U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chondritis

MedGen UID:
707861
•Concept ID:
C1285334
•
Disease or Syndrome
Synonyms: Cartilage inflammation; Inflammatory disorder of cartilage
SNOMED CT: Chondritis (363173007); Inflammatory disorder of cartilage (363173007)
 
HPO: HP:0100662

Definition

Inflammation of cartilage. [from HPO]

Professional guidelines

PubMed

French practical guidelines for the diagnosis and management of relapsing polychondritis.
Arnaud L, Costedoat-Chalumeau N, Mathian A, Sailler L, Belot A, Dion J, Morel N, Moulis G; Collaborators
Rev Med Interne 2023 Jun;44(6):282-294. Epub 2023 May 24 doi: 10.1016/j.revmed.2023.05.005. PMID: 37236870
Auricular Cartilage Resection for Treatment-Refractory Idiopathic Chronic Chondritis: A Case Series.
Gordon SA, Nassiri AM, Driscoll CL, Carlson ML, Patel NS
Otol Neurotol 2022 Jan 1;43(1):e92-e96. doi: 10.1097/MAO.0000000000003358. PMID: 34889844
Relapsing polychondritis: A 2016 update on clinical features, diagnostic tools, treatment and biological drug use.
Mathian A, Miyara M, Cohen-Aubart F, Haroche J, Hie M, Pha M, Grenier P, Amoura Z
Best Pract Res Clin Rheumatol 2016 Apr;30(2):316-333. Epub 2016 Oct 1 doi: 10.1016/j.berh.2016.08.001. PMID: 27886803

Recent clinical studies

Etiology

Skin Manifestations of VEXAS Syndrome and Associated Genotypes.
Tan IJ, Ferrada MA, Ahmad S, Fike A, Quinn KA, Groarke EM, Beck DB, Allbritton J, Castelo-Soccio L, Young NS, Patel BA, Grayson PC, Cowen EW
JAMA Dermatol 2024 Aug 1;160(8):822-829. doi: 10.1001/jamadermatol.2024.1657. PMID: 38865133Free PMC Article
Strategies to prevent suppurative chondritis following auricular burns: a systematic review.
Nasrallah F, Brewer CF, Arkoulis N, Mabvuure NT
J Wound Care 2022 May 2;31(5):394-397. doi: 10.12968/jowc.2022.31.5.394. PMID: 35579312
Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients.
Georgin-Lavialle S, Terrier B, Guedon AF, Heiblig M, Comont T, Lazaro E, Lacombe V, Terriou L, Ardois S, Bouaziz JD, Mathian A, Le Guenno G, Aouba A, Outh R, Meyer A, Roux-Sauvat M, Ebbo M, Zhao LP, Bigot A, Jamilloux Y, Guillotin V, Flamarion E, Henneton P, Vial G, Jachiet V, Rossignol J, Vinzio S, Weitten T, Vinit J, Deligny C, Humbert S, Samson M, Magy-Bertrand N, Moulinet T, Bourguiba R, Hanslik T, Bachmeyer C, Sebert M, Kostine M, Bienvenu B, Biscay P, Liozon E, Sailler L, Chasset F, Audemard-Verger A, Duroyon E, Sarrabay G, Borlot F, Dieval C, Cluzeau T, Marianetti P, Lobbes H, Boursier G, Gerfaud-Valentin M, Jeannel J, Servettaz A, Audia S, Larue M, Henriot B, Faucher B, Graveleau J, de Sainte Marie B, Galland J, Bouillet L, Arnaud C, Ades L, Carrat F, Hirsch P, Fenaux P, Fain O, Sujobert P, Kosmider O, Mekinian A; French VEXAS group; GFEV, GFM, CEREMAIA, MINHEMON
Br J Dermatol 2022 Mar;186(3):564-574. Epub 2021 Nov 28 doi: 10.1111/bjd.20805. PMID: 34632574
Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS.
van der Made CI, Potjewijd J, Hoogstins A, Willems HPJ, Kwakernaak AJ, de Sevaux RGL, van Daele PLA, Simons A, Heijstek M, Beck DB, Netea MG, van Paassen P, Elizabeth Hak A, van der Veken LT, van Gijn ME, Hoischen A, van de Veerdonk FL, Leavis HL, Rutgers A
J Allergy Clin Immunol 2022 Jan;149(1):432-439.e4. Epub 2021 May 25 doi: 10.1016/j.jaci.2021.05.014. PMID: 34048852
Relapsing polychondritis: state-of-the-art review with three case presentations.
Grygiel-Górniak B, Tariq H, Mitchell J, Mohammed A, Samborski W
Postgrad Med 2021 Nov;133(8):953-963. Epub 2021 Sep 30 doi: 10.1080/00325481.2021.1979873. PMID: 34533099

