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Cutaneous Lymphoma

MedGen UID:
699354
•Concept ID:
C1276146
•
Neoplastic Process
Synonym: Skin Lymphoma

Definition

A lymphoma involving the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Lymphoma

Professional guidelines

PubMed

Diagnosis and Management of Cutaneous Lymphomas Including Cutaneous T-cell Lymphoma.
Zic JA
Med Clin North Am 2021 Jul;105(4):737-755. doi: 10.1016/j.mcna.2021.04.010. PMID: 34059248
Mycosis fungoides-clinical and histopathologic features, differential diagnosis, and treatment.
Cerroni L
Semin Cutan Med Surg 2018 Mar;37(1):2-10. doi: 10.12788/j.sder.2018.002. PMID: 29719014
European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome - Update 2017.
Trautinger F, Eder J, Assaf C, Bagot M, Cozzio A, Dummer R, Gniadecki R, Klemke CD, Ortiz-Romero PL, Papadavid E, Pimpinelli N, Quaglino P, Ranki A, Scarisbrick J, Stadler R, Väkevä L, Vermeer MH, Whittaker S, Willemze R, Knobler R
Eur J Cancer 2017 May;77:57-74. Epub 2017 Mar 31 doi: 10.1016/j.ejca.2017.02.027. PMID: 28365528

Recent clinical studies

Etiology

Recent advances in cutaneous lymphoma-implications for current and future classifications.
Goodlad JR, Cerroni L, Swerdlow SH
Virchows Arch 2023 Jan;482(1):281-298. Epub 2022 Oct 24 doi: 10.1007/s00428-022-03421-5. PMID: 36278991Free PMC Article
Cutaneous T-cell Lymphoma.
Pulitzer M
Clin Lab Med 2017 Sep;37(3):527-546. doi: 10.1016/j.cll.2017.06.006. PMID: 28802499Free PMC Article
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):223.e1-17; quiz 240-2. doi: 10.1016/j.jaad.2013.08.033. PMID: 24438970
Cutaneous lymphomas.
Klemke CD
J Dtsch Dermatol Ges 2014 Jan;12(1):7-28; quiz 29-30. doi: 10.1111/ddg.12237. PMID: 24393310
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma.
Kempf W, Pfaltz K, Vermeer MH, Cozzio A, Ortiz-Romero PL, Bagot M, Olsen E, Kim YH, Dummer R, Pimpinelli N, Whittaker S, Hodak E, Cerroni L, Berti E, Horwitz S, Prince HM, Guitart J, Estrach T, Sanches JA, Duvic M, Ranki A, Dreno B, Ostheeren-Michaelis S, Knobler R, Wood G, Willemze R
Blood 2011 Oct 13;118(15):4024-35. Epub 2011 Aug 12 doi: 10.1182/blood-2011-05-351346. PMID: 21841159Free PMC Article

Diagnosis

Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC.
Olsen EA, Whittaker S, Willemze R, Pinter-Brown L, Foss F, Geskin L, Schwartz L, Horwitz S, Guitart J, Zic J, Kim YH, Wood GS, Duvic M, Ai W, Girardi M, Gru A, Guenova E, Hodak E, Hoppe R, Kempf W, Kim E, Lechowicz MJ, Ortiz-Romero P, Papadavid E, Quaglino P, Pittelkow M, Prince HM, Sanches JA, Sugaya M, Vermeer M, Zain J, Knobler R, Stadler R, Bagot M, Scarisbrick J
Blood 2022 Aug 4;140(5):419-437. doi: 10.1182/blood.2021012057. PMID: 34758074Free PMC Article
Diagnosis and Management of Cutaneous Lymphomas Including Cutaneous T-cell Lymphoma.
Zic JA
Med Clin North Am 2021 Jul;105(4):737-755. doi: 10.1016/j.mcna.2021.04.010. PMID: 34059248
Cutaneous leishmaniasis: A great imitator.
Gurel MS, Tekin B, Uzun S
Clin Dermatol 2020 Mar-Apr;38(2):140-151. Epub 2019 Oct 24 doi: 10.1016/j.clindermatol.2019.10.008. PMID: 32513395
Mycosis fungoides-clinical and histopathologic features, differential diagnosis, and treatment.
Cerroni L
Semin Cutan Med Surg 2018 Mar;37(1):2-10. doi: 10.12788/j.sder.2018.002. PMID: 29719014
Cutaneous T-cell Lymphoma.
Pulitzer M
Clin Lab Med 2017 Sep;37(3):527-546. doi: 10.1016/j.cll.2017.06.006. PMID: 28802499Free PMC Article

