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Caplan syndrome

MedGen UID:
743
•Concept ID:
C0006915
•
Disease or Syndrome
Synonyms: Caplan Syndrome; Caplan Syndromes; Caplan's Syndrome; Caplans Syndrome
SNOMED CT: Rheumatoid pneumoconiosis (398640008); Caplan's syndrome (398640008); Caplans syndrome (398640008); Rheumatoid arthritis with pneumoconiosis (398640008)
 
Monarch Initiative: MONDO:0005690

Definition

A combination of rheumatoid arthritis (RA) and pneumoconiosis that manifests as intrapulmonary nodules, which appear homogenous and well-defined on chest X-ray. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCaplan syndrome

Professional guidelines

PubMed

12-month Success of Cracked Teeth Treated with Orthograde Root Canal Treatment.
Krell KV, Caplan DJ
J Endod 2018 Apr;44(4):543-548. Epub 2018 Feb 21 doi: 10.1016/j.joen.2017.12.025. PMID: 29429822
Prevention and management of glucocorticoid-induced side effects: A comprehensive review: Gastrointestinal and endocrinologic side effects.
Caplan A, Fett N, Rosenbach M, Werth VP, Micheletti RG
J Am Acad Dermatol 2017 Jan;76(1):11-16. doi: 10.1016/j.jaad.2016.02.1239. PMID: 27986133
Haptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage.
Murthy SB, Caplan J, Levy AP, Pradilla G, Moradiya Y, Schneider EB, Shalom H, Ziai WC, Tamargo RJ, Nyquist PA
Neurosurgery 2016 Jan;78(1):71-6. doi: 10.1227/NEU.0000000000001000. PMID: 26348010

Recent clinical studies

Etiology

Pulmonary manifestations of collagen diseases.
Gómez Carrera L, Bonilla Hernan G
Arch Bronconeumol 2013 Jun;49(6):249-60. Epub 2013 Feb 4 doi: 10.1016/j.arbres.2012.11.005. PMID: 23683373
Computed tomography findings of Caplan syndrome.
Arakawa H, Honma K, Shida H, Saito Y, Morikubo H
J Comput Assist Tomogr 2003 Sep-Oct;27(5):758-60. doi: 10.1097/00004728-200309000-00013. PMID: 14501367
HLA-A, B and DR antigens and properdin factor B allotypes in Caplan's syndrome.
Darke C, Wagner MM, Nuki G, Dyer PA
Br J Dis Chest 1983 Jul;77(3):235-42. PMID: 6577907
HLA-A and B antigen frequencies in Welsh coalworkers with pneumoconiosis and Caplan's syndrome.
Wagner MM, Darke C
Tissue Antigens 1979 Aug;14(2):165-8. doi: 10.1111/j.1399-0039.1979.tb00834.x. PMID: 91226
Pulmonary function in coal workers with Caplan's syndrome and non-rheumatoid complicated pneumosoniosis.
Constantinidis K, Musk AW, Jenkins JP, Berry G
Thorax 1978 Dec;33(6):764-8. doi: 10.1136/thx.33.6.764. PMID: 746502Free PMC Article

Diagnosis

Diagnosing Caplan syndrome in a patient with silicosis and rheumatoid arthritis: imaging shows miliary pattern and cavity lung lesions.
Saavedra FT, Sierra LL, Zuluaica AM, Botero EC
Lancet 2023 Jun 24;401(10394):2148. doi: 10.1016/S0140-6736(23)01090-5. PMID: 37355292
Treatment with Rituximab in Rheumatoid Pneumoconiosis: A Case Report.
Yasmine M, Kaouther M, Dhia K, Hanene F, Wafa T, Dorra BN, Wafa H
Curr Drug Saf 2023;18(3):383-385. doi: 10.2174/1574886317666220428132311. PMID: 37254279
Amyloid A amyloidosis in a patient with Caplan's syndrome, with special reference to genetic predisposition.
Nakamura T, Shiraishi N, Morikami Y, Fujii H, Yoshinaga T
Mod Rheumatol Case Rep 2020 Jul;4(2):212-217. Epub 2020 Apr 20 doi: 10.1080/24725625.2020.1749361. PMID: 33087017
What to do with all of these lung nodules?
Rozenberg D, Shapera S
Can Respir J 2014 May-Jun;21(3):e52-4. doi: 10.1155/2014/593430. PMID: 24914609Free PMC Article
Pulmonary manifestations of collagen diseases.
Gómez Carrera L, Bonilla Hernan G
Arch Bronconeumol 2013 Jun;49(6):249-60. Epub 2013 Feb 4 doi: 10.1016/j.arbres.2012.11.005. PMID: 23683373

