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Whipple disease

MedGen UID:
7347
Concept ID:
C0023788
Disease or Syndrome
Synonyms: Intestinal lipodystrophy; Intestinal lipophagic granulomatosis; Secondary Non-tropical Sprue; Tropheryma whippelii infection; Whipple's disease
SNOMED CT: WD - Whipple's disease (41545003); Intestinal Whipple's disease (41545003); Whipple disease (41545003); Whipple's disease (41545003); Intestinal lipodystrophy (41545003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005116
Orphanet: ORPHA3452

Definition

A rare chronic infectious disorder in which almost all organ systems can be invaded by the rod-shaped bacterium Tropheryma whipplei (<i>TW</i>). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWhipple disease

Professional guidelines

PubMed

Caillet Portillo D, Puéchal X, Masson M, Kostine M, Michaut A, Ramon A, Wendling D, Costedoat-Chalumeau N, Richette P, Marotte H, Vix-Portet J, Dubost JJ, Ottaviani S, Mouterde G, Grasland A, Frazier A, Germain V, Coury F, Tournadre A, Soubrier M, Cavalie L, Brevet P, Zabraniecki L, Jamard B, Couture G, Arnaud L, Richez C, Degboé Y, Ruyssen-Witrand A, Constantin A
J Infect 2024 Feb;88(2):132-138. Epub 2023 Dec 22 doi: 10.1016/j.jinf.2023.12.010. PMID: 38141787
Morales-Briceño H, Fung V
Neurology 2019 Mar 12;92(11):544-545. doi: 10.1212/WNL.0000000000007088. PMID: 30858248
Bally JF, Lang AE
Neurology 2019 Mar 12;92(11):544. doi: 10.1212/WNL.0000000000007087. PMID: 30858247

Recent clinical studies

Etiology

Friebel J, Schinnerling K, Geelhaar-Karsch A, Allers K, Schneider T, Moos V
Immun Inflamm Dis 2022 May;10(5):e622. doi: 10.1002/iid3.622. PMID: 35478447Free PMC Article
Puéchal X
Joint Bone Spine 2016 Dec;83(6):631-635. Epub 2016 Aug 5 doi: 10.1016/j.jbspin.2016.07.001. PMID: 27502365
Ojeda E, Cosme A, Lapaza J, Torrado J, Arruabarrena I, Alzate L
Rev Esp Enferm Dig 2010 Feb;102(2):108-23. doi: 10.4321/s1130-01082010000200006. PMID: 20361847
Moreillon P, Que YA
Lancet 2004 Jan 10;363(9403):139-49. doi: 10.1016/S0140-6736(03)15266-X. PMID: 14726169
Woodrow JC
Baillieres Clin Rheumatol 1988 Dec;2(3):603-22. doi: 10.1016/s0950-3579(88)80031-1. PMID: 2465836

Diagnosis

Boumaza A, Ben Azzouz E, Arrindell J, Lepidi H, Mezouar S, Desnues B
Lancet Infect Dis 2022 Oct;22(10):e280-e291. Epub 2022 Apr 12 doi: 10.1016/S1473-3099(22)00128-1. PMID: 35427488
Sarvananthan S, Velissaris T, Miskolczi S, Yam T, Shah BN
Echocardiography 2021 Apr;38(4):697-700. Epub 2021 Mar 12 doi: 10.1111/echo.15007. PMID: 33711181
El-Abassi R, Soliman MY, Williams F, England JD
J Neurol Sci 2017 Jun 15;377:197-206. Epub 2017 Feb 16 doi: 10.1016/j.jns.2017.01.048. PMID: 28477696
Dolmans RA, Boel CH, Lacle MM, Kusters JG
Clin Microbiol Rev 2017 Apr;30(2):529-555. doi: 10.1128/CMR.00033-16. PMID: 28298472Free PMC Article
Marth T, Moos V, Müller C, Biagi F, Schneider T
Lancet Infect Dis 2016 Mar;16(3):e13-22. Epub 2016 Feb 6 doi: 10.1016/S1473-3099(15)00537-X. PMID: 26856775

