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Aseptic meningitis

MedGen UID:
7534
•Concept ID:
C0025290
•
Disease or Syndrome
Synonyms: Aseptic Meningitis; Meningitis, Aseptic
SNOMED CT: Aseptic meningitis (301770000)
 
Monarch Initiative: MONDO:0006662

Definition

Inflammation of the membranes surrounding the brain and spinal cord without a bacterial pathogen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAseptic meningitis

Professional guidelines

PubMed

Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention.
Mount HR, Boyle SD
Am Fam Physician 2017 Sep 1;96(5):314-322. PMID: 28925647
Aseptic meningitis in adults and children: Diagnostic and management challenges.
Shukla B, Aguilera EA, Salazar L, Wootton SH, Kaewpoowat Q, Hasbun R
J Clin Virol 2017 Sep;94:110-114. Epub 2017 Aug 4 doi: 10.1016/j.jcv.2017.07.016. PMID: 28806629Free PMC Article
Aseptic meningitis: diagnosis and management.
Kumar R
Indian J Pediatr 2005 Jan;72(1):57-63. doi: 10.1007/BF02760582. PMID: 15684450

Recent clinical studies

Etiology

Current Status of Mumps Virus Infection: Epidemiology, Pathogenesis, and Vaccine.
Su SB, Chang HL, Chen AK
Int J Environ Res Public Health 2020 Mar 5;17(5) doi: 10.3390/ijerph17051686. PMID: 32150969Free PMC Article
Aseptic meningitis.
Tattevin P, Tchamgoué S, Belem A, Bénézit F, Pronier C, Revest M
Rev Neurol (Paris) 2019 Sep-Oct;175(7-8):475-480. Epub 2019 Jul 30 doi: 10.1016/j.neurol.2019.07.005. PMID: 31375286
Drug-induced aseptic meningitis: a mini-review.
Yelehe-Okouma M, Czmil-Garon J, Pape E, Petitpain N, Gillet P
Fundam Clin Pharmacol 2018 Jun;32(3):252-260. Epub 2018 Mar 9 doi: 10.1111/fcp.12349. PMID: 29364542
Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention.
Mount HR, Boyle SD
Am Fam Physician 2017 Sep 1;96(5):314-322. PMID: 28925647
Meningitis.
Putz K, Hayani K, Zar FA
Prim Care 2013 Sep;40(3):707-26. Epub 2013 Jul 25 doi: 10.1016/j.pop.2013.06.001. PMID: 23958365

Diagnosis

Aseptic meningitis.
Tattevin P, Tchamgoué S, Belem A, Bénézit F, Pronier C, Revest M
Rev Neurol (Paris) 2019 Sep-Oct;175(7-8):475-480. Epub 2019 Jul 30 doi: 10.1016/j.neurol.2019.07.005. PMID: 31375286
Drug-induced aseptic meningitis: a mini-review.
Yelehe-Okouma M, Czmil-Garon J, Pape E, Petitpain N, Gillet P
Fundam Clin Pharmacol 2018 Jun;32(3):252-260. Epub 2018 Mar 9 doi: 10.1111/fcp.12349. PMID: 29364542
Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention.
Mount HR, Boyle SD
Am Fam Physician 2017 Sep 1;96(5):314-322. PMID: 28925647
Aseptic meningitis in adults and children: Diagnostic and management challenges.
Shukla B, Aguilera EA, Salazar L, Wootton SH, Kaewpoowat Q, Hasbun R
J Clin Virol 2017 Sep;94:110-114. Epub 2017 Aug 4 doi: 10.1016/j.jcv.2017.07.016. PMID: 28806629Free PMC Article
Herpes simplex virus.
Widener RW, Whitley RJ
Handb Clin Neurol 2014;123:251-63. doi: 10.1016/B978-0-444-53488-0.00011-0. PMID: 25015489

Therapy

Vaccines for measles, mumps, rubella, and varicella in children.
Di Pietrantonj C, Rivetti A, Marchione P, Debalini MG, Demicheli V
Cochrane Database Syst Rev 2020 Apr 20;4(4):CD004407. doi: 10.1002/14651858.CD004407.pub4. PMID: 32309885Free PMC Article
Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention.
Mount HR, Boyle SD
Am Fam Physician 2017 Sep 1;96(5):314-322. PMID: 28925647
Recurrent Meningitis.
Rosenberg J, Galen BT
Curr Pain Headache Rep 2017 Jul;21(7):33. doi: 10.1007/s11916-017-0635-7. PMID: 28551737
Meningitis.
Putz K, Hayani K, Zar FA
Prim Care 2013 Sep;40(3):707-26. Epub 2013 Jul 25 doi: 10.1016/j.pop.2013.06.001. PMID: 23958365
Intravenous immunoglobulin: adverse effects and safe administration.
Orbach H, Katz U, Sherer Y, Shoenfeld Y
Clin Rev Allergy Immunol 2005 Dec;29(3):173-84. doi: 10.1385/CRIAI:29:3:173. PMID: 16391392

