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Cutaneous lupus erythematosus

MedGen UID:
7401
•Concept ID:
C0024137
•
Disease or Syndrome
Synonyms: Cutaneous Lupus Erythematosus; Lupus Erythematosus, Cutaneous
SNOMED CT: Cutaneous lupus erythematosus (7119001)
 
Monarch Initiative: MONDO:0005282

Definition

Disease of skin in someone with Lupus erythematosus, though not necessarily systemic or subacute. [from SNOMEDCT_US]

Professional guidelines

PubMed

Adverse cutaneous toxicities by PD-1/PD-L1 immune checkpoint inhibitors: pathogenesis, treatment, and surveillance.
Bhardwaj M, Chiu MN, Pilkhwal Sah S
Cutan Ocul Toxicol 2022 Mar;41(1):73-90. Epub 2022 Feb 20 doi: 10.1080/15569527.2022.2034842. PMID: 35107396
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article

Recent clinical studies

Etiology

Cutaneous Involvement in Systemic Lupus Erythematosus: A Review for the Rheumatologist.
Stull C, Sprow G, Werth VP
J Rheumatol 2023 Jan;50(1):27-35. Epub 2022 Sep 15 doi: 10.3899/jrheum.220089. PMID: 36109075Free PMC Article
Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Guideline for the diagnosis, treatment and long-term management of cutaneous lupus erythematosus.
Lu Q, Long H, Chow S, Hidayat S, Danarti R, Listiawan Y, Deng D, Guo Q, Fang H, Tao J, Zhao M, Xiang L, Che N, Li F, Zhao H, Lau CS, Ip FC, Ho KM, Paliza AC, Vicheth C, Godse K, Cho S, Seow CS, Miyachi Y, Khang TH, Ungpakorn R, Galadari H, Shah R, Yang K, Zhou Y, Selmi C, Sawalha AH, Zhang X, Chen Y, Lin CS
J Autoimmun 2021 Sep;123:102707. Epub 2021 Aug 5 doi: 10.1016/j.jaut.2021.102707. PMID: 34364171
Systemic Lupus Erythematosus Classification and Diagnosis.
Aringer M, Johnson SR
Rheum Dis Clin North Am 2021 Aug;47(3):501-511. Epub 2021 Jun 10 doi: 10.1016/j.rdc.2021.04.011. PMID: 34215376
Cutaneous Lupus Erythematosus: Progress and Challenges.
Petty AJ, Floyd L, Henderson C, Nicholas MW
Curr Allergy Asthma Rep 2020 Apr 4;20(5):12. doi: 10.1007/s11882-020-00906-8. PMID: 32248318Free PMC Article

Diagnosis

Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions.
Niebel D, de Vos L, Fetter T, Brägelmann C, Wenzel J
Am J Clin Dermatol 2023 Jul;24(4):521-540. Epub 2023 May 4 doi: 10.1007/s40257-023-00774-8. PMID: 37140884Free PMC Article
Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects.
Vale ECSD, Garcia LC
An Bras Dermatol 2023 May-Jun;98(3):355-372. Epub 2023 Mar 1 doi: 10.1016/j.abd.2022.09.005. PMID: 36868923Free PMC Article
Systemic Lupus Erythematosus Classification and Diagnosis.
Aringer M, Johnson SR
Rheum Dis Clin North Am 2021 Aug;47(3):501-511. Epub 2021 Jun 10 doi: 10.1016/j.rdc.2021.04.011. PMID: 34215376
Cutaneous Lupus Erythematosus: Progress and Challenges.
Petty AJ, Floyd L, Henderson C, Nicholas MW
Curr Allergy Asthma Rep 2020 Apr 4;20(5):12. doi: 10.1007/s11882-020-00906-8. PMID: 32248318Free PMC Article
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article

Therapy

Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions.
Niebel D, de Vos L, Fetter T, Brägelmann C, Wenzel J
Am J Clin Dermatol 2023 Jul;24(4):521-540. Epub 2023 May 4 doi: 10.1007/s40257-023-00774-8. PMID: 37140884Free PMC Article
Trial of Anti-BDCA2 Antibody Litifilimab for Cutaneous Lupus Erythematosus.
Werth VP, Furie RA, Romero-Diaz J, Navarra S, Kalunian K, van Vollenhoven RF, Nyberg F, Kaffenberger BH, Sheikh SZ, Radunovic G, Huang X, Clark G, Carroll H, Naik H, Gaudreault F, Meyers A, Barbey C, Musselli C, Franchimont N; LILAC Trial Investigators
N Engl J Med 2022 Jul 28;387(4):321-331. doi: 10.1056/NEJMoa2118024. PMID: 35939578
Interventions for cutaneous disease in systemic lupus erythematosus.
Hannon CW, McCourt C, Lima HC, Chen S, Bennett C
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2. PMID: 33687069Free PMC Article
Cutaneous Lupus Erythematosus: Progress and Challenges.
Petty AJ, Floyd L, Henderson C, Nicholas MW
Curr Allergy Asthma Rep 2020 Apr 4;20(5):12. doi: 10.1007/s11882-020-00906-8. PMID: 32248318Free PMC Article
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article

