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Increased bone marrow iron

MedGen UID:
714392
•Concept ID:
C1292133
•
Finding
Synonym: Bone marrow: iron stores increased
SNOMED CT: Increased bone marrow iron (110372005)
 
HPO: HP:0034499

Definition

An increased amount of iron in the bone marrow. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased bone marrow iron

Professional guidelines

PubMed

Momelotinib for the treatment of myelofibrosis with anemia.
Tremblay D, Mesa R
Future Oncol 2022 Jun;18(20):2559-2571. Epub 2022 May 23 doi: 10.2217/fon-2022-0276. PMID: 35603634
Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia.
Barcellini W, Fattizzo B
Dis Markers 2015;2015:635670. Epub 2015 Dec 27 doi: 10.1155/2015/635670. PMID: 26819490Free PMC Article
Microcytic anemia. Differential diagnosis and management of iron deficiency anemia.
Massey AC
Med Clin North Am 1992 May;76(3):549-66. doi: 10.1016/s0025-7125(16)30339-x. PMID: 1578956

Recent clinical studies

Etiology

Increased Bone Marrow Iron Scores Are Strongly Correlated With Elevated Serum Ferritin Levels and Poorer Survival in Patients With Iron Overload That Underwent Allogeneic Hematopoietic Stem Cell Transplantation: A Single Center Experience.
Sivgin S, Nazlim S, Zararsiz G, Baspinar O, Kaynar L, Deniz K, Cetin M, Unal A, Eser B
Clin Lymphoma Myeloma Leuk 2016 Oct;16(10):582-587. Epub 2016 Aug 24 doi: 10.1016/j.clml.2016.08.002. PMID: 27769559
The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis.
Ibrahim AS, Gebremariam T, French SW, Edwards JE Jr, Spellberg B
J Antimicrob Chemother 2010 Feb;65(2):289-92. Epub 2009 Nov 26 doi: 10.1093/jac/dkp426. PMID: 19942619Free PMC Article
Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation.
Kontoyiannis DP, Chamilos G, Lewis RE, Giralt S, Cortes J, Raad II, Manning JT, Han X
Cancer 2007 Sep 15;110(6):1303-6. doi: 10.1002/cncr.22909. PMID: 17614303
Treatment of primary defective iron-reutilization syndrome: revisited.
Besa EC, Kim PW, Haurani FI
Ann Hematol 2000 Aug;79(8):465-8. doi: 10.1007/s002770000180. PMID: 10985370
Red cell ferritin and iron stores in patients with chronic disease.
Brown RD, Benfatto J, Gibson J, Kronenberg H
Eur J Haematol 1988 Feb;40(2):136-41. doi: 10.1111/j.1600-0609.1988.tb00810.x. PMID: 3345827

Diagnosis

Increased Bone Marrow Iron Scores Are Strongly Correlated With Elevated Serum Ferritin Levels and Poorer Survival in Patients With Iron Overload That Underwent Allogeneic Hematopoietic Stem Cell Transplantation: A Single Center Experience.
Sivgin S, Nazlim S, Zararsiz G, Baspinar O, Kaynar L, Deniz K, Cetin M, Unal A, Eser B
Clin Lymphoma Myeloma Leuk 2016 Oct;16(10):582-587. Epub 2016 Aug 24 doi: 10.1016/j.clml.2016.08.002. PMID: 27769559
Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation.
Kontoyiannis DP, Chamilos G, Lewis RE, Giralt S, Cortes J, Raad II, Manning JT, Han X
Cancer 2007 Sep 15;110(6):1303-6. doi: 10.1002/cncr.22909. PMID: 17614303
Clinicohaematological profile in chronic renal failure.
Talwar VK, Gupta HL, Shashinarayan
J Assoc Physicians India 2002 Feb;50:228-33. PMID: 12038654
Treatment of primary defective iron-reutilization syndrome: revisited.
Besa EC, Kim PW, Haurani FI
Ann Hematol 2000 Aug;79(8):465-8. doi: 10.1007/s002770000180. PMID: 10985370

Therapy

Increased Bone Marrow Iron Scores Are Strongly Correlated With Elevated Serum Ferritin Levels and Poorer Survival in Patients With Iron Overload That Underwent Allogeneic Hematopoietic Stem Cell Transplantation: A Single Center Experience.
Sivgin S, Nazlim S, Zararsiz G, Baspinar O, Kaynar L, Deniz K, Cetin M, Unal A, Eser B
Clin Lymphoma Myeloma Leuk 2016 Oct;16(10):582-587. Epub 2016 Aug 24 doi: 10.1016/j.clml.2016.08.002. PMID: 27769559
The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis.
Ibrahim AS, Gebremariam T, French SW, Edwards JE Jr, Spellberg B
J Antimicrob Chemother 2010 Feb;65(2):289-92. Epub 2009 Nov 26 doi: 10.1093/jac/dkp426. PMID: 19942619Free PMC Article
Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation.
Kontoyiannis DP, Chamilos G, Lewis RE, Giralt S, Cortes J, Raad II, Manning JT, Han X
Cancer 2007 Sep 15;110(6):1303-6. doi: 10.1002/cncr.22909. PMID: 17614303
Treatment of primary defective iron-reutilization syndrome: revisited.
Besa EC, Kim PW, Haurani FI
Ann Hematol 2000 Aug;79(8):465-8. doi: 10.1007/s002770000180. PMID: 10985370
Serum ferritin assay and iron status in chronic renal failure and haemodialysis.
Hussein S, Prieto J, O'Shea M, Hoffbrand AV, Baillod RA, Moorhead JF
Br Med J 1975 Mar 8;1(5957):546-8. doi: 10.1136/bmj.1.5957.546. PMID: 49205Free PMC Article

Prognosis

Increased Bone Marrow Iron Scores Are Strongly Correlated With Elevated Serum Ferritin Levels and Poorer Survival in Patients With Iron Overload That Underwent Allogeneic Hematopoietic Stem Cell Transplantation: A Single Center Experience.
Sivgin S, Nazlim S, Zararsiz G, Baspinar O, Kaynar L, Deniz K, Cetin M, Unal A, Eser B
Clin Lymphoma Myeloma Leuk 2016 Oct;16(10):582-587. Epub 2016 Aug 24 doi: 10.1016/j.clml.2016.08.002. PMID: 27769559

Clinical prediction guides

Increased Bone Marrow Iron Scores Are Strongly Correlated With Elevated Serum Ferritin Levels and Poorer Survival in Patients With Iron Overload That Underwent Allogeneic Hematopoietic Stem Cell Transplantation: A Single Center Experience.
Sivgin S, Nazlim S, Zararsiz G, Baspinar O, Kaynar L, Deniz K, Cetin M, Unal A, Eser B
Clin Lymphoma Myeloma Leuk 2016 Oct;16(10):582-587. Epub 2016 Aug 24 doi: 10.1016/j.clml.2016.08.002. PMID: 27769559
Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation.
Kontoyiannis DP, Chamilos G, Lewis RE, Giralt S, Cortes J, Raad II, Manning JT, Han X
Cancer 2007 Sep 15;110(6):1303-6. doi: 10.1002/cncr.22909. PMID: 17614303
Clinicohaematological profile in chronic renal failure.
Talwar VK, Gupta HL, Shashinarayan
J Assoc Physicians India 2002 Feb;50:228-33. PMID: 12038654

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