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Chondritis

MedGen UID:
707861
•Concept ID:
C1285334
•
Disease or Syndrome
Synonyms: Cartilage inflammation; Inflammatory disorder of cartilage
SNOMED CT: Chondritis (363173007); Inflammatory disorder of cartilage (363173007)
 
HPO: HP:0100662

Definition

Inflammation of cartilage. [from HPO]

Professional guidelines

PubMed

French practical guidelines for the diagnosis and management of relapsing polychondritis.
Arnaud L, Costedoat-Chalumeau N, Mathian A, Sailler L, Belot A, Dion J, Morel N, Moulis G; Collaborators
Rev Med Interne 2023 Jun;44(6):282-294. Epub 2023 May 24 doi: 10.1016/j.revmed.2023.05.005. PMID: 37236870
Gentamicin ointment versus petrolatum for management of auricular wounds.
Campbell RM, Perlis CS, Fisher E, Gloster HM Jr
Dermatol Surg 2005 Jun;31(6):664-9. doi: 10.1111/j.1524-4725.2005.31610. PMID: 15996417
Simplified treatment of postoperative mediastinitis.
Merrill WH, Akhter SA, Wolf RK, Schneeberger EW, Flege JB Jr
Ann Thorac Surg 2004 Aug;78(2):608-12; discussion 608-12. doi: 10.1016/j.athoracsur.2004.02.089. PMID: 15276531

Recent clinical studies

Etiology

Relapsing polychondritis - A single Centre study in the United Kingdom.
Sangle SR, Hughes CD, Barry L, Qureshi S, Cheah CK, Poh YJ, D'Cruz DP
Autoimmun Rev 2023 Aug;22(8):103352. Epub 2023 May 4 doi: 10.1016/j.autrev.2023.103352. PMID: 37146927
Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients.
Georgin-Lavialle S, Terrier B, Guedon AF, Heiblig M, Comont T, Lazaro E, Lacombe V, Terriou L, Ardois S, Bouaziz JD, Mathian A, Le Guenno G, Aouba A, Outh R, Meyer A, Roux-Sauvat M, Ebbo M, Zhao LP, Bigot A, Jamilloux Y, Guillotin V, Flamarion E, Henneton P, Vial G, Jachiet V, Rossignol J, Vinzio S, Weitten T, Vinit J, Deligny C, Humbert S, Samson M, Magy-Bertrand N, Moulinet T, Bourguiba R, Hanslik T, Bachmeyer C, Sebert M, Kostine M, Bienvenu B, Biscay P, Liozon E, Sailler L, Chasset F, Audemard-Verger A, Duroyon E, Sarrabay G, Borlot F, Dieval C, Cluzeau T, Marianetti P, Lobbes H, Boursier G, Gerfaud-Valentin M, Jeannel J, Servettaz A, Audia S, Larue M, Henriot B, Faucher B, Graveleau J, de Sainte Marie B, Galland J, Bouillet L, Arnaud C, Ades L, Carrat F, Hirsch P, Fenaux P, Fain O, Sujobert P, Kosmider O, Mekinian A; French VEXAS group; GFEV, GFM, CEREMAIA, MINHEMON
Br J Dermatol 2022 Mar;186(3):564-574. Epub 2021 Nov 28 doi: 10.1111/bjd.20805. PMID: 34632574
Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS.
van der Made CI, Potjewijd J, Hoogstins A, Willems HPJ, Kwakernaak AJ, de Sevaux RGL, van Daele PLA, Simons A, Heijstek M, Beck DB, Netea MG, van Paassen P, Elizabeth Hak A, van der Veken LT, van Gijn ME, Hoischen A, van de Veerdonk FL, Leavis HL, Rutgers A
J Allergy Clin Immunol 2022 Jan;149(1):432-439.e4. Epub 2021 May 25 doi: 10.1016/j.jaci.2021.05.014. PMID: 34048852
Relapsing polychondritis: state-of-the-art review with three case presentations.
Grygiel-Górniak B, Tariq H, Mitchell J, Mohammed A, Samborski W
Postgrad Med 2021 Nov;133(8):953-963. Epub 2021 Sep 30 doi: 10.1080/00325481.2021.1979873. PMID: 34533099
Diagnosis and classification of relapsing polychondritis.
Cantarini L, Vitale A, Brizi MG, Caso F, Frediani B, Punzi L, Galeazzi M, Rigante D
J Autoimmun 2014 Feb-Mar;48-49:53-9. Epub 2014 Jan 24 doi: 10.1016/j.jaut.2014.01.026. PMID: 24461536