Prognosis

Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions.
Niebel D, de Vos L, Fetter T, Brägelmann C, Wenzel J
Am J Clin Dermatol 2023 Jul;24(4):521-540. Epub 2023 May 4 doi: 10.1007/s40257-023-00774-8. PMID: 37140884Free PMC Article
Cutaneous Involvement in Systemic Lupus Erythematosus: A Review for the Rheumatologist.
Stull C, Sprow G, Werth VP
J Rheumatol 2023 Jan;50(1):27-35. Epub 2022 Sep 15 doi: 10.3899/jrheum.220089. PMID: 36109075Free PMC Article
Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation.
Billi AC, Ma F, Plazyo O, Gharaee-Kermani M, Wasikowski R, Hile GA, Xing X, Yee CM, Rizvi SM, Maz MP, Berthier CC, Wen F, Tsoi LC, Pellegrini M, Modlin RL, Gudjonsson JE, Kahlenberg JM
Sci Transl Med 2022 Apr 27;14(642):eabn2263. doi: 10.1126/scitranslmed.abn2263. PMID: 35476593Free PMC Article
New insights into the progression from cutaneous lupus to systemic lupus erythematosus.
Zhou W, Wu H, Zhao M, Lu Q
Expert Rev Clin Immunol 2020 Aug;16(8):829-837. Epub 2020 Sep 29 doi: 10.1080/1744666X.2020.1805316. PMID: 32746644

Clinical prediction guides

Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions.
Niebel D, de Vos L, Fetter T, Brägelmann C, Wenzel J
Am J Clin Dermatol 2023 Jul;24(4):521-540. Epub 2023 May 4 doi: 10.1007/s40257-023-00774-8. PMID: 37140884Free PMC Article
Trial of Anti-BDCA2 Antibody Litifilimab for Cutaneous Lupus Erythematosus.
Werth VP, Furie RA, Romero-Diaz J, Navarra S, Kalunian K, van Vollenhoven RF, Nyberg F, Kaffenberger BH, Sheikh SZ, Radunovic G, Huang X, Clark G, Carroll H, Naik H, Gaudreault F, Meyers A, Barbey C, Musselli C, Franchimont N; LILAC Trial Investigators
N Engl J Med 2022 Jul 28;387(4):321-331. doi: 10.1056/NEJMoa2118024. PMID: 35939578
Cutaneous adverse events caused by immune checkpoint inhibitors.
Quach HT, Johnson DB, LeBoeuf NR, Zwerner JP, Dewan AK
J Am Acad Dermatol 2021 Oct;85(4):956-966. Epub 2021 Jul 28 doi: 10.1016/j.jaad.2020.09.054. PMID: 34332798
New insights into the progression from cutaneous lupus to systemic lupus erythematosus.
Zhou W, Wu H, Zhao M, Lu Q
Expert Rev Clin Immunol 2020 Aug;16(8):829-837. Epub 2020 Sep 29 doi: 10.1080/1744666X.2020.1805316. PMID: 32746644
Drug-induced lupus erythematosus: an update on drugs and mechanisms.
He Y, Sawalha AH
Curr Opin Rheumatol 2018 Sep;30(5):490-497. doi: 10.1097/BOR.0000000000000522. PMID: 29870500Free PMC Article

Recent systematic reviews

Efficacy and safety of Janus kinase inhibitors in systemic and cutaneous lupus erythematosus: A systematic review and meta-analysis.
Ma L, Peng L, Zhao J, Bai W, Jiang N, Zhang S, Wu C, Wang L, Xu D, Leng X, Wang Q, Zhang W, Zhao Y, Tian X, Li M, Zeng X
Autoimmun Rev 2023 Dec;22(12):103440. Epub 2023 Sep 9 doi: 10.1016/j.autrev.2023.103440. PMID: 37678618
A Systematic Review of the Progression of Cutaneous Lupus to Systemic Lupus Erythematosus.
Curtiss P, Walker AM, Chong BF
Front Immunol 2022;13:866319. Epub 2022 Mar 11 doi: 10.3389/fimmu.2022.866319. PMID: 35359921Free PMC Article
Interventions for cutaneous disease in systemic lupus erythematosus.
Hannon CW, McCourt C, Lima HC, Chen S, Bennett C
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2. PMID: 33687069Free PMC Article
Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions.
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346
Dermatological adverse events with taxane chemotherapy.
Sibaud V, Lebœuf NR, Roche H, Belum VR, Gladieff L, Deslandres M, Montastruc M, Eche A, Vigarios E, Dalenc F, Lacouture ME
Eur J Dermatol 2016 Oct 1;26(5):427-443. doi: 10.1684/ejd.2016.2833. PMID: 27550571Free PMC Article

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