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Lichen Planus-Like Keratosis

MedGen UID:
697923
•Concept ID:
C1274594
•
Neoplastic Process
Synonyms: Lichen planus-like keratosis; Lichenoid actinic keratosis; Lichenoid Keratosis; Lichenoid keratosis
SNOMED CT: Lichenoid actinic keratosis (403198004); Lichen planus-like keratosis (403198004); Lichenoid keratosis (403198004)

Definition

A benign intraepidermal squamoproliferative neoplasm characterized by irregular acanthosis, hyperkeratosis, parakeratosis, and prominent chronic inflammation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLichen Planus-Like Keratosis

Professional guidelines

PubMed

Lentigo maligna: diagnosis and treatment.
De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288
Reflectance confocal microscopy in the diagnosis of pigmented macules of the face: differential diagnosis and margin definition.
Farnetani F , Manfredini M , Chester J , Ciardo S , Gonzalez S , Pellacani G
Photochem Photobiol Sci 2019 May 15;18(5):963-969. doi: 10.1039/c8pp00525g. PMID: 30938378
Lentigo maligna: review of salient characteristics and management.
Kallini JR, Jain SK, Khachemoune A
Am J Clin Dermatol 2013 Dec;14(6):473-80. doi: 10.1007/s40257-013-0044-6. PMID: 24019181

Recent clinical studies

Etiology

Clinical and dermatoscopic characteristics of lichen planus-like keratosis in a West-Asian population.
Ansari MS, Akay BN, Cengiz FP, Rosendahl N, Mahmoudi H, Daneshpazhooh M, Rosendahl C
Australas J Dermatol 2021 Feb;62(1):e55-e61. Epub 2020 Nov 17 doi: 10.1111/ajd.13455. PMID: 33200822
Reflectance confocal microscopy terminology glossary for nonmelanocytic skin lesions: A systematic review.
Navarrete-Dechent C, DeRosa AP, Longo C, Liopyris K, Oliviero M, Rabinovitz H, Marghoob AA, Halpern AC, Pellacani G, Scope A, Jain M
J Am Acad Dermatol 2019 May;80(5):1414-1427.e3. Epub 2018 Dec 8 doi: 10.1016/j.jaad.2018.12.007. PMID: 30529706Free PMC Article
Clinical and dermoscopic features associated with lichen planus-like keratoses that undergo skin biopsy: A single-center, observational study.
Liopyris K, Navarrete-Dechent C, Dusza SW, Marghoob AA, Deng L, Wilson BB, Marchetti MA
Australas J Dermatol 2019 May;60(2):e119-e126. Epub 2018 Nov 18 doi: 10.1111/ajd.12955. PMID: 30450536Free PMC Article
Lichen planus and other lichenoid dermatoses: Kids are not just little people.
Payette MJ, Weston G, Humphrey S, Yu J, Holland KE
Clin Dermatol 2015 Nov-Dec;33(6):631-43. Epub 2015 Sep 12 doi: 10.1016/j.clindermatol.2015.09.006. PMID: 26686015
Dermoscopy of lichen planus-like keratosis: a model of inflammatory regression.
Bugatti L, Filosa G
J Eur Acad Dermatol Venereol 2007 Nov;21(10):1392-7. doi: 10.1111/j.1468-3083.2007.02296.x. PMID: 17958847

Diagnosis

Lichen planus-like keratosis: what do we know about it?
Pogorzelska-Antkowiak A
Clin Exp Dermatol 2022 Nov;47(11):1923-1927. doi: 10.1111/ced.15318. PMID: 35775867
Lentigo maligna: diagnosis and treatment.
De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288
Lichen planus-like keratosis: clinicopathological evaluation of 1366 cases.
Vincek V
Int J Dermatol 2019 Jul;58(7):830-833. Epub 2018 Dec 18 doi: 10.1111/ijd.14358. PMID: 30565224
Multiple lichen planus-like keratoses: Lichenoid drug eruption simulant and under-recognised cause of pruritic eruptions in the elderly.
Pitney L, Weedon D, Pitney M
Australas J Dermatol 2016 Feb;57(1):54-6. Epub 2015 Mar 5 doi: 10.1111/ajd.12288. PMID: 25753682
Lichen planus and other lichenoid dermatoses: Kids are not just little people.
Payette MJ, Weston G, Humphrey S, Yu J, Holland KE
Clin Dermatol 2015 Nov-Dec;33(6):631-43. Epub 2015 Sep 12 doi: 10.1016/j.clindermatol.2015.09.006. PMID: 26686015