Therapy

Treatment with Rituximab in Rheumatoid Pneumoconiosis: A Case Report.
Yasmine M, Kaouther M, Dhia K, Hanene F, Wafa T, Dorra BN, Wafa H
Curr Drug Saf 2023;18(3):383-385. doi: 10.2174/1574886317666220428132311. PMID: 37254279
Atypical presentation of rheumatoid arthritis: a case of massive bilateral pleural effusions in a patient with Caplan syndrome.
Wu Y, Dittmar PC
BMJ Case Rep 2019 Oct 25;12(10) doi: 10.1136/bcr-2019-231899. PMID: 31653636Free PMC Article
Parkinsonism in Caplan's syndrome.
Rizzo G, Scaglione C, Lopane G, Pollini A, Tommasoni E, Martinelli P
Neurol Sci 2006 Apr;27(1):67-9. doi: 10.1007/s10072-006-0567-1. PMID: 16688603
Coal workers' pneumoconiosis.
Green FH, Laqueur WA
Pathol Annu 1980;15(Pt 2):333-410. PMID: 7005843
Treatment of rapidly progressive rheumatoid pneumoconiosis.
Davies D
Br J Ind Med 1973 Oct;30(4):396-401. doi: 10.1136/oem.30.4.396. PMID: 4753724Free PMC Article

Prognosis

Rheumatoid pneumoconiosis (Caplan's syndrome).
Schreiber J, Koschel D, Kekow J, Waldburg N, Goette A, Merget R
Eur J Intern Med 2010 Jun;21(3):168-72. Epub 2010 Mar 2 doi: 10.1016/j.ejim.2010.02.004. PMID: 20493416
Computed tomography findings of Caplan syndrome.
Arakawa H, Honma K, Shida H, Saito Y, Morikubo H
J Comput Assist Tomogr 2003 Sep-Oct;27(5):758-60. doi: 10.1097/00004728-200309000-00013. PMID: 14501367
Rheumatoid "pneumoconiosis" (Caplan's syndrome) in an asbestos worker: a 17 years' follow-up.
Greaves IA
Thorax 1979 Jun;34(3):404-5. doi: 10.1136/thx.34.3.404. PMID: 483218Free PMC Article
Caplan's syndrome in miners.
Kandus J, Sitaj S, Ondrásík M
Rev Czech Med 1977;23(4):236-45. PMID: 413171

Clinical prediction guides

Changes of the lung in rheumatoid arthritis--rheumatoid pneumonia. A clinicopathological study.
Bély M, Apáthy A
Acta Morphol Hung 1991;39(2):117-56. PMID: 1789145
Pulmonary function in coal workers with Caplan's syndrome and non-rheumatoid complicated pneumosoniosis.
Constantinidis K, Musk AW, Jenkins JP, Berry G
Thorax 1978 Dec;33(6):764-8. doi: 10.1136/thx.33.6.764. PMID: 746502Free PMC Article
Incidence of hepatitis associated antigen HAA and homologous antibody in patients with rheumatoid arthritis.
Marcolongo R, Debolini A
Vox Sang 1975;28(1):9-18. doi: 10.1111/j.1423-0410.1975.tb02735.x. PMID: 1114790

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