U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vulvar lichen sclerosus

MedGen UID:
7228
•Concept ID:
C0022783
•
Disease or Syndrome
Synonyms: Kraurosis Vulvae; Lichen Sclerosus of Vulva; Lichen Sclerosus, Vulvar; Sclerosus, Vulvar Lichen; Vulva Lichen Sclerosus; Vulvae, Kraurosis; Vulvar Lichen Sclerosus
SNOMED CT: Leukoplakia of vulva (198380007); Kraurosis of vulva (895491007); Kraurosis vulvae (895491007); Lichen sclerosus of female external genitalia (895491007); Lichen sclerosus of vulva (895491007)
 
Monarch Initiative: MONDO:0006491

Definition

The presence of hyperkeratotic white patches on the vulvar epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar lichen sclerosus

Professional guidelines

PubMed

Quality of Life and Treatment Adherence in Patients with Vulvar Lichen Sclerosus.
Geisler AN, Koptyev J, Strunk A, Shah PR, Garg A
Dermatology 2023;239(3):494-498. Epub 2023 Mar 10 doi: 10.1159/000530108. PMID: 36907177
Meet the expert: Topical management of vulvar dermatoses.
Jakuboski SH, Noor SJ
J Geriatr Oncol 2022 Apr;13(3):282-286. Epub 2021 Nov 22 doi: 10.1016/j.jgo.2021.10.011. PMID: 34824022
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650

Recent clinical studies

Etiology

Pediatric vulvar lichen sclerosus: Does it resolve or does it persist after menarche?
Boero V, Cavalli R, Caia C, Berrettini A, Cetera GE, Monti E, Barbara G, Albertini GC, Restelli E, Libutti G, Motta T, Lazzari C, Vercellini P
Pediatr Dermatol 2023 May-Jun;40(3):472-475. Epub 2023 Mar 30 doi: 10.1111/pde.15308. PMID: 36998082
Lichen Sclerosus throughout Childhood and Adolescence: Not Only a Premenarchal Disease.
Winfrey OK, Fei YF, Dendrinos ML, Rosen MW, Smith YR, Quint EH
J Pediatr Adolesc Gynecol 2022 Dec;35(6):624-628. Epub 2022 Aug 26 doi: 10.1016/j.jpag.2022.08.011. PMID: 36038010
Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Diagnosis

Vulvar Lichen Sclerosus.
Kraus CN
JAMA Dermatol 2022 Sep 1;158(9):1088. doi: 10.1001/jamadermatol.2022.0359. PMID: 35793083
Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Evidence-based (S3) Guideline on (anogenital) Lichen sclerosus.
Kirtschig G, Becker K, Günthert A, Jasaitiene D, Cooper S, Chi CC, Kreuter A, Rall KK, Aberer W, Riechardt S, Casabona F, Powell J, Brackenbury F, Erdmann R, Lazzeri M, Barbagli G, Wojnarowska F
J Eur Acad Dermatol Venereol 2015 Oct;29(10):e1-43. Epub 2015 Jul 22 doi: 10.1111/jdv.13136. PMID: 26202852
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Therapy

Vulvar lichen sclerosus.
Cleminson K, Baxter ML
CMAJ 2021 Oct 12;193(40):E1572. doi: 10.1503/cmaj.210448. PMID: 34642161Free PMC Article
Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Inflammatory Vulvar Dermatoses.
Guerrero A, Venkatesan A
Clin Obstet Gynecol 2015 Sep;58(3):464-75. doi: 10.1097/GRF.0000000000000125. PMID: 26125955
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Prognosis

Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists.
Lee A, Fischer G
Am J Clin Dermatol 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7. PMID: 29987650
Lichen sclerosus and lichen planus in women and girls.
Schlosser BJ, Mirowski GW
Clin Obstet Gynecol 2015 Mar;58(1):125-42. doi: 10.1097/GRF.0000000000000090. PMID: 25608255
Vulvar dermatosis.
Moyal-Barracco M, Wendling J
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):946-58. Epub 2014 Jul 18 doi: 10.1016/j.bpobgyn.2014.07.005. PMID: 25132276
Influence of treatments on prognosis for vulvar lichen sclerosus: facts and controversies.
Brodrick B, Belkin ZR, Goldstein AT
Clin Dermatol 2013 Nov-Dec;31(6):780-6. doi: 10.1016/j.clindermatol.2013.05.017. PMID: 24160287
Lichen sclerosus in children and adolescents.
Dendrinos ML, Quint EH
Curr Opin Obstet Gynecol 2013 Oct;25(5):370-4. doi: 10.1097/GCO.0b013e328363a53c. PMID: 23812382

Clinical prediction guides

Vulvar Lichen Sclerosus Clinical Severity Scales and Histopathologic Correlation: A Case Series.
Pyle HJ, Evans JC, Vandergriff TW, Mauskar MM
Am J Dermatopathol 2023 Aug 1;45(8):588-592. doi: 10.1097/DAD.0000000000002471. PMID: 37462209
Pediatric vulvar lichen sclerosus: Does it resolve or does it persist after menarche?
Boero V, Cavalli R, Caia C, Berrettini A, Cetera GE, Monti E, Barbara G, Albertini GC, Restelli E, Libutti G, Motta T, Lazzari C, Vercellini P
Pediatr Dermatol 2023 May-Jun;40(3):472-475. Epub 2023 Mar 30 doi: 10.1111/pde.15308. PMID: 36998082
Quality of Life and Treatment Adherence in Patients with Vulvar Lichen Sclerosus.
Geisler AN, Koptyev J, Strunk A, Shah PR, Garg A
Dermatology 2023;239(3):494-498. Epub 2023 Mar 10 doi: 10.1159/000530108. PMID: 36907177
Vulvar vitiligo and lichen sclerosus in children: A clinical challenge.
Veronesi G, Virdi A, Leuzzi M, Gurioli C, Chessa MA, Guglielmo A, Neri I
Pediatr Dermatol 2021 Sep;38(5):1012-1019. Epub 2021 Sep 24 doi: 10.1111/pde.14771. PMID: 34561885
Photodynamic Therapy for Vulvar Lichen Sclerosus-A Systematic Review.
Prodromidou A, Chatziioannou E, Daskalakis G, Stergios K, Pergialiotis V
J Low Genit Tract Dis 2018 Jan;22(1):58-65. doi: 10.1097/LGT.0000000000000362. PMID: 29271859

Recent systematic reviews

Lichen Sclerosus and Sexual Dysfunction: A Systematic Review and Meta-Analysis.
Pope R, Lee MH, Myers A, Song J, Abou Ghayda R, Kim JY, Hong SH, Lee SB, Koyanagi A, Jacob L, Smith L, Shin JI
J Sex Med 2022 Nov;19(11):1616-1624. Epub 2022 Sep 15 doi: 10.1016/j.jsxm.2022.07.011. PMID: 36115787
Vulvar vitiligo and lichen sclerosus in children: A clinical challenge.
Veronesi G, Virdi A, Leuzzi M, Gurioli C, Chessa MA, Guglielmo A, Neri I
Pediatr Dermatol 2021 Sep;38(5):1012-1019. Epub 2021 Sep 24 doi: 10.1111/pde.14771. PMID: 34561885
Pediatric Vulvar Lichen Sclerosus-A Review of the Literature.
Orszulak D, Dulska A, Niziński K, Skowronek K, Bodziony J, Stojko R, Drosdzol-Cop A
Int J Environ Res Public Health 2021 Jul 4;18(13) doi: 10.3390/ijerph18137153. PMID: 34281089Free PMC Article
Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Photodynamic Therapy for Vulvar Lichen Sclerosus-A Systematic Review.
Prodromidou A, Chatziioannou E, Daskalakis G, Stergios K, Pergialiotis V
J Low Genit Tract Dis 2018 Jan;22(1):58-65. doi: 10.1097/LGT.0000000000000362. PMID: 29271859

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...