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Kaposi varicelliform eruption

MedGen UID:
7194
•Concept ID:
C0022504
•
Disease or Syndrome
Synonyms: Eruption, Kaposi Varicelliform; Eruption, Kaposi's Varicelliform; Kaposi Varicelliform Eruption; Kaposi's Varicelliform Eruption; Kaposis Varicelliform Eruption; Varicelliform Eruption, Kaposi; Varicelliform Eruption, Kaposi's
SNOMED CT: Kaposi's varicelliform eruption (186535001); Eczema herpeticum - Kaposi's varicelliform eruption (186535001)

Definition

A disseminated vesicular-pustular eruption caused by the herpes simplex virus (HERPESVIRUS HOMINIS), the VACCINIA VIRUS, or Varicella zoster (HERPESVIRUS 3, HUMAN). It is usually superimposed on a preexisting, inactive or active, atopic dermatitis (DERMATITIS, ATOPIC). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKaposi varicelliform eruption

Professional guidelines

PubMed

Common Cutaneous Infections: Patient Presentation, Clinical Course, and Treatment Options.
Preda-Naumescu A, Elewski B, Mayo TT
Med Clin North Am 2021 Jul;105(4):783-797. doi: 10.1016/j.mcna.2021.04.012. PMID: 34059250
Atopic dermatitis in children: clinical features, pathophysiology, and treatment.
Lyons JJ, Milner JD, Stone KD
Immunol Allergy Clin North Am 2015 Feb;35(1):161-83. Epub 2014 Nov 21 doi: 10.1016/j.iac.2014.09.008. PMID: 25459583Free PMC Article
Immunological and molecular targets of atopic dermatitis treatment.
Wollenberg A, Seba A, Antal AS
Br J Dermatol 2014 Jul;170 Suppl 1:7-11. Epub 2014 May 9 doi: 10.1111/bjd.12975. PMID: 24720588

Recent clinical studies

Etiology

High recurrence rate of eczema herpeticum in moderate/severe atopic dermatitis -TREATgermany registry analysis.
Traidl S, Heinrich L, Siegels D, Rösner L, Haufe E, Harder I, Abraham S, Ertner K, Kleinheinz A, Schäkel K, Wollenberg A, Effendy I, Quist S, Asmussen A, Wildberger J, Weisshaar E, Wiemers F, Brücher JJ, Weidinger S, Schmitt J, Werfel T; TREATgermany Study Group
J Dtsch Dermatol Ges 2023 Dec;21(12):1490-1498. Epub 2023 Oct 9 doi: 10.1111/ddg.15205. PMID: 37814394
The Genetics of Eczema Herpeticum.
Hodara E, Ong PY
Clin Rev Allergy Immunol 2022 Dec;63(3):390-397. Epub 2022 Sep 17 doi: 10.1007/s12016-022-08953-x. PMID: 36114947
Eczema herpeticum in atopic dermatitis.
Traidl S, Roesner L, Zeitvogel J, Werfel T
Allergy 2021 Oct;76(10):3017-3027. Epub 2021 May 3 doi: 10.1111/all.14853. PMID: 33844308
Eczema Herpeticum: Clinical and Pathophysiological Aspects.
Damour A, Garcia M, Seneschal J, Lévêque N, Bodet C
Clin Rev Allergy Immunol 2020 Aug;59(1):1-18. doi: 10.1007/s12016-019-08768-3. PMID: 31836943
Infectious Complications in Atopic Dermatitis.
Sun D, Ong PY
Immunol Allergy Clin North Am 2017 Feb;37(1):75-93. doi: 10.1016/j.iac.2016.08.015. PMID: 27886912

Diagnosis

Kaposi Varicelliform Eruption on Sunburned Skin.
Rogel-Vence M, González-Ruiz L, Franco-Muñoz M, Garrido-Martín JA
Actas Dermosifiliogr (Engl Ed) 2021 Jan;112(1):71. Epub 2020 Sep 25 doi: 10.1016/j.ad.2018.12.013. PMID: 32986970
Pediatric dermatology emergencies.
Robinson SK, Jefferson IS, Agidi A, Moy L, Lake E, Kim W
Cutis 2020 Mar;105(3):132-136. PMID: 32352437
Eczema Herpeticum.
Cooper BL
J Emerg Med 2017 Sep;53(3):412-413. doi: 10.1016/j.jemermed.2016.12.004. PMID: 28992872
Pediatric dermatology emergencies.
Kress DW
Curr Opin Pediatr 2011 Aug;23(4):403-6. doi: 10.1097/MOP.0b013e3283483efd. PMID: 21670682
Kaposi's varicelliform eruption.
Mooney MA, Janniger CK, Schwartz RA
Cutis 1994 May;53(5):243-5. PMID: 8039414