Diagnosis

VEXAS syndrome: An update.
Khitri MY, Hadjadj J, Mekinian A, Jachiet V
Joint Bone Spine 2024 Jul;91(4):105700. Epub 2024 Feb 1 doi: 10.1016/j.jbspin.2024.105700. PMID: 38307404
French practical guidelines for the diagnosis and management of relapsing polychondritis.
Arnaud L, Costedoat-Chalumeau N, Mathian A, Sailler L, Belot A, Dion J, Morel N, Moulis G; Collaborators
Rev Med Interne 2023 Jun;44(6):282-294. Epub 2023 May 24 doi: 10.1016/j.revmed.2023.05.005. PMID: 37236870
VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) for the dermatologist.
Sterling D, Duncan ME, Philippidou M, Salisbury JR, Kulasekararaj AG, Basu TN
J Am Acad Dermatol 2023 Dec;89(6):1209-1214. Epub 2022 Feb 2 doi: 10.1016/j.jaad.2022.01.042. PMID: 35121074
Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients.
Georgin-Lavialle S, Terrier B, Guedon AF, Heiblig M, Comont T, Lazaro E, Lacombe V, Terriou L, Ardois S, Bouaziz JD, Mathian A, Le Guenno G, Aouba A, Outh R, Meyer A, Roux-Sauvat M, Ebbo M, Zhao LP, Bigot A, Jamilloux Y, Guillotin V, Flamarion E, Henneton P, Vial G, Jachiet V, Rossignol J, Vinzio S, Weitten T, Vinit J, Deligny C, Humbert S, Samson M, Magy-Bertrand N, Moulinet T, Bourguiba R, Hanslik T, Bachmeyer C, Sebert M, Kostine M, Bienvenu B, Biscay P, Liozon E, Sailler L, Chasset F, Audemard-Verger A, Duroyon E, Sarrabay G, Borlot F, Dieval C, Cluzeau T, Marianetti P, Lobbes H, Boursier G, Gerfaud-Valentin M, Jeannel J, Servettaz A, Audia S, Larue M, Henriot B, Faucher B, Graveleau J, de Sainte Marie B, Galland J, Bouillet L, Arnaud C, Ades L, Carrat F, Hirsch P, Fenaux P, Fain O, Sujobert P, Kosmider O, Mekinian A; French VEXAS group; GFEV, GFM, CEREMAIA, MINHEMON
Br J Dermatol 2022 Mar;186(3):564-574. Epub 2021 Nov 28 doi: 10.1111/bjd.20805. PMID: 34632574
Relapsing polychondritis: state-of-the-art review with three case presentations.
Grygiel-Górniak B, Tariq H, Mitchell J, Mohammed A, Samborski W
Postgrad Med 2021 Nov;133(8):953-963. Epub 2021 Sep 30 doi: 10.1080/00325481.2021.1979873. PMID: 34533099

Therapy

French practical guidelines for the diagnosis and management of relapsing polychondritis.
Arnaud L, Costedoat-Chalumeau N, Mathian A, Sailler L, Belot A, Dion J, Morel N, Moulis G; Collaborators
Rev Med Interne 2023 Jun;44(6):282-294. Epub 2023 May 24 doi: 10.1016/j.revmed.2023.05.005. PMID: 37236870
Relapsing polychondritis: state-of-the-art review with three case presentations.
Grygiel-Górniak B, Tariq H, Mitchell J, Mohammed A, Samborski W
Postgrad Med 2021 Nov;133(8):953-963. Epub 2021 Sep 30 doi: 10.1080/00325481.2021.1979873. PMID: 34533099
Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS.
Ferrada MA, Sikora KA, Luo Y, Wells KV, Patel B, Groarke EM, Ospina Cardona D, Rominger E, Hoffmann P, Le MT, Deng Z, Quinn KA, Rose E, Tsai WL, Wigerblad G, Goodspeed W, Jones A, Wilson L, Schnappauf O, Laird RS, Kim J, Allen C, Sirajuddin A, Chen M, Gadina M, Calvo KR, Kaplan MJ, Colbert RA, Aksentijevich I, Young NS, Savic S, Kastner DL, Ombrello AK, Beck DB, Grayson PC
Arthritis Rheumatol 2021 Oct;73(10):1886-1895. Epub 2021 Aug 31 doi: 10.1002/art.41743. PMID: 33779074
Relapsing polychondritis.
Chopra R, Chaudhary N, Kay J
Rheum Dis Clin North Am 2013 May;39(2):263-76. doi: 10.1016/j.rdc.2013.03.002. PMID: 23597963
Relapsing polychondritis.
Rapini RP, Warner NB
Clin Dermatol 2006 Nov-Dec;24(6):482-5. doi: 10.1016/j.clindermatol.2006.07.018. PMID: 17113965

