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Follicular lymphoma

MedGen UID:
7417
Concept ID:
C0024301
Neoplastic Process
Synonym: FOLLICULAR LYMPHOMA, SOMATIC
SNOMED CT: Giant follicular lymphoma (55150002); Nodular lymphosarcoma (55150002); Follicular lymphosarcoma (55150002); Brill - Symmers' disease (55150002); Malignant lymphoma, follicle center, follicular (55150002); Malignant lymphoma, follicle center (55150002); Malignant lymphoma, centroblastic-centrocytic, follicular (55150002); Follicular lymphoma (55150002); Malignant lymphoma, follicular (55150002); Follicular non-Hodgkin lymphoma (308121000); Nodular lymphoma (269476000); Follicular low grade B-cell lymphoma (277618009); Nodular malignant lymphoma (277618009); Germinoblastoma, follicular (307637005); Malignant lymphoma, centroblastic-centrocytic, follicular (307637005); Follicular non-Hodgkin's lymphoma (308121000); Malignant lymphoma, nodular (55150002); Malignant lymphoma, lymphocytic, nodular (55150002)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0033125
Monarch Initiative: MONDO:0018906
Orphanet: ORPHA545

Definition

An indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma is characterized by diffuse lymphadenopathy, bone marrow involvement, splenomegaly and less commonly other extranodal sites of involvement. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFollicular lymphoma
Follow this link to review classifications for Follicular lymphoma in Orphanet.

Conditions with this feature

Follicular lymphoma, susceptibility to, 1
MedGen UID:
442784
Concept ID:
C2751665
Finding
Follicular non-Hodgkin lymphoma is an indolent B-cell malignancy with an annual incidence exceeding 10,000 cases in the United States (Bohen et al., 2003). One form of susceptibility to follicular lymphoma (FL1) is associated with a region on chromosome 6p21.33.

Professional guidelines

PubMed

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040
Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107
Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2023

Recent clinical studies

Etiology

Friedberg JW
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):43-47. doi: 10.1002/hon.3138. PMID: 37294960Free PMC Article
Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040
Cerhan JR
Hematol Oncol Clin North Am 2020 Aug;34(4):631-646. Epub 2020 May 5 doi: 10.1016/j.hoc.2020.02.001. PMID: 32586570Free PMC Article
Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159
Fischer T, Zing NPC, Chiattone CS, Federico M, Luminari S
Ann Hematol 2018 Jan;97(1):17-29. Epub 2017 Oct 18 doi: 10.1007/s00277-017-3151-2. PMID: 29043381

Diagnosis

Friedberg JW
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):43-47. doi: 10.1002/hon.3138. PMID: 37294960Free PMC Article
Laurent C, Cook JR, Yoshino T, Quintanilla-Martinez L, Jaffe ES
Virchows Arch 2023 Jan;482(1):149-162. Epub 2022 Nov 17 doi: 10.1007/s00428-022-03432-2. PMID: 36394631Free PMC Article
Gordon MJ, Smith MR, Nastoupil LJ
Blood Rev 2023 Jan;57:100992. Epub 2022 Jul 23 doi: 10.1016/j.blre.2022.100992. PMID: 35908982
Mozas P, Sorigué M, López-Guillermo A
Med Clin (Barc) 2021 Nov 12;157(9):440-448. Epub 2021 Jun 29 doi: 10.1016/j.medcli.2021.03.041. PMID: 34210513
Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

Therapy

Ghione P, Palomba ML, Patel AR, Bobillo S, Deighton K, Jacobson CA, Nahas M, Hatswell AJ, Jung AS, Kanters S, Snider JT, Neelapu SS, Ribeiro MT, Brookhart MA, Ghesquieres H, Radford J, Gribben JG
Blood 2022 Aug 25;140(8):851-860. doi: 10.1182/blood.2021014375. PMID: 35679476Free PMC Article
Hoy SM
Drugs 2020 Nov;80(16):1731-1737. doi: 10.1007/s40265-020-01405-w. PMID: 32946059
Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159
Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752
Morschhauser F, Fowler NH, Feugier P, Bouabdallah R, Tilly H, Palomba ML, Fruchart C, Libby EN, Casasnovas RO, Flinn IW, Haioun C, Maisonneuve H, Ysebaert L, Bartlett NL, Bouabdallah K, Brice P, Ribrag V, Daguindau N, Le Gouill S, Pica GM, Martin Garcia-Sancho A, López-Guillermo A, Larouche JF, Ando K, Gomes da Silva M, André M, Zachée P, Sehn LH, Tobinai K, Cartron G, Liu D, Wang J, Xerri L, Salles GA; RELEVANCE Trial Investigators
N Engl J Med 2018 Sep 6;379(10):934-947. doi: 10.1056/NEJMoa1805104. PMID: 30184451Free PMC Article

