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Linear scleroderma

MedGen UID:
75518
Concept ID:
C0263409
Disease or Syndrome
Synonym: Linear scleroderma (subtype)
SNOMED CT: Linear scleroderma (22784002); Linear morphea (22784002)
 
Monarch Initiative: MONDO:0043294

Definition

A type of localized scleroderma characterized by a long strip of indurated skin, which is typically found unilaterally on an arm or leg, and sometimes on the forehead or trunk. This disorder often affects the tissues beneath the skin, causing damage to bones, muscle or other organs. It can limit movement, alter growth, and disfigure the affected area. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLinear scleroderma

Professional guidelines

PubMed

Zulian F, Tirelli F
Curr Rheumatol Rep 2020 Jun 26;22(8):45. doi: 10.1007/s11926-020-00910-x. PMID: 32591919
Peña-Romero AG, García-Romero MT
Curr Opin Pediatr 2019 Aug;31(4):482-490. doi: 10.1097/MOP.0000000000000785. PMID: 31157654
Bielsa Marsol I
Actas Dermosifiliogr 2013 Oct;104(8):654-66. Epub 2013 Aug 13 doi: 10.1016/j.adengl.2012.10.012. PMID: 23948159

Recent clinical studies

Etiology

Speeckaert R, Lambert J, Bulat V, Belpaire A, Speeckaert M, van Geel N
Front Immunol 2020;11:568447. Epub 2020 Oct 27 doi: 10.3389/fimmu.2020.568447. PMID: 33193342Free PMC Article
Zulian F, Tirelli F
Curr Rheumatol Rep 2020 Jun 26;22(8):45. doi: 10.1007/s11926-020-00910-x. PMID: 32591919
Li SC, Zheng RJ
World J Pediatr 2020 Feb;16(1):5-18. Epub 2019 Nov 30 doi: 10.1007/s12519-019-00320-9. PMID: 31786801
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article
Jablonska S, Blaszczyk M
Adv Exp Med Biol 1999;455:85-92. doi: 10.1007/978-1-4615-4857-7_12. PMID: 10599327

Diagnosis

Li SC, Zheng RJ
World J Pediatr 2020 Feb;16(1):5-18. Epub 2019 Nov 30 doi: 10.1007/s12519-019-00320-9. PMID: 31786801
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article
Bucher F, Fricke J, Neugebauer A, Cursiefen C, Heindl LM
Surv Ophthalmol 2016 Nov-Dec;61(6):693-701. Epub 2016 Apr 1 doi: 10.1016/j.survophthal.2016.03.009. PMID: 27045226
Adnan ZA
Acta Med Indones 2008 Apr;40(2):109-12. PMID: 18560030
Krafchik BR
Semin Dermatol 1992 Mar;11(1):65-72. PMID: 1550717

Therapy

Zulian F, Tirelli F
Curr Rheumatol Rep 2020 Jun 26;22(8):45. doi: 10.1007/s11926-020-00910-x. PMID: 32591919
Li SC, Zheng RJ
World J Pediatr 2020 Feb;16(1):5-18. Epub 2019 Nov 30 doi: 10.1007/s12519-019-00320-9. PMID: 31786801
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article
Bielsa Marsol I
Actas Dermosifiliogr 2013 Oct;104(8):654-66. Epub 2013 Aug 13 doi: 10.1016/j.adengl.2012.10.012. PMID: 23948159
Silverman AK, Fairley J, Wong RC
J Am Acad Dermatol 1988 Apr;18(4 Pt 1):721-41. doi: 10.1016/s0190-9622(88)70096-1. PMID: 2967311

Prognosis

Martini G, Saggioro L, Culpo R, Vittadello F, Meneghel A, Zulian F
Rheumatology (Oxford) 2021 Mar 2;60(3):1387-1391. doi: 10.1093/rheumatology/keaa392. PMID: 32978631Free PMC Article
Zulian F, Vallongo C, de Oliveira SK, Punaro MG, Ros J, Mazur-Zielinska H, Galea P, Da Dalt L, Eichenfield LF
J Pediatr 2006 Aug;149(2):248-51. doi: 10.1016/j.jpeds.2006.04.052. PMID: 16887444
Jablonska S, Blaszczyk M
Adv Exp Med Biol 1999;455:85-92. doi: 10.1007/978-1-4615-4857-7_12. PMID: 10599327
Krafchik BR
Semin Dermatol 1992 Mar;11(1):65-72. PMID: 1550717
Falanga V, Medsger TA Jr, Reichlin M, Rodnan GP
Ann Intern Med 1986 Jun;104(6):849-57. doi: 10.7326/0003-4819-104-6-849. PMID: 3486617

Clinical prediction guides

Jindal AK, Handa S, Loganathan SK, Sudhakar M, Kaushik A, Suri D, Pandiarajan V, Rawat A, Gupta A, De D, Mahajan R, Singh S
J Eur Acad Dermatol Venereol 2023 Mar;37(3):598-604. Epub 2022 Dec 3 doi: 10.1111/jdv.18765. PMID: 36413107
Speeckaert R, Lambert J, Bulat V, Belpaire A, Speeckaert M, van Geel N
Front Immunol 2020;11:568447. Epub 2020 Oct 27 doi: 10.3389/fimmu.2020.568447. PMID: 33193342Free PMC Article
Zulian F, Tirelli F
Curr Rheumatol Rep 2020 Jun 26;22(8):45. doi: 10.1007/s11926-020-00910-x. PMID: 32591919
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article
Cassano N, Amerio P, D'Ovidio R, Vena GA
G Ital Dermatol Venereol 2014 Oct;149(5):555-65. Epub 2014 Jun 30 PMID: 24975949

Recent systematic reviews

Sanchez-Espino LF, Luca N, Pope E, Laxer RM, Knight AM, Sibbald C
Arthritis Care Res (Hoboken) 2024 Mar;76(3):340-349. Epub 2024 Jan 7 doi: 10.1002/acr.25243. PMID: 37750181
Hixon AM, Christensen E, Hamilton R, Drees C
Epilepsy Behav 2021 Aug;121(Pt A):108068. Epub 2021 May 28 doi: 10.1016/j.yebeh.2021.108068. PMID: 34052630
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article

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