Prognosis

French practical guidelines for the diagnosis and management of relapsing polychondritis.
Arnaud L, Costedoat-Chalumeau N, Mathian A, Sailler L, Belot A, Dion J, Morel N, Moulis G; Collaborators
Rev Med Interne 2023 Jun;44(6):282-294. Epub 2023 May 24 doi: 10.1016/j.revmed.2023.05.005. PMID: 37236870
Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis.
Ferrada MA, Savic S, Cardona DO, Collins JC, Alessi H, Gutierrez-Rodrigues F, Kumar DBU, Wilson L, Goodspeed W, Topilow JS, Paik JJ, Poulter JA, Kermani TA, Koster MJ, Warrington KJ, Cargo C, Tattersall RS, Duncan CJA, Cantor A, Hoffmann P, Payne EM, Bonnekoh H, Krause K, Cowen EW, Calvo KR, Patel BA, Ombrello AK, Kastner DL, Young NS, Werner A, Grayson PC, Beck DB
Blood 2022 Sep 29;140(13):1496-1506. doi: 10.1182/blood.2022016985. PMID: 35793467Free PMC Article
Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients.
Georgin-Lavialle S, Terrier B, Guedon AF, Heiblig M, Comont T, Lazaro E, Lacombe V, Terriou L, Ardois S, Bouaziz JD, Mathian A, Le Guenno G, Aouba A, Outh R, Meyer A, Roux-Sauvat M, Ebbo M, Zhao LP, Bigot A, Jamilloux Y, Guillotin V, Flamarion E, Henneton P, Vial G, Jachiet V, Rossignol J, Vinzio S, Weitten T, Vinit J, Deligny C, Humbert S, Samson M, Magy-Bertrand N, Moulinet T, Bourguiba R, Hanslik T, Bachmeyer C, Sebert M, Kostine M, Bienvenu B, Biscay P, Liozon E, Sailler L, Chasset F, Audemard-Verger A, Duroyon E, Sarrabay G, Borlot F, Dieval C, Cluzeau T, Marianetti P, Lobbes H, Boursier G, Gerfaud-Valentin M, Jeannel J, Servettaz A, Audia S, Larue M, Henriot B, Faucher B, Graveleau J, de Sainte Marie B, Galland J, Bouillet L, Arnaud C, Ades L, Carrat F, Hirsch P, Fenaux P, Fain O, Sujobert P, Kosmider O, Mekinian A; French VEXAS group; GFEV, GFM, CEREMAIA, MINHEMON
Br J Dermatol 2022 Mar;186(3):564-574. Epub 2021 Nov 28 doi: 10.1111/bjd.20805. PMID: 34632574
Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS.
van der Made CI, Potjewijd J, Hoogstins A, Willems HPJ, Kwakernaak AJ, de Sevaux RGL, van Daele PLA, Simons A, Heijstek M, Beck DB, Netea MG, van Paassen P, Elizabeth Hak A, van der Veken LT, van Gijn ME, Hoischen A, van de Veerdonk FL, Leavis HL, Rutgers A
J Allergy Clin Immunol 2022 Jan;149(1):432-439.e4. Epub 2021 May 25 doi: 10.1016/j.jaci.2021.05.014. PMID: 34048852
Relapsing polychondritis.
Rapini RP, Warner NB
Clin Dermatol 2006 Nov-Dec;24(6):482-5. doi: 10.1016/j.clindermatol.2006.07.018. PMID: 17113965

