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Lassa fever

MedGen UID:
7276
Concept ID:
C0023092
Disease or Syndrome
Synonyms: Fever, Lassa; Infection, Lassa Virus; Lassa Fever; Lassa Fevers; Lassa Virus Infection; Lassa Virus Infections; Virus Infection, Lassa
SNOMED CT: Lassa fever (19065005); Lassa hemorrhagic fever (19065005)
 
Monarch Initiative: MONDO:0005820
Orphanet: ORPHA99824

Definition

Lassa fever (LF) is a potentially severe viral hemorrhagic disease caused by Lassa virus and characterized by initial fever and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock and multi-organ system failure. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLassa fever
Follow this link to review classifications for Lassa fever in Orphanet.

Professional guidelines

PubMed

Reyna RA, Littlefield KE, Shehu N, Makishima T, Maruyama J, Paessler S
Viruses 2024 Feb 7;16(2) doi: 10.3390/v16020266. PMID: 38400041Free PMC Article
Grant DS, Samuels RJ, Garry RF, Schieffelin JS
Curr Top Microbiol Immunol 2023;440:165-192. doi: 10.1007/82_2023_263. PMID: 37106159
Asogun DA, Günther S, Akpede GO, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):933-951. doi: 10.1016/j.idc.2019.08.002. PMID: 31668199

Recent clinical studies

Etiology

Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Müller-Kräuter H, Müller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep 2023 May 30;42(5):112524. Epub 2023 May 18 doi: 10.1016/j.celrep.2023.112524. PMID: 37209096Free PMC Article
Klitting R, Mehta SB, Oguzie JU, Oluniyi PE, Pauthner MG, Siddle KJ, Andersen KG, Happi CT, Sabeti PC
Curr Top Microbiol Immunol 2023;440:23-65. doi: 10.1007/82_2020_212. PMID: 32418034
Raabe V, Mehta AK, Evans JD; Science Working Group of the National Emerging Special Pathogens Training and Education Center (NETEC) Special Pathogens Research Network (SPRN)
Int J Infect Dis 2022 Jun;119:187-200. Epub 2022 Apr 6 doi: 10.1016/j.ijid.2022.04.004. PMID: 35395384
Asogun DA, Günther S, Akpede GO, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):933-951. doi: 10.1016/j.idc.2019.08.002. PMID: 31668199
Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1027-1043. Epub 2019 Apr 11 doi: 10.1016/j.idc.2019.03.001. PMID: 30981594Free PMC Article

Diagnosis

Asogun DA, Günther S, Akpede GO, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):933-951. doi: 10.1016/j.idc.2019.08.002. PMID: 31668199
Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1027-1043. Epub 2019 Apr 11 doi: 10.1016/j.idc.2019.03.001. PMID: 30981594Free PMC Article
Houlihan C, Behrens R
BMJ 2017 Jul 12;358:j2986. doi: 10.1136/bmj.j2986. PMID: 28701331
Raabe V, Koehler J
J Clin Microbiol 2017 Jun;55(6):1629-1637. Epub 2017 Apr 12 doi: 10.1128/JCM.00170-17. PMID: 28404674Free PMC Article
Günther S, Lenz O
Crit Rev Clin Lab Sci 2004;41(4):339-90. doi: 10.1080/10408360490497456. PMID: 15487592

Therapy

Raabe V, Mehta AK, Evans JD; Science Working Group of the National Emerging Special Pathogens Training and Education Center (NETEC) Special Pathogens Research Network (SPRN)
Int J Infect Dis 2022 Jun;119:187-200. Epub 2022 Apr 6 doi: 10.1016/j.ijid.2022.04.004. PMID: 35395384
Salami K, Gouglas D, Schmaljohn C, Saville M, Tornieporth N
Curr Opin Virol 2019 Aug;37:105-111. Epub 2019 Aug 28 doi: 10.1016/j.coviro.2019.07.006. PMID: 31472333
Cross RW, Hastie KM, Mire CE, Robinson JE, Geisbert TW, Branco LM, Ollmann Saphire E, Garry RF
Curr Opin Virol 2019 Aug;37:97-104. Epub 2019 Aug 8 doi: 10.1016/j.coviro.2019.07.003. PMID: 31401518
Purushotham J, Lambe T, Gilbert SC
Immunol Lett 2019 Nov;215:1-11. Epub 2019 Apr 23 doi: 10.1016/j.imlet.2019.03.008. PMID: 31026485Free PMC Article
Williamson ED
Clin Exp Immunol 2019 May;196(2):155-156. doi: 10.1111/cei.13303. PMID: 30993689Free PMC Article

