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Retinopathy of prematurity stage 3

MedGen UID:
730846
Concept ID:
C1443383
Disease or Syndrome
Synonyms: Retinopathy of prematurity stage 3 - ridge with extraretinal fibrovascular proliferation; Retinopathy of Prematurity Stage 3 Ridge with Extraretinal Fibroblastic Proliferation; ROP stage 3
SNOMED CT: Retinopathy of prematurity stage 3 - ridge with extraretinal fibrovascular proliferation (408849009)
 
HPO: HP:0500052

Definition

The neovascularization accumulates at the edge of the vascularized retina and extends into the vitreous (also called extra retinal fibrosis proliferation). In cases of Zone 2 and Zone 3, this may be sausage shaped. In more posterior Zone 1 disease, the stage 3 can appear as a direct extension of the normal retinal vessels but extending tangentially over the avascular retina. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinopathy of prematurity stage 3

Professional guidelines

PubMed

Öztürk T, Karataş Yiğitaslan E, Teke Kısa P, Onay H, Saatci AO
Turk J Ophthalmol 2021 Oct 26;51(5):313-316. doi: 10.4274/tjo.galenos.2021.50051. PMID: 34702847Free PMC Article
Koucheki R, Isaac M, N Tehrani N, Mireskandari K
Clin Exp Ophthalmol 2020 Sep;48(7):956-963. Epub 2020 Aug 6 doi: 10.1111/ceo.13827. PMID: 32643860
Noonan CP, Clark DI
Br J Ophthalmol 1996 Apr;80(4):278-81. doi: 10.1136/bjo.80.4.278. PMID: 8703873Free PMC Article

Recent clinical studies

Etiology

Berrocal AM, Fan KC, Al-Khersan H, Negron CI, Murray T
Am J Ophthalmol 2022 Jan;233:189-215. Epub 2021 Jul 21 doi: 10.1016/j.ajo.2021.07.016. PMID: 34298009Free PMC Article
Ge G, Zhang Y, Zhang M
Acta Ophthalmol 2021 Dec;99(8):e1263-e1273. Epub 2021 Feb 21 doi: 10.1111/aos.14827. PMID: 33611839
Narnaware SH, Bawankule PK
Lasers Med Sci 2021 Jul;36(5):989-993. Epub 2020 Sep 3 doi: 10.1007/s10103-020-03130-y. PMID: 32880773
Simkin SK, Misra SL, Han JV, McGhee CNJ, Dai S
Clin Exp Ophthalmol 2019 Dec;47(9):1122-1130. Epub 2019 Aug 7 doi: 10.1111/ceo.13593. PMID: 31313447
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article

Diagnosis

Robinson DT, Calkins KL, Chen Y, Cober MP, Falciglia GH, Church DD, Mey J, McKeever L, Sentongo T
JPEN J Parenter Enteral Nutr 2023 Sep;47(7):830-858. Epub 2023 Aug 23 doi: 10.1002/jpen.2550. PMID: 37610837
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, Binenbaum G, Blair M, Peter Campbell J, Capone A Jr, Chen Y, Dai S, Ells A, Fleck BW, Good WV, Elizabeth Hartnett M, Holmstrom G, Kusaka S, Kychenthal A, Lepore D, Lorenz B, Martinez-Castellanos MA, Özdek Ş, Ademola-Popoola D, Reynolds JD, Shah PK, Shapiro M, Stahl A, Toth C, Vinekar A, Visser L, Wallace DK, Wu WC, Zhao P, Zin A
Ophthalmology 2021 Oct;128(10):e51-e68. Epub 2021 Jul 8 doi: 10.1016/j.ophtha.2021.05.031. PMID: 34247850Free PMC Article
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Hartnett ME
Curr Opin Ophthalmol 2017 May;28(3):282-288. doi: 10.1097/ICU.0000000000000360. PMID: 28141765Free PMC Article

Therapy

Schmitz T, Doret-Dion M, Sentilhes L, Parant O, Claris O, Renesme L, Abbal J, Girault A, Torchin H, Houllier M, Le Saché N, Vivanti AJ, De Luca D, Winer N, Flamant C, Thuillier C, Boileau P, Blanc J, Brevaut V, Bouet PE, Gascoin G, Beucher G, Datin-Dorriere V, Bounan S, Bolot P, Poncelet C, Alberti C, Ursino M, Aupiais C, Baud O; BETADOSE trial study group; Groupe de Recherche en Obstétrique et Gynécologie
Lancet 2022 Aug 20;400(10352):592-604. doi: 10.1016/S0140-6736(22)01535-5. PMID: 35988568
Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article