Prognosis

Alderuccio JP, Kahl BS
Oncology (Williston Park) 2022 Apr 6;36(4):206-215. doi: 10.46883/2022.25920956. PMID: 35436062
Kanas G, Ge W, Quek RGW, Keeven K, Nersesyan K, Jon E Arnason
Leuk Lymphoma 2022 Jan;63(1):54-63. Epub 2021 Sep 11 doi: 10.1080/10428194.2021.1975188. PMID: 34510995
Dreyling M, Ghielmini M, Rule S, Salles G, Ladetto M, Tonino SH, Herfarth K, Seymour JF, Jerkeman M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Mar;32(3):298-308. Epub 2020 Nov 26 doi: 10.1016/j.annonc.2020.11.008. PMID: 33249059
Cerhan JR
Hematol Oncol Clin North Am 2020 Aug;34(4):631-646. Epub 2020 May 5 doi: 10.1016/j.hoc.2020.02.001. PMID: 32586570Free PMC Article
Olsen TG, Heegaard S
Surv Ophthalmol 2019 Jan-Feb;64(1):45-66. Epub 2018 Aug 23 doi: 10.1016/j.survophthal.2018.08.002. PMID: 30144455

Clinical prediction guides

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040
Casulo C, Dixon JG, Le-Rademacher J, Hoster E, Hochster HS, Hiddemann W, Marcus R, Kimby E, Herold M, Sebban C, Gyan E, Foon K, Nielsen T, Vitolo U, Salles GA, Shi Q, Flowers CR
Blood 2022 Mar 17;139(11):1684-1693. doi: 10.1182/blood.2020010263. PMID: 34614146Free PMC Article
Batlevi CL, Sha F, Alperovich A, Ni A, Smith K, Ying Z, Soumerai JD, Caron PC, Falchi L, Hamilton A, Hamlin PA, Horwitz SM, Joffe E, Kumar A, Matasar MJ, Moskowitz AJ, Moskowitz CH, Noy A, Owens C, Palomba LM, Straus D, von Keudell G, Zelenetz AD, Seshan VE, Younes A
Blood Cancer J 2020 Jul 17;10(7):74. doi: 10.1038/s41408-020-00340-z. PMID: 32678074Free PMC Article
Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159
Hoster E, Dreyling M, Klapper W, Gisselbrecht C, van Hoof A, Kluin-Nelemans HC, Pfreundschuh M, Reiser M, Metzner B, Einsele H, Peter N, Jung W, Wörmann B, Ludwig WD, Dührsen U, Eimermacher H, Wandt H, Hasford J, Hiddemann W, Unterhalt M; German Low Grade Lymphoma Study Group (GLSG); European Mantle Cell Lymphoma Network
Blood 2008 Jan 15;111(2):558-65. Epub 2007 Oct 25 doi: 10.1182/blood-2007-06-095331. PMID: 17962512

Recent systematic reviews

Si T, Ma X, Zhu W, Zhou Y
Hematology 2023 Dec;28(1):2284047. Epub 2023 Nov 27 doi: 10.1080/16078454.2023.2284047. PMID: 38010876
Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592
Odutola MK, Benke G, Fritschi L, Giles GG, van Leeuwen MT, Vajdic CM
Environ Res 2021 Jun;197:110887. Epub 2021 Feb 17 doi: 10.1016/j.envres.2021.110887. PMID: 33607095
Arzuaga-Mendez J, Lopez-Santillan M, Garcia-Ruiz JC, Lopez-Lopez E, Martin-Guerrero I
Crit Rev Oncol Hematol 2021 Mar;159:103247. Epub 2021 Jan 27 doi: 10.1016/j.critrevonc.2021.103247. PMID: 33515703
Police RL, Trask PC, Wang J, Olivares R, Khan S, Abbe A, Colosia A, Njue A, Sherril B, Ruiz-Soto R, Kaye JA, Hamadani M
J Oncol Pharm Pract 2016 Oct;22(5):666-78. Epub 2015 Aug 28 doi: 10.1177/1078155215603230. PMID: 26320127

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2023

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