Prognosis

de Oliveira T, Baxter C
Science 2024 Jan 5;383(6678):eadn4168. Epub 2024 Jan 4 doi: 10.1126/science.adn4168. PMID: 38175901
Grant DS, Samuels RJ, Garry RF, Schieffelin JS
Curr Top Microbiol Immunol 2023;440:165-192. doi: 10.1007/82_2023_263. PMID: 37106159
Garry RF
Nat Rev Microbiol 2023 Feb;21(2):87-96. Epub 2022 Sep 12 doi: 10.1038/s41579-022-00789-8. PMID: 36097163Free PMC Article
De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, Hoft DF, Ross TM, Noe AR, Takahashi Y, Kotraiah V, Silk SE, Nielsen CM, Minassian AM, Ashfield R, Ardito M, Draper SJ, Martin WD
Front Immunol 2020;11:442. Epub 2020 Apr 7 doi: 10.3389/fimmu.2020.00442. PMID: 32318055Free PMC Article
Purushotham J, Lambe T, Gilbert SC
Immunol Lett 2019 Nov;215:1-11. Epub 2019 Apr 23 doi: 10.1016/j.imlet.2019.03.008. PMID: 31026485Free PMC Article

Clinical prediction guides

Arruda LB, Haider N, Olayemi A, Simons D, Ehichioya D, Yinka-Ogunleye A, Ansumana R, Thomason MJ, Asogun D, Ihekweazu C, Fichet-Calvet E, Kock RA
Ann Clin Microbiol Antimicrob 2021 Apr 24;20(1):29. doi: 10.1186/s12941-021-00431-0. PMID: 33894784Free PMC Article
Beebeejaun K, Elston J, Oliver I, Ihueze A, Ukenedo C, Aruna O, Makava F, Obiefuna E, Eteng W, Niyang M, Okereke E, Gobir B, Ilori E, Ojo O, Ihekweazu C
Emerg Infect Dis 2021 Mar;27(3):694-702. doi: 10.3201/eid2703.200141. PMID: 33622473Free PMC Article
De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, Hoft DF, Ross TM, Noe AR, Takahashi Y, Kotraiah V, Silk SE, Nielsen CM, Minassian AM, Ashfield R, Ardito M, Draper SJ, Martin WD
Front Immunol 2020;11:442. Epub 2020 Apr 7 doi: 10.3389/fimmu.2020.00442. PMID: 32318055Free PMC Article
Purushotham J, Lambe T, Gilbert SC
Immunol Lett 2019 Nov;215:1-11. Epub 2019 Apr 23 doi: 10.1016/j.imlet.2019.03.008. PMID: 31026485Free PMC Article
Salvato MS, Lukashevich IS, Yang Y, Medina-Moreno S, Djavani M, Bryant J, Rodas JD, Zapata JC
Methods Mol Biol 2018;1604:279-290. doi: 10.1007/978-1-4939-6981-4_22. PMID: 28986843

Recent systematic reviews

Sulis G, Peebles A, Basta NE
Trop Med Int Health 2023 Jun;28(6):420-431. Epub 2023 Apr 24 doi: 10.1111/tmi.13876. PMID: 37095630Free PMC Article
Salam AP, Duvignaud A, Jaspard M, Malvy D, Carroll M, Tarning J, Olliaro PL, Horby PW
PLoS Negl Trop Dis 2022 Mar;16(3):e0010289. Epub 2022 Mar 30 doi: 10.1371/journal.pntd.0010289. PMID: 35353804Free PMC Article
Wolf T, Ellwanger R, Goetsch U, Wetzstein N, Gottschalk R
J Travel Med 2020 Jul 14;27(4) doi: 10.1093/jtm/taaa035. PMID: 32219400
Kayem ND, Benson C, Aye CYL, Barker S, Tome M, Kennedy S, Ariana P, Horby P
Trans R Soc Trop Med Hyg 2020 May 7;114(5):385-396. doi: 10.1093/trstmh/traa011. PMID: 32125412Free PMC Article
Takah NF, Brangel P, Shrestha P, Peeling R
BMC Infect Dis 2019 Jul 19;19(1):647. doi: 10.1186/s12879-019-4242-6. PMID: 31324229Free PMC Article

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