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Levotransposition of the great arteries

MedGen UID:
699035
•Concept ID:
C1275809
•
Congenital Abnormality
Synonyms: L - transposition of the great vessels; L-TGA; Levotransposition
SNOMED CT: L - transposition of the great vessels (399046008); Levotransposition (399046008); Levotransposition of the great arteries (399046008)
 
HPO: HP:0031349

Definition

A type of transposition of the great arteries (TGA) in which aorta is in front of and primarily to the left of the pulmonary artery. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLevotransposition of the great arteries

Recent clinical studies

Etiology

Case report: Pulmonary artery thrombosis in cyanotic congenital heart disease.
Shan A, Zubairi S, Mirza H, Amanullah M, Khan MZ
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):205-207. Epub 2021 Feb 20 doi: 10.1177/0218492321996519. PMID: 33611948
An Analysis of Left Ventricular Retraining in Patients With Dextro- and Levo-Transposition of the Great Arteries.
Mainwaring RD, Patrick WL, Ibrahimiye AN, Watanabe N, Lui GK, Hanley FL
Ann Thorac Surg 2018 Mar;105(3):823-829. Epub 2017 Dec 20 doi: 10.1016/j.athoracsur.2017.11.047. PMID: 29274314
Safety and efficacy of atrial antitachycardia pacing in congenital heart disease.
Kramer CC, Maldonado JR, Olson MD, Gingerich JC, Ochoa LA, Law IH
Heart Rhythm 2018 Apr;15(4):543-547. Epub 2017 Dec 12 doi: 10.1016/j.hrthm.2017.12.016. PMID: 29246827
Comparison of Simpson's method and three-dimensional reconstruction for measurement of right ventricular volume in patients with complete or corrected transposition of the great arteries.
Moroseos T, Mitsumori L, Kerwin WS, Sahn DJ, Helbing WA, Kilner PJ, Shurman A, Litt H, Sheehan FH
Am J Cardiol 2010 Jun 1;105(11):1603-9. Epub 2010 Apr 21 doi: 10.1016/j.amjcard.2010.01.025. PMID: 20494670
Levotransposition of the aorta: identification of segmental cardiac anatomy using MR imaging.
Guit GL, Bluemm R, Rohmer J, Wenink AC, Chin JG, Doornbos J, van Voorthuisen AE
Radiology 1986 Dec;161(3):673-9. doi: 10.1148/radiology.161.3.3786718. PMID: 3786718

Diagnosis

Case report: Pulmonary artery thrombosis in cyanotic congenital heart disease.
Shan A, Zubairi S, Mirza H, Amanullah M, Khan MZ
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):205-207. Epub 2021 Feb 20 doi: 10.1177/0218492321996519. PMID: 33611948
Acute Pulmonary Edema in a Pregnant Patient with Undiagnosed Levo-Transposition of the Great Arteries.
Karamchandani K, Benrud J, Swick JT
Am J Case Rep 2018 Dec 6;19:1445-1448. doi: 10.12659/AJCR.912168. PMID: 30518743Free PMC Article
Safety and efficacy of atrial antitachycardia pacing in congenital heart disease.
Kramer CC, Maldonado JR, Olson MD, Gingerich JC, Ochoa LA, Law IH
Heart Rhythm 2018 Apr;15(4):543-547. Epub 2017 Dec 12 doi: 10.1016/j.hrthm.2017.12.016. PMID: 29246827
Comparison of Simpson's method and three-dimensional reconstruction for measurement of right ventricular volume in patients with complete or corrected transposition of the great arteries.
Moroseos T, Mitsumori L, Kerwin WS, Sahn DJ, Helbing WA, Kilner PJ, Shurman A, Litt H, Sheehan FH
Am J Cardiol 2010 Jun 1;105(11):1603-9. Epub 2010 Apr 21 doi: 10.1016/j.amjcard.2010.01.025. PMID: 20494670
Levotransposition of the aorta: identification of segmental cardiac anatomy using MR imaging.
Guit GL, Bluemm R, Rohmer J, Wenink AC, Chin JG, Doornbos J, van Voorthuisen AE
Radiology 1986 Dec;161(3):673-9. doi: 10.1148/radiology.161.3.3786718. PMID: 3786718

