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Systemic inflammatory response syndrome

MedGen UID:
69303
Concept ID:
C0242966
Disease or Syndrome
Synonyms: Inflammatory Response Syndrome, Systemic; Sepsis Syndrome; Sepsis Syndromes; Syndrome, Sepsis; Syndromes, Sepsis; Systemic Inflammatory Response Syndrome
SNOMED CT: SIRS - System inflammatory response syndrome (238149007); Systemic inflammatory response syndrome (238149007); Sepsis syndrome (238150007); Septic syndrome (238150007)

Definition

A generalized state of dysregulated inflammation induced by noninfectious processes. It is characterized by two or more of the following signs and symptoms: fever or hypothermia, increased heart rate, increased respiratory rate, and abnormal white blood cell count. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSystemic inflammatory response syndrome

Professional guidelines

PubMed

Baron TH, DiMaio CJ, Wang AY, Morgan KA
Gastroenterology 2020 Jan;158(1):67-75.e1. Epub 2019 Aug 31 doi: 10.1053/j.gastro.2019.07.064. PMID: 31479658
Tenner S, Baillie J, DeWitt J, Vege SS; American College of Gastroenterology
Am J Gastroenterol 2013 Sep;108(9):1400-15; 1416. Epub 2013 Jul 30 doi: 10.1038/ajg.2013.218. PMID: 23896955
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ
Chest 1992 Jun;101(6):1644-55. doi: 10.1378/chest.101.6.1644. PMID: 1303622

Recent clinical studies

Etiology

Millar JE, Fanning JP, McDonald CI, McAuley DF, Fraser JF
Crit Care 2016 Nov 28;20(1):387. doi: 10.1186/s13054-016-1570-4. PMID: 27890016Free PMC Article
Brudno JN, Kochenderfer JN
Blood 2016 Jun 30;127(26):3321-30. Epub 2016 May 20 doi: 10.1182/blood-2016-04-703751. PMID: 27207799Free PMC Article
Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R
N Engl J Med 2015 Apr 23;372(17):1629-38. Epub 2015 Mar 17 doi: 10.1056/NEJMoa1415236. PMID: 25776936
Balk RA
Virulence 2014 Jan 1;5(1):20-6. Epub 2013 Nov 13 doi: 10.4161/viru.27135. PMID: 24280933Free PMC Article
Sihler KC, Napolitano LM
Chest 2010 Jan;137(1):209-20. doi: 10.1378/chest.09-0252. PMID: 20051407

Diagnosis

Patel JM
Curr Allergy Asthma Rep 2022 May;22(5):53-60. Epub 2022 Mar 22 doi: 10.1007/s11882-022-01031-4. PMID: 35314921Free PMC Article
Jaramillo-Bustamante JC, Piñeres-Olave BE, González-Dambrauskas S
Bol Med Hosp Infant Mex 2020;77(6):293-302. doi: 10.24875/BMHIM.20000202. PMID: 33186343
Margraf A, Ludwig N, Zarbock A, Rossaint J
Anesth Analg 2020 Dec;131(6):1693-1707. doi: 10.1213/ANE.0000000000005175. PMID: 33186158
Varela ML, Mogildea M, Moreno I, Lopes A
Inflammation 2018 Aug;41(4):1115-1127. doi: 10.1007/s10753-018-0739-1. PMID: 29404872
Balk RA
Virulence 2014 Jan 1;5(1):20-6. Epub 2013 Nov 13 doi: 10.4161/viru.27135. PMID: 24280933Free PMC Article

Therapy

Baron TH, DiMaio CJ, Wang AY, Morgan KA
Gastroenterology 2020 Jan;158(1):67-75.e1. Epub 2019 Aug 31 doi: 10.1053/j.gastro.2019.07.064. PMID: 31479658
Futier E, Lefrant JY, Guinot PG, Godet T, Lorne E, Cuvillon P, Bertran S, Leone M, Pastene B, Piriou V, Molliex S, Albanese J, Julia JM, Tavernier B, Imhoff E, Bazin JE, Constantin JM, Pereira B, Jaber S; INPRESS Study Group
JAMA 2017 Oct 10;318(14):1346-1357. doi: 10.1001/jama.2017.14172. PMID: 28973220Free PMC Article
Taeb AM, Hooper MH, Marik PE
Nutr Clin Pract 2017 Jun;32(3):296-308. Epub 2017 Mar 17 doi: 10.1177/0884533617695243. PMID: 28537517
Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis
Pediatr Crit Care Med 2005 Jan;6(1):2-8. doi: 10.1097/01.PCC.0000149131.72248.E6. PMID: 15636651
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group
N Engl J Med 2001 Nov 8;345(19):1368-77. doi: 10.1056/NEJMoa010307. PMID: 11794169

