C, Merchant J, Mujica CA, Perlis RH, Ongur D
Am J Psychiatry 2024 Oct 1;181(10):901-909. Epub 2024 Sep 12 doi: 10.1176/appi.ajp.20230329. PMID: 39262211
Phentermine in the Modern Era of Obesity Pharmacotherapy: Does It Still Have a Role in Treatment?
Lewis KH, Gudzune KA, Ard JD
Curr Obes Rep 2024 Mar;13(1):132-140. Epub 2024 Jan 3 doi: 10.1007/s13679-023-00546-9. PMID: 38172485
Prescription psychostimulants for the treatment of amphetamine-type stimulant use disorder: A systematic review and meta-analysis of randomized placebo-controlled trials.
Sharafi H, Bakouni H, McAnulty C, Drouin S, Coronado-Montoya S, Bahremand A, Bach P, Ezard N, Le Foll B, Schütz CG, Siefried KJ, Tardelli VS, Ziegler D, Jutras-Aswad D
Addiction 2024 Feb;119(2):211-224. Epub 2023 Oct 25 doi: 10.1111/add.16347. PMID: 37880829
A systematic literature review and meta-analysis of the effect of psilocybin and methylenedioxymethamphetamine on mental, behavioural or developmental disorders.
Kisely S, Connor M, Somogyi AA, Siskind D
Aust N Z J Psychiatry 2023 Mar;57(3):362-378. Epub 2022 Mar 12 doi: 10.1177/00048674221083868. PMID: 35285280
Psychedelics and Psychedelic-Assisted Psychotherapy.
Reiff CM, Richman EE, Nemeroff CB, Carpenter LL, Widge AS, Rodriguez CI, Kalin NH, McDonald WM; the Work Group on Biomarkers and Novel Treatments, a Division of the American Psychiatric Association Council of Research
Am J Psychiatry 2020 May 1;177(5):391-410. Epub 2020 Feb 26 doi: 10.1176/appi.ajp.2019.19010035. PMID: 32098487

Recent systematic reviews

Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis.
Yao Y, Guo D, Lu TS, Liu FL, Huang SH, Diao MQ, Li SX, Zhang XJ, Kosten TR, Shi J, Bao YP, Lu L, Han Y
Psychiatry Res 2024 May;335:115886. Epub 2024 Mar 28 doi: 10.1016/j.psychres.2024.115886. PMID: 38574699
Prescription psychostimulants for the treatment of amphetamine-type stimulant use disorder: A systematic review and meta-analysis of randomized placebo-controlled trials.
Sharafi H, Bakouni H, McAnulty C, Drouin S, Coronado-Montoya S, Bahremand A, Bach P, Ezard N, Le Foll B, Schütz CG, Siefried KJ, Tardelli VS, Ziegler D, Jutras-Aswad D
Addiction 2024 Feb;119(2):211-224. Epub 2023 Oct 25 doi: 10.1111/add.16347. PMID: 37880829
Buprenorphine versus methadone for the treatment of opioid dependence: a systematic review and meta-analysis of randomised and observational studies.
Degenhardt L, Clark B, Macpherson G, Leppan O, Nielsen S, Zahra E, Larance B, Kimber J, Martino-Burke D, Hickman M, Farrell M
Lancet Psychiatry 2023 Jun;10(6):386-402. Epub 2023 May 8 doi: 10.1016/S2215-0366(23)00095-0. PMID: 37167985
Pharmacological Treatment of Methamphetamine/Amphetamine Dependence: A Systematic Review.
Siefried KJ, Acheson LS, Lintzeris N, Ezard N
CNS Drugs 2020 Apr;34(4):337-365. doi: 10.1007/s40263-020-00711-x. PMID: 32185696Free PMC Article
Prevention, early intervention, harm reduction, and treatment of substance use in young people.
Stockings E, Hall WD, Lynskey M, Morley KI, Reavley N, Strang J, Patton G, Degenhardt L
Lancet Psychiatry 2016 Mar;3(3):280-96. Epub 2016 Feb 18 doi: 10.1016/S2215-0366(16)00002-X. PMID: 26905481

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...