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Primary Cutaneous Diffuse Large B-Cell Lymphoma

MedGen UID:
698597
•Concept ID:
C1275325
•
Neoplastic Process
Synonym: Primary cutaneous diffuse large cell B-cell lymphoma
SNOMED CT: Primary cutaneous diffuse large cell B-cell lymphoma (404144008)

Definition

A diffuse large B-cell lymphoma that arises from the skin. This category includes primary cutaneous diffuse large B-cell lymphoma, leg type, and primary cutaneous diffuse large B-cell lymphoma, other, which includes primary cutaneous intravascular large B-cell lymphoma and primary cutaneous T-cell/histiocyte-rich large B-cell lymphoma. [from NCI]

Professional guidelines

PubMed

Update in Diagnosis and Management of Primary Cutaneous B-Cell Lymphomas.
Krenitsky A, Klager S, Hatch L, Sarriera-Lazaro C, Chen PL, Seminario-Vidal L
Am J Clin Dermatol 2022 Sep;23(5):689-706. Epub 2022 Jul 19 doi: 10.1007/s40257-022-00704-0. PMID: 35854102
Cutaneous B-cell lymphomas: Update on diagnosis, risk-stratification, and management.
Fava P, Roccuzzo G, Alberti-Violetti S, Grandi V, Pileri A, Pimpinelli N, Berti E, Quaglino P
Presse Med 2022 Mar;51(1):104109. Epub 2022 Jan 11 doi: 10.1016/j.lpm.2022.104109. PMID: 35026390
Cutaneous B-cell lymphomas: 2019 update on diagnosis, risk stratification, and management.
Wilcox RA
Am J Hematol 2018 Nov;93(11):1427-1430. doi: 10.1002/ajh.25224. PMID: 30039522

Recent clinical studies

Etiology

Cutaneous B-cell lymphomas: Update on diagnosis, risk-stratification, and management.
Fava P, Roccuzzo G, Alberti-Violetti S, Grandi V, Pileri A, Pimpinelli N, Berti E, Quaglino P
Presse Med 2022 Mar;51(1):104109. Epub 2022 Jan 11 doi: 10.1016/j.lpm.2022.104109. PMID: 35026390
Outcomes in primary cutaneous diffuse large B-cell lymphoma, leg type.
Kraft RM, Ansell SM, Villasboas JC, Bennani NN, Wang Y, Habermann TM, Thanarajasingam G, Lester SC, Macon W, Inwards DJ, Porrata LF, Micallef IN, Witzig TE, Thompson CA, Johnston PB, Nowakowski GS, Lin Y, Paludo J
Hematol Oncol 2021 Dec;39(5):658-663. Epub 2021 Aug 28 doi: 10.1002/hon.2919. PMID: 34453851
Primary cutaneous B-cell lymphoma: narrative review of the literature.
Grandi V, Alberti Violetti S, La Selva R, Cicchelli S, Delfino C, Fava P, Fierro MT, Pileri A, Pimpinelli N, Quaglino P, Berti E
G Ital Dermatol Venereol 2019 Aug;154(4):466-479. Epub 2017 Nov 16 doi: 10.23736/S0392-0488.17.05670-X. PMID: 29144099
Cutaneous B-cell lymphomas: 2019 update on diagnosis, risk stratification, and management.
Wilcox RA
Am J Hematol 2018 Nov;93(11):1427-1430. doi: 10.1002/ajh.25224. PMID: 30039522
Primary Cutaneous B-cell Lymphomas.
Hope CB, Pincus LB
Clin Lab Med 2017 Sep;37(3):547-574. doi: 10.1016/j.cll.2017.05.009. PMID: 28802500

Diagnosis

Diffuse large B-cell lymphoma variants: an update.
Sukswai N, Lyapichev K, Khoury JD, Medeiros LJ
Pathology 2020 Jan;52(1):53-67. Epub 2019 Nov 15 doi: 10.1016/j.pathol.2019.08.013. PMID: 31735345
Cutaneous B-Cell Lymphoma.
Goyal A, LeBlanc RE, Carter JB
Hematol Oncol Clin North Am 2019 Feb;33(1):149-161. doi: 10.1016/j.hoc.2018.08.006. PMID: 30497672
Primary Cutaneous Follicle Center Lymphoma.
Skala SL, Hristov B, Hristov AC
Arch Pathol Lab Med 2018 Nov;142(11):1313-1321. doi: 10.5858/arpa.2018-0215-RA. PMID: 30407851
Cutaneous B-cell lymphomas: 2019 update on diagnosis, risk stratification, and management.
Wilcox RA
Am J Hematol 2018 Nov;93(11):1427-1430. doi: 10.1002/ajh.25224. PMID: 30039522
Primary Cutaneous B-cell Lymphomas.
Hope CB, Pincus LB
Clin Lab Med 2017 Sep;37(3):547-574. doi: 10.1016/j.cll.2017.05.009. PMID: 28802500

