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Whipple disease

MedGen UID:
7347
Concept ID:
C0023788
Disease or Syndrome
Synonyms: Intestinal lipodystrophy; Intestinal lipophagic granulomatosis; Secondary Non-tropical Sprue; Tropheryma whippelii infection; Whipple's disease
SNOMED CT: WD - Whipple's disease (41545003); Intestinal Whipple's disease (41545003); Whipple disease (41545003); Whipple's disease (41545003); Intestinal lipodystrophy (41545003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005116
Orphanet: ORPHA3452

Definition

A rare chronic infectious disorder in which almost all organ systems can be invaded by the rod-shaped bacterium Tropheryma whipplei (<i>TW</i>). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWhipple disease

Professional guidelines

PubMed

Caillet Portillo D, Puéchal X, Masson M, Kostine M, Michaut A, Ramon A, Wendling D, Costedoat-Chalumeau N, Richette P, Marotte H, Vix-Portet J, Dubost JJ, Ottaviani S, Mouterde G, Grasland A, Frazier A, Germain V, Coury F, Tournadre A, Soubrier M, Cavalie L, Brevet P, Zabraniecki L, Jamard B, Couture G, Arnaud L, Richez C, Degboé Y, Ruyssen-Witrand A, Constantin A
J Infect 2024 Feb;88(2):132-138. Epub 2023 Dec 22 doi: 10.1016/j.jinf.2023.12.010. PMID: 38141787
Morales-Briceño H, Fung V
Neurology 2019 Mar 12;92(11):544-545. doi: 10.1212/WNL.0000000000007088. PMID: 30858248
Bally JF, Lang AE
Neurology 2019 Mar 12;92(11):544. doi: 10.1212/WNL.0000000000007087. PMID: 30858247

Recent clinical studies

Etiology

Tison A, Preuss P, Leleu C, Robin F, Le Pluart A, Vix J, Le Mélédo G, Goupille P, Gervais E, Cormier G, Albert JD, Perdriger A, Bouvard B, Berthelot JM, Foulquier N, Saraux A
Sci Rep 2021 Jun 10;11(1):12278. doi: 10.1038/s41598-021-91671-9. PMID: 34112875Free PMC Article
Puéchal X
Joint Bone Spine 2016 Dec;83(6):631-635. Epub 2016 Aug 5 doi: 10.1016/j.jbspin.2016.07.001. PMID: 27502365
Moreillon P, Que YA
Lancet 2004 Jan 10;363(9403):139-49. doi: 10.1016/S0140-6736(03)15266-X. PMID: 14726169
Marth T, Raoult D
Lancet 2003 Jan 18;361(9353):239-46. doi: 10.1016/S0140-6736(03)12274-X. PMID: 12547551
Ratnaike RN
Postgrad Med J 2000 Dec;76(902):760-6. doi: 10.1136/pmj.76.902.760. PMID: 11085766Free PMC Article

Diagnosis

Boumaza A, Ben Azzouz E, Arrindell J, Lepidi H, Mezouar S, Desnues B
Lancet Infect Dis 2022 Oct;22(10):e280-e291. Epub 2022 Apr 12 doi: 10.1016/S1473-3099(22)00128-1. PMID: 35427488
El-Abassi R, Soliman MY, Williams F, England JD
J Neurol Sci 2017 Jun 15;377:197-206. Epub 2017 Feb 16 doi: 10.1016/j.jns.2017.01.048. PMID: 28477696
Dolmans RA, Boel CH, Lacle MM, Kusters JG
Clin Microbiol Rev 2017 Apr;30(2):529-555. doi: 10.1128/CMR.00033-16. PMID: 28298472Free PMC Article
Puéchal X
Joint Bone Spine 2016 Dec;83(6):631-635. Epub 2016 Aug 5 doi: 10.1016/j.jbspin.2016.07.001. PMID: 27502365
Marth T, Moos V, Müller C, Biagi F, Schneider T
Lancet Infect Dis 2016 Mar;16(3):e13-22. Epub 2016 Feb 6 doi: 10.1016/S1473-3099(15)00537-X. PMID: 26856775