Prognosis

Santos MO, Gonçalves LC, Silva PAN, Moreira ALE, Ito CRM, Peixoto FAO, Wastowski IJ, Carneiro LC, Avelino MAG
J Pediatr (Rio J) 2022 Jul-Aug;98(4):338-349. Epub 2021 Dec 3 doi: 10.1016/j.jped.2021.08.006. PMID: 34863701Free PMC Article
Jaramillo-Bustamante JC, Piñeres-Olave BE, González-Dambrauskas S
Bol Med Hosp Infant Mex 2020;77(6):293-302. doi: 10.24875/BMHIM.20000202. PMID: 33186343
Ferguson A, Coates DE, Osborn S, Blackmore CC, Williams B
Am J Nurs 2019 Jan;119(1):52-58. doi: 10.1097/01.NAJ.0000552614.89028.d6. PMID: 30589710
Serafim R, Gomes JA, Salluh J, Póvoa P
Chest 2018 Mar;153(3):646-655. Epub 2017 Dec 28 doi: 10.1016/j.chest.2017.12.015. PMID: 29289687
Sihler KC, Napolitano LM
Chest 2010 Jan;137(1):209-20. doi: 10.1378/chest.09-0252. PMID: 20051407

Clinical prediction guides

Wang C, Xu R, Zeng Y, Zhao Y, Hu X
PLoS One 2022;17(4):e0266755. Epub 2022 Apr 15 doi: 10.1371/journal.pone.0266755. PMID: 35427367Free PMC Article
Wong A, Otles E, Donnelly JP, Krumm A, McCullough J, DeTroyer-Cooley O, Pestrue J, Phillips M, Konye J, Penoza C, Ghous M, Singh K
JAMA Intern Med 2021 Aug 1;181(8):1065-1070. doi: 10.1001/jamainternmed.2021.2626. PMID: 34152373Free PMC Article
Serafim R, Gomes JA, Salluh J, Póvoa P
Chest 2018 Mar;153(3):646-655. Epub 2017 Dec 28 doi: 10.1016/j.chest.2017.12.015. PMID: 29289687
Crouser ED, Parrillo JE, Seymour C, Angus DC, Bicking K, Tejidor L, Magari R, Careaga D, Williams J, Closser DR, Samoszuk M, Herren L, Robart E, Chaves F
Chest 2017 Sep;152(3):518-526. Epub 2017 Jun 15 doi: 10.1016/j.chest.2017.05.039. PMID: 28625579Free PMC Article
Churpek MM, Snyder A, Han X, Sokol S, Pettit N, Howell MD, Edelson DP
Am J Respir Crit Care Med 2017 Apr 1;195(7):906-911. doi: 10.1164/rccm.201604-0854OC. PMID: 27649072Free PMC Article

Recent systematic reviews

Tong T, Yao X, Lin Z, Tao Y, Xu J, Xu X, Fang Z, Geng Z, Fu S, Wang W, Xie C, Zhang Y, Wang Y, Gong F
Pediatr Rheumatol Online J 2022 Dec 5;20(1):112. doi: 10.1186/s12969-022-00771-x. PMID: 36471327Free PMC Article
Santos MO, Gonçalves LC, Silva PAN, Moreira ALE, Ito CRM, Peixoto FAO, Wastowski IJ, Carneiro LC, Avelino MAG
J Pediatr (Rio J) 2022 Jul-Aug;98(4):338-349. Epub 2021 Dec 3 doi: 10.1016/j.jped.2021.08.006. PMID: 34863701Free PMC Article
Milosavljevic MN, Milosavljevic JZ, Kocovic AG, Stefanovic SM, Jankovic SM, Djesevic M, Milentijevic MN
Rev Inst Med Trop Sao Paulo 2021;63:e49. Epub 2021 Jun 18 doi: 10.1590/S1678-9946202163049. PMID: 34161555Free PMC Article
Hoste L, Van Paemel R, Haerynck F
Eur J Pediatr 2021 Jul;180(7):2019-2034. Epub 2021 Feb 18 doi: 10.1007/s00431-021-03993-5. PMID: 33599835Free PMC Article
Serafim R, Gomes JA, Salluh J, Póvoa P
Chest 2018 Mar;153(3):646-655. Epub 2017 Dec 28 doi: 10.1016/j.chest.2017.12.015. PMID: 29289687

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