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Cardiac sarcoma

MedGen UID:
68657
•Concept ID:
C0238152
•
Neoplastic Process
Synonyms: Cardiac Sarcoma; cardiac sarcoma; Heart Sarcoma; heart sarcoma; Sarcoma of Heart; sarcoma of heart; Sarcoma of the Heart; sarcoma of the heart
 
HPO: HP:0031350
Monarch Initiative: MONDO:0003354

Definition

A malignant soft tissue neoplasm that arises from the heart. [from HPO]

Professional guidelines

PubMed

Surgical and multimodality treatment of cardiac sarcomas: A systematic review and meta-analysis.
Torabi S, Arjomandi Rad A, Vardanyan R, Lopuszko AT, Van den Eynde J, Zubarevich A, Sá MPBO, Szczechowicz M, Weymann A
J Card Surg 2021 Jul;36(7):2476-2485. Epub 2021 Apr 2 doi: 10.1111/jocs.15538. PMID: 33797789
Current clinical management of primary cardiac sarcoma.
Siontis BL, Leja M, Chugh R
Expert Rev Anticancer Ther 2020 Jan;20(1):45-51. Epub 2020 Jan 9 doi: 10.1080/14737140.2020.1711738. PMID: 31914831
Cardiac tumors--diagnosis and surgical treatment.
Hoffmeier A, Sindermann JR, Scheld HH, Martens S
Dtsch Arztebl Int 2014 Mar 21;111(12):205-11. doi: 10.3238/arztebl.2014.0205. PMID: 24717305Free PMC Article

Recent clinical studies

Etiology

Primary cardiac sarcomas: Treatment strategies.
Chan EY, Ali A, Zubair MM, Nguyen DT, Ibarra-Cortez SH, Graviss EA, Shapira OM, Ravi V, MacGillivray TE, Reardon MJ
J Thorac Cardiovasc Surg 2023 Sep;166(3):828-838.e2. Epub 2022 Feb 1 doi: 10.1016/j.jtcvs.2021.10.070. PMID: 35219517
Surgical and multimodality treatment of cardiac sarcomas: A systematic review and meta-analysis.
Torabi S, Arjomandi Rad A, Vardanyan R, Lopuszko AT, Van den Eynde J, Zubarevich A, Sá MPBO, Szczechowicz M, Weymann A
J Card Surg 2021 Jul;36(7):2476-2485. Epub 2021 Apr 2 doi: 10.1111/jocs.15538. PMID: 33797789
Left heart sarcomas.
Rice DC, Reardon MJ
Methodist Debakey Cardiovasc J 2010 Jul-Sep;6(3):49-56. doi: 10.14797/mdcj-6-3-49. PMID: 20834212
Primary cardiac sarcoma.
Hamidi M, Moody JS, Weigel TL, Kozak KR
Ann Thorac Surg 2010 Jul;90(1):176-81. doi: 10.1016/j.athoracsur.2010.03.065. PMID: 20609770Free PMC Article
Primary cardiac sarcoma.
Shanmugam G
Eur J Cardiothorac Surg 2006 Jun;29(6):925-32. Epub 2006 May 3 doi: 10.1016/j.ejcts.2006.03.034. PMID: 16675225

Diagnosis

Primary cardiac sarcomas: Treatment strategies.
Chan EY, Ali A, Zubair MM, Nguyen DT, Ibarra-Cortez SH, Graviss EA, Shapira OM, Ravi V, MacGillivray TE, Reardon MJ
J Thorac Cardiovasc Surg 2023 Sep;166(3):828-838.e2. Epub 2022 Feb 1 doi: 10.1016/j.jtcvs.2021.10.070. PMID: 35219517
Current clinical management of primary cardiac sarcoma.
Siontis BL, Leja M, Chugh R
Expert Rev Anticancer Ther 2020 Jan;20(1):45-51. Epub 2020 Jan 9 doi: 10.1080/14737140.2020.1711738. PMID: 31914831
Cardiac tumors--diagnosis and surgical treatment.
Hoffmeier A, Sindermann JR, Scheld HH, Martens S
Dtsch Arztebl Int 2014 Mar 21;111(12):205-11. doi: 10.3238/arztebl.2014.0205. PMID: 24717305Free PMC Article
Primary cardiac sarcoma.
Hamidi M, Moody JS, Weigel TL, Kozak KR
Ann Thorac Surg 2010 Jul;90(1):176-81. doi: 10.1016/j.athoracsur.2010.03.065. PMID: 20609770Free PMC Article
Primary cardiac sarcoma.
Shanmugam G
Eur J Cardiothorac Surg 2006 Jun;29(6):925-32. Epub 2006 May 3 doi: 10.1016/j.ejcts.2006.03.034. PMID: 16675225