Therapy

Complex congenital heart disease in a complicated and precious pregnancy.
Elsherif Z, Mahmood N, Jamil S, Wagas H
BMJ Case Rep 2015 Jul 1;2015 doi: 10.1136/bcr-2015-209388. PMID: 26135488Free PMC Article
Maternal smoking and congenital heart defects in the Baltimore-Washington Infant Study.
Alverson CJ, Strickland MJ, Gilboa SM, Correa A
Pediatrics 2011 Mar;127(3):e647-53. Epub 2011 Feb 28 doi: 10.1542/peds.2010-1399. PMID: 21357347
Cardiac transplantation for end-stage congenital heart defects: the Mayo Clinic experience. Mayo Cardiothoracic Transplant Team.
Speziali G, Driscoll DJ, Danielson GK, Julsrud PR, Porter CJ, Dearani JA, Daly RC, McGregor CG
Mayo Clin Proc 1998 Oct;73(10):923-8. doi: 10.4065/73.10.923. PMID: 9787738
Identification of the conduction system in corrected transposition and common ventricle at operation.
Maloney JD, Ritter DG, McGoon DC, Danielson GK
Mayo Clin Proc 1975 Jul;50(7):387-94. PMID: 1152532

Prognosis

Acute Pulmonary Edema in a Pregnant Patient with Undiagnosed Levo-Transposition of the Great Arteries.
Karamchandani K, Benrud J, Swick JT
Am J Case Rep 2018 Dec 6;19:1445-1448. doi: 10.12659/AJCR.912168. PMID: 30518743Free PMC Article
An Analysis of Left Ventricular Retraining in Patients With Dextro- and Levo-Transposition of the Great Arteries.
Mainwaring RD, Patrick WL, Ibrahimiye AN, Watanabe N, Lui GK, Hanley FL
Ann Thorac Surg 2018 Mar;105(3):823-829. Epub 2017 Dec 20 doi: 10.1016/j.athoracsur.2017.11.047. PMID: 29274314
Safety and efficacy of atrial antitachycardia pacing in congenital heart disease.
Kramer CC, Maldonado JR, Olson MD, Gingerich JC, Ochoa LA, Law IH
Heart Rhythm 2018 Apr;15(4):543-547. Epub 2017 Dec 12 doi: 10.1016/j.hrthm.2017.12.016. PMID: 29246827
Maternal smoking and congenital heart defects in the Baltimore-Washington Infant Study.
Alverson CJ, Strickland MJ, Gilboa SM, Correa A
Pediatrics 2011 Mar;127(3):e647-53. Epub 2011 Feb 28 doi: 10.1542/peds.2010-1399. PMID: 21357347
Experience with one and a half ventricle repair.
Kreutzer C, Mayorquim RC, Kreutzer GO, Conejeros W, Roman MI, Vazquez H, Schlichter AJ, Kreutzer EA
J Thorac Cardiovasc Surg 1999 Apr;117(4):662-8. doi: 10.1016/S0022-5223(99)70285-0. PMID: 10096960

Clinical prediction guides

An Analysis of Left Ventricular Retraining in Patients With Dextro- and Levo-Transposition of the Great Arteries.
Mainwaring RD, Patrick WL, Ibrahimiye AN, Watanabe N, Lui GK, Hanley FL
Ann Thorac Surg 2018 Mar;105(3):823-829. Epub 2017 Dec 20 doi: 10.1016/j.athoracsur.2017.11.047. PMID: 29274314
Complex congenital heart disease in a complicated and precious pregnancy.
Elsherif Z, Mahmood N, Jamil S, Wagas H
BMJ Case Rep 2015 Jul 1;2015 doi: 10.1136/bcr-2015-209388. PMID: 26135488Free PMC Article
Maternal smoking and congenital heart defects in the Baltimore-Washington Infant Study.
Alverson CJ, Strickland MJ, Gilboa SM, Correa A
Pediatrics 2011 Mar;127(3):e647-53. Epub 2011 Feb 28 doi: 10.1542/peds.2010-1399. PMID: 21357347

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