Therapy

Odio CD, O'Brien CR, Jacox J, Jain D, Lee AI
N Engl J Med 2020 Jul 2;383(1):68-74. doi: 10.1056/NEJMcps1817531. PMID: 32609985
Marth T, Moos V, Müller C, Biagi F, Schneider T
Lancet Infect Dis 2016 Mar;16(3):e13-22. Epub 2016 Feb 6 doi: 10.1016/S1473-3099(15)00537-X. PMID: 26856775
Deriban G, Marth T
Curr Med Chem 2006;13(24):2921-6. doi: 10.2174/092986706778521913. PMID: 17073638
Bai JC, Mazure RM, Vazquez H, Niveloni SI, Smecuol E, Pedreira S, Mauriño E
Clin Gastroenterol Hepatol 2004 Oct;2(10):849-60. doi: 10.1016/s1542-3565(04)00387-8. PMID: 15476147
Moreillon P, Que YA
Lancet 2004 Jan 10;363(9403):139-49. doi: 10.1016/S0140-6736(03)15266-X. PMID: 14726169

Prognosis

El-Abassi R, Soliman MY, Williams F, England JD
J Neurol Sci 2017 Jun 15;377:197-206. Epub 2017 Feb 16 doi: 10.1016/j.jns.2017.01.048. PMID: 28477696
Puéchal X
Joint Bone Spine 2016 Dec;83(6):631-635. Epub 2016 Aug 5 doi: 10.1016/j.jbspin.2016.07.001. PMID: 27502365
Marth T, Moos V, Müller C, Biagi F, Schneider T
Lancet Infect Dis 2016 Mar;16(3):e13-22. Epub 2016 Feb 6 doi: 10.1016/S1473-3099(15)00537-X. PMID: 26856775
Touitou V, Fenollar F, Cassoux N, Merle-Beral H, LeHoang P, Amoura Z, Drancourt M, Bodaghi B
Ophthalmology 2012 Jul;119(7):1465-9. Epub 2012 Mar 13 doi: 10.1016/j.ophtha.2012.01.024. PMID: 22420960
Bai JC, Mazure RM, Vazquez H, Niveloni SI, Smecuol E, Pedreira S, Mauriño E
Clin Gastroenterol Hepatol 2004 Oct;2(10):849-60. doi: 10.1016/s1542-3565(04)00387-8. PMID: 15476147

Clinical prediction guides

Friebel J, Schinnerling K, Geelhaar-Karsch A, Allers K, Schneider T, Moos V
Immun Inflamm Dis 2022 May;10(5):e622. doi: 10.1002/iid3.622. PMID: 35478447Free PMC Article
Karlowee V, Kolakshyapati M, Amatya VJ, Takayasu T, Nosaka R, Sugiyama K, Kurisu K, Yamasaki F
Childs Nerv Syst 2017 Aug;33(8):1411-1414. Epub 2017 Apr 5 doi: 10.1007/s00381-017-3405-2. PMID: 28382437
Fenollar F, Célard M, Lagier JC, Lepidi H, Fournier PE, Raoult D
Emerg Infect Dis 2013 Nov;19(11):1721-30. doi: 10.3201/eid1911.121356. PMID: 24207100Free PMC Article
Thomson RB Jr, Bertram H
Infect Dis Clin North Am 2001 Dec;15(4):1047-71. doi: 10.1016/s0891-5520(05)70186-0. PMID: 11780267
Dingemans KP, Mooi WJ, van den Bergh Weerman MA
Ultrastruct Pathol 1983 Sep-Oct;5(2-3):113-22. doi: 10.3109/01913128309141830. PMID: 6199876

Recent systematic reviews

Ioannou P, Kourtidis M, Mytilinis DO, Psyllaki A, Baliou S, Kofteridis D
Infect Dis (Lond) 2023 Jul;55(7):447-457. Epub 2023 May 17 doi: 10.1080/23744235.2023.2214610. PMID: 37198913
Manini A, Querzola G, Lovati C, Pantoni L
Neurol Sci 2022 Feb;43(2):907-926. Epub 2022 Jan 3 doi: 10.1007/s10072-021-05844-5. PMID: 34981284Free PMC Article
Marth T
Aliment Pharmacol Ther 2015 Apr;41(8):709-24. Epub 2015 Feb 19 doi: 10.1111/apt.13140. PMID: 25693648
Mohamed W, Neil E, Kupsky WJ, Juhász C, Mittal S, Santhakumar S
J Neurol Sci 2011 Sep 15;308(1-2):1-8. Epub 2011 Jun 22 doi: 10.1016/j.jns.2011.05.029. PMID: 21696776
Williamson E, Williams M, Gates S, Lamb SE
Pain 2008 Mar;135(1-2):20-30. Epub 2007 Jun 13 doi: 10.1016/j.pain.2007.04.035. PMID: 17570588

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