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Toxic methemoglobinemia with cyanosis

MedGen UID:
688234
Concept ID:
C1263992
Disease or Syndrome
Synonym: Toxic Methemoglobinemia with Cyanosis
SNOMED CT: Toxic methemoglobinemia with cyanosis (127037003)

Definition

Blue skin coloration due to elevated blood levels of methemoglobin. The degree of cyanosis is directly correlated to the concentration of methemoglobin in the blood. As methemoglobin is not suitable for carrying oxygen, hypoxemia becomes a serious sequela. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToxic methemoglobinemia with cyanosis

Professional guidelines

Recent clinical studies

Etiology

Masavkar SS, Mauskar A, Patwardhan G, Bhat V, Manglani MV
Indian Pediatr 2017 Jun 15;54(6):473-475. doi: 10.1007/s13312-017-1050-1. PMID: 28667718
Bittmann S, Krüger C
Br J Nurs 2011 Feb 10-23;20(3):168-70. doi: 10.12968/bjon.2011.20.3.168. PMID: 21378638
Percy MJ, McFerran NV, Lappin TR
Blood Rev 2005 Mar;19(2):61-8. doi: 10.1016/j.blre.2004.02.001. PMID: 15603910
Wilburn-Goo D, Lloyd LM
J Am Dent Assoc 1999 Jun;130(6):826-31. doi: 10.14219/jada.archive.1999.0306. PMID: 10377640
Kross BC, Ayebo AD, Fuortes LJ
Am Fam Physician 1992 Jul;46(1):183-8. PMID: 1621630

Diagnosis

Lerner RP, Lee E
Am J Emerg Med 2019 Nov;37(11):2119.e1-2119.e2. Epub 2019 Aug 24 doi: 10.1016/j.ajem.2019.158415. PMID: 31477356
Bittmann S, Krüger C
Br J Nurs 2011 Feb 10-23;20(3):168-70. doi: 10.12968/bjon.2011.20.3.168. PMID: 21378638
Khemiri M, Labassi A Jr, Tlili Y Jr, Barsaoui S
Int Emerg Nurs 2009 Jul;17(3):181-3. Epub 2009 Mar 18 doi: 10.1016/j.ienj.2008.12.005. PMID: 19577206
Sachdeva SM, Mani KV, Adaval SK, Jalpota YP, Rasela KC, Chadha DS
J Assoc Physicians India 1992 Apr;40(4):239-40. PMID: 1452530
Curry SC, Arnold-Capell P
Crit Care Clin 1991 Jul;7(3):555-81. PMID: 1907524

Therapy

Lerner RP, Lee E
Am J Emerg Med 2019 Nov;37(11):2119.e1-2119.e2. Epub 2019 Aug 24 doi: 10.1016/j.ajem.2019.158415. PMID: 31477356
Bittmann S, Krüger C
Br J Nurs 2011 Feb 10-23;20(3):168-70. doi: 10.12968/bjon.2011.20.3.168. PMID: 21378638
Khemiri M, Labassi A Jr, Tlili Y Jr, Barsaoui S
Int Emerg Nurs 2009 Jul;17(3):181-3. Epub 2009 Mar 18 doi: 10.1016/j.ienj.2008.12.005. PMID: 19577206
Sachdeva SM, Mani KV, Adaval SK, Jalpota YP, Rasela KC, Chadha DS
J Assoc Physicians India 1992 Apr;40(4):239-40. PMID: 1452530
Curry SC, Arnold-Capell P
Crit Care Clin 1991 Jul;7(3):555-81. PMID: 1907524

Prognosis

Sonck E, Bourmanne E, Bruteyn J, Dolip W
J Med Case Rep 2022 Jun 21;16(1):244. doi: 10.1186/s13256-022-03475-8. PMID: 35725643Free PMC Article
Bittmann S, Krüger C
Br J Nurs 2011 Feb 10-23;20(3):168-70. doi: 10.12968/bjon.2011.20.3.168. PMID: 21378638
Yang CC, Hwang SF, Chou MM, Deng JF
J Toxicol Clin Toxicol 1995;33(6):713-6. doi: 10.3109/15563659509010635. PMID: 8523499
Taylor CW, Alberts DS, Peng YM, McCloskey TM, Matzner M, Roe DJ, Plezia PM, Grindey GB, Hamilton M, Seitz D
J Natl Cancer Inst 1992 Dec 2;84(23):1798-802. doi: 10.1093/jnci/84.23.1798. PMID: 1433369

Clinical prediction guides

Shi L, Yu G, Zhao L, Wen Z, Li Y, Kan B, Jian X
Front Public Health 2022;10:942003. Epub 2022 Jul 7 doi: 10.3389/fpubh.2022.942003. PMID: 35875039Free PMC Article
Carfora A, Campobasso CP, Cassandro P, La Sala F, Maiellaro A, Perna A, Petrella R, Borriello R
Forensic Sci Int 2019 Apr;297:e1-e7. Epub 2019 Feb 7 doi: 10.1016/j.forsciint.2019.01.044. PMID: 30777401
D'sa SR, Victor P, Jagannati M, Sudarsan TI, Carey RA, Peter JV
Clin Toxicol (Phila) 2014 Sep-Oct;52(8):897-900. Epub 2014 Aug 12 doi: 10.3109/15563650.2014.947377. PMID: 25116418
Bradberry SM
Toxicol Rev 2003;22(1):13-27. doi: 10.2165/00139709-200322010-00003. PMID: 14579544
Gold NA, Bithoney WG
J Emerg Med 2003 Aug;25(2):143-8. doi: 10.1016/s0736-4679(03)00162-8. PMID: 12901999

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