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Infectious mononucleosis

MedGen UID:
7069
•Concept ID:
C0021345
•
Disease or Syndrome
Synonyms: Fever, Glandular; Glandular Fever; Infectious Mononucleosis; Mononucleosis, Infectious
SNOMED CT: Pfeiffer's disease (271558008); Gammaherpesviral mononucleosis (186668002); Infectious mononucleosis (271558008); Infective mononucleosis (271558008); Glandular fever (271558008); GF - Glandular fever (271558008); Monocytic angina (271558008); IM - Infective mononucleosis (271558008); IM - Infectious mononucleosis (271558008)
 
Monarch Initiative: MONDO:0005810

Definition

A clinical syndrome of fever, sore throat, fatigue, and lymphadenopathy caused by infection with the Epstein-Barr virus. Subsequent physical findings may include hepatomegaly, palatal petechiae, jaundice, uvular edema, and splenomegaly. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfectious mononucleosis

Professional guidelines

PubMed

Splenomegaly: Diagnosis and Management in Adults.
Aldulaimi S, Mendez AM
Am Fam Physician 2021 Sep 1;104(3):271-276. PMID: 34523897
Infectious Mononucleosis Management in Athletes.
Ceraulo AS, Bytomski JR
Clin Sports Med 2019 Oct;38(4):555-561. Epub 2019 Jul 29 doi: 10.1016/j.csm.2019.06.002. PMID: 31472766
Current diagnosis and management of infectious mononucleosis.
Vouloumanou EK, Rafailidis PI, Falagas ME
Curr Opin Hematol 2012 Jan;19(1):14-20. doi: 10.1097/MOH.0b013e32834daa08. PMID: 22123662

Recent clinical studies

Etiology

Infectious Mononucleosis: Rapid Evidence Review.
Sylvester JE, Buchanan BK, Silva TW
Am Fam Physician 2023 Jan;107(1):71-78. PMID: 36689975
Primary Epstein-Barr virus infection with and without infectious mononucleosis.
Rostgaard K, Balfour HH Jr, Jarrett R, Erikstrup C, Pedersen O, Ullum H, Nielsen LP, Voldstedlund M, Hjalgrim H
PLoS One 2019;14(12):e0226436. Epub 2019 Dec 17 doi: 10.1371/journal.pone.0226436. PMID: 31846480Free PMC Article
Epstein-Barr virus and its association with disease - a review of relevance to general practice.
Fugl A, Andersen CL
BMC Fam Pract 2019 May 14;20(1):62. doi: 10.1186/s12875-019-0954-3. PMID: 31088382Free PMC Article
Primary Epstein-Barr virus infection.
Dunmire SK, Verghese PS, Balfour HH Jr
J Clin Virol 2018 May;102:84-92. Epub 2018 Mar 5 doi: 10.1016/j.jcv.2018.03.001. PMID: 29525635
Common questions about infectious mononucleosis.
Womack J, Jimenez M
Am Fam Physician 2015 Mar 15;91(6):372-6. PMID: 25822555

Diagnosis

Infectious Mononucleosis: Rapid Evidence Review.
Sylvester JE, Buchanan BK, Silva TW
Am Fam Physician 2023 Jan;107(1):71-78. PMID: 36689975
Infectious Mononucleosis Management in Athletes.
Ceraulo AS, Bytomski JR
Clin Sports Med 2019 Oct;38(4):555-561. Epub 2019 Jul 29 doi: 10.1016/j.csm.2019.06.002. PMID: 31472766
Infectious mononucleosis.
Schwartzkopf J
JAAPA 2018 Nov;31(11):52-53. doi: 10.1097/01.JAA.0000546488.73851.dd. PMID: 30358681
Current diagnosis and management of infectious mononucleosis.
Vouloumanou EK, Rafailidis PI, Falagas ME
Curr Opin Hematol 2012 Jan;19(1):14-20. doi: 10.1097/MOH.0b013e32834daa08. PMID: 22123662
Infectious mononucleosis.
Cozad J
Nurse Pract 1996 Mar;21(3):14-6, 23, 27-8. PMID: 8710247

Therapy

Amoxicillin Rash in Infectious Mononucleosis.
Mergoum AM
N Engl J Med 2021 Sep 9;385(11):1033. doi: 10.1056/NEJMicm2104358. PMID: 34496177
Vaccine Development for Epstein-Barr Virus.
Cohen JI
Adv Exp Med Biol 2018;1045:477-493. doi: 10.1007/978-981-10-7230-7_22. PMID: 29896681Free PMC Article
Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses.
Belbasis L, Bellou V, Evangelou E, Ioannidis JP, Tzoulaki I
Lancet Neurol 2015 Mar;14(3):263-73. Epub 2015 Feb 4 doi: 10.1016/S1474-4422(14)70267-4. PMID: 25662901
Current diagnosis and management of infectious mononucleosis.
Vouloumanou EK, Rafailidis PI, Falagas ME
Curr Opin Hematol 2012 Jan;19(1):14-20. doi: 10.1097/MOH.0b013e32834daa08. PMID: 22123662
Epstein-Barr virus infectious mononucleosis.
Ebell MH
Am Fam Physician 2004 Oct 1;70(7):1279-87. PMID: 15508538

