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Organic failure to thrive

MedGen UID:
744213
•Concept ID:
C1997142
•
Disease or Syndrome
Synonyms: OFTT - Organic failure to thrive; Organic Failure to Thrive; Organic FTT
SNOMED CT: OFTT - Organic failure to thrive (428484005); Organic failure to thrive (428484005)

Definition

Failure to thrive (FTT), that occurs in less than five percent of FTT cases; it is caused by acute or chronic disorders that interfere with nutritional uptake, including cleft palate, malabsorption due to cystic fibrosis, and short gut syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrganic failure to thrive

Professional guidelines

PubMed

Current topics in the diagnosis and management of the pediatric non organic feeding disorders (NOFEDs).
Romano C, Hartman C, Privitera C, Cardile S, Shamir R
Clin Nutr 2015 Apr;34(2):195-200. Epub 2014 Sep 15 doi: 10.1016/j.clnu.2014.08.013. PMID: 25240803

Recent clinical studies

Etiology

Failure to thrive in infant and toddlers: a practical flowchart-based approach in a hospital setting.
Franceschi R, Rizzardi C, Maines E, Liguori A, Soffiati M, Tornese G
Ital J Pediatr 2021 Mar 10;47(1):62. doi: 10.1186/s13052-021-01017-4. PMID: 33691756Free PMC Article
Current topics in the diagnosis and management of the pediatric non organic feeding disorders (NOFEDs).
Romano C, Hartman C, Privitera C, Cardile S, Shamir R
Clin Nutr 2015 Apr;34(2):195-200. Epub 2014 Sep 15 doi: 10.1016/j.clnu.2014.08.013. PMID: 25240803
Failure to thrive and the risk of child abuse: a prospective population survey.
Skuse DH, Gill D, Reilly S, Wolke D, Lynch MA
J Med Screen 1995;2(3):145-9. doi: 10.1177/096914139500200309. PMID: 8536184
Assessment of the child with failure to thrive.
Leung AK, Robson WM, Fagan JE
Am Fam Physician 1993 Dec;48(8):1432-8. PMID: 8249774
Child and family attributes of failure-to-thrive.
Bithoney WG, Newberger EH
J Dev Behav Pediatr 1987 Feb;8(1):32-6. PMID: 3818963

Diagnosis

Interesting presentation of postnatal depression and infant failure to thrive.
Murgan N, Harrison B
BMJ Case Rep 2022 Apr 29;15(4) doi: 10.1136/bcr-2022-249205. PMID: 35487627Free PMC Article
Failure to thrive in infant and toddlers: a practical flowchart-based approach in a hospital setting.
Franceschi R, Rizzardi C, Maines E, Liguori A, Soffiati M, Tornese G
Ital J Pediatr 2021 Mar 10;47(1):62. doi: 10.1186/s13052-021-01017-4. PMID: 33691756Free PMC Article
Current topics in the diagnosis and management of the pediatric non organic feeding disorders (NOFEDs).
Romano C, Hartman C, Privitera C, Cardile S, Shamir R
Clin Nutr 2015 Apr;34(2):195-200. Epub 2014 Sep 15 doi: 10.1016/j.clnu.2014.08.013. PMID: 25240803
Non-organic failure to thrive: a reappraisal.
Skuse DH
Arch Dis Child 1985 Feb;60(2):173-8. doi: 10.1136/adc.60.2.173. PMID: 3883912Free PMC Article
Non-organic failure to thrive.
Oates RK
Aust Paediatr J 1984 May;20(2):95-100. doi: 10.1111/j.1440-1754.1984.tb00052.x. PMID: 6380482

Therapy

Effects of oral zinc supplementation on zinc status and catch-up growth during the first 2 years of life in children with non-organic failure to thrive born preterm and at term.
Cho JM, Kim JY, Yang HR
Pediatr Neonatol 2019 Apr;60(2):201-209. Epub 2018 Jun 25 doi: 10.1016/j.pedneo.2018.06.006. PMID: 30031808
The endocannabinoid-CB(1) receptor system in pre- and postnatal life.
Fride E
Eur J Pharmacol 2004 Oct 1;500(1-3):289-97. doi: 10.1016/j.ejphar.2004.07.033. PMID: 15464041
Copper and zinc blood levels among children with nonorganic failure to thrive.
Berkovitch M, Heyman E, Afriat R, Matz-Khromchenko I, Avgil M, Greenberg R, Zimmerman DR, Berman S, Weissgarten J
Clin Nutr 2003 Apr;22(2):183-6. doi: 10.1054/clnu.2002.0619. PMID: 12706136
Use of energy-dense formula for treating infants with non-organic failure to thrive.
Khoshoo V, Reifen R
Eur J Clin Nutr 2002 Sep;56(9):921-4. doi: 10.1038/sj.ejcn.1601406. PMID: 12209382

Prognosis

Diagnosis on a positive fashion of nonorganic failure to thrive.
Panetta F, Magazzù D, Sferlazzas C, Lombardo M, Magazzù G, Lucanto MC
Acta Paediatr 2008 Sep;97(9):1281-4. doi: 10.1111/j.1651-2227.2008.00912.x. PMID: 18616628
Infant sucking ability, non-organic failure to thrive, maternal characteristics, and feeding practices: a prospective cohort study.
Ramsay M, Gisel EG, McCusker J, Bellavance F, Platt R
Dev Med Child Neurol 2002 Jun;44(6):405-14. doi: 10.1017/s0012162201002286. PMID: 12088309
Long-term follow-up and outcome of infants with non-organic failure to thrive.
Reif S, Beler B, Villa Y, Spirer Z
Isr J Med Sci 1995 Aug;31(8):483-9. PMID: 7543467
Assessment of the child with failure to thrive.
Leung AK, Robson WM, Fagan JE
Am Fam Physician 1993 Dec;48(8):1432-8. PMID: 8249774
Prospective evaluation of weight gain in both nonorganic and organic failure-to-thrive children: an outpatient trial of a multidisciplinary team intervention strategy.
Bithoney WG, McJunkin J, Michalek J, Egan H, Snyder J, Munier A
J Dev Behav Pediatr 1989 Feb;10(1):27-31. PMID: 2925865

Clinical prediction guides

Failure to thrive in infant and toddlers: a practical flowchart-based approach in a hospital setting.
Franceschi R, Rizzardi C, Maines E, Liguori A, Soffiati M, Tornese G
Ital J Pediatr 2021 Mar 10;47(1):62. doi: 10.1186/s13052-021-01017-4. PMID: 33691756Free PMC Article
Effects of oral zinc supplementation on zinc status and catch-up growth during the first 2 years of life in children with non-organic failure to thrive born preterm and at term.
Cho JM, Kim JY, Yang HR
Pediatr Neonatol 2019 Apr;60(2):201-209. Epub 2018 Jun 25 doi: 10.1016/j.pedneo.2018.06.006. PMID: 30031808
Professional failure to thrive: a threat to high-quality care?
Stamler LL, Gabriel AM
Nurs Leadersh (Tor Ont) 2010 Mar;23(1):22-31. doi: 10.12927/cjnl.2010.21726. PMID: 20383077
Non-organic failure to thrive: a reappraisal.
Skuse DH
Arch Dis Child 1985 Feb;60(2):173-8. doi: 10.1136/adc.60.2.173. PMID: 3883912Free PMC Article
Non-organic failure to thrive: decision for placement and videotaped evaluations.
Haynes CF, Cutler C, Gray J, O'Keefe K, Kempe RS
Child Abuse Negl 1983;7(3):309-19. doi: 10.1016/0145-2134(83)90009-1. PMID: 6686477

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