Therapy

Comparison of the accuracy of human readers versus machine-learning algorithms for pigmented skin lesion classification: an open, web-based, international, diagnostic study.
Tschandl P, Codella N, Akay BN, Argenziano G, Braun RP, Cabo H, Gutman D, Halpern A, Helba B, Hofmann-Wellenhof R, Lallas A, Lapins J, Longo C, Malvehy J, Marchetti MA, Marghoob A, Menzies S, Oakley A, Paoli J, Puig S, Rinner C, Rosendahl C, Scope A, Sinz C, Soyer HP, Thomas L, Zalaudek I, Kittler H
Lancet Oncol 2019 Jul;20(7):938-947. Epub 2019 Jun 12 doi: 10.1016/S1470-2045(19)30333-X. PMID: 31201137Free PMC Article
Diffuse lichen planus-like keratoses and clinical pseudo-progression associated with avelumab treatment for Merkel cell carcinoma, a case report.
Cardis MA, Jiang H, Strauss J, Gulley JL, Brownell I
BMC Cancer 2019 Jun 4;19(1):539. doi: 10.1186/s12885-019-5759-1. PMID: 31164102Free PMC Article
Diagnosis and management of facial pigmented macules.
Lallas A, Argenziano G, Moscarella E, Longo C, Simonetti V, Zalaudek I
Clin Dermatol 2014 Jan-Feb;32(1):94-100. doi: 10.1016/j.clindermatol.2013.05.030. PMID: 24314382
Large-cell acanthoma is a solar lentigo.
Roewert HJ, Ackerman AB
Am J Dermatopathol 1992 Apr;14(2):122-32. doi: 10.1097/00000372-199204000-00006. PMID: 1533104

Prognosis

Lentigo maligna of the face: A quantitative simple method to identify individual patient risk probability on dermoscopy.
Carbone A, Ferrari A, Paolino G, Buccini P, De Simone P, Eibenschutz L, Piemonte P, Silipo V, Sperduti I, Catricalà C, Frascione P
Australas J Dermatol 2017 Nov;58(4):286-291. Epub 2017 Jun 7 doi: 10.1111/ajd.12595. PMID: 28589538
Performance of the First Step of the 2-Step Dermoscopy Algorithm.
Chen LL, Dusza SW, Jaimes N, Marghoob AA
JAMA Dermatol 2015 Jul;151(7):715-21. doi: 10.1001/jamadermatol.2014.4642. PMID: 25714607

Clinical prediction guides

Clinical and dermoscopic features associated with lichen planus-like keratoses that undergo skin biopsy: A single-center, observational study.
Liopyris K, Navarrete-Dechent C, Dusza SW, Marghoob AA, Deng L, Wilson BB, Marchetti MA
Australas J Dermatol 2019 May;60(2):e119-e126. Epub 2018 Nov 18 doi: 10.1111/ajd.12955. PMID: 30450536Free PMC Article
Folliculotropism in pigmented facial macules: Differential diagnosis with reflectance confocal microscopy.
Persechino F, De Carvalho N, Ciardo S, De Pace B, Casari A, Chester J, Kaleci S, Stanganelli I, Longo C, Farnetani F, Pellacani G
Exp Dermatol 2018 Mar;27(3):227-232. doi: 10.1111/exd.13487. PMID: 29274094
Dermoscopy of lichen planus-like keratosis: a model of inflammatory regression.
Bugatti L, Filosa G
J Eur Acad Dermatol Venereol 2007 Nov;21(10):1392-7. doi: 10.1111/j.1468-3083.2007.02296.x. PMID: 17958847
Clinical and pathological study of lichen-planus-like keratosis in China.
Zhang Q, Wang WH, Zhao M, Shen L, Cheng JH, Zhang BY, Li LF
J Dermatol 2006 Jul;33(7):457-61. doi: 10.1111/j.1346-8138.2006.00109.x. PMID: 16848817
Lichen planus-like keratosis. A clinical and histological reexamination.
Prieto VG, Casal M, McNutt NS
Am J Surg Pathol 1993 Mar;17(3):259-63. doi: 10.1097/00000478-199303000-00006. PMID: 8434706

Recent systematic reviews

Reflectance confocal microscopy terminology glossary for nonmelanocytic skin lesions: A systematic review.
Navarrete-Dechent C, DeRosa AP, Longo C, Liopyris K, Oliviero M, Rabinovitz H, Marghoob AA, Halpern AC, Pellacani G, Scope A, Jain M
J Am Acad Dermatol 2019 May;80(5):1414-1427.e3. Epub 2018 Dec 8 doi: 10.1016/j.jaad.2018.12.007. PMID: 30529706Free PMC Article

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