Regressed Testicular Germ Cell Tumor

MedGen UID:: 698672
•Concept ID:: C1275403
•: Neoplastic Process

Synonyms:	Burnt out germ cell tumor; Burnt-Out Germ Cell Tumor; Regressed Germ Cell Tumor; Regressed germ cell tumor
SNOMED CT:	Regressed germ cell tumor (399523002); Burnt out germ cell tumor (399523002)

Definition

A testicular germ cell tumor that has undergone either partial or complete regression, resulting in the creation of a fibrotic nodule in the testis. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRegressed Testicular Germ Cell Tumor

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Morphology
      - Germ cell tumor
        Germ cell tumor of testis
        Regressed Testicular Germ Cell Tumor

Recent clinical studies

Etiology

Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.

Dubey D, Wilson MR, Clarkson B, Giannini C, Gandhi M, Cheville J, Lennon VA, Eggers S, Devine MF, Mandel-Brehm C, Kryzer T, Hinson SR, Khazaie K, Hales C, Kattah J, Pavelko KD, Andrews P, Eaton JE, Jitprapaikulsan J, Mills JR, Flanagan EP, Zekeridou A, Leibovich B, Fryer J, Torre M, Kaufman C, Thoreson JB, Sagen J, Linnoila JJ, DeRisi JL, Howe CL, McKeon A, Pittock SJ
JAMA Neurol 2020 Nov 1;77(11):1420-1429. doi: 10.1001/jamaneurol.2020.2231. PMID: 32744608 Free PMC Article

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Diagnosis

Unresectable Metastatic Testicular Germ Cell Tumor With Low-grade Neuroglial Neoplasm, Stable After Radiation and Chemotherapy.

Tabibi S, Kamanda S, Llosa N, Pratilas CA, Duncan BB, Esteves RS, Matoso A
Appl Immunohistochem Mol Morphol 2023 Jan 1;31(1):47-50. Epub 2022 Oct 26 doi: 10.1097/PAI.0000000000001081. PMID: 36476600 Free PMC Article

Leucine Zipper 4 Autoantibody: A Novel Germ Cell Tumor and Paraneoplastic Biomarker.

Dubey D, Kryzer T, Guo Y, Clarkson B, Cheville JC, Costello BA, Leibovich BC, Algeciras-Schimnich A, Lucchinnetti C, Hammami MB, Knight AM, Howe C, Lennon VA, McKeon A, Pittock SJ
Ann Neurol 2021 May;89(5):1001-1010. Epub 2021 Feb 28 doi: 10.1002/ana.26050. PMID: 33583072

Burned-out testicular germ cell tumour presenting as acute inferior vena cava syndrome.

de Souza P, So CW, Batura D, Gayed W, Vrentzou E
BMJ Case Rep 2020 Nov 17;13(11) doi: 10.1136/bcr-2020-237481. PMID: 33203785 Free PMC Article

Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.

Choriocarcinoma involving the pancreas as first manifestation of a metastatic regressing mixed testicular germ cell tumor.

Wang L, Pitman MB, Castillo CF, Dal Cin P, Oliva E
Mod Pathol 2004 Dec;17(12):1573-80. doi: 10.1038/modpathol.3800226. PMID: 15545958

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Therapy

Two cases of retroperitoneal metastasis from a completely regressed burned-out testicular cancer.

Gurioli A, Oderda M, Vigna D, Peraldo F, Giona S, Soria F, Cassenti A, Pacchioni D, Gontero P
Urologia 2013 Jan-Mar;80(1):74-9. Epub 2013 Feb 26 doi: 10.5301/RU.2013.10768. PMID: 23504866

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