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Myelodysplastic Syndrome, Unclassifiable

MedGen UID:
692784
Concept ID:
C1268964
Neoplastic Process
Synonyms: Unclassifiable MDS; Unclassifiable Myelodysplastic Syndrome

Definition

A subtype of myelodysplastic syndrome which initially lacks findings appropriate for classification into any other myelodysplastic category. There are no specific morphologic findings. The diagnosis can be made in the following instances: 1. in cases of refractory cytopenia with unilineage dysplasia or refractory cytopenia with multilineage dysplasia but with 1% blasts in the peripheral blood; 2: in cases of myelodysplastic syndrome with unilineage dysplasia which are associated with pancytopenia; 3: in cases with persistent cytopenia (s) with 1% or fewer blasts in the blood and fewer than 5% in the bone marrow, unequivocal dysplasia in less than 10% of the cells in one or more myeloid lineages, and cytogenetic abnormalities considered as presumptive evidence of myelodysplastic syndrome. (WHO, 2008) [from NCI]

Professional guidelines

PubMed

Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article
Irons RD, Gross SA, Le A, Wang XQ, Chen Y, Ryder J, Schnatter AR
Chem Biol Interact 2010 Mar 19;184(1-2):30-8. Epub 2009 Nov 24 doi: 10.1016/j.cbi.2009.11.016. PMID: 19941839
Tefferi A, Elliott MA, Pardanani A
Mayo Clin Proc 2006 Apr;81(4):553-63. doi: 10.4065/81.4.553. PMID: 16610578

Recent clinical studies

Etiology

Baidoun F, Chen D, Patnaik M, Gangat N, Begna K, Elliott M, Hogan W, Litzow M, Al-Kali A
Leuk Lymphoma 2019 Oct;60(10):2483-2487. Epub 2019 Mar 7 doi: 10.1080/10428194.2019.1581930. PMID: 31609151
Margolskee E, Hasserjian RP, Hassane D, Tam W, Mathew S, Ok CY, Wang SA, Oak J, Arber DA, Orazi A
Am J Clin Pathol 2017 Jul 1;148(1):49-57. doi: 10.1093/ajcp/aqx043. PMID: 28927162
Warlick ED, Cioc A, Defor T, Dolan M, Weisdorf D
Biol Blood Marrow Transplant 2009 Jan;15(1):30-8. doi: 10.1016/j.bbmt.2008.10.012. PMID: 19135940

Diagnosis

Baidoun F, Chen D, Patnaik M, Gangat N, Begna K, Elliott M, Hogan W, Litzow M, Al-Kali A
Leuk Lymphoma 2019 Oct;60(10):2483-2487. Epub 2019 Mar 7 doi: 10.1080/10428194.2019.1581930. PMID: 31609151
Min GJ, Park S, Park SS, Yoon JH, Lee SE, Cho BS, Eom KS, Lee S, Kim HJ, Min CK, Cho SG, Kim DW, Lee JW, Kim YJ
Int J Hematol 2019 Nov;110(5):635-639. Epub 2019 Jul 15 doi: 10.1007/s12185-019-02702-1. PMID: 31309419

Therapy

Min GJ, Park S, Park SS, Yoon JH, Lee SE, Cho BS, Eom KS, Lee S, Kim HJ, Min CK, Cho SG, Kim DW, Lee JW, Kim YJ
Int J Hematol 2019 Nov;110(5):635-639. Epub 2019 Jul 15 doi: 10.1007/s12185-019-02702-1. PMID: 31309419

Prognosis

Margolskee E, Hasserjian RP, Hassane D, Tam W, Mathew S, Ok CY, Wang SA, Oak J, Arber DA, Orazi A
Am J Clin Pathol 2017 Jul 1;148(1):49-57. doi: 10.1093/ajcp/aqx043. PMID: 28927162
Warlick ED, Cioc A, Defor T, Dolan M, Weisdorf D
Biol Blood Marrow Transplant 2009 Jan;15(1):30-8. doi: 10.1016/j.bbmt.2008.10.012. PMID: 19135940

Clinical prediction guides

Warlick ED, Cioc A, Defor T, Dolan M, Weisdorf D
Biol Blood Marrow Transplant 2009 Jan;15(1):30-8. doi: 10.1016/j.bbmt.2008.10.012. PMID: 19135940

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