U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Red Man Syndrome

MedGen UID:
727160
•Concept ID:
C1306792
•
Disease or Syndrome

Definition

An abrupt onset drug reaction characterized by a red rash that involves the face, neck, and upper torso. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRed Man Syndrome

Professional guidelines

PubMed

A risk-benefit assessment of teicoplanin in the treatment of infections.
de Lalla F, Tramarin A
Drug Saf 1995 Nov;13(5):317-28. doi: 10.2165/00002018-199513050-00005. PMID: 8785019
Anti-infective treatment in intensive care: the role of glycopeptides.
Grüneberg RN, Wilson AP
Intensive Care Med 1994 Nov;20 Suppl 4:S17-22. doi: 10.1007/BF01713978. PMID: 7699151
Current treatment of gram-positive infections: focus on efficacy, safety, and cost minimalization analysis of teicoplanin.
Crane VS, Garabedian-Ruffalo SM
Hosp Formul 1992 Dec;27(12):1199-200, 1203-4, 1207-10. PMID: 10122506

Recent clinical studies

Etiology

Drugs-associated with red man syndrome: An integrative approach using disproportionality analysis and Pharmip.
M Shaju A, Panicker N, Chandni V, Lakshmi Prasanna VM, Nair G, Subeesh V
J Clin Pharm Ther 2022 Oct;47(10):1650-1658. Epub 2022 Jun 22 doi: 10.1111/jcpt.13716. PMID: 35730973
Road Less Traveled: Drug Hypersensitivity to Fluoroquinolones, Vancomycin, Tetracyclines, and Macrolides.
Zhu LJ, Liu AY, Wong PH, Arroyo AC
Clin Rev Allergy Immunol 2022 Jun;62(3):505-518. Epub 2022 Jan 29 doi: 10.1007/s12016-021-08919-5. PMID: 35092578Free PMC Article
Linezolid versus vancomycin for skin and soft tissue infections.
Yue J, Dong BR, Yang M, Chen X, Wu T, Liu GJ
Cochrane Database Syst Rev 2016 Jan 7;2016(1):CD008056. doi: 10.1002/14651858.CD008056.pub3. PMID: 26758498Free PMC Article
The use of vancomycin with its therapeutic and adverse effects: a review.
Bruniera FR, Ferreira FM, Saviolli LR, Bacci MR, Feder D, da Luz Gonçalves Pedreira M, Sorgini Peterlini MA, Azzalis LA, Campos Junqueira VB, Fonseca FL
Eur Rev Med Pharmacol Sci 2015 Feb;19(4):694-700. PMID: 25753888
Vancomycin-induced red man syndrome.
Levy M, Koren G, Dupuis L, Read SE
Pediatrics 1990 Oct;86(4):572-80. PMID: 2216623

Diagnosis

Road Less Traveled: Drug Hypersensitivity to Fluoroquinolones, Vancomycin, Tetracyclines, and Macrolides.
Zhu LJ, Liu AY, Wong PH, Arroyo AC
Clin Rev Allergy Immunol 2022 Jun;62(3):505-518. Epub 2022 Jan 29 doi: 10.1007/s12016-021-08919-5. PMID: 35092578Free PMC Article
Vancomycin Infusion Reaction - Moving beyond "Red Man Syndrome".
Alvarez-Arango S, Ogunwole SM, Sequist TD, Burk CM, Blumenthal KG
N Engl J Med 2021 Apr 8;384(14):1283-1286. Epub 2021 Apr 3 doi: 10.1056/NEJMp2031891. PMID: 33830710Free PMC Article
Adverse reactions to vancomycin and cross-reactivity with other antibiotics.
De Luca JF, Holmes NE, Trubiano JA
Curr Opin Allergy Clin Immunol 2020 Aug;20(4):352-361. doi: 10.1097/ACI.0000000000000665. PMID: 32590503
Vancomycin-associated Henoch-Schönlein purpura.
Min Z, Garcia RR, Murillo M, Uchin JM, Bhanot N
J Infect Chemother 2017 Mar;23(3):180-184. Epub 2016 Sep 25 doi: 10.1016/j.jiac.2016.08.012. PMID: 27681233
Vancomycin-induced leukocytoclastic vasculitis.
Felix-Getzik E, Sylvia LM
Pharmacotherapy 2009 Jul;29(7):846-51. doi: 10.1592/phco.29.7.846. PMID: 19558258

Therapy

Drugs-associated with red man syndrome: An integrative approach using disproportionality analysis and Pharmip.
M Shaju A, Panicker N, Chandni V, Lakshmi Prasanna VM, Nair G, Subeesh V
J Clin Pharm Ther 2022 Oct;47(10):1650-1658. Epub 2022 Jun 22 doi: 10.1111/jcpt.13716. PMID: 35730973
Road Less Traveled: Drug Hypersensitivity to Fluoroquinolones, Vancomycin, Tetracyclines, and Macrolides.
Zhu LJ, Liu AY, Wong PH, Arroyo AC
Clin Rev Allergy Immunol 2022 Jun;62(3):505-518. Epub 2022 Jan 29 doi: 10.1007/s12016-021-08919-5. PMID: 35092578Free PMC Article
Vancomycin Infusion Reaction - Moving beyond "Red Man Syndrome".
Alvarez-Arango S, Ogunwole SM, Sequist TD, Burk CM, Blumenthal KG
N Engl J Med 2021 Apr 8;384(14):1283-1286. Epub 2021 Apr 3 doi: 10.1056/NEJMp2031891. PMID: 33830710Free PMC Article
Linezolid versus vancomycin for skin and soft tissue infections.
Yue J, Dong BR, Yang M, Chen X, Wu T, Liu GJ
Cochrane Database Syst Rev 2016 Jan 7;2016(1):CD008056. doi: 10.1002/14651858.CD008056.pub3. PMID: 26758498Free PMC Article
The use of vancomycin with its therapeutic and adverse effects: a review.
Bruniera FR, Ferreira FM, Saviolli LR, Bacci MR, Feder D, da Luz Gonçalves Pedreira M, Sorgini Peterlini MA, Azzalis LA, Campos Junqueira VB, Fonseca FL
Eur Rev Med Pharmacol Sci 2015 Feb;19(4):694-700. PMID: 25753888

