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HER2 positive breast carcinoma

MedGen UID:
743175
•Concept ID:
C1960398
•
Neoplastic Process
Synonyms: ERBB2 Overexpressing Subtype of Breast Carcinoma; ERBB2 Overexpressing subtype of breast carcinoma; HER2 Overexpressing Breast Carcinoma; HER2 Overexpressing breast carcinoma; HER2 Overexpressing Subtype of Breast Carcinoma; HER2 Overexpressing subtype of breast carcinoma; HER2 Positive Breast Cancer; HER2 Positive breast cancer; HER2 Positive Breast Carcinoma; HER2-Positive Breast Carcinoma; HER2-positive carcinoma of breast; Her2-receptor positive breast cancer; Human epidermal growth factor 2 positive carcinoma of breast
SNOMED CT: HER2-positive carcinoma of breast (427685000); Human epidermal growth factor 2 positive carcinoma of breast (427685000)
 
Monarch Initiative: MONDO:0006244

Definition

A biologic subset of breast carcinoma defined by high expression of HER2, GRB7, and TRAP100, and by lack of expression of estrogen receptor (ER). [from NCI]

Professional guidelines

PubMed

Successful intracranial delivery of trastuzumab by gene-therapy for treatment of HER2-positive breast cancer brain metastases.
Zafir-Lavie I, Sherbo S, Goltsman H, Badinter F, Yeini E, Ofek P, Miari R, Tal O, Liran A, Shatil T, Krispel S, Shapir N, Neil GA, Benhar I, Panet A, Satchi-Fainaro R
J Control Release 2018 Dec 10;291:80-89. Epub 2018 Oct 17 doi: 10.1016/j.jconrel.2018.10.017. PMID: 30342077
Trastuzumab emtansine for the treatment of HER2-positive metastatic breast cancer.
Haddley K
Drugs Today (Barc) 2013 Nov;49(11):701-15. doi: 10.1358/dot.2013.49.11.2020937. PMID: 24308017
The HER2 World: Better Treatment Selection for Better Outcome.
Tagliabue E, Campiglio M, Pupa SM, Balsari A, Ménard S
J Natl Cancer Inst Monogr 2011;2011(43):82-5. doi: 10.1093/jncimonographs/lgr041. PMID: 22043048

Recent clinical studies

Etiology

Poor histologic tumor response after adjuvant therapy in basal-like HER2-positive breast carcinoma.
Zhao D, Fu X, Rohr J, Wang Y, Li M, Zhang X, Qin J, Xu M, Li C, Sun G, Wang Z, Guo S
Pathol Res Pract 2021 Dec;228:153677. Epub 2021 Oct 30 doi: 10.1016/j.prp.2021.153677. PMID: 34775151
ER staining levels affect HER2 staining and heterogeneity.
Akashi M, Yamaguchi R, Kusano H, Yamaguchi M, Akiba J, Kakuma T, Tanaka M, Akagi Y, Yano H
Breast Cancer 2021 May;28(3):720-726. Epub 2021 Jan 9 doi: 10.1007/s12282-020-01208-7. PMID: 33423217
p63 expression is associated with high histological grade, aberrant p53 expression and TP53 mutation in HER2-positive breast carcinoma.
Guo S, Wang Y, Rohr J, Shang L, Ma J
J Clin Pathol 2021 Oct;74(10):641-645. Epub 2020 Sep 1 doi: 10.1136/jclinpath-2020-206643. PMID: 32873702
Diverse histomorphology of HER2-positive breast carcinomas based on differential ER expression.
Akashi M, Yamaguchi R, Kusano H, Obara H, Yamaguchi M, Toh U, Akiba J, Kakuma T, Tanaka M, Akagi Y, Yano H
Histopathology 2020 Mar;76(4):560-571. Epub 2020 Feb 3 doi: 10.1111/his.14003. PMID: 31554015
Role of Genomic Alterations in HER2 Positive Breast Carcinoma: Focus on Susceptibility and Trastuzumab-therapy.
Singla H, Kalra S, Kheterpal P, Kumar V, Munshi A
Curr Cancer Drug Targets 2017;17(4):344-356. doi: 10.2174/1568009616666161216094026. PMID: 27993117

Diagnosis

rBC2LCN lectin as a potential probe of early-stage HER2-positive breast carcinoma.
Mawaribuchi S, Haramoto Y, Tateno H, Onuma Y, Aiki Y, Ito Y
FEBS Open Bio 2020 Jun;10(6):1056-1064. Epub 2020 May 5 doi: 10.1002/2211-5463.12852. PMID: 32237061Free PMC Article
Role of Genomic Alterations in HER2 Positive Breast Carcinoma: Focus on Susceptibility and Trastuzumab-therapy.
Singla H, Kalra S, Kheterpal P, Kumar V, Munshi A
Curr Cancer Drug Targets 2017;17(4):344-356. doi: 10.2174/1568009616666161216094026. PMID: 27993117
Breast Carcinoma in Young Women: No Evidence of Increasing Rates of Metastatic Breast Carcinoma in a Single Tertiary Center Review.
Conlon N, Howard J, Catalano J, Gallagher M, Tan LK, Corben AD
Breast J 2016 May;22(3):287-92. Epub 2016 Feb 29 doi: 10.1111/tbj.12575. PMID: 26923423Free PMC Article
Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma.
Keyaerts M, Xavier C, Heemskerk J, Devoogdt N, Everaert H, Ackaert C, Vanhoeij M, Duhoux FP, Gevaert T, Simon P, Schallier D, Fontaine C, Vaneycken I, Vanhove C, De Greve J, Lamote J, Caveliers V, Lahoutte T
J Nucl Med 2016 Jan;57(1):27-33. Epub 2015 Oct 8 doi: 10.2967/jnumed.115.162024. PMID: 26449837
Trastuzumab-induced HER reprogramming in "resistant" breast carcinoma cells.
Narayan M, Wilken JA, Harris LN, Baron AT, Kimbler KD, Maihle NJ
Cancer Res 2009 Mar 15;69(6):2191-4. Epub 2009 Mar 10 doi: 10.1158/0008-5472.CAN-08-1056. PMID: 19276389