Prognosis

Enterovirus-Associated Hand-Foot and Mouth Disease and Neurological Complications in Japan and the Rest of the World.
Gonzalez G, Carr MJ, Kobayashi M, Hanaoka N, Fujimoto T
Int J Mol Sci 2019 Oct 20;20(20) doi: 10.3390/ijms20205201. PMID: 31635198Free PMC Article
Adverse Effects of Immunoglobulin Therapy.
Guo Y, Tian X, Wang X, Xiao Z
Front Immunol 2018;9:1299. Epub 2018 Jun 8 doi: 10.3389/fimmu.2018.01299. PMID: 29951056Free PMC Article
Drug-induced aseptic meningitis: a mini-review.
Yelehe-Okouma M, Czmil-Garon J, Pape E, Petitpain N, Gillet P
Fundam Clin Pharmacol 2018 Jun;32(3):252-260. Epub 2018 Mar 9 doi: 10.1111/fcp.12349. PMID: 29364542
Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention.
Mount HR, Boyle SD
Am Fam Physician 2017 Sep 1;96(5):314-322. PMID: 28925647
Molecular biology, pathogenesis and pathology of mumps virus.
Rubin S, Eckhaus M, Rennick LJ, Bamford CG, Duprex WP
J Pathol 2015 Jan;235(2):242-52. doi: 10.1002/path.4445. PMID: 25229387Free PMC Article

Clinical prediction guides

Adenovirus-Associated Central Nervous System Disease in Children.
Schwartz KL, Richardson SE, MacGregor D, Mahant S, Raghuram K, Bitnun A
J Pediatr 2019 Feb;205:130-137. Epub 2018 Nov 6 doi: 10.1016/j.jpeds.2018.09.036. PMID: 30413311
Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration.
Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Masson GS, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M
Nat Neurosci 2018 Sep;21(9):1209-1217. Epub 2018 Aug 27 doi: 10.1038/s41593-018-0213-2. PMID: 30150661Free PMC Article
Drug-induced aseptic meningitis: a mini-review.
Yelehe-Okouma M, Czmil-Garon J, Pape E, Petitpain N, Gillet P
Fundam Clin Pharmacol 2018 Jun;32(3):252-260. Epub 2018 Mar 9 doi: 10.1111/fcp.12349. PMID: 29364542
Molecular biology, pathogenesis and pathology of mumps virus.
Rubin S, Eckhaus M, Rennick LJ, Bamford CG, Duprex WP
J Pathol 2015 Jan;235(2):242-52. doi: 10.1002/path.4445. PMID: 25229387Free PMC Article
Aseptic meningitis.
Nigrovic LE
Handb Clin Neurol 2013;112:1153-6. doi: 10.1016/B978-0-444-52910-7.00035-0. PMID: 23622323

Recent systematic reviews

Central Inflammatory Cytokines in Tuberculous Meningitis: A Systematic Review and Meta-analysis.
Saghazadeh A, Rezaei N
J Interferon Cytokine Res 2022 Mar;42(3):95-107. doi: 10.1089/jir.2021.0176. PMID: 35298290
Vaccines for measles, mumps, rubella, and varicella in children.
Di Pietrantonj C, Rivetti A, Marchione P, Debalini MG, Demicheli V
Cochrane Database Syst Rev 2021 Nov 22;11(11):CD004407. doi: 10.1002/14651858.CD004407.pub5. PMID: 34806766Free PMC Article
Aseptic meningitis and leptomeningeal enhancement associated with anti-MOG antibodies: A review.
Gombolay GY, Gadde JA
J Neuroimmunol 2021 Sep 15;358:577653. Epub 2021 Jul 1 doi: 10.1016/j.jneuroim.2021.577653. PMID: 34229204
Vaccines for measles, mumps, rubella, and varicella in children.
Di Pietrantonj C, Rivetti A, Marchione P, Debalini MG, Demicheli V
Cochrane Database Syst Rev 2020 Apr 20;4(4):CD004407. doi: 10.1002/14651858.CD004407.pub4. PMID: 32309885Free PMC Article
"Meningitis-retention syndrome": a review.
Sakakibara R, Kishi M, Tsuyusaki Y, Tateno A, Tateno F, Uchiyama T, Yamamoto T, Yamanishi T, Yano M
Neurourol Urodyn 2013 Jan;32(1):19-23. Epub 2012 Jun 5 doi: 10.1002/nau.22279. PMID: 22674777

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