U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Osteoradionecrosis of the mandible

MedGen UID:
713081
Concept ID:
C1290728
Disease or Syndrome
Synonym: osteoradionecrosis of the mandible
SNOMED CT: Osteoradionecrosis of the mandible (109716001)
 
Monarch Initiative: MONDO:0033839
Orphanet: ORPHA521127

Definition

A rare radiation-induced disorder characterized by exposed irradiated bone that fails to heal over a period of three months without evidence of persisting or recurrent tumor. Patients present with pain, dysesthesia, dysgeusia, fetor oris, trismus, ulceration or necrosis of the mucosa with exposure of necrotic bone, and local suppuration. Complications include pathological fractures, formation of intra- or extra-oral fistulae, and infection. MRI shows cortical destruction, abnormal bone marrow signal, and irregular contrast enhancement. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteoradionecrosis of the mandible

Professional guidelines

PubMed

Gaio-Lima C, Castedo J, Cruz M, Candeias M, Camacho Ó
Clin Transl Oncol 2022 Dec;24(12):2466-2474. Epub 2022 Aug 17 doi: 10.1007/s12094-022-02892-x. PMID: 35976581
Costa DA, Costa TP, Netto EC, Joaquim N, Ventura I, Pratas AC, Winckler P, Silva IP, Pinho AC, Sargento IG, Guerreiro FG, Moreira AR
Head Neck 2016 Nov;38(11):1708-1716. Epub 2016 May 30 doi: 10.1002/hed.24495. PMID: 27240248
Robard L, Louis MY, Blanchard D, Babin E, Delanian S
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):333-338. Epub 2014 Jun 30 doi: 10.1016/j.anorl.2013.11.006. PMID: 24993781

Recent clinical studies

Etiology

Boromand G, Haugen-Cange H, Asparusova M, Ekestubbe A, Kjeller G
Acta Odontol Scand 2024 Jan;82(1):48-54. Epub 2023 Dec 28 doi: 10.1080/00016357.2023.2257316. PMID: 37772879
Gaio-Lima C, Castedo J, Cruz M, Candeias M, Camacho Ó
Clin Transl Oncol 2022 Dec;24(12):2466-2474. Epub 2022 Aug 17 doi: 10.1007/s12094-022-02892-x. PMID: 35976581
Li X, Han Y, Tang X, Zhu F, He Y
J Craniofac Surg 2022 Jan-Feb 01;33(1):e39-e43. doi: 10.1097/SCS.0000000000007906. PMID: 34320577Free PMC Article
Robard L, Louis MY, Blanchard D, Babin E, Delanian S
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):333-338. Epub 2014 Jun 30 doi: 10.1016/j.anorl.2013.11.006. PMID: 24993781
Teng MS, Futran ND
Curr Opin Otolaryngol Head Neck Surg 2005 Aug;13(4):217-21. doi: 10.1097/01.moo.0000170527.59017.ff. PMID: 16012245

Diagnosis

Boromand G, Haugen-Cange H, Asparusova M, Ekestubbe A, Kjeller G
Acta Odontol Scand 2024 Jan;82(1):48-54. Epub 2023 Dec 28 doi: 10.1080/00016357.2023.2257316. PMID: 37772879
He Y, Ma C, Hou J, Li X, Peng X, Wang H, Wang S, Liu L, Liu B, Tian L, Liu Z, Liu X, Xu X, Zhang D, Jiang C, Wang J, Yao Y, Zhu G, Bai Y, Wang S, Sun C, Li J, He S, Wang C, Zhang Z, Qiu W
Int J Oral Maxillofac Surg 2020 Mar;49(3):411-419. Epub 2019 Jul 26 doi: 10.1016/j.ijom.2019.06.015. PMID: 31353174
Deshpande SS, Thakur MH, Dholam K, Mahajan A, Arya S, Juvekar S
Clin Radiol 2015 Feb;70(2):197-205. Epub 2014 Oct 18 doi: 10.1016/j.crad.2014.09.012. PMID: 25446325
Lambade PN, Lambade D, Goel M
Oral Maxillofac Surg 2013 Dec;17(4):243-9. Epub 2012 Sep 28 doi: 10.1007/s10006-012-0363-4. PMID: 23053252
Jacobson AS, Buchbinder D, Hu K, Urken ML
Oral Oncol 2010 Nov;46(11):795-801. Epub 2010 Sep 16 doi: 10.1016/j.oraloncology.2010.08.007. PMID: 20843728