Therapy

Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC.
Olsen EA, Whittaker S, Willemze R, Pinter-Brown L, Foss F, Geskin L, Schwartz L, Horwitz S, Guitart J, Zic J, Kim YH, Wood GS, Duvic M, Ai W, Girardi M, Gru A, Guenova E, Hodak E, Hoppe R, Kempf W, Kim E, Lechowicz MJ, Ortiz-Romero P, Papadavid E, Quaglino P, Pittelkow M, Prince HM, Sanches JA, Sugaya M, Vermeer M, Zain J, Knobler R, Stadler R, Bagot M, Scarisbrick J
Blood 2022 Aug 4;140(5):419-437. doi: 10.1182/blood.2021012057. PMID: 34758074Free PMC Article
Safety and Danger Considerations of Novel Treatments for Atopic Dermatitis in Context of Primary Cutaneous Lymphomas.
Kołkowski K, Trzeciak M, Sokołowska-Wojdyło M
Int J Mol Sci 2021 Dec 13;22(24) doi: 10.3390/ijms222413388. PMID: 34948183Free PMC Article
Diagnosis and Management of Cutaneous Lymphomas Including Cutaneous T-cell Lymphoma.
Zic JA
Med Clin North Am 2021 Jul;105(4):737-755. doi: 10.1016/j.mcna.2021.04.010. PMID: 34059248
Advances in gene therapy and their application to skin diseases: A review.
Shinkuma S
J Dermatol Sci 2021 Jul;103(1):2-9. Epub 2021 May 21 doi: 10.1016/j.jdermsci.2021.05.004. PMID: 34049771
Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors.
Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545

Prognosis

Cutaneous T-cell lymphoma: diagnosing subtypes and the challenges.
Hague C, Farquharson N, Menasce L, Parry E, Cowan R
Br J Hosp Med (Lond) 2022 Apr 2;83(4):1-7. Epub 2022 Apr 14 doi: 10.12968/hmed.2021.0149. PMID: 35506718
Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC.
Olsen EA, Whittaker S, Willemze R, Pinter-Brown L, Foss F, Geskin L, Schwartz L, Horwitz S, Guitart J, Zic J, Kim YH, Wood GS, Duvic M, Ai W, Girardi M, Gru A, Guenova E, Hodak E, Hoppe R, Kempf W, Kim E, Lechowicz MJ, Ortiz-Romero P, Papadavid E, Quaglino P, Pittelkow M, Prince HM, Sanches JA, Sugaya M, Vermeer M, Zain J, Knobler R, Stadler R, Bagot M, Scarisbrick J
Blood 2022 Aug 4;140(5):419-437. doi: 10.1182/blood.2021012057. PMID: 34758074Free PMC Article
Diagnosis and Management of Cutaneous Lymphomas Including Cutaneous T-cell Lymphoma.
Zic JA
Med Clin North Am 2021 Jul;105(4):737-755. doi: 10.1016/j.mcna.2021.04.010. PMID: 34059248
Cutaneous leishmaniasis: A great imitator.
Gurel MS, Tekin B, Uzun S
Clin Dermatol 2020 Mar-Apr;38(2):140-151. Epub 2019 Oct 24 doi: 10.1016/j.clindermatol.2019.10.008. PMID: 32513395
Mycosis fungoides-clinical and histopathologic features, differential diagnosis, and treatment.
Cerroni L
Semin Cutan Med Surg 2018 Mar;37(1):2-10. doi: 10.12788/j.sder.2018.002. PMID: 29719014