Therapy

Eczema Herpeticum.
Cooper BL
J Emerg Med 2017 Sep;53(3):412-413. doi: 10.1016/j.jemermed.2016.12.004. PMID: 28992872
Kaposi's varicelliform eruption.
Min Z, Gnann JW Jr
Intern Emerg Med 2014 Feb;9(1):101-2. Epub 2013 Sep 14 doi: 10.1007/s11739-013-1001-3. PMID: 24036906
Eczema vaccinatum.
Reed JL, Scott DE, Bray M
Clin Infect Dis 2012 Mar;54(6):832-40. Epub 2012 Jan 30 doi: 10.1093/cid/cir952. PMID: 22291103
Pediatric dermatology emergencies.
Kress DW
Curr Opin Pediatr 2011 Aug;23(4):403-6. doi: 10.1097/MOP.0b013e3283483efd. PMID: 21670682
Kaposi's varicelliform eruption.
Mooney MA, Janniger CK, Schwartz RA
Cutis 1994 May;53(5):243-5. PMID: 8039414

Prognosis

Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.
Bosma AL, Ascott A, Iskandar R, Farquhar K, Matthewman J, Langendam MW, Mulick A, Abuabara K, Williams HC, Spuls PI, Langan SM, Middelkamp-Hup MA
J Eur Acad Dermatol Venereol 2022 Jun;36(6):807-819. Epub 2022 Feb 25 doi: 10.1111/jdv.18008. PMID: 35170821Free PMC Article
Kaposi-Juliusberg varicelliform eruption in patients suffering from Darier-White Disease: a case report and review of the literature.
Molinelli E, Ricotti F, Campanati A, Cataldi I, Ganzetti G, Liberati G, Bianchelli T, Offidani A
G Ital Dermatol Venereol 2016 Oct;151(5):558-61. Epub 2014 Dec 11 PMID: 25502366
Kaposi's varicelliform eruption. Absence of ocular involvement.
Fivenson DP, Breneman DL, Wander AH
Arch Dermatol 1990 Aug;126(8):1037-9. PMID: 2200344
Life-threatening dermatoses.
Cram DL
Calif Med 1973 Feb;118(2):5-12. PMID: 4701711Free PMC Article
ECZEMA VACCINATUM.
COPEMAN PW, WALLACE HJ
Br Med J 1964 Oct 10;2(5414):906-8. doi: 10.1136/bmj.2.5414.906. PMID: 14185655Free PMC Article

Clinical prediction guides

High recurrence rate of eczema herpeticum in moderate/severe atopic dermatitis -TREATgermany registry analysis.
Traidl S, Heinrich L, Siegels D, Rösner L, Haufe E, Harder I, Abraham S, Ertner K, Kleinheinz A, Schäkel K, Wollenberg A, Effendy I, Quist S, Asmussen A, Wildberger J, Weisshaar E, Wiemers F, Brücher JJ, Weidinger S, Schmitt J, Werfel T; TREATgermany Study Group
J Dtsch Dermatol Ges 2023 Dec;21(12):1490-1498. Epub 2023 Oct 9 doi: 10.1111/ddg.15205. PMID: 37814394
Safety of tralokinumab in adult patients with moderate-to-severe atopic dermatitis: pooled analysis of five randomized, double-blind, placebo-controlled phase II and phase III trials.
Simpson EL, Merola JF, Silverberg JI, Reich K, Warren RB, Staumont-Sallé D, Girolomoni G, Papp K, de Bruin-Weller M, Thyssen JP, Zachariae R, Olsen CK, Wollenberg A
Br J Dermatol 2022 Dec;187(6):888-899. Epub 2022 Oct 26 doi: 10.1111/bjd.21867. PMID: 36082590Free PMC Article
Phenotype of atopic dermatitis subjects with a history of eczema herpeticum.
Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY
J Allergy Clin Immunol 2009 Aug;124(2):260-9, 269.e1-7. Epub 2009 Jun 27 doi: 10.1016/j.jaci.2009.05.020. PMID: 19541356Free PMC Article
Psoriasis herpeticum: three cases of Kaposi's varicelliform eruption in psoriasis.
Santmyire-Rosenberger BR, Nigra TP
J Am Acad Dermatol 2005 Jul;53(1):52-6. doi: 10.1016/j.jaad.2005.01.140. PMID: 15965420
Revisit to Kaposi's varicelliform eruption: role of IL-4.
Raychaudhuri SP, Raychaudhuri SK
Int J Dermatol 1995 Dec;34(12):854-6. doi: 10.1111/j.1365-4362.1995.tb04421.x. PMID: 8647664

Recent systematic reviews

Atypical cutaneous findings of hand-foot-mouth disease in children: A systematic review.
Starkey SY, Mar K, Khaslavsky S, Seeburruth D, Khalid B, Virmani D, Lam JM, Mukovozov I
Pediatr Dermatol 2024 Jan-Feb;41(1):23-27. Epub 2023 Oct 25 doi: 10.1111/pde.15461. PMID: 37877202
Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.
Bosma AL, Ascott A, Iskandar R, Farquhar K, Matthewman J, Langendam MW, Mulick A, Abuabara K, Williams HC, Spuls PI, Langan SM, Middelkamp-Hup MA
J Eur Acad Dermatol Venereol 2022 Jun;36(6):807-819. Epub 2022 Feb 25 doi: 10.1111/jdv.18008. PMID: 35170821Free PMC Article

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