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Angioma serpiginosum

MedGen UID:
75528
Concept ID:
C0263637
Neoplastic Process
Synonyms: Angioma Serpiginosum; angioma serpiginosum; Angioma serpiginosum of skin; angioma serpiginosum of skin
SNOMED CT: Angioma serpiginosum of skin (49465005); Angioma serpiginosum (49465005)
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
X-linked recessive inheritance
MedGen UID:
375779
Concept ID:
C1845977
Finding
Source: Orphanet
A mode of inheritance that is observed for recessive traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked recessive disorders manifest in males (who have one copy of the X chromosome and are thus hemizygotes), but generally not in female heterozygotes who have one mutant and one normal allele.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019803
Orphanet: ORPHA95429

Definition

A benign congenital skin disease characterised by progressive dilation of the subepidermal skin vessels manifesting as purple punctate lesions usually appearing on the lower limbs and buttocks and following the lines of Blaschko. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAngioma serpiginosum

Professional guidelines

PubMed

Madan V, August PJ, Ferguson JE
Clin Exp Dermatol 2009 Jul;34(5):e186-8. Epub 2008 Dec 10 doi: 10.1111/j.1365-2230.2008.03017.x. PMID: 19077096
Polla LL, Tan OT, Garden JM, Parrish JA
Dermatologica 1987;174(1):11-7. doi: 10.1159/000248973. PMID: 2433166

Recent clinical studies

Etiology

Happle R
J Eur Acad Dermatol Venereol 2015 Dec;29(12):2295-305. Epub 2015 Apr 10 doi: 10.1111/jdv.13147. PMID: 25864701
Bayramgurler D, Filinte D, Kiran R
Eur J Dermatol 2008 Nov-Dec;18(6):708-9. Epub 2008 Oct 27 doi: 10.1684/ejd.2008.0524. PMID: 18955205
Chen JH, Wang KH, Hu CH, Chiu JS
Yonsei Med J 2008 Jun 30;49(3):509-13. doi: 10.3349/ymj.2008.49.3.509. PMID: 18581605Free PMC Article
Erkek E, Bozdogan O, Akarsu C, Atasoy P, Koçak M
Am J Clin Dermatol 2006;7(6):383-6. doi: 10.2165/00128071-200607060-00007. PMID: 17173473
Al Hawsawi K, Al Aboud K, Al Aboud D, Al Githami A
Pediatr Dermatol 2003 Mar-Apr;20(2):167-8. doi: 10.1046/j.1525-1470.2003.20217.x. PMID: 12657019

Diagnosis

Kanji A, Laguda B, Roberts N
Br J Hosp Med (Lond) 2023 Jul 2;84(7):1. Epub 2023 Jul 18 doi: 10.12968/hmed.2023.0030. PMID: 37490440
Panigrahi A, Chakraborty S, Das S, Sil A
J Pediatr 2020 Oct;225:272-273. Epub 2020 May 21 doi: 10.1016/j.jpeds.2020.05.021. PMID: 32445648
Diociaiuti A, Cutrone M, Rotunno R, De Vito R, Neri I, Pisaneschi E, El Hachem M
Ital J Pediatr 2019 Apr 27;45(1):53. doi: 10.1186/s13052-019-0644-8. PMID: 31029177Free PMC Article
Namazi MR, Handjani F
Dermatol Online J 2003 Aug;9(3):19. PMID: 12952766
Whyte MP
Int J Dermatol 1978 Dec;17(10):793-8. doi: 10.1111/j.1365-4362.1978.tb05982.x. PMID: 103847

Therapy

Panigrahi A, Chakraborty S, Das S, Sil A
J Pediatr 2020 Oct;225:272-273. Epub 2020 May 21 doi: 10.1016/j.jpeds.2020.05.021. PMID: 32445648
Rho NK, Kim H, Kim HS
J Dermatol 2014 Nov;41(11):996-8. Epub 2014 Oct 9 doi: 10.1111/1346-8138.12624. PMID: 25297653
Madan V, August PJ, Ferguson JE
Clin Exp Dermatol 2009 Jul;34(5):e186-8. Epub 2008 Dec 10 doi: 10.1111/j.1365-2230.2008.03017.x. PMID: 19077096
Chen JH, Wang KH, Hu CH, Chiu JS
Yonsei Med J 2008 Jun 30;49(3):509-13. doi: 10.3349/ymj.2008.49.3.509. PMID: 18581605Free PMC Article
Polla LL, Tan OT, Garden JM, Parrish JA
Dermatologica 1987;174(1):11-7. doi: 10.1159/000248973. PMID: 2433166

Prognosis

Al Hawsawi K, Al Aboud K, Al Aboud D, Al Githami A
Pediatr Dermatol 2003 Mar-Apr;20(2):167-8. doi: 10.1046/j.1525-1470.2003.20217.x. PMID: 12657019

Clinical prediction guides

Blinkenberg EO, Brendehaug A, Sandvik AK, Vatne O, Hennekam RC, Houge G
Eur J Hum Genet 2007 May;15(5):543-7. Epub 2007 Mar 7 doi: 10.1038/sj.ejhg.5201800. PMID: 17342156
Erkek E, Bozdogan O, Akarsu C, Atasoy P, Koçak M
Am J Clin Dermatol 2006;7(6):383-6. doi: 10.2165/00128071-200607060-00007. PMID: 17173473
Ohnishi T, Nagayama T, Morita T, Miyazaki T, Okada H, Ohara K, Watanabe S
Arch Dermatol 1999 Nov;135(11):1366-8. doi: 10.1001/archderm.135.11.1366. PMID: 10566835
Polla LL, Tan OT, Garden JM, Parrish JA
Dermatologica 1987;174(1):11-7. doi: 10.1159/000248973. PMID: 2433166
Marriott PJ, Munro DD, Ryan T
Br J Dermatol 1975 Dec;93(6):701-6. doi: 10.1111/j.1365-2133.1975.tb05122.x. PMID: 1220816

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