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Vaginal dryness

MedGen UID:
69141
Concept ID:
C0241633
Finding
Synonym: Vaginal Dryness
SNOMED CT: Vaginal dryness (31908003)
 
HPO: HP:0031088

Definition

Persistent vaginal dryness. [from HPO]

Conditions with this feature

Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
MedGen UID:
98032
Concept ID:
C0406709
Disease or Syndrome
The TP63-related disorders comprise six overlapping phenotypes: Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome (which includes Rapp-Hodgkin syndrome). Acro-dermo-ungual-lacrimal-tooth (ADULT) syndrome. Ectrodactyly, ectodermal dysplasia, cleft lip/palate syndrome 3 (EEC3). Limb-mammary syndrome. Split-hand/foot malformation type 4 (SHFM4). Isolated cleft lip/cleft palate (orofacial cleft 8). Individuals typically have varying combinations of ectodermal dysplasia (hypohidrosis, nail dysplasia, sparse hair, tooth abnormalities), cleft lip/palate, split-hand/foot malformation/syndactyly, lacrimal duct obstruction, hypopigmentation, hypoplastic breasts and/or nipples, and hypospadias. Findings associated with a single phenotype include ankyloblepharon filiforme adnatum (tissue strands that completely or partially fuse the upper and lower eyelids), skin erosions especially on the scalp associated with areas of scarring, and alopecia, trismus, and excessive freckling.

Professional guidelines

PubMed

Benini V, Ruffolo AF, Casiraghi A, Degliuomini RS, Frigerio M, Braga A, Serati M, Torella M, Candiani M, Salvatore S
Medicina (Kaunas) 2022 Jun 6;58(6) doi: 10.3390/medicina58060770. PMID: 35744033Free PMC Article
Crean-Tate KK, Faubion SS, Pederson HJ, Vencill JA, Batur P
Am J Obstet Gynecol 2020 Feb;222(2):103-113. Epub 2019 Aug 29 doi: 10.1016/j.ajog.2019.08.043. PMID: 31473229
Santoro N, Epperson CN, Mathews SB
Endocrinol Metab Clin North Am 2015 Sep;44(3):497-515. doi: 10.1016/j.ecl.2015.05.001. PMID: 26316239Free PMC Article

Recent clinical studies

Etiology

Muzii L, Di Tucci C, Galati G, Carbone F, Palaia I, Bogani G, Perniola G, Tomao F, Kontopantelis E, Di Donato V
Reprod Sci 2023 Nov;30(11):3135-3143. Epub 2023 May 22 doi: 10.1007/s43032-023-01266-0. PMID: 37217824Free PMC Article
Cattani L, De Maeyer L, Verbakel JY, Bosteels J, Deprest J
BJOG 2022 Jun;129(7):1017-1028. Epub 2021 Oct 17 doi: 10.1111/1471-0528.16934. PMID: 34536325
Reisman Y
Sex Med Rev 2017 Oct;5(4):429-433. Epub 2017 Jun 20 doi: 10.1016/j.sxmr.2017.05.002. PMID: 28642048
Franco OH, Chowdhury R, Troup J, Voortman T, Kunutsor S, Kavousi M, Oliver-Williams C, Muka T
JAMA 2016 Jun 21;315(23):2554-63. doi: 10.1001/jama.2016.8012. PMID: 27327802
Roberts H, Hickey M
Maturitas 2016 Apr;86:53-8. Epub 2016 Jan 22 doi: 10.1016/j.maturitas.2016.01.007. PMID: 26921929

Diagnosis

Arthur SS, Dorfman CS, Massa LA, Shelby RA
Urol Oncol 2022 Aug;40(8):359-365. Epub 2021 Jul 8 doi: 10.1016/j.urolonc.2021.06.006. PMID: 34247907Free PMC Article
Marino JM
J Midwifery Womens Health 2021 Nov;66(6):729-739. Epub 2021 Aug 31 doi: 10.1111/jmwh.13277. PMID: 34464022
Santoro N, Epperson CN, Mathews SB
Endocrinol Metab Clin North Am 2015 Sep;44(3):497-515. doi: 10.1016/j.ecl.2015.05.001. PMID: 26316239Free PMC Article
Hainer BL, Gibson MV
Am Fam Physician 2011 Apr 1;83(7):807-15. PMID: 21524046
Stika CS
Dermatol Ther 2010 Sep-Oct;23(5):514-22. doi: 10.1111/j.1529-8019.2010.01354.x. PMID: 20868405