Clinical prediction guides

Efficacy and Safety of Topical Hypericin Photodynamic Therapy for Early-Stage Cutaneous T-Cell Lymphoma (Mycosis Fungoides): The FLASH Phase 3 Randomized Clinical Trial.
Kim EJ, Mangold AR, DeSimone JA, Wong HK, Seminario-Vidal L, Guitart J, Appel J, Geskin L, Lain E, Korman NJ, Zeitouni N, Nikbakht N, Dawes K, Akilov O, Carter J, Shinohara M, Kuzel TM, Piette W, Bhatia N, Musiek A, Pariser D, Kim YH, Elston D, Boh E, Duvic M, Huen A, Pacheco T, Zwerner JP, Lee ST, Girardi M, Querfeld C, Bohjanen K, Olsen E, Wood GS, Rumage A, Donini O, Haulenbeek A, Schaber CJ, Straube R, Pullion C, Rook AH, Poligone B
JAMA Dermatol 2022 Sep 1;158(9):1031-1039. doi: 10.1001/jamadermatol.2022.2749. PMID: 35857290Free PMC Article
Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma.
Rindler K, Jonak C, Alkon N, Thaler FM, Kurz H, Shaw LE, Stingl G, Weninger W, Halbritter F, Bauer WM, Farlik M, Brunner PM
Mol Cancer 2021 Sep 28;20(1):124. doi: 10.1186/s12943-021-01419-2. PMID: 34583709Free PMC Article
Anti-HMGCR myopathy: clinical and histopathological features, and prognosis.
Kurashige T
Curr Opin Rheumatol 2021 Nov 1;33(6):554-562. doi: 10.1097/BOR.0000000000000832. PMID: 34456255
Outcomes in primary cutaneous diffuse large B-cell lymphoma, leg type.
Kraft RM, Ansell SM, Villasboas JC, Bennani NN, Wang Y, Habermann TM, Thanarajasingam G, Lester SC, Macon W, Inwards DJ, Porrata LF, Micallef IN, Witzig TE, Thompson CA, Johnston PB, Nowakowski GS, Lin Y, Paludo J
Hematol Oncol 2021 Dec;39(5):658-663. Epub 2021 Aug 28 doi: 10.1002/hon.2919. PMID: 34453851
Treatment of a first patient with FLASH-radiotherapy.
Bourhis J, Sozzi WJ, Jorge PG, Gaide O, Bailat C, Duclos F, Patin D, Ozsahin M, Bochud F, Germond JF, Moeckli R, Vozenin MC
Radiother Oncol 2019 Oct;139:18-22. Epub 2019 Jul 11 doi: 10.1016/j.radonc.2019.06.019. PMID: 31303340

Recent systematic reviews

Clinicopathological and prognostic study of primary cutaneous extranodal natural killer/T-cell lymphoma, nasal type: A systematic review.
Jung JM, Yang HJ, Won CH, Chang SE, Lee MW, Lee WJ
J Dermatol 2021 Oct;48(10):1499-1510. Epub 2021 Jun 1 doi: 10.1111/1346-8138.15972. PMID: 34060130
Borrelia burgdorferi in primary cutaneous lymphomas: a systematic review and meta-analysis.
Travaglino A, Varricchio S, Pace M, Russo D, Picardi M, Baldo A, Staibano S, Mascolo M
J Dtsch Dermatol Ges 2020 Dec;18(12):1379-1384. Epub 2020 Oct 8 doi: 10.1111/ddg.14289. PMID: 33029842
Interventions for mycosis fungoides.
Valipour A, Jäger M, Wu P, Schmitt J, Bunch C, Weberschock T
Cochrane Database Syst Rev 2020 Jul 7;7(7):CD008946. doi: 10.1002/14651858.CD008946.pub3. PMID: 32632956Free PMC Article
Atypical presentations of cutaneous leishmaniasis: A systematic review.
Meireles CB, Maia LC, Soares GC, Teodoro IPP, Gadelha MDSV, da Silva CGL, de Lima MAP
Acta Trop 2017 Aug;172:240-254. Epub 2017 May 17 doi: 10.1016/j.actatropica.2017.05.022. PMID: 28526427
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma.
Kempf W, Pfaltz K, Vermeer MH, Cozzio A, Ortiz-Romero PL, Bagot M, Olsen E, Kim YH, Dummer R, Pimpinelli N, Whittaker S, Hodak E, Cerroni L, Berti E, Horwitz S, Prince HM, Guitart J, Estrach T, Sanches JA, Duvic M, Ranki A, Dreno B, Ostheeren-Michaelis S, Knobler R, Wood G, Willemze R
Blood 2011 Oct 13;118(15):4024-35. Epub 2011 Aug 12 doi: 10.1182/blood-2011-05-351346. PMID: 21841159Free PMC Article

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