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Delayed adrenarche

MedGen UID:
699438
Concept ID:
C1276238
Disease or Syndrome
SNOMED CT: Delayed adrenarche (124748007)
 
HPO: HP:0025453

Definition

Occurrence of adrenarche at a later than normal age. Adrenarche normally occurs between six and eight years of age with increased adrenal androgen secretion; its exact biologic role is not well understood. It is accompanied by changes in pilosebaceous units, a transient growth spurt and the appearance of axillary and pubic hair in some children, but no sexual development. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDelayed adrenarche

Professional guidelines

PubMed

Wakeling EL, Brioude F, Lokulo-Sodipe O, O'Connell SM, Salem J, Bliek J, Canton AP, Chrzanowska KH, Davies JH, Dias RP, Dubern B, Elbracht M, Giabicani E, Grimberg A, Grønskov K, Hokken-Koelega AC, Jorge AA, Kagami M, Linglart A, Maghnie M, Mohnike K, Monk D, Moore GE, Murray PG, Ogata T, Petit IO, Russo S, Said E, Toumba M, Tümer Z, Binder G, Eggermann T, Harbison MD, Temple IK, Mackay DJ, Netchine I
Nat Rev Endocrinol 2017 Feb;13(2):105-124. Epub 2016 Sep 2 doi: 10.1038/nrendo.2016.138. PMID: 27585961
Joustra SD, Heinen CA, Schoenmakers N, Bonomi M, Ballieux BE, Turgeon MO, Bernard DJ, Fliers E, van Trotsenburg AS, Losekoot M, Persani L, Wit JM, Biermasz NR, Pereira AM, Oostdijk W; IGSF1 Clinical Care Group
J Clin Endocrinol Metab 2016 Apr;101(4):1627-36. Epub 2016 Feb 3 doi: 10.1210/jc.2015-3880. PMID: 26840047Free PMC Article
Sklar CA, Lew LQ, Yoon DJ, David R
Am J Dis Child 1987 Mar;141(3):327-30. doi: 10.1001/archpedi.1987.04460030105036. PMID: 3028128

Recent clinical studies

Etiology

Van Hulle S, Craen M, Callewaert B, Joustra S, Oostdijk W, Losekoot M, Wit JM, Turgeon MO, Bernard DJ, De Schepper J
J Clin Res Pediatr Endocrinol 2016 Mar 5;8(1):86-91. Epub 2015 Dec 18 doi: 10.4274/jcrpe.2512. PMID: 26757742Free PMC Article
Melo KF, Martin RM, Costa EM, Carvalho FM, Jorge AA, Arnhold IJ, Mendonca BB
J Clin Endocrinol Metab 2002 Jun;87(6):2500-5. doi: 10.1210/jcem.87.6.8521. PMID: 12050205
Filosa A, Di Maio S, Esposito G, De Martinis F, De Terlizzi F
J Pediatr Endocrinol Metab 2001 Apr;14(4):407-14. doi: 10.1515/jpem.2001.14.4.407. PMID: 11327374
Filosa A, Di Maio S, Saviano A, Vocca S, Esposito G
J Pediatr Endocrinol Metab 1996 May-Jun;9(3):401-6. doi: 10.1515/jpem.1996.9.3.401. PMID: 8887150

Diagnosis

Papadimitriou A, Papadopoulou A, Kleanthous K, Papadimitriou DT, Papaevangelou V
J Clin Res Pediatr Endocrinol 2020 Jun 3;12(2):218-222. Epub 2019 Aug 26 doi: 10.4274/jcrpe.galenos.2019.2019.0085. PMID: 31448769Free PMC Article
Melo KF, Martin RM, Costa EM, Carvalho FM, Jorge AA, Arnhold IJ, Mendonca BB
J Clin Endocrinol Metab 2002 Jun;87(6):2500-5. doi: 10.1210/jcem.87.6.8521. PMID: 12050205

Therapy

Van Hulle S, Craen M, Callewaert B, Joustra S, Oostdijk W, Losekoot M, Wit JM, Turgeon MO, Bernard DJ, De Schepper J
J Clin Res Pediatr Endocrinol 2016 Mar 5;8(1):86-91. Epub 2015 Dec 18 doi: 10.4274/jcrpe.2512. PMID: 26757742Free PMC Article
Filosa A, Di Maio S, Esposito G, De Martinis F, De Terlizzi F
J Pediatr Endocrinol Metab 2001 Apr;14(4):407-14. doi: 10.1515/jpem.2001.14.4.407. PMID: 11327374

Prognosis

Van Hulle S, Craen M, Callewaert B, Joustra S, Oostdijk W, Losekoot M, Wit JM, Turgeon MO, Bernard DJ, De Schepper J
J Clin Res Pediatr Endocrinol 2016 Mar 5;8(1):86-91. Epub 2015 Dec 18 doi: 10.4274/jcrpe.2512. PMID: 26757742Free PMC Article
Melo KF, Martin RM, Costa EM, Carvalho FM, Jorge AA, Arnhold IJ, Mendonca BB
J Clin Endocrinol Metab 2002 Jun;87(6):2500-5. doi: 10.1210/jcem.87.6.8521. PMID: 12050205

Clinical prediction guides

Van Hulle S, Craen M, Callewaert B, Joustra S, Oostdijk W, Losekoot M, Wit JM, Turgeon MO, Bernard DJ, De Schepper J
J Clin Res Pediatr Endocrinol 2016 Mar 5;8(1):86-91. Epub 2015 Dec 18 doi: 10.4274/jcrpe.2512. PMID: 26757742Free PMC Article
Taha D, Mullis PE, Ibáñez L, de Zegher F
Horm Res 2005;64(4):175-9. Epub 2005 Oct 4 doi: 10.1159/000088793. PMID: 16210857
Melo KF, Martin RM, Costa EM, Carvalho FM, Jorge AA, Arnhold IJ, Mendonca BB
J Clin Endocrinol Metab 2002 Jun;87(6):2500-5. doi: 10.1210/jcem.87.6.8521. PMID: 12050205
Filosa A, Di Maio S, Esposito G, De Martinis F, De Terlizzi F
J Pediatr Endocrinol Metab 2001 Apr;14(4):407-14. doi: 10.1515/jpem.2001.14.4.407. PMID: 11327374
Cohen HN, Paterson KR, Wallace AM, Beastall GH, Manderson WG, MacCuish AC
Clin Endocrinol (Oxf) 1984 Jun;20(6):717-24. doi: 10.1111/j.1365-2265.1984.tb00122.x. PMID: 6235985

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