Prognosis

Ling XC, Kang EY, Chen KJ, Wang NK, Liu L, Chen YP, Hwang YS, Lai CC, Yang SF, Wu WC
Invest Ophthalmol Vis Sci 2023 Jun 1;64(7):11. doi: 10.1167/iovs.64.7.11. PMID: 37272765Free PMC Article
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Cao Y, Jiang S, Sun J, Hei M, Wang L, Zhang H, Ma X, Wu H, Li X, Sun H, Zhou W, Shi Y, Wang Y, Gu X, Yang T, Lu Y, Du L, Chen C, Lee SK, Zhou W; Chinese Neonatal Network
JAMA Netw Open 2021 Aug 2;4(8):e2118904. doi: 10.1001/jamanetworkopen.2021.18904. PMID: 34338792Free PMC Article
Ge G, Zhang Y, Zhang M
Acta Ophthalmol 2021 Dec;99(8):e1263-e1273. Epub 2021 Feb 21 doi: 10.1111/aos.14827. PMID: 33611839
Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, Kuhn P, Langer B, Matis J, Hernandorena X, Chabanier P, Joly-Pedespan L, Lecomte B, Vendittelli F, Dreyfus M, Guillois B, Burguet A, Sagot P, Sizun J, Beuchée A, Rouget F, Favreau A, Saliba E, Bednarek N, Morville P, Thiriez G, Marpeau L, Marret S, Kayem G, Durrmeyer X, Granier M, Baud O, Jarreau PH, Mitanchez D, Boileau P, Boulot P, Cambonie G, Daudé H, Bédu A, Mons F, Fresson J, Vieux R, Alberge C, Arnaud C, Vayssière C, Truffert P, Pierrat V, Subtil D, D'Ercole C, Gire C, Simeoni U, Bongain A, Sentilhes L, Rozé JC, Gondry J, Leke A, Deiber M, Claris O, Picaud JC, Ego A, Debillon T, Poulichet A, Coliné E, Favre A, Fléchelles O, Samperiz S, Ramful D, Branger B, Benhammou V, Foix-L'Hélias L, Marchand-Martin L, Kaminski M
JAMA Pediatr 2015 Mar;169(3):230-8. doi: 10.1001/jamapediatrics.2014.3351. PMID: 25621457

Clinical prediction guides

Ling XC, Kang EY, Chen KJ, Wang NK, Liu L, Chen YP, Hwang YS, Lai CC, Yang SF, Wu WC
Invest Ophthalmol Vis Sci 2023 Jun 1;64(7):11. doi: 10.1167/iovs.64.7.11. PMID: 37272765Free PMC Article
Young BK, Cole ED, Shah PK, Ostmo S, Subramaniam P, Venkatapathy N, Tsai ASH, Coyner AS, Gupta A, Singh P, Chiang MF, Kalpathy-Cramer J, Chan RVP, Campbell JP
JAMA Ophthalmol 2023 Jun 1;141(6):582-588. doi: 10.1001/jamaophthalmol.2023.1466. PMID: 37166816Free PMC Article
Hans A, Narang S, Sindhu M, Jain S, Chawla D
Eye (Lond) 2022 Aug;36(8):1604-1609. Epub 2021 Jul 21 doi: 10.1038/s41433-021-01694-9. PMID: 34290444Free PMC Article
Narnaware SH, Bawankule PK
Lasers Med Sci 2021 Jul;36(5):989-993. Epub 2020 Sep 3 doi: 10.1007/s10103-020-03130-y. PMID: 32880773
Hartnett ME, Toth CA
Ophthalmic Surg Lasers Imaging Retina 2019 Apr 1;50(4):228-234. doi: 10.3928/23258160-20190401-05. PMID: 30998244

Recent systematic reviews

Huang J, Tang Y, Zhu T, Li Y, Chun H, Qu Y, Mu D
Medicine (Baltimore) 2019 Oct;98(42):e17512. doi: 10.1097/MD.0000000000017512. PMID: 31626109Free PMC Article
Wang X, Tang K, Chen L, Cheng S, Xu H
BMJ Open 2019 May 24;9(5):e025440. doi: 10.1136/bmjopen-2018-025440. PMID: 31129577Free PMC Article
Azami M, Jaafari Z, Rahmati S, Farahani AD, Badfar G
BMC Ophthalmol 2018 Apr 2;18(1):83. doi: 10.1186/s12886-018-0732-3. PMID: 29606108Free PMC Article
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Qureshi MJ, Kumar M
Cochrane Database Syst Rev 2013 Sep 3;2013(9):CD001073. doi: 10.1002/14651858.CD001073.pub2. PMID: 24002688Free PMC Article

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