Therapy

Zipper R, Lamvu G
J Comp Eff Res 2022 Aug;11(11):843-851. Epub 2022 Jun 21 doi: 10.2217/cer-2021-0281. PMID: 35726603
Potter N, Panay N
Climacteric 2021 Feb;24(1):19-24. Epub 2020 Sep 29 doi: 10.1080/13697137.2020.1820478. PMID: 32990054
Muhleisen AL, Herbst-Kralovetz MM
Maturitas 2016 Sep;91:42-50. Epub 2016 Jun 1 doi: 10.1016/j.maturitas.2016.05.015. PMID: 27451320
Rahn DD, Carberry C, Sanses TV, Mamik MM, Ward RM, Meriwether KV, Olivera CK, Abed H, Balk EM, Murphy M; Society of Gynecologic Surgeons Systematic Review Group
Obstet Gynecol 2014 Dec;124(6):1147-1156. doi: 10.1097/AOG.0000000000000526. PMID: 25415166Free PMC Article
Nelson HD
Lancet 2008 Mar 1;371(9614):760-70. doi: 10.1016/S0140-6736(08)60346-3. PMID: 18313505

Prognosis

Cattani L, De Maeyer L, Verbakel JY, Bosteels J, Deprest J
BJOG 2022 Jun;129(7):1017-1028. Epub 2021 Oct 17 doi: 10.1111/1471-0528.16934. PMID: 34536325
Logue CA, Pugh J, Jayson G
Int J Gynecol Cancer 2020 Dec;30(12):1983-1989. Epub 2020 Oct 28 doi: 10.1136/ijgc-2020-002001. PMID: 33115791Free PMC Article
Al-Safi ZA, Santoro N
Fertil Steril 2014 Apr;101(4):905-15. Epub 2014 Mar 6 doi: 10.1016/j.fertnstert.2014.02.032. PMID: 24613533
Llaneza P, García-Portilla MP, Llaneza-Suárez D, Armott B, Pérez-López FR
Maturitas 2012 Feb;71(2):120-30. Epub 2011 Dec 21 doi: 10.1016/j.maturitas.2011.11.017. PMID: 22196311
Lange MM, van de Velde CJ
Nat Rev Urol 2011 Jan;8(1):51-7. Epub 2010 Dec 7 doi: 10.1038/nrurol.2010.206. PMID: 21135876

Clinical prediction guides

Junqueira DR, Bennett D, Huh SY, Casañas I Comabella C
Pharmaceut Med 2023 Mar;37(2):153-166. Epub 2023 Feb 17 doi: 10.1007/s40290-023-00462-2. PMID: 36800148Free PMC Article
Cattani L, De Maeyer L, Verbakel JY, Bosteels J, Deprest J
BJOG 2022 Jun;129(7):1017-1028. Epub 2021 Oct 17 doi: 10.1111/1471-0528.16934. PMID: 34536325
Farenhorst CA, de Wolff L, Arends S, van Nimwegen JF, Kroese FGM, Verstappen GM, Bootsma H
Clin Exp Rheumatol 2021 Nov-Dec;39 Suppl 133(6):73-79. Epub 2021 Oct 7 doi: 10.55563/clinexprheumatol/hzveng. PMID: 34665706
Bui KT, Willson ML, Goel S, Beith J, Goodwin A
Cochrane Database Syst Rev 2020 Mar 6;3(3):CD013538. doi: 10.1002/14651858.CD013538. PMID: 32141074Free PMC Article
Franco OH, Chowdhury R, Troup J, Voortman T, Kunutsor S, Kavousi M, Oliver-Williams C, Muka T
JAMA 2016 Jun 21;315(23):2554-63. doi: 10.1001/jama.2016.8012. PMID: 27327802

Recent systematic reviews

Cattani L, De Maeyer L, Verbakel JY, Bosteels J, Deprest J
BJOG 2022 Jun;129(7):1017-1028. Epub 2021 Oct 17 doi: 10.1111/1471-0528.16934. PMID: 34536325
Dos Santos CCM, Uggioni MLR, Colonetti T, Colonetti L, Grande AJ, Da Rosa MI
J Sex Med 2021 Jan;18(1):156-166. Epub 2020 Dec 5 doi: 10.1016/j.jsxm.2020.10.016. PMID: 33293236
Hill DA, Crider M, Hill SR
Am Fam Physician 2016 Dec 1;94(11):884-889. PMID: 27929271
Franco OH, Chowdhury R, Troup J, Voortman T, Kunutsor S, Kavousi M, Oliver-Williams C, Muka T
JAMA 2016 Jun 21;315(23):2554-63. doi: 10.1001/jama.2016.8012. PMID: 27327802
Rahn DD, Carberry C, Sanses TV, Mamik MM, Ward RM, Meriwether KV, Olivera CK, Abed H, Balk EM, Murphy M; Society of Gynecologic Surgeons Systematic Review Group
Obstet Gynecol 2014 Dec;124(6):1147-1156. doi: 10.1097/AOG.0000000000000526. PMID: 25415166Free PMC Article

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