Diagnosis

VEXAS syndrome: An update.
Khitri MY, Hadjadj J, Mekinian A, Jachiet V
Joint Bone Spine 2024 Jul;91(4):105700. Epub 2024 Feb 1 doi: 10.1016/j.jbspin.2024.105700. PMID: 38307404
VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) for the dermatologist.
Sterling D, Duncan ME, Philippidou M, Salisbury JR, Kulasekararaj AG, Basu TN
J Am Acad Dermatol 2023 Dec;89(6):1209-1214. Epub 2022 Feb 2 doi: 10.1016/j.jaad.2022.01.042. PMID: 35121074
Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients.
Georgin-Lavialle S, Terrier B, Guedon AF, Heiblig M, Comont T, Lazaro E, Lacombe V, Terriou L, Ardois S, Bouaziz JD, Mathian A, Le Guenno G, Aouba A, Outh R, Meyer A, Roux-Sauvat M, Ebbo M, Zhao LP, Bigot A, Jamilloux Y, Guillotin V, Flamarion E, Henneton P, Vial G, Jachiet V, Rossignol J, Vinzio S, Weitten T, Vinit J, Deligny C, Humbert S, Samson M, Magy-Bertrand N, Moulinet T, Bourguiba R, Hanslik T, Bachmeyer C, Sebert M, Kostine M, Bienvenu B, Biscay P, Liozon E, Sailler L, Chasset F, Audemard-Verger A, Duroyon E, Sarrabay G, Borlot F, Dieval C, Cluzeau T, Marianetti P, Lobbes H, Boursier G, Gerfaud-Valentin M, Jeannel J, Servettaz A, Audia S, Larue M, Henriot B, Faucher B, Graveleau J, de Sainte Marie B, Galland J, Bouillet L, Arnaud C, Ades L, Carrat F, Hirsch P, Fenaux P, Fain O, Sujobert P, Kosmider O, Mekinian A; French VEXAS group; GFEV, GFM, CEREMAIA, MINHEMON
Br J Dermatol 2022 Mar;186(3):564-574. Epub 2021 Nov 28 doi: 10.1111/bjd.20805. PMID: 34632574
Relapsing polychondritis.
Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C
Joint Bone Spine 2014 Mar;81(2):118-24. Epub 2014 Feb 18 doi: 10.1016/j.jbspin.2014.01.001. PMID: 24556284
Relapsing polychondritis.
Molina JF, Espinoza LR
Baillieres Best Pract Res Clin Rheumatol 2000 Mar;14(1):97-109. doi: 10.1053/berh.1999.0079. PMID: 10882216

Therapy

French practical guidelines for the diagnosis and management of relapsing polychondritis.
Arnaud L, Costedoat-Chalumeau N, Mathian A, Sailler L, Belot A, Dion J, Morel N, Moulis G; Collaborators
Rev Med Interne 2023 Jun;44(6):282-294. Epub 2023 May 24 doi: 10.1016/j.revmed.2023.05.005. PMID: 37236870
Relapsing polychondritis: state-of-the-art review with three case presentations.
Grygiel-Górniak B, Tariq H, Mitchell J, Mohammed A, Samborski W
Postgrad Med 2021 Nov;133(8):953-963. Epub 2021 Sep 30 doi: 10.1080/00325481.2021.1979873. PMID: 34533099
Relapsing polychondritis: A clinical update.
Longo L, Greco A, Rea A, Lo Vasco VR, De Virgilio A, De Vincentiis M
Autoimmun Rev 2016 Jun;15(6):539-43. Epub 2016 Feb 11 doi: 10.1016/j.autrev.2016.02.013. PMID: 26876384
Relapsing polychondritis.
Rapini RP, Warner NB
Clin Dermatol 2006 Nov-Dec;24(6):482-5. doi: 10.1016/j.clindermatol.2006.07.018. PMID: 17113965
Relapsing polychondritis.
Molina JF, Espinoza LR
Baillieres Best Pract Res Clin Rheumatol 2000 Mar;14(1):97-109. doi: 10.1053/berh.1999.0079. PMID: 10882216

