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Levotransposition of the great arteries

MedGen UID:
699035
•Concept ID:
C1275809
•
Congenital Abnormality
Synonyms: L - transposition of the great vessels; L-TGA; Levotransposition
SNOMED CT: L - transposition of the great vessels (399046008); Levotransposition (399046008); Levotransposition of the great arteries (399046008)
 
HPO: HP:0031349

Definition

A type of transposition of the great arteries (TGA) in which aorta is in front of and primarily to the left of the pulmonary artery. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLevotransposition of the great arteries

Recent clinical studies

Etiology

Comparison of long-term outcomes of atrial switch with Rastelli and physiological repair using left ventricle-to-pulmonary artery conduit for levo-transposition of the great arteries.
Ono Y, Hoashi T, Imai K, Okuda N, Komori M, Tanimoto K, Kurosaki K, Ichikawa H
J Thorac Cardiovasc Surg 2023 Mar;165(3):1205-1215.e1. Epub 2022 Sep 2 doi: 10.1016/j.jtcvs.2022.08.018. PMID: 36241450
Case report: Pulmonary artery thrombosis in cyanotic congenital heart disease.
Shan A, Zubairi S, Mirza H, Amanullah M, Khan MZ
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):205-207. Epub 2021 Feb 20 doi: 10.1177/0218492321996519. PMID: 33611948
An Analysis of Left Ventricular Retraining in Patients With Dextro- and Levo-Transposition of the Great Arteries.
Mainwaring RD, Patrick WL, Ibrahimiye AN, Watanabe N, Lui GK, Hanley FL
Ann Thorac Surg 2018 Mar;105(3):823-829. Epub 2017 Dec 20 doi: 10.1016/j.athoracsur.2017.11.047. PMID: 29274314
Safety and efficacy of atrial antitachycardia pacing in congenital heart disease.
Kramer CC, Maldonado JR, Olson MD, Gingerich JC, Ochoa LA, Law IH
Heart Rhythm 2018 Apr;15(4):543-547. Epub 2017 Dec 12 doi: 10.1016/j.hrthm.2017.12.016. PMID: 29246827
Levotransposition of the aorta: identification of segmental cardiac anatomy using MR imaging.
Guit GL, Bluemm R, Rohmer J, Wenink AC, Chin JG, Doornbos J, van Voorthuisen AE
Radiology 1986 Dec;161(3):673-9. doi: 10.1148/radiology.161.3.3786718. PMID: 3786718

Diagnosis

Case report: Pulmonary artery thrombosis in cyanotic congenital heart disease.
Shan A, Zubairi S, Mirza H, Amanullah M, Khan MZ
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):205-207. Epub 2021 Feb 20 doi: 10.1177/0218492321996519. PMID: 33611948
Acute Pulmonary Edema in a Pregnant Patient with Undiagnosed Levo-Transposition of the Great Arteries.
Karamchandani K, Benrud J, Swick JT
Am J Case Rep 2018 Dec 6;19:1445-1448. doi: 10.12659/AJCR.912168. PMID: 30518743Free PMC Article
Safety and efficacy of atrial antitachycardia pacing in congenital heart disease.
Kramer CC, Maldonado JR, Olson MD, Gingerich JC, Ochoa LA, Law IH
Heart Rhythm 2018 Apr;15(4):543-547. Epub 2017 Dec 12 doi: 10.1016/j.hrthm.2017.12.016. PMID: 29246827
Levotransposition of the aorta: identification of segmental cardiac anatomy using MR imaging.
Guit GL, Bluemm R, Rohmer J, Wenink AC, Chin JG, Doornbos J, van Voorthuisen AE
Radiology 1986 Dec;161(3):673-9. doi: 10.1148/radiology.161.3.3786718. PMID: 3786718
Echocardiographic manifestations of single ventricle.
Felner JM, Brewer DB, Franch RH
Am J Cardiol 1976 Jul;38(1):80-4. doi: 10.1016/0002-9149(76)90066-7. PMID: 937203

