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Cellular Nerve Sheath Myxoma

MedGen UID:
699180
•Concept ID:
C1275959
•
Neoplastic Process
Synonyms: Cellular nerve sheath myxoma; Cellular Neurothekeoma; Cellular neurothekeoma
SNOMED CT: Cellular neurothekeoma (399922004); Cellular nerve sheath myxoma (399922004)

Definition

A nerve sheath myxoma with increased cellularity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular Nerve Sheath Myxoma

Recent clinical studies

Etiology

Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis.
Sheth S, Li X, Binder S, Dry SM
Mod Pathol 2011 Mar;24(3):343-54. Epub 2011 Feb 4 doi: 10.1038/modpathol.2010.203. PMID: 21297585
Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature.
Prado JD, Andrade RG, Silva-Sousa YT, Andrade MF, Soares FA, Perez DE
J Periodontol 2007 Aug;78(8):1639-43. doi: 10.1902/jop.2007.060425. PMID: 17668985
Neurothekeoma.
Ward JL, Prieto VG, Joseph A, Chevray P, Kronowitz S, Sturgis EM
Otolaryngol Head Neck Surg 2005 Jan;132(1):86-9. doi: 10.1016/j.otohns.2004.05.031. PMID: 15632914
Ultrastructural spectrum of cutaneous nerve sheath myxoma/cellular neurothekeoma.
Argenyi ZB, Kutzner H, Seaba MM
J Cutan Pathol 1995 Apr;22(2):137-45. doi: 10.1111/j.1600-0560.1995.tb01396.x. PMID: 7560346
Nerve sheath myxoma (neurothekeoma) of the skin: light microscopic and immunohistochemical reappraisal of the cellular variant.
Argenyi ZB, LeBoit PE, Santa Cruz D, Swanson PE, Kutzner H
J Cutan Pathol 1993 Aug;20(4):294-303. doi: 10.1111/j.1600-0560.1993.tb01265.x. PMID: 7693776

Diagnosis

Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Telocytes in the Normal and Pathological Peripheral Nervous System.
Díaz-Flores L, Gutiérrez R, García MP, Gayoso S, Gutiérrez E, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2020 Jun 17;21(12) doi: 10.3390/ijms21124320. PMID: 32560571Free PMC Article
Benign cutaneous neural tumors.
Rodríguez-Peralto JL, Riveiro-Falkenbach E, Carrillo R
Semin Diagn Pathol 2013 Feb;30(1):45-57. doi: 10.1053/j.semdp.2012.01.008. PMID: 23327729
Neurothekeoma.
Ward JL, Prieto VG, Joseph A, Chevray P, Kronowitz S, Sturgis EM
Otolaryngol Head Neck Surg 2005 Jan;132(1):86-9. doi: 10.1016/j.otohns.2004.05.031. PMID: 15632914
Cellular neurothekeoma.
Tomasini C, Aloi F, Pippione M
Dermatology 1996;192(2):160-3. doi: 10.1159/000246348. PMID: 8829503

Therapy

Atypical cellular neurothekeoma--a diagnosis to be aware of.
Wilson AD, Rigby H, Orlando A
J Plast Reconstr Aesthet Surg 2008;61(2):186-8. Epub 2007 Aug 20 doi: 10.1016/j.bjps.2007.01.078. PMID: 17709307

Prognosis

Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature.
Prado JD, Andrade RG, Silva-Sousa YT, Andrade MF, Soares FA, Perez DE
J Periodontol 2007 Aug;78(8):1639-43. doi: 10.1902/jop.2007.060425. PMID: 17668985
Atypical neurothekeoma: a new case and review of the literature.
Campanati A, Brandozzi G, Sisti S, Bernardini ML, Offidani AM
J Cutan Pathol 2007 May;34(5):435-7. doi: 10.1111/j.1600-0560.2006.00637.x. PMID: 17448203
Nerve sheath myxoma: a clinicopathologic and immunohistochemical analysis of 57 morphologically distinctive, S-100 protein- and GFAP-positive, myxoid peripheral nerve sheath tumors with a predilection for the extremities and a high local recurrence rate.
Fetsch JF, Laskin WB, Miettinen M
Am J Surg Pathol 2005 Dec;29(12):1615-24. doi: 10.1097/01.pas.0000173025.87476.a4. PMID: 16327434
Nerve-sheath myxoma (perineurial myxoma).
Pulitzer DR, Reed RJ
Am J Dermatopathol 1985 Oct;7(5):409-21. doi: 10.1097/00000372-198510000-00003. PMID: 4091218

Clinical prediction guides

Multiple myxoid cellular neurothekeomas in a patient with systemic lupus erythematosus.
Lau SK, Cassarino DS, Koh SS
J Cutan Pathol 2021 Jul;48(7):980-985. Epub 2021 May 9 doi: 10.1111/cup.14025. PMID: 33844324
Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Telocytes in the Normal and Pathological Peripheral Nervous System.
Díaz-Flores L, Gutiérrez R, García MP, Gayoso S, Gutiérrez E, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2020 Jun 17;21(12) doi: 10.3390/ijms21124320. PMID: 32560571Free PMC Article
Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature.
Prado JD, Andrade RG, Silva-Sousa YT, Andrade MF, Soares FA, Perez DE
J Periodontol 2007 Aug;78(8):1639-43. doi: 10.1902/jop.2007.060425. PMID: 17668985
Nerve sheath myxoma of the oral cavity: case report and review.
Tiffee JC, Pulitzer DR
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996 Oct;82(4):423-5. doi: 10.1016/s1079-2104(96)80308-8. PMID: 8899781

Recent systematic reviews

Pediatric cellular neurothekeoma: Seven cases and systematic review of the literature.
Murphrey M, Huy Nguyen A, White KP, Krol A, Bernert R, Yarbrough K
Pediatr Dermatol 2020 Mar;37(2):320-325. Epub 2020 Jan 12 doi: 10.1111/pde.14043. PMID: 31930561

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