Clinical prediction guides

Efficient detection of somatic UBA1 variants and clinical scoring system predicting patients with variants in VEXAS syndrome.
Maeda A, Tsuchida N, Uchiyama Y, Horita N, Kobayashi S, Kishimoto M, Kobayashi D, Matsumoto H, Asano T, Migita K, Kato A, Mori I, Morita H, Matsubara A, Marumo Y, Ito Y, Machiyama T, Shirai T, Ishii T, Kishibe M, Yoshida Y, Hirata S, Akao S, Higuchi A, Rokutanda R, Nagahata K, Takahashi H, Katsuo K, Ohtani T, Fujiwara H, Nagano H, Hosokawa T, Ito T, Haji Y, Yamaguchi H, Hagino N, Shimizu T, Koga T, Kawakami A, Kageyama G, Kobayashi H, Aoki A, Mizokami A, Takeuchi Y, Motohashi R, Hagiyama H, Itagane M, Teruya H, Kato T, Miyoshi Y, Kise T, Yokogawa N, Ishida T, Umeda N, Isogai S, Naniwa T, Yamabe T, Uchino K, Kanasugi J, Takami A, Kondo Y, Furuhashi K, Saito K, Ohno S, Kishimoto D, Yamamoto M, Fujita Y, Fujieda Y, Araki S, Tsushima H, Misawa K, Katagiri A, Kobayashi T, Hashimoto K, Sone T, Hidaka Y, Ida H, Nishikomori R, Doi H, Fujimaki K, Akasaka K, Amano M, Matsushima H, Kashino K, Ohnishi H, Miwa Y, Takahashi N, Takase-Minegishi K, Yoshimi R, Kirino Y, Nakajima H, Matsumoto N
Rheumatology (Oxford) 2024 Aug 1;63(8):2056-2064. doi: 10.1093/rheumatology/kead425. PMID: 37606963
Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis.
Ferrada MA, Savic S, Cardona DO, Collins JC, Alessi H, Gutierrez-Rodrigues F, Kumar DBU, Wilson L, Goodspeed W, Topilow JS, Paik JJ, Poulter JA, Kermani TA, Koster MJ, Warrington KJ, Cargo C, Tattersall RS, Duncan CJA, Cantor A, Hoffmann P, Payne EM, Bonnekoh H, Krause K, Cowen EW, Calvo KR, Patel BA, Ombrello AK, Kastner DL, Young NS, Werner A, Grayson PC, Beck DB
Blood 2022 Sep 29;140(13):1496-1506. doi: 10.1182/blood.2022016985. PMID: 35793467Free PMC Article
Strategies to prevent suppurative chondritis following auricular burns: a systematic review.
Nasrallah F, Brewer CF, Arkoulis N, Mabvuure NT
J Wound Care 2022 May 2;31(5):394-397. doi: 10.12968/jowc.2022.31.5.394. PMID: 35579312
Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS.
Ferrada MA, Sikora KA, Luo Y, Wells KV, Patel B, Groarke EM, Ospina Cardona D, Rominger E, Hoffmann P, Le MT, Deng Z, Quinn KA, Rose E, Tsai WL, Wigerblad G, Goodspeed W, Jones A, Wilson L, Schnappauf O, Laird RS, Kim J, Allen C, Sirajuddin A, Chen M, Gadina M, Calvo KR, Kaplan MJ, Colbert RA, Aksentijevich I, Young NS, Savic S, Kastner DL, Ombrello AK, Beck DB, Grayson PC
Arthritis Rheumatol 2021 Oct;73(10):1886-1895. Epub 2021 Aug 31 doi: 10.1002/art.41743. PMID: 33779074
Relapsing polychondritis: A clinical update.
Longo L, Greco A, Rea A, Lo Vasco VR, De Virgilio A, De Vincentiis M
Autoimmun Rev 2016 Jun;15(6):539-43. Epub 2016 Feb 11 doi: 10.1016/j.autrev.2016.02.013. PMID: 26876384

Recent systematic reviews

Systematic Literature Review of the Presentation and Management of Pediatric Relapsing Polychondritis.
Montero ML, Panda RM, Palacios VJ, Solis RN, Levi JR
Ann Otol Rhinol Laryngol 2024 Nov;133(11):933-939. Epub 2024 Aug 20 doi: 10.1177/00034894241275474. PMID: 39162098
Strategies to prevent suppurative chondritis following auricular burns: a systematic review.
Nasrallah F, Brewer CF, Arkoulis N, Mabvuure NT
J Wound Care 2022 May 2;31(5):394-397. doi: 10.12968/jowc.2022.31.5.394. PMID: 35579312
ANCA-associated vasculitis in patients with primary Sjögren's syndrome: detailed analysis of 7 new cases and systematic literature review.
Guellec D, Cornec-Le Gall E, Groh M, Hachulla E, Karras A, Charles P, Dunogué B, Abad S, Alvarez F, Gérard F, Devauchelle-Pensec V, Pers JO, Puéchal X, Guillevin L, Saraux A, Cornec D; CRI (Club Rhumatismes et Inflammation) and the French Vasculitis Study Group
Autoimmun Rev 2015 Aug;14(8):742-50. Epub 2015 Apr 24 doi: 10.1016/j.autrev.2015.04.009. PMID: 25916811
Transcartilaginous ear piercing and infectious complications: a systematic review and critical analysis of outcomes.
Sosin M, Weissler JM, Pulcrano M, Rodriguez ED
Laryngoscope 2015 Aug;125(8):1827-34. Epub 2015 Mar 30 doi: 10.1002/lary.25238. PMID: 25825232
Pediatric-onset relapsing polychondritis: case series and systematic review.
Belot A, Duquesne A, Job-Deslandre C, Costedoat-Chalumeau N, Boudjemaa S, Wechsler B, Cochat P, Piette JC, Cimaz R
J Pediatr 2010 Mar;156(3):484-9. Epub 2009 Nov 1 doi: 10.1016/j.jpeds.2009.09.045. PMID: 19880136

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...