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Acute myeloid leukemia, M6 type

MedGen UID:
7316
Concept ID:
C0023440
Neoplastic Process
Synonyms: Acute erythroid leukemia; Acute erythroleukemia; Acute erythroleukemia - M6a subtype; Acute erythroleukemia - M6b subtype; Acute myeloid leukemia FAB-M6; Di Guglielmo's syndrome; Erythroleukemia, FAB M6
SNOMED CT: Acute erythroid leukemia (14317002); Acute myeloid leukemia, M6 type (14317002); Di Guglielmo's disease (93451002); Erythroleukemia, FAB M6 (93451002); Erythroleukemia (14317002); Erythremic myelosis (14317002); AML (acute myeloid leukemia), M6 type (14317002); Erythremic myelosis (93451002); M6 - Acute erythroleukemia (93451002); Erythroleukemia (93451002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Related gene: ERBB3
 
Monarch Initiative: MONDO:0017858
Orphanet: ORPHA318

Definition

A rare unclassified acute myeloid leukemia characterized by a proliferation of immature cells exclusively of the erythroid lineage without a significant myeloblastic component. Microscopically, the cells may be undifferentiated or proerythroblastic in appearance. Patients may present with pancytopenia with fatigue, infections, and mucocutaneous bleedings, as well as weight loss, fever, and night sweats. Prognosis is poor. [from ORDO]

Professional guidelines

PubMed

Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Bertoli S, Sterin A, Tavitian S, Oberic L, Ysebaert L, Bouabdallah R, Vergez F, Sarry A, Bérard E, Huguet F, Laurent G, Prébet T, Vey N, Récher C
Oncotarget 2016 Dec 27;7(52):85937-85947. doi: 10.18632/oncotarget.13262. PMID: 27852053Free PMC Article
Santos FP, Bueso-Ramos CE, Ravandi F
Expert Rev Hematol 2010 Dec;3(6):705-18. doi: 10.1586/ehm.10.62. PMID: 21091147

Recent clinical studies

Therapy

Kakafika MG, Lyta AA, Gavriilidis GI, Tsiftsoglou SA, Miliotou AN, Pappas IS, Vizirianakis IS, Papadopoulou LC, Tsiftsoglou AS
Int J Oncol 2024 Apr;64(4) Epub 2024 Mar 1 doi: 10.3892/ijo.2024.5630. PMID: 38426621Free PMC Article
Briot T, Roger E, Bou Haidar N, Bejaud J, Lautram N, Guillet C, Thépot S, Legeay S, Lagarce F
Int J Nanomedicine 2019;14:2091-2102. Epub 2019 Mar 26 doi: 10.2147/IJN.S190482. PMID: 30988610Free PMC Article
Creutzig U, Zimmermann M, Dworzak MN, Ritter J, Schellong G, Reinhardt D
Klin Padiatr 2013 May;225 Suppl 1:S79-86. Epub 2013 May 22 doi: 10.1055/s-0033-1337968. PMID: 23700063
Hengel CL, Russell PA, Gould PA, Kaye DM
Heart Lung Circ 2006 Feb;15(1):59-61. Epub 2005 Nov 11 doi: 10.1016/j.hlc.2005.06.003. PMID: 16473794
Rosner F, Grünwald H
Am J Med 1975 Mar;58(3):339-53. doi: 10.1016/0002-9343(75)90600-2. PMID: 1090158

Prognosis

Cieśla M, Ngoc PCT, Muthukumar S, Todisco G, Madej M, Fritz H, Dimitriou M, Incarnato D, Hellström-Lindberg E, Bellodi C
Mol Cell 2023 Apr 6;83(7):1165-1179.e11. Epub 2023 Mar 20 doi: 10.1016/j.molcel.2023.02.024. PMID: 36944332
Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Liao Z, Li J, Wu J, Liu J, Sun S
Curr Mol Med 2021;21(10):819-831. doi: 10.2174/1566524021666210121142316. PMID: 33475071
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Zuo Z, Polski JM, Kasyan A, Medeiros LJ
Arch Pathol Lab Med 2010 Sep;134(9):1261-70. doi: 10.5858/2009-0350-RA.1. PMID: 20807044

Clinical prediction guides

Redondo Monte E, Leubolt G, Windisch R, Kerbs P, Dutta S, Landspersky T, Istvánffy R, Oostendorp RAJ, Chen-Wichmann L, Herold T, Cusan M, Schotta G, Wichmann C, Greif PA
Exp Hematol 2022 Apr;108:26-35. Epub 2022 Feb 16 doi: 10.1016/j.exphem.2022.02.002. PMID: 35181392
Margolskee E, Mikita G, Rea B, Bagg A, Zuo Z, Sun Y, Goswami M, Wang SA, Oak J, Arber DA, Allen MB, George TI, Rogers HJ, Hsi E, Hasserjian RP, Orazi A
Mod Pathol 2018 Jun;31(6):873-880. Epub 2018 Feb 5 doi: 10.1038/s41379-018-0001-2. PMID: 29403082
Ishiyama K, Yamaguchi T, Eto T, Ohashi K, Uchida N, Kanamori H, Fukuda T, Miyamura K, Inoue Y, Taguchi J, Mori T, Iwato K, Morishima Y, Nagamura-Inoue T, Atsuta Y, Sakamaki H, Takami A
Leuk Res 2016 Aug;47:47-53. Epub 2016 May 12 doi: 10.1016/j.leukres.2016.04.017. PMID: 27244257
El Rassi F, Ward KC, Flowers CR, Heffner LT, Waller EK, Winton EF, Vaughn J, Hill BG, Langston A, Nooka A, Arellano M, Khoury HJ
South Med J 2014 Aug;107(8):497-500. doi: 10.14423/SMJ.0000000000000146. PMID: 25084186
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165

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