Therapy

Poor histologic tumor response after adjuvant therapy in basal-like HER2-positive breast carcinoma.
Zhao D, Fu X, Rohr J, Wang Y, Li M, Zhang X, Qin J, Xu M, Li C, Sun G, Wang Z, Guo S
Pathol Res Pract 2021 Dec;228:153677. Epub 2021 Oct 30 doi: 10.1016/j.prp.2021.153677. PMID: 34775151
rBC2LCN lectin as a potential probe of early-stage HER2-positive breast carcinoma.
Mawaribuchi S, Haramoto Y, Tateno H, Onuma Y, Aiki Y, Ito Y
FEBS Open Bio 2020 Jun;10(6):1056-1064. Epub 2020 May 5 doi: 10.1002/2211-5463.12852. PMID: 32237061Free PMC Article
Role of Genomic Alterations in HER2 Positive Breast Carcinoma: Focus on Susceptibility and Trastuzumab-therapy.
Singla H, Kalra S, Kheterpal P, Kumar V, Munshi A
Curr Cancer Drug Targets 2017;17(4):344-356. doi: 10.2174/1568009616666161216094026. PMID: 27993117
Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma.
Keyaerts M, Xavier C, Heemskerk J, Devoogdt N, Everaert H, Ackaert C, Vanhoeij M, Duhoux FP, Gevaert T, Simon P, Schallier D, Fontaine C, Vaneycken I, Vanhove C, De Greve J, Lamote J, Caveliers V, Lahoutte T
J Nucl Med 2016 Jan;57(1):27-33. Epub 2015 Oct 8 doi: 10.2967/jnumed.115.162024. PMID: 26449837
Trastuzumab emtansine for the treatment of HER2-positive metastatic breast cancer.
Haddley K
Drugs Today (Barc) 2013 Nov;49(11):701-15. doi: 10.1358/dot.2013.49.11.2020937. PMID: 24308017

Prognosis

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Diverse histomorphology of HER2-positive breast carcinomas based on differential ER expression.
Akashi M, Yamaguchi R, Kusano H, Obara H, Yamaguchi M, Toh U, Akiba J, Kakuma T, Tanaka M, Akagi Y, Yano H
Histopathology 2020 Mar;76(4):560-571. Epub 2020 Feb 3 doi: 10.1111/his.14003. PMID: 31554015
Role of Genomic Alterations in HER2 Positive Breast Carcinoma: Focus on Susceptibility and Trastuzumab-therapy.
Singla H, Kalra S, Kheterpal P, Kumar V, Munshi A
Curr Cancer Drug Targets 2017;17(4):344-356. doi: 10.2174/1568009616666161216094026. PMID: 27993117
Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma.
Keyaerts M, Xavier C, Heemskerk J, Devoogdt N, Everaert H, Ackaert C, Vanhoeij M, Duhoux FP, Gevaert T, Simon P, Schallier D, Fontaine C, Vaneycken I, Vanhove C, De Greve J, Lamote J, Caveliers V, Lahoutte T
J Nucl Med 2016 Jan;57(1):27-33. Epub 2015 Oct 8 doi: 10.2967/jnumed.115.162024. PMID: 26449837
Trastuzumab emtansine for the treatment of HER2-positive metastatic breast cancer.
Haddley K
Drugs Today (Barc) 2013 Nov;49(11):701-15. doi: 10.1358/dot.2013.49.11.2020937. PMID: 24308017

Clinical prediction guides

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Diverse histomorphology of HER2-positive breast carcinomas based on differential ER expression.
Akashi M, Yamaguchi R, Kusano H, Obara H, Yamaguchi M, Toh U, Akiba J, Kakuma T, Tanaka M, Akagi Y, Yano H
Histopathology 2020 Mar;76(4):560-571. Epub 2020 Feb 3 doi: 10.1111/his.14003. PMID: 31554015
Role of Genomic Alterations in HER2 Positive Breast Carcinoma: Focus on Susceptibility and Trastuzumab-therapy.
Singla H, Kalra S, Kheterpal P, Kumar V, Munshi A
Curr Cancer Drug Targets 2017;17(4):344-356. doi: 10.2174/1568009616666161216094026. PMID: 27993117
Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma.
Keyaerts M, Xavier C, Heemskerk J, Devoogdt N, Everaert H, Ackaert C, Vanhoeij M, Duhoux FP, Gevaert T, Simon P, Schallier D, Fontaine C, Vaneycken I, Vanhove C, De Greve J, Lamote J, Caveliers V, Lahoutte T
J Nucl Med 2016 Jan;57(1):27-33. Epub 2015 Oct 8 doi: 10.2967/jnumed.115.162024. PMID: 26449837
Trastuzumab emtansine for the treatment of HER2-positive metastatic breast cancer.
Haddley K
Drugs Today (Barc) 2013 Nov;49(11):701-15. doi: 10.1358/dot.2013.49.11.2020937. PMID: 24308017

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