Therapy

Complex congenital heart disease in a complicated and precious pregnancy.
Elsherif Z, Mahmood N, Jamil S, Wagas H
BMJ Case Rep 2015 Jul 1;2015 doi: 10.1136/bcr-2015-209388. PMID: 26135488Free PMC Article
Maternal smoking and congenital heart defects in the Baltimore-Washington Infant Study.
Alverson CJ, Strickland MJ, Gilboa SM, Correa A
Pediatrics 2011 Mar;127(3):e647-53. Epub 2011 Feb 28 doi: 10.1542/peds.2010-1399. PMID: 21357347
Cardiac transplantation for end-stage congenital heart defects: the Mayo Clinic experience. Mayo Cardiothoracic Transplant Team.
Speziali G, Driscoll DJ, Danielson GK, Julsrud PR, Porter CJ, Dearani JA, Daly RC, McGregor CG
Mayo Clin Proc 1998 Oct;73(10):923-8. doi: 10.4065/73.10.923. PMID: 9787738
Identification of the conduction system in corrected transposition and common ventricle at operation.
Maloney JD, Ritter DG, McGoon DC, Danielson GK
Mayo Clin Proc 1975 Jul;50(7):387-94. PMID: 1152532

Prognosis

Comparison of long-term outcomes of atrial switch with Rastelli and physiological repair using left ventricle-to-pulmonary artery conduit for levo-transposition of the great arteries.
Ono Y, Hoashi T, Imai K, Okuda N, Komori M, Tanimoto K, Kurosaki K, Ichikawa H
J Thorac Cardiovasc Surg 2023 Mar;165(3):1205-1215.e1. Epub 2022 Sep 2 doi: 10.1016/j.jtcvs.2022.08.018. PMID: 36241450
Acute Pulmonary Edema in a Pregnant Patient with Undiagnosed Levo-Transposition of the Great Arteries.
Karamchandani K, Benrud J, Swick JT
Am J Case Rep 2018 Dec 6;19:1445-1448. doi: 10.12659/AJCR.912168. PMID: 30518743Free PMC Article
An Analysis of Left Ventricular Retraining in Patients With Dextro- and Levo-Transposition of the Great Arteries.
Mainwaring RD, Patrick WL, Ibrahimiye AN, Watanabe N, Lui GK, Hanley FL
Ann Thorac Surg 2018 Mar;105(3):823-829. Epub 2017 Dec 20 doi: 10.1016/j.athoracsur.2017.11.047. PMID: 29274314
Safety and efficacy of atrial antitachycardia pacing in congenital heart disease.
Kramer CC, Maldonado JR, Olson MD, Gingerich JC, Ochoa LA, Law IH
Heart Rhythm 2018 Apr;15(4):543-547. Epub 2017 Dec 12 doi: 10.1016/j.hrthm.2017.12.016. PMID: 29246827
Maternal smoking and congenital heart defects in the Baltimore-Washington Infant Study.
Alverson CJ, Strickland MJ, Gilboa SM, Correa A
Pediatrics 2011 Mar;127(3):e647-53. Epub 2011 Feb 28 doi: 10.1542/peds.2010-1399. PMID: 21357347

Clinical prediction guides

Comparison of long-term outcomes of atrial switch with Rastelli and physiological repair using left ventricle-to-pulmonary artery conduit for levo-transposition of the great arteries.
Ono Y, Hoashi T, Imai K, Okuda N, Komori M, Tanimoto K, Kurosaki K, Ichikawa H
J Thorac Cardiovasc Surg 2023 Mar;165(3):1205-1215.e1. Epub 2022 Sep 2 doi: 10.1016/j.jtcvs.2022.08.018. PMID: 36241450
An Analysis of Left Ventricular Retraining in Patients With Dextro- and Levo-Transposition of the Great Arteries.
Mainwaring RD, Patrick WL, Ibrahimiye AN, Watanabe N, Lui GK, Hanley FL
Ann Thorac Surg 2018 Mar;105(3):823-829. Epub 2017 Dec 20 doi: 10.1016/j.athoracsur.2017.11.047. PMID: 29274314
Complex congenital heart disease in a complicated and precious pregnancy.
Elsherif Z, Mahmood N, Jamil S, Wagas H
BMJ Case Rep 2015 Jul 1;2015 doi: 10.1136/bcr-2015-209388. PMID: 26135488Free PMC Article
Maternal smoking and congenital heart defects in the Baltimore-Washington Infant Study.
Alverson CJ, Strickland MJ, Gilboa SM, Correa A
Pediatrics 2011 Mar;127(3):e647-53. Epub 2011 Feb 28 doi: 10.1542/peds.2010-1399. PMID: 21357347

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