Prognosis

French practical guidelines for the diagnosis and management of relapsing polychondritis.
Arnaud L, Costedoat-Chalumeau N, Mathian A, Sailler L, Belot A, Dion J, Morel N, Moulis G; Collaborators
Rev Med Interne 2023 Jun;44(6):282-294. Epub 2023 May 24 doi: 10.1016/j.revmed.2023.05.005. PMID: 37236870
Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis.
Ferrada MA, Savic S, Cardona DO, Collins JC, Alessi H, Gutierrez-Rodrigues F, Kumar DBU, Wilson L, Goodspeed W, Topilow JS, Paik JJ, Poulter JA, Kermani TA, Koster MJ, Warrington KJ, Cargo C, Tattersall RS, Duncan CJA, Cantor A, Hoffmann P, Payne EM, Bonnekoh H, Krause K, Cowen EW, Calvo KR, Patel BA, Ombrello AK, Kastner DL, Young NS, Werner A, Grayson PC, Beck DB
Blood 2022 Sep 29;140(13):1496-1506. doi: 10.1182/blood.2022016985. PMID: 35793467Free PMC Article
Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients.
Georgin-Lavialle S, Terrier B, Guedon AF, Heiblig M, Comont T, Lazaro E, Lacombe V, Terriou L, Ardois S, Bouaziz JD, Mathian A, Le Guenno G, Aouba A, Outh R, Meyer A, Roux-Sauvat M, Ebbo M, Zhao LP, Bigot A, Jamilloux Y, Guillotin V, Flamarion E, Henneton P, Vial G, Jachiet V, Rossignol J, Vinzio S, Weitten T, Vinit J, Deligny C, Humbert S, Samson M, Magy-Bertrand N, Moulinet T, Bourguiba R, Hanslik T, Bachmeyer C, Sebert M, Kostine M, Bienvenu B, Biscay P, Liozon E, Sailler L, Chasset F, Audemard-Verger A, Duroyon E, Sarrabay G, Borlot F, Dieval C, Cluzeau T, Marianetti P, Lobbes H, Boursier G, Gerfaud-Valentin M, Jeannel J, Servettaz A, Audia S, Larue M, Henriot B, Faucher B, Graveleau J, de Sainte Marie B, Galland J, Bouillet L, Arnaud C, Ades L, Carrat F, Hirsch P, Fenaux P, Fain O, Sujobert P, Kosmider O, Mekinian A; French VEXAS group; GFEV, GFM, CEREMAIA, MINHEMON
Br J Dermatol 2022 Mar;186(3):564-574. Epub 2021 Nov 28 doi: 10.1111/bjd.20805. PMID: 34632574
Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS.
van der Made CI, Potjewijd J, Hoogstins A, Willems HPJ, Kwakernaak AJ, de Sevaux RGL, van Daele PLA, Simons A, Heijstek M, Beck DB, Netea MG, van Paassen P, Elizabeth Hak A, van der Veken LT, van Gijn ME, Hoischen A, van de Veerdonk FL, Leavis HL, Rutgers A
J Allergy Clin Immunol 2022 Jan;149(1):432-439.e4. Epub 2021 May 25 doi: 10.1016/j.jaci.2021.05.014. PMID: 34048852
Relapsing polychondritis.
Rapini RP, Warner NB
Clin Dermatol 2006 Nov-Dec;24(6):482-5. doi: 10.1016/j.clindermatol.2006.07.018. PMID: 17113965