Therapy

Marth T
Acta Clin Belg 2016 Dec;71(6):373-378. Epub 2016 Nov 24 doi: 10.1080/17843286.2016.1256586. PMID: 27884091
Puéchal X
Joint Bone Spine 2016 Dec;83(6):631-635. Epub 2016 Aug 5 doi: 10.1016/j.jbspin.2016.07.001. PMID: 27502365
Marth T, Moos V, Müller C, Biagi F, Schneider T
Lancet Infect Dis 2016 Mar;16(3):e13-22. Epub 2016 Feb 6 doi: 10.1016/S1473-3099(15)00537-X. PMID: 26856775
Puéchal X
Ann Rheum Dis 2013 Jun;72(6):797-803. Epub 2013 Jan 3 doi: 10.1136/annrheumdis-2012-202684. PMID: 23291386
Biagi F, Trotta L, Corazza GR
Intern Emerg Med 2012 Oct;7 Suppl 3:S209-13. doi: 10.1007/s11739-012-0801-1. PMID: 23073859

Prognosis

El-Abassi R, Soliman MY, Williams F, England JD
J Neurol Sci 2017 Jun 15;377:197-206. Epub 2017 Feb 16 doi: 10.1016/j.jns.2017.01.048. PMID: 28477696
Puéchal X
Joint Bone Spine 2016 Dec;83(6):631-635. Epub 2016 Aug 5 doi: 10.1016/j.jbspin.2016.07.001. PMID: 27502365
Marth T, Moos V, Müller C, Biagi F, Schneider T
Lancet Infect Dis 2016 Mar;16(3):e13-22. Epub 2016 Feb 6 doi: 10.1016/S1473-3099(15)00537-X. PMID: 26856775
Marth T, Raoult D
Lancet 2003 Jan 18;361(9353):239-46. doi: 10.1016/S0140-6736(03)12274-X. PMID: 12547551
Fantry GT, James SP
Dig Dis 1995 Mar-Apr;13(2):108-18. doi: 10.1159/000171492. PMID: 7586631

Clinical prediction guides

Tison A, Preuss P, Leleu C, Robin F, Le Pluart A, Vix J, Le Mélédo G, Goupille P, Gervais E, Cormier G, Albert JD, Perdriger A, Bouvard B, Berthelot JM, Foulquier N, Saraux A
Sci Rep 2021 Jun 10;11(1):12278. doi: 10.1038/s41598-021-91671-9. PMID: 34112875Free PMC Article
Ferrieres L, Laroche M, Bonnet D, Alric L
Eur J Gastroenterol Hepatol 2020 Mar;32(3):325-328. doi: 10.1097/MEG.0000000000001611. PMID: 31764405
Lagier JC, Raoult D
Curr Opin Infect Dis 2018 Dec;31(6):463-470. doi: 10.1097/QCO.0000000000000489. PMID: 30299363
Fenollar F, Célard M, Lagier JC, Lepidi H, Fournier PE, Raoult D
Emerg Infect Dis 2013 Nov;19(11):1721-30. doi: 10.3201/eid1911.121356. PMID: 24207100Free PMC Article
Fenollar F, Raoult D
Curr Gastroenterol Rep 2003 Oct;5(5):379-85. doi: 10.1007/s11894-003-0050-6. PMID: 12959718

Recent systematic reviews

Ioannou P, Kourtidis M, Mytilinis DO, Psyllaki A, Baliou S, Kofteridis D
Infect Dis (Lond) 2023 Jul;55(7):447-457. Epub 2023 May 17 doi: 10.1080/23744235.2023.2214610. PMID: 37198913
Manini A, Querzola G, Lovati C, Pantoni L
Neurol Sci 2022 Feb;43(2):907-926. Epub 2022 Jan 3 doi: 10.1007/s10072-021-05844-5. PMID: 34981284Free PMC Article
Bally JF, Méneret A, Roze E, Anderson M, Grabli D, Lang AE
Mov Disord 2018 Nov;33(11):1700-1711. Epub 2018 Oct 19 doi: 10.1002/mds.27419. PMID: 30338868
Marth T
Aliment Pharmacol Ther 2015 Apr;41(8):709-24. Epub 2015 Feb 19 doi: 10.1111/apt.13140. PMID: 25693648
Mohamed W, Neil E, Kupsky WJ, Juhász C, Mittal S, Santhakumar S
J Neurol Sci 2011 Sep 15;308(1-2):1-8. Epub 2011 Jun 22 doi: 10.1016/j.jns.2011.05.029. PMID: 21696776

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