Prognosis

The Role of Mast Cells in the Induction and Maintenance of Inflammation in Selected Skin Diseases.
Woźniak E, Owczarczyk-Saczonek A, Lange M, Czarny J, Wygonowska E, Placek W, Nedoszytko B
Int J Mol Sci 2023 Apr 10;24(8) doi: 10.3390/ijms24087021. PMID: 37108184Free PMC Article
Road Less Traveled: Drug Hypersensitivity to Fluoroquinolones, Vancomycin, Tetracyclines, and Macrolides.
Zhu LJ, Liu AY, Wong PH, Arroyo AC
Clin Rev Allergy Immunol 2022 Jun;62(3):505-518. Epub 2022 Jan 29 doi: 10.1007/s12016-021-08919-5. PMID: 35092578Free PMC Article
A risk-benefit assessment of teicoplanin in the treatment of infections.
de Lalla F, Tramarin A
Drug Saf 1995 Nov;13(5):317-28. doi: 10.2165/00002018-199513050-00005. PMID: 8785019
Prospective evaluation of red man syndrome in patients receiving vancomycin.
O'Sullivan TL, Ruffing MJ, Lamp KC, Warbasse LH, Rybak MJ
J Infect Dis 1993 Sep;168(3):773-6. doi: 10.1093/infdis/168.3.773. PMID: 8354921
Vancomycin skin tests and prediction of "red man syndrome" in healthy volunteers.
Polk RE, Israel D, Wang J, Venitz J, Miller J, Stotka J
Antimicrob Agents Chemother 1993 Oct;37(10):2139-43. doi: 10.1128/AAC.37.10.2139. PMID: 8257136Free PMC Article

Clinical prediction guides

Drugs-associated with red man syndrome: An integrative approach using disproportionality analysis and Pharmip.
M Shaju A, Panicker N, Chandni V, Lakshmi Prasanna VM, Nair G, Subeesh V
J Clin Pharm Ther 2022 Oct;47(10):1650-1658. Epub 2022 Jun 22 doi: 10.1111/jcpt.13716. PMID: 35730973
Road Less Traveled: Drug Hypersensitivity to Fluoroquinolones, Vancomycin, Tetracyclines, and Macrolides.
Zhu LJ, Liu AY, Wong PH, Arroyo AC
Clin Rev Allergy Immunol 2022 Jun;62(3):505-518. Epub 2022 Jan 29 doi: 10.1007/s12016-021-08919-5. PMID: 35092578Free PMC Article
The clinical efficacy and safety of vancomycin loading dose: A systematic review and meta-analysis.
Mei H, Wang J, Che H, Wang R, Cai Y
Medicine (Baltimore) 2019 Oct;98(43):e17639. doi: 10.1097/MD.0000000000017639. PMID: 31651882Free PMC Article
Defining risk factors for red man syndrome in children and adults.
Myers AL, Gaedigk A, Dai H, James LP, Jones BL, Neville KA
Pediatr Infect Dis J 2012 May;31(5):464-8. doi: 10.1097/INF.0b013e31824e10d7. PMID: 22327873Free PMC Article
Vancomycin-induced red man syndrome.
Levy M, Koren G, Dupuis L, Read SE
Pediatrics 1990 Oct;86(4):572-80. PMID: 2216623

Recent systematic reviews

The clinical efficacy and safety of vancomycin loading dose: A systematic review and meta-analysis.
Mei H, Wang J, Che H, Wang R, Cai Y
Medicine (Baltimore) 2019 Oct;98(43):e17639. doi: 10.1097/MD.0000000000017639. PMID: 31651882Free PMC Article
Linezolid versus vancomycin for skin and soft tissue infections.
Yue J, Dong BR, Yang M, Chen X, Wu T, Liu GJ
Cochrane Database Syst Rev 2016 Jan 7;2016(1):CD008056. doi: 10.1002/14651858.CD008056.pub3. PMID: 26758498Free PMC Article
Linezolid versus vancomycin for skin and soft tissue infections.
Yue J, Dong BR, Yang M, Chen X, Wu T, Liu GJ
Cochrane Database Syst Rev 2013 Jul 12;(7):CD008056. doi: 10.1002/14651858.CD008056.pub2. PMID: 23846850
Teicoplanin versus vancomycin for proven or suspected infection.
Cavalcanti AB, Goncalves AR, Almeida CS, Bugano DD, Silva E
Cochrane Database Syst Rev 2010 Jun 16;(6):CD007022. doi: 10.1002/14651858.CD007022.pub2. PMID: 20556772
Comparative efficacy and safety of vancomycin versus teicoplanin: systematic review and meta-analysis.
Svetitsky S, Leibovici L, Paul M
Antimicrob Agents Chemother 2009 Oct;53(10):4069-79. Epub 2009 Jul 13 doi: 10.1128/AAC.00341-09. PMID: 19596875Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...