Therapy

Gaio-Lima C, Castedo J, Cruz M, Candeias M, Camacho Ó
Clin Transl Oncol 2022 Dec;24(12):2466-2474. Epub 2022 Aug 17 doi: 10.1007/s12094-022-02892-x. PMID: 35976581
Costa DA, Costa TP, Netto EC, Joaquim N, Ventura I, Pratas AC, Winckler P, Silva IP, Pinho AC, Sargento IG, Guerreiro FG, Moreira AR
Head Neck 2016 Nov;38(11):1708-1716. Epub 2016 May 30 doi: 10.1002/hed.24495. PMID: 27240248
Robard L, Louis MY, Blanchard D, Babin E, Delanian S
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):333-338. Epub 2014 Jun 30 doi: 10.1016/j.anorl.2013.11.006. PMID: 24993781
Lambade PN, Lambade D, Goel M
Oral Maxillofac Surg 2013 Dec;17(4):243-9. Epub 2012 Sep 28 doi: 10.1007/s10006-012-0363-4. PMID: 23053252
Teng MS, Futran ND
Curr Opin Otolaryngol Head Neck Surg 2005 Aug;13(4):217-21. doi: 10.1097/01.moo.0000170527.59017.ff. PMID: 16012245

Prognosis

Boromand G, Haugen-Cange H, Asparusova M, Ekestubbe A, Kjeller G
Acta Odontol Scand 2024 Jan;82(1):48-54. Epub 2023 Dec 28 doi: 10.1080/00016357.2023.2257316. PMID: 37772879
Gaio-Lima C, Castedo J, Cruz M, Candeias M, Camacho Ó
Clin Transl Oncol 2022 Dec;24(12):2466-2474. Epub 2022 Aug 17 doi: 10.1007/s12094-022-02892-x. PMID: 35976581
Studer G, Bredell M, Studer S, Huber G, Glanzmann C
Strahlenther Onkol 2016 Jan;192(1):32-9. Epub 2015 Aug 12 doi: 10.1007/s00066-015-0875-6. PMID: 26265308Free PMC Article
Lambade PN, Lambade D, Goel M
Oral Maxillofac Surg 2013 Dec;17(4):243-9. Epub 2012 Sep 28 doi: 10.1007/s10006-012-0363-4. PMID: 23053252
Teng MS, Futran ND
Curr Opin Otolaryngol Head Neck Surg 2005 Aug;13(4):217-21. doi: 10.1097/01.moo.0000170527.59017.ff. PMID: 16012245

Clinical prediction guides

Boromand G, Haugen-Cange H, Asparusova M, Ekestubbe A, Kjeller G
Acta Odontol Scand 2024 Jan;82(1):48-54. Epub 2023 Dec 28 doi: 10.1080/00016357.2023.2257316. PMID: 37772879
Aarup-Kristensen S, Hansen CR, Forner L, Brink C, Eriksen JG, Johansen J
Acta Oncol 2019 Oct;58(10):1373-1377. Epub 2019 Jul 31 doi: 10.1080/0284186X.2019.1643037. PMID: 31364903
Lee M, Chin RY, Eslick GD, Sritharan N, Paramaesvaran S
J Craniomaxillofac Surg 2015 Dec;43(10):2026-33. Epub 2015 Mar 20 doi: 10.1016/j.jcms.2015.03.006. PMID: 26427619
Chronopoulos A, Zarra T, Tröltzsch M, Mahaini S, Ehrenfeld M, Otto S
J Craniomaxillofac Surg 2015 Jul;43(6):837-46. Epub 2015 Apr 1 doi: 10.1016/j.jcms.2015.03.024. PMID: 25939311
Robard L, Louis MY, Blanchard D, Babin E, Delanian S
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):333-338. Epub 2014 Jun 30 doi: 10.1016/j.anorl.2013.11.006. PMID: 24993781

Recent systematic reviews

Gundestrup AK, Lynggaard CD, Forner L, Heino TJ, Jakobsen KK, Fischer-Nielsen A, Grønhøj C, von Buchwald C
Stem Cell Rev Rep 2020 Dec;16(6):1208-1221. doi: 10.1007/s12015-020-10034-5. PMID: 32869179
Lee M, Chin RY, Eslick GD, Sritharan N, Paramaesvaran S
J Craniomaxillofac Surg 2015 Dec;43(10):2026-33. Epub 2015 Mar 20 doi: 10.1016/j.jcms.2015.03.006. PMID: 26427619

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...