Clinical prediction guides

Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis.
Ferrada MA, Savic S, Cardona DO, Collins JC, Alessi H, Gutierrez-Rodrigues F, Kumar DBU, Wilson L, Goodspeed W, Topilow JS, Paik JJ, Poulter JA, Kermani TA, Koster MJ, Warrington KJ, Cargo C, Tattersall RS, Duncan CJA, Cantor A, Hoffmann P, Payne EM, Bonnekoh H, Krause K, Cowen EW, Calvo KR, Patel BA, Ombrello AK, Kastner DL, Young NS, Werner A, Grayson PC, Beck DB
Blood 2022 Sep 29;140(13):1496-1506. doi: 10.1182/blood.2022016985. PMID: 35793467Free PMC Article
Strategies to prevent suppurative chondritis following auricular burns: a systematic review.
Nasrallah F, Brewer CF, Arkoulis N, Mabvuure NT
J Wound Care 2022 May 2;31(5):394-397. doi: 10.12968/jowc.2022.31.5.394. PMID: 35579312
Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS.
Ferrada MA, Sikora KA, Luo Y, Wells KV, Patel B, Groarke EM, Ospina Cardona D, Rominger E, Hoffmann P, Le MT, Deng Z, Quinn KA, Rose E, Tsai WL, Wigerblad G, Goodspeed W, Jones A, Wilson L, Schnappauf O, Laird RS, Kim J, Allen C, Sirajuddin A, Chen M, Gadina M, Calvo KR, Kaplan MJ, Colbert RA, Aksentijevich I, Young NS, Savic S, Kastner DL, Ombrello AK, Beck DB, Grayson PC
Arthritis Rheumatol 2021 Oct;73(10):1886-1895. Epub 2021 Aug 31 doi: 10.1002/art.41743. PMID: 33779074
Relapsing polychondritis: A clinical update.
Longo L, Greco A, Rea A, Lo Vasco VR, De Virgilio A, De Vincentiis M
Autoimmun Rev 2016 Jun;15(6):539-43. Epub 2016 Feb 11 doi: 10.1016/j.autrev.2016.02.013. PMID: 26876384
Relapsing polychondritis.
Molina JF, Espinoza LR
Baillieres Best Pract Res Clin Rheumatol 2000 Mar;14(1):97-109. doi: 10.1053/berh.1999.0079. PMID: 10882216

Recent systematic reviews

Strategies to prevent suppurative chondritis following auricular burns: a systematic review.
Nasrallah F, Brewer CF, Arkoulis N, Mabvuure NT
J Wound Care 2022 May 2;31(5):394-397. doi: 10.12968/jowc.2022.31.5.394. PMID: 35579312
ANCA-associated vasculitis in patients with primary Sjögren's syndrome: detailed analysis of 7 new cases and systematic literature review.
Guellec D, Cornec-Le Gall E, Groh M, Hachulla E, Karras A, Charles P, Dunogué B, Abad S, Alvarez F, Gérard F, Devauchelle-Pensec V, Pers JO, Puéchal X, Guillevin L, Saraux A, Cornec D; CRI (Club Rhumatismes et Inflammation) and the French Vasculitis Study Group
Autoimmun Rev 2015 Aug;14(8):742-50. Epub 2015 Apr 24 doi: 10.1016/j.autrev.2015.04.009. PMID: 25916811
Transcartilaginous ear piercing and infectious complications: a systematic review and critical analysis of outcomes.
Sosin M, Weissler JM, Pulcrano M, Rodriguez ED
Laryngoscope 2015 Aug;125(8):1827-34. Epub 2015 Mar 30 doi: 10.1002/lary.25238. PMID: 25825232
Pediatric-onset relapsing polychondritis: case series and systematic review.
Belot A, Duquesne A, Job-Deslandre C, Costedoat-Chalumeau N, Boudjemaa S, Wechsler B, Cochat P, Piette JC, Cimaz R
J Pediatr 2010 Mar;156(3):484-9. Epub 2009 Nov 1 doi: 10.1016/j.jpeds.2009.09.045. PMID: 19880136

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