Therapy

Surgical and multimodality treatment of cardiac sarcomas: A systematic review and meta-analysis.
Torabi S, Arjomandi Rad A, Vardanyan R, Lopuszko AT, Van den Eynde J, Zubarevich A, Sá MPBO, Szczechowicz M, Weymann A
J Card Surg 2021 Jul;36(7):2476-2485. Epub 2021 Apr 2 doi: 10.1111/jocs.15538. PMID: 33797789
Current clinical management of primary cardiac sarcoma.
Siontis BL, Leja M, Chugh R
Expert Rev Anticancer Ther 2020 Jan;20(1):45-51. Epub 2020 Jan 9 doi: 10.1080/14737140.2020.1711738. PMID: 31914831
The impact of postoperative therapy on primary cardiac sarcoma.
Wu Y, Million L, Moding EJ, Scott G, Berry M, Ganjoo KN
J Thorac Cardiovasc Surg 2018 Dec;156(6):2194-2203. Epub 2018 Jun 6 doi: 10.1016/j.jtcvs.2018.04.127. PMID: 30454911
Postoperative Complications and Long-Term Results after Primary Cardiac Sarcoma Resection.
Kavakbasi E, Scheld HH, Kessler T, Sindermann JR, Kösek V, Tjan TDT, Martens S, Hoffmeier A
Thorac Cardiovasc Surg 2018 Nov;66(8):637-644. Epub 2017 Jun 11 doi: 10.1055/s-0037-1603790. PMID: 28602018
Right heart sarcomas.
Vaporciyan A, Reardon MJ
Methodist Debakey Cardiovasc J 2010 Jul-Sep;6(3):44-8. doi: 10.14797/mdcj-6-3-44. PMID: 20834211

Prognosis

Primary cardiac sarcomas: A clinicopathologic study in a single institution with 25 years of experience with an emphasis on MDM2 expression and adjuvant therapy for prognosis.
Cho H, Song IH, Jo U, Jeong JS, Koo HJ, Yang DH, Jung SH, Song JS, Cho KJ
Cancer Med 2023 Aug;12(16):16815-16828. Epub 2023 Jul 3 doi: 10.1002/cam4.6303. PMID: 37395142Free PMC Article
Current clinical management of primary cardiac sarcoma.
Siontis BL, Leja M, Chugh R
Expert Rev Anticancer Ther 2020 Jan;20(1):45-51. Epub 2020 Jan 9 doi: 10.1080/14737140.2020.1711738. PMID: 31914831
Left heart sarcomas.
Rice DC, Reardon MJ
Methodist Debakey Cardiovasc J 2010 Jul-Sep;6(3):49-56. doi: 10.14797/mdcj-6-3-49. PMID: 20834212
Primary cardiac sarcoma.
Hamidi M, Moody JS, Weigel TL, Kozak KR
Ann Thorac Surg 2010 Jul;90(1):176-81. doi: 10.1016/j.athoracsur.2010.03.065. PMID: 20609770Free PMC Article
Primary cardiac sarcoma.
Shanmugam G
Eur J Cardiothorac Surg 2006 Jun;29(6):925-32. Epub 2006 May 3 doi: 10.1016/j.ejcts.2006.03.034. PMID: 16675225

Clinical prediction guides

PET/CT morphology and cardiac conduction disorders help discriminate primary cardiac lymphoma from primary cardiac sarcoma.
Yuan H, Qiu J, Chiu KWH, Chan LWC, Zhang F, Wei X, Jiang L
J Nucl Cardiol 2022 Dec;29(6):2866-2877. Epub 2022 Jul 5 doi: 10.1007/s12350-022-03042-0. PMID: 35790691
Surgical and multimodality treatment of cardiac sarcomas: A systematic review and meta-analysis.
Torabi S, Arjomandi Rad A, Vardanyan R, Lopuszko AT, Van den Eynde J, Zubarevich A, Sá MPBO, Szczechowicz M, Weymann A
J Card Surg 2021 Jul;36(7):2476-2485. Epub 2021 Apr 2 doi: 10.1111/jocs.15538. PMID: 33797789
Cardiac radiation-induced sarcomas: A SEER population-based study and a literature review.
Loap P, Fourquet A, Kirova Y
Cancer Radiother 2021 Feb;25(1):21-25. Epub 2020 Dec 28 doi: 10.1016/j.canrad.2020.05.019. PMID: 33384223
Right heart sarcomas.
Vaporciyan A, Reardon MJ
Methodist Debakey Cardiovasc J 2010 Jul-Sep;6(3):44-8. doi: 10.14797/mdcj-6-3-44. PMID: 20834211
Pulmonary artery sarcoma.
Blackmon SH, Reardon MJ
Methodist Debakey Cardiovasc J 2010 Jul-Sep;6(3):38-43. doi: 10.14797/mdcj-6-3-38. PMID: 20834210

Recent systematic reviews

Surgical and multimodality treatment of cardiac sarcomas: A systematic review and meta-analysis.
Torabi S, Arjomandi Rad A, Vardanyan R, Lopuszko AT, Van den Eynde J, Zubarevich A, Sá MPBO, Szczechowicz M, Weymann A
J Card Surg 2021 Jul;36(7):2476-2485. Epub 2021 Apr 2 doi: 10.1111/jocs.15538. PMID: 33797789

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