Prognosis

The Evolving Epidemiology of Nasopharyngeal Carcinoma.
Chang ET, Ye W, Zeng YX, Adami HO
Cancer Epidemiol Biomarkers Prev 2021 Jun;30(6):1035-1047. Epub 2021 Apr 13 doi: 10.1158/1055-9965.EPI-20-1702. PMID: 33849968
Infectious Mononucleosis: diagnosis and clinical interpretation.
Naughton P, Healy M, Enright F, Lucey B
Br J Biomed Sci 2021 Jul;78(3):107-116. Epub 2021 Apr 14 doi: 10.1080/09674845.2021.1903683. PMID: 33721513
The rash with maculopapules and fever in adults.
Muzumdar S, Rothe MJ, Grant-Kels JM
Clin Dermatol 2019 Mar-Apr;37(2):109-118. Epub 2018 Dec 5 doi: 10.1016/j.clindermatol.2018.12.004. PMID: 30981291
Antibiotic-Induced Rash in Patients With Infectious Mononucleosis.
Thompson DF, Ramos CL
Ann Pharmacother 2017 Feb;51(2):154-162. Epub 2016 Oct 1 doi: 10.1177/1060028016669525. PMID: 27620494
Epstein-Barr virus infectious mononucleosis.
Ebell MH
Am Fam Physician 2004 Oct 1;70(7):1279-87. PMID: 15508538

Clinical prediction guides

Infectious Mononucleosis: diagnosis and clinical interpretation.
Naughton P, Healy M, Enright F, Lucey B
Br J Biomed Sci 2021 Jul;78(3):107-116. Epub 2021 Apr 14 doi: 10.1080/09674845.2021.1903683. PMID: 33721513
Lipschütz's acute vulvar ulcer: a systematic review.
Vismara SA, Lava SAG, Kottanattu L, Simonetti GD, Zgraggen L, Clericetti CM, Bianchetti MG, Milani GP
Eur J Pediatr 2020 Oct;179(10):1559-1567. Epub 2020 Apr 15 doi: 10.1007/s00431-020-03647-y. PMID: 32296983
Primary Epstein-Barr virus infection.
Dunmire SK, Verghese PS, Balfour HH Jr
J Clin Virol 2018 May;102:84-92. Epub 2018 Mar 5 doi: 10.1016/j.jcv.2018.03.001. PMID: 29525635
Antibiotic-Induced Rash in Patients With Infectious Mononucleosis.
Thompson DF, Ramos CL
Ann Pharmacother 2017 Feb;51(2):154-162. Epub 2016 Oct 1 doi: 10.1177/1060028016669525. PMID: 27620494
Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses.
Belbasis L, Bellou V, Evangelou E, Ioannidis JP, Tzoulaki I
Lancet Neurol 2015 Mar;14(3):263-73. Epub 2015 Feb 4 doi: 10.1016/S1474-4422(14)70267-4. PMID: 25662901

Recent systematic reviews

Accuracy of Signs, Symptoms, and Hematologic Parameters for the Diagnosis of Infectious Mononucleosis: A Systematic Review and Meta-Analysis.
Cai X, Ebell MH, Haines L
J Am Board Fam Med 2021 Nov-Dec;34(6):1141-1156. doi: 10.3122/jabfm.2021.06.210217. PMID: 34772769
Lipschütz's acute vulvar ulcer: a systematic review.
Vismara SA, Lava SAG, Kottanattu L, Simonetti GD, Zgraggen L, Clericetti CM, Bianchetti MG, Milani GP
Eur J Pediatr 2020 Oct;179(10):1559-1567. Epub 2020 Apr 15 doi: 10.1007/s00431-020-03647-y. PMID: 32296983
Systematic review and meta-analysis of the association between Epstein-Barr virus, multiple sclerosis and other risk factors.
Jacobs BM, Giovannoni G, Cuzick J, Dobson R
Mult Scler 2020 Oct;26(11):1281-1297. Epub 2020 Mar 23 doi: 10.1177/1352458520907901. PMID: 32202208Free PMC Article
Tonsillitis.
Georgalas CC, Tolley NS, Narula PA
BMJ Clin Evid 2014 Jul 22;2014 PMID: 25051184Free PMC Article
Tonsillitis.
Georgalas CC, Tolley NS, Narula A
BMJ Clin Evid 2009 Oct 26;2009 PMID: 21718574Free PMC Article

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