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Hemicrania continua

MedGen UID:
748511
Concept ID:
C2349425
Disease or Syndrome
Synonyms: Hemicrania Continua; hemicrania continua
SNOMED CT: Hemicrania continua (443095000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018615
Orphanet: ORPHA443070

Definition

A rare trigeminal autonomic cephalalgia characterized by indomethacin-sensitive, persistent, strictly unilateral headache lasting for more than three months, associated with ipsilateral conjunctival injection, lacrimation, nasal congestion, rhinorrhea, forehead and facial sweating, miosis, ptosis, eyelid edema, and/or restlessness or agitation, and not better accounted for by another type of headache. Migrainous symptoms such as photophobia are often observed. The headache may be continuous (unremitting subtype) or interrupted by remission periods of more than 24 hours (remitting subtype). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemicrania continua

Professional guidelines

PubMed

Bahra A
Cephalalgia 2023 Nov;43(11):3331024231214239. doi: 10.1177/03331024231214239. PMID: 37950675
Diener HC, Tassorelli C, Dodick DW
JAMA Neurol 2023 Mar 1;80(3):308-319. doi: 10.1001/jamaneurol.2022.4804. PMID: 36648786
Mehta A, Chilakamarri P, Zubair A, Kuruvilla DE
Curr Neurol Neurosci Rep 2018 Oct 17;18(12):95. doi: 10.1007/s11910-018-0899-2. PMID: 30328517

Recent clinical studies

Etiology

Wei DY, Goadsby PJ
Semin Neurol 2022 Aug;42(4):474-478. Epub 2022 Nov 2 doi: 10.1055/s-0042-1758043. PMID: 36323300
Villar-Martínez MD, Moreno-Ajona D, Chan C, Goadsby PJ
Headache 2021 May;61(5):700-714. doi: 10.1111/head.14111. PMID: 34105154
Burish MJ, Rozen TD
Neurol Clin 2019 Nov;37(4):847-869. Epub 2019 Aug 24 doi: 10.1016/j.ncl.2019.07.001. PMID: 31563236
Newman LC
Continuum (Minneap Minn) 2015 Aug;21(4 Headache):1041-57. doi: 10.1212/CON.0000000000000190. PMID: 26252590
VanderPluym J
Curr Neurol Neurosci Rep 2015;15(2):516. doi: 10.1007/s11910-014-0516-y. PMID: 25467407

Diagnosis

Goadsby PJ
Continuum (Minneap Minn) 2024 Apr 1;30(2):488-497. doi: 10.1212/CON.0000000000001409. PMID: 38568495
Bahra A
Cephalalgia 2023 Nov;43(11):3331024231214239. doi: 10.1177/03331024231214239. PMID: 37950675
Diener HC, Tassorelli C, Dodick DW
JAMA Neurol 2023 Mar 1;80(3):308-319. doi: 10.1001/jamaneurol.2022.4804. PMID: 36648786
Burish MJ, Rozen TD
Neurol Clin 2019 Nov;37(4):847-869. Epub 2019 Aug 24 doi: 10.1016/j.ncl.2019.07.001. PMID: 31563236
Charlson RW, Robbins MS
Curr Neurol Neurosci Rep 2014 Mar;14(3):436. doi: 10.1007/s11910-013-0436-2. PMID: 24452694

Therapy

Goadsby PJ
Continuum (Minneap Minn) 2024 Apr 1;30(2):488-497. doi: 10.1212/CON.0000000000001409. PMID: 38568495
Bahra A
Cephalalgia 2023 Nov;43(11):3331024231214239. doi: 10.1177/03331024231214239. PMID: 37950675
Diener HC, Tassorelli C, Dodick DW
JAMA Neurol 2023 Mar 1;80(3):308-319. doi: 10.1001/jamaneurol.2022.4804. PMID: 36648786
Burish MJ, Rozen TD
Neurol Clin 2019 Nov;37(4):847-869. Epub 2019 Aug 24 doi: 10.1016/j.ncl.2019.07.001. PMID: 31563236
Charlson RW, Robbins MS
Curr Neurol Neurosci Rep 2014 Mar;14(3):436. doi: 10.1007/s11910-013-0436-2. PMID: 24452694

Prognosis

Foo EC, Tanti M, Cliffe H, Randall M
Pract Neurol 2021 Oct;21(5):442-444. Epub 2021 May 7 doi: 10.1136/practneurol-2021-002928. PMID: 33963085
Barloese MCJ
Clin Auton Res 2018 Jun;28(3):315-324. Epub 2017 Sep 23 doi: 10.1007/s10286-017-0468-9. PMID: 28942483
Nappi G, Perrotta A, Rossi P, Sandrini G
Expert Rev Neurother 2008 Mar;8(3):361-84. doi: 10.1586/14737175.8.3.361. PMID: 18345968
Láinez MJ, Monzón MJ
Curr Neurol Neurosci Rep 2001 Mar;1(2):118-24. doi: 10.1007/s11910-001-0006-x. PMID: 11898507
Silberstein SD, Lipton RB
Curr Opin Neurol 2000 Jun;13(3):277-83. doi: 10.1097/00019052-200006000-00008. PMID: 10871251

Clinical prediction guides

Bahra A
Cephalalgia 2023 Nov;43(11):3331024231214239. doi: 10.1177/03331024231214239. PMID: 37950675
Diener HC, Tassorelli C, Dodick DW
JAMA Neurol 2023 Mar 1;80(3):308-319. doi: 10.1001/jamaneurol.2022.4804. PMID: 36648786
Al-Khazali HM, Al-Khazali S, Iljazi A, Christensen RH, Ashina S, Lipton RB, Amin FM, Ashina H
Cephalalgia 2023 Jan;43(1):3331024221131343. doi: 10.1177/03331024221131343. PMID: 36588185
Ramusino MC, Perini G, Antonaci F, Costa A
J Oral Facial Pain Headache 2019 Winter;33(1):89-104. doi: 10.11607/ofph.1922. PMID: 30703174
Sánchez Del Rio M, Alvarez-Linera J
Handb Clin Neurol 2010;97:781-7. doi: 10.1016/S0072-9752(10)97064-4. PMID: 20816470

Recent systematic reviews

Al-Khazali HM, Al-Khazali S, Iljazi A, Christensen RH, Ashina S, Lipton RB, Amin FM, Ashina H
Cephalalgia 2023 Jan;43(1):3331024221131343. doi: 10.1177/03331024221131343. PMID: 36588185
Wöber C
Headache 2017 Nov;57(10):1635-1647. Epub 2017 May 19 doi: 10.1111/head.13099. PMID: 28542727
Viana M, Tassorelli C, Allena M, Nappi G, Sjaastad O, Antonaci F
J Headache Pain 2013 Feb 18;14(1):14. doi: 10.1186/1129-2377-14-14. PMID: 23565739Free PMC Article
Moura LM, Bezerra JM, Fleming NR
Rev Bras Anestesiol 2012 Mar-Apr;62(2):173-87. doi: 10.1016/S0034-7094(12)70116-2. PMID: 22440373
Jasper JF, Hayek SM
Pain Physician 2008 Mar-Apr;11(2):187-200. PMID: 18354711

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