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HER2 positive breast carcinoma

MedGen UID:
743175
Concept ID:
C1960398
Neoplastic Process
Synonyms: ERBB2 Overexpressing Subtype of Breast Carcinoma; ERBB2 Overexpressing subtype of breast carcinoma; HER2 Overexpressing Breast Carcinoma; HER2 Overexpressing breast carcinoma; HER2 Overexpressing Subtype of Breast Carcinoma; HER2 Overexpressing subtype of breast carcinoma; HER2 Positive Breast Cancer; HER2 Positive breast cancer; HER2 Positive Breast Carcinoma; HER2-Positive Breast Carcinoma; HER2-positive carcinoma of breast; Her2-receptor positive breast cancer; Human epidermal growth factor 2 positive carcinoma of breast
SNOMED CT: HER2-positive carcinoma of breast (427685000); Human epidermal growth factor 2 positive carcinoma of breast (427685000)
 
Monarch Initiative: MONDO:0006244

Definition

A biologic subset of breast carcinoma defined by high expression of HER2, GRB7, and TRAP100, and by lack of expression of estrogen receptor (ER). [from NCI]

Professional guidelines

PubMed

Cheal SM, Xu H, Guo HF, Patel M, Punzalan B, Fung EK, Lee SG, Bell M, Singh M, Jungbluth AA, Zanzonico PB, Piersigilli A, Larson SM, Cheung NV
Theranostics 2018;8(18):5106-5125. Epub 2018 Oct 6 doi: 10.7150/thno.26585. PMID: 30429889Free PMC Article
Zafir-Lavie I, Sherbo S, Goltsman H, Badinter F, Yeini E, Ofek P, Miari R, Tal O, Liran A, Shatil T, Krispel S, Shapir N, Neil GA, Benhar I, Panet A, Satchi-Fainaro R
J Control Release 2018 Dec 10;291:80-89. Epub 2018 Oct 17 doi: 10.1016/j.jconrel.2018.10.017. PMID: 30342077
Haddley K
Drugs Today (Barc) 2013 Nov;49(11):701-15. doi: 10.1358/dot.2013.49.11.2020937. PMID: 24308017

Recent clinical studies

Therapy

Narwadkar YS, Parghane RV, Sahu S, Lad S, Deep K, Wanage G, Suralkar T, Banerjee S, Gupta S, Basu S, Badwe RA
Clin Nucl Med 2024 Apr 1;49(4):e149-e155. Epub 2024 Feb 1 doi: 10.1097/RLU.0000000000005067. PMID: 38350067
Zhao D, Fu X, Rohr J, Wang Y, Li M, Zhang X, Qin J, Xu M, Li C, Sun G, Wang Z, Guo S
Pathol Res Pract 2021 Dec;228:153677. Epub 2021 Oct 30 doi: 10.1016/j.prp.2021.153677. PMID: 34775151
Singla H, Kalra S, Kheterpal P, Kumar V, Munshi A
Curr Cancer Drug Targets 2017;17(4):344-356. doi: 10.2174/1568009616666161216094026. PMID: 27993117
Keyaerts M, Xavier C, Heemskerk J, Devoogdt N, Everaert H, Ackaert C, Vanhoeij M, Duhoux FP, Gevaert T, Simon P, Schallier D, Fontaine C, Vaneycken I, Vanhove C, De Greve J, Lamote J, Caveliers V, Lahoutte T
J Nucl Med 2016 Jan;57(1):27-33. Epub 2015 Oct 8 doi: 10.2967/jnumed.115.162024. PMID: 26449837
Haddley K
Drugs Today (Barc) 2013 Nov;49(11):701-15. doi: 10.1358/dot.2013.49.11.2020937. PMID: 24308017

Prognosis

Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Akashi M, Yamaguchi R, Kusano H, Obara H, Yamaguchi M, Toh U, Akiba J, Kakuma T, Tanaka M, Akagi Y, Yano H
Histopathology 2020 Mar;76(4):560-571. Epub 2020 Feb 3 doi: 10.1111/his.14003. PMID: 31554015
Singla H, Kalra S, Kheterpal P, Kumar V, Munshi A
Curr Cancer Drug Targets 2017;17(4):344-356. doi: 10.2174/1568009616666161216094026. PMID: 27993117
Keyaerts M, Xavier C, Heemskerk J, Devoogdt N, Everaert H, Ackaert C, Vanhoeij M, Duhoux FP, Gevaert T, Simon P, Schallier D, Fontaine C, Vaneycken I, Vanhove C, De Greve J, Lamote J, Caveliers V, Lahoutte T
J Nucl Med 2016 Jan;57(1):27-33. Epub 2015 Oct 8 doi: 10.2967/jnumed.115.162024. PMID: 26449837
Haddley K
Drugs Today (Barc) 2013 Nov;49(11):701-15. doi: 10.1358/dot.2013.49.11.2020937. PMID: 24308017

Clinical prediction guides

Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Akashi M, Yamaguchi R, Kusano H, Obara H, Yamaguchi M, Toh U, Akiba J, Kakuma T, Tanaka M, Akagi Y, Yano H
Histopathology 2020 Mar;76(4):560-571. Epub 2020 Feb 3 doi: 10.1111/his.14003. PMID: 31554015
Singla H, Kalra S, Kheterpal P, Kumar V, Munshi A
Curr Cancer Drug Targets 2017;17(4):344-356. doi: 10.2174/1568009616666161216094026. PMID: 27993117
Keyaerts M, Xavier C, Heemskerk J, Devoogdt N, Everaert H, Ackaert C, Vanhoeij M, Duhoux FP, Gevaert T, Simon P, Schallier D, Fontaine C, Vaneycken I, Vanhove C, De Greve J, Lamote J, Caveliers V, Lahoutte T
J Nucl Med 2016 Jan;57(1):27-33. Epub 2015 Oct 8 doi: 10.2967/jnumed.115.162024. PMID: 26449837
Haddley K
Drugs Today (Barc) 2013 Nov;49(11):701-15. doi: 10.1358/dot.2013.49.11.2020937. PMID: 24308017

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