Therapy

Outcomes in primary cutaneous diffuse large B-cell lymphoma, leg type.
Kraft RM, Ansell SM, Villasboas JC, Bennani NN, Wang Y, Habermann TM, Thanarajasingam G, Lester SC, Macon W, Inwards DJ, Porrata LF, Micallef IN, Witzig TE, Thompson CA, Johnston PB, Nowakowski GS, Lin Y, Paludo J
Hematol Oncol 2021 Dec;39(5):658-663. Epub 2021 Aug 28 doi: 10.1002/hon.2919. PMID: 34453851
Cutaneous B-cell lymphomas: 2019 update on diagnosis, risk stratification, and management.
Wilcox RA
Am J Hematol 2018 Nov;93(11):1427-1430. doi: 10.1002/ajh.25224. PMID: 30039522
Primary cutaneous B-cell lymphomas: part II. Therapy and future directions.
Suárez AL, Querfeld C, Horwitz S, Pulitzer M, Moskowitz A, Myskowski PL
J Am Acad Dermatol 2013 Sep;69(3):343.e1-11; quiz 355-6. doi: 10.1016/j.jaad.2013.06.011. PMID: 23957985
Cutaneous B-cell lymphomas: 2013 update on diagnosis, risk-stratification, and management.
Wilcox RA
Am J Hematol 2013 Jan;88(1):73-6. doi: 10.1002/ajh.23360. PMID: 23379008
Primary cutaneous B-cell lymphomas: recent advances in diagnosis and management.
Sokol L, Naghashpour M, Glass LF
Cancer Control 2012 Jul;19(3):236-44. doi: 10.1177/107327481201900308. PMID: 22710899

Prognosis

Cutaneous B-cell lymphomas: Update on diagnosis, risk-stratification, and management.
Fava P, Roccuzzo G, Alberti-Violetti S, Grandi V, Pileri A, Pimpinelli N, Berti E, Quaglino P
Presse Med 2022 Mar;51(1):104109. Epub 2022 Jan 11 doi: 10.1016/j.lpm.2022.104109. PMID: 35026390
Outcomes in primary cutaneous diffuse large B-cell lymphoma, leg type.
Kraft RM, Ansell SM, Villasboas JC, Bennani NN, Wang Y, Habermann TM, Thanarajasingam G, Lester SC, Macon W, Inwards DJ, Porrata LF, Micallef IN, Witzig TE, Thompson CA, Johnston PB, Nowakowski GS, Lin Y, Paludo J
Hematol Oncol 2021 Dec;39(5):658-663. Epub 2021 Aug 28 doi: 10.1002/hon.2919. PMID: 34453851
Cutaneous B-Cell Lymphoma.
Goyal A, LeBlanc RE, Carter JB
Hematol Oncol Clin North Am 2019 Feb;33(1):149-161. doi: 10.1016/j.hoc.2018.08.006. PMID: 30497672
Primary Cutaneous Follicle Center Lymphoma.
Skala SL, Hristov B, Hristov AC
Arch Pathol Lab Med 2018 Nov;142(11):1313-1321. doi: 10.5858/arpa.2018-0215-RA. PMID: 30407851
Cutaneous B-cell lymphomas: 2019 update on diagnosis, risk stratification, and management.
Wilcox RA
Am J Hematol 2018 Nov;93(11):1427-1430. doi: 10.1002/ajh.25224. PMID: 30039522

Clinical prediction guides

Outcomes in primary cutaneous diffuse large B-cell lymphoma, leg type.
Kraft RM, Ansell SM, Villasboas JC, Bennani NN, Wang Y, Habermann TM, Thanarajasingam G, Lester SC, Macon W, Inwards DJ, Porrata LF, Micallef IN, Witzig TE, Thompson CA, Johnston PB, Nowakowski GS, Lin Y, Paludo J
Hematol Oncol 2021 Dec;39(5):658-663. Epub 2021 Aug 28 doi: 10.1002/hon.2919. PMID: 34453851
Double expressor and double/triple hit status among primary cutaneous diffuse large B-cell lymphoma: a comparison between leg type and not otherwise specified subtypes.
Lucioni M, Pescia C, Bonometti A, Fraticelli S, Moltrasio C, Ramponi A, Riboni R, Roccio S, Ferrario G, Arcaini L, Goteri G, Berti E, Paulli M
Hum Pathol 2021 May;111:1-9. Epub 2021 Feb 3 doi: 10.1016/j.humpath.2021.01.006. PMID: 33548250
Tumor Microenvironment and Checkpoint Molecules in Primary Cutaneous Diffuse Large B-Cell Lymphoma-New Therapeutic Targets.
Mitteldorf C, Berisha A, Pfaltz MC, Broekaert SMC, Schön MP, Kerl K, Kempf W
Am J Surg Pathol 2017 Jul;41(7):998-1004. doi: 10.1097/PAS.0000000000000851. PMID: 28504999
Primary cutaneous B-cell lymphomas: part II. Therapy and future directions.
Suárez AL, Querfeld C, Horwitz S, Pulitzer M, Moskowitz A, Myskowski PL
J Am Acad Dermatol 2013 Sep;69(3):343.e1-11; quiz 355-6. doi: 10.1016/j.jaad.2013.06.011. PMID: 23957985
Primary cutaneous diffuse large B-cell lymphoma, leg type: clinicopathologic features and prognostic analysis in 60 cases.
Grange F, Beylot-Barry M, Courville P, Maubec E, Bagot M, Vergier B, Souteyrand P, Machet L, Dalac S, Esteve E, Templier I, Delaporte E, Avril MF, Robert C, Dalle S, Laroche L, Delaunay M, Joly P, Wechsler J, Petrella T
Arch Dermatol 2007 Sep;143(9):1144-50. doi: 10.1001/archderm.143.9.1144. PMID: 17875875

Recent systematic reviews

Prognostic value of Bcl2 and Bcl6 in primary cutaneous large B-cell lymphoma: A systematic review and meta-analysis.
Russo D, Travaglino A, Varricchio S, Pace M, Cretella P, Baldo A, Severino A, Picardi M, Mascolo M
Pathol Res Pract 2022 Apr;232:153812. Epub 2022 Feb 22 doi: 10.1016/j.prp.2022.153812. PMID: 35220171
Primary cutaneous B-cell lymphomas: recent advances in diagnosis and management.
Sokol L, Naghashpour M, Glass LF
Cancer Control 2012 Jul;19(3):236-44. doi: 10.1177/107327481201900308. PMID: 22710899

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