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Angioma serpiginosum

MedGen UID:
75528
•Concept ID:
C0263637
•
Neoplastic Process
Synonyms: Angioma Serpiginosum; angioma serpiginosum; Angioma serpiginosum of skin; angioma serpiginosum of skin
SNOMED CT: Angioma serpiginosum of skin (49465005); Angioma serpiginosum (49465005)
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
•Concept ID:
C0443147
•
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
X-linked recessive inheritance
MedGen UID:
375779
•Concept ID:
C1845977
•
Finding
Source: Orphanet
A mode of inheritance that is observed for recessive traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked recessive disorders manifest in males (who have one copy of the X chromosome and are thus hemizygotes), but generally not in female heterozygotes who have one mutant and one normal allele.
See: This record
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Autosomal dominant inheritance (Orphanet)
X-linked recessive inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019803
Orphanet: ORPHA95429

Definition

A benign congenital skin disease characterised by progressive dilation of the subepidermal skin vessels manifesting as purple punctate lesions usually appearing on the lower limbs and buttocks and following the lines of Blaschko. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAngioma serpiginosum

Professional guidelines

PubMed

Pulsed-dye laser treatment of angioma serpiginosum.
Madan V, August PJ, Ferguson JE
Clin Exp Dermatol 2009 Jul;34(5):e186-8. Epub 2008 Dec 10 doi: 10.1111/j.1365-2230.2008.03017.x. PMID: 19077096
Tunable pulsed dye laser for the treatment of benign cutaneous vascular ectasia.
Polla LL, Tan OT, Garden JM, Parrish JA
Dermatologica 1987;174(1):11-7. doi: 10.1159/000248973. PMID: 2433166

Recent clinical studies

Etiology

Capillary malformations: a classification using specific names for specific skin disorders.
Happle R
J Eur Acad Dermatol Venereol 2015 Dec;29(12):2295-305. Epub 2015 Apr 10 doi: 10.1111/jdv.13147. PMID: 25864701
Atypical angioma serpiginosum.
Chen JH, Wang KH, Hu CH, Chiu JS
Yonsei Med J 2008 Jun 30;49(3):509-13. doi: 10.3349/ymj.2008.49.3.509. PMID: 18581605Free PMC Article
Absence of estrogen and progesterone receptors around the affected vessels of angioma serpiginosum: case report.
Erkek E, Bozdogan O, Akarsu C, Atasoy P, Koçak M
Am J Clin Dermatol 2006;7(6):383-6. doi: 10.2165/00128071-200607060-00007. PMID: 17173473
Angioma serpiginosum: dermoscopy for diagnosis, pulsed dye laser for treatment.
Ilknur T, Fetil E, Akarsu S, Altiner DD, Ulukuş C, Güneş AT
J Dermatol 2006 Apr;33(4):252-5. doi: 10.1111/j.1346-8138.2006.00061.x. PMID: 16674788
Linear angioma serpiginosum.
Al Hawsawi K, Al Aboud K, Al Aboud D, Al Githami A
Pediatr Dermatol 2003 Mar-Apr;20(2):167-8. doi: 10.1046/j.1525-1470.2003.20217.x. PMID: 12657019

Diagnosis

Angioma serpiginosum.
Kanji A, Laguda B, Roberts N
Br J Hosp Med (Lond) 2023 Jul 2;84(7):1. Epub 2023 Jul 18 doi: 10.12968/hmed.2023.0030. PMID: 37490440
Angioma serpiginosum: a case report and review of the literature.
Diociaiuti A, Cutrone M, Rotunno R, De Vito R, Neri I, Pisaneschi E, El Hachem M
Ital J Pediatr 2019 Apr 27;45(1):53. doi: 10.1186/s13052-019-0644-8. PMID: 31029177Free PMC Article
Angioma serpiginosum: report of an unusual acral case and review of the literature.
Freites-Martinez A, Moreno-Torres A, Núñez AH, Martinez-Sanchez D, Huerta-Brogeras M, Borbujo J
An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):26-8. doi: 10.1590/abd1806-4841.20153794. PMID: 26312666Free PMC Article
Angioma serpiginosum with linear distribution: case report and review of the literature.
Kalisiak MS, Haber RM
J Cutan Med Surg 2008 Jul-Aug;12(4):180-3. doi: 10.2310/7750.2008.07039. PMID: 18627698
Angioma serpiginosum.
Namazi MR, Handjani F
Dermatol Online J 2003 Aug;9(3):19. PMID: 12952766

Therapy

Blaschkoid Angioma Serpiginosum: A Clinicodermoscopic Diagnosis.
Panigrahi A, Chakraborty S, Das S, Sil A
J Pediatr 2020 Oct;225:272-273. Epub 2020 May 21 doi: 10.1016/j.jpeds.2020.05.021. PMID: 32445648
Successful treatment of angioma serpiginosum using a novel 532 nm potassium titanyl phosphate (KTP) laser.
Rho NK, Kim H, Kim HS
J Dermatol 2014 Nov;41(11):996-8. Epub 2014 Oct 9 doi: 10.1111/1346-8138.12624. PMID: 25297653
Pulsed-dye laser treatment of angioma serpiginosum.
Madan V, August PJ, Ferguson JE
Clin Exp Dermatol 2009 Jul;34(5):e186-8. Epub 2008 Dec 10 doi: 10.1111/j.1365-2230.2008.03017.x. PMID: 19077096
Atypical angioma serpiginosum.
Chen JH, Wang KH, Hu CH, Chiu JS
Yonsei Med J 2008 Jun 30;49(3):509-13. doi: 10.3349/ymj.2008.49.3.509. PMID: 18581605Free PMC Article
Tunable pulsed dye laser for the treatment of benign cutaneous vascular ectasia.
Polla LL, Tan OT, Garden JM, Parrish JA
Dermatologica 1987;174(1):11-7. doi: 10.1159/000248973. PMID: 2433166

Prognosis

Linear angioma serpiginosum.
Al Hawsawi K, Al Aboud K, Al Aboud D, Al Githami A
Pediatr Dermatol 2003 Mar-Apr;20(2):167-8. doi: 10.1046/j.1525-1470.2003.20217.x. PMID: 12657019

Clinical prediction guides

Angioma serpiginosum with oesophageal papillomatosis is an X-linked dominant condition that maps to Xp11.3-Xq12.
Blinkenberg EO, Brendehaug A, Sandvik AK, Vatne O, Hennekam RC, Houge G
Eur J Hum Genet 2007 May;15(5):543-7. Epub 2007 Mar 7 doi: 10.1038/sj.ejhg.5201800. PMID: 17342156
Absence of estrogen and progesterone receptors around the affected vessels of angioma serpiginosum: case report.
Erkek E, Bozdogan O, Akarsu C, Atasoy P, Koçak M
Am J Clin Dermatol 2006;7(6):383-6. doi: 10.2165/00128071-200607060-00007. PMID: 17173473
Angioma serpiginosum: a report of 2 cases identified using epiluminescence microscopy.
Ohnishi T, Nagayama T, Morita T, Miyazaki T, Okada H, Ohara K, Watanabe S
Arch Dermatol 1999 Nov;135(11):1366-8. doi: 10.1001/archderm.135.11.1366. PMID: 10566835
Tunable pulsed dye laser for the treatment of benign cutaneous vascular ectasia.
Polla LL, Tan OT, Garden JM, Parrish JA
Dermatologica 1987;174(1):11-7. doi: 10.1159/000248973. PMID: 2433166
Angioma serpiginosum--familial incidence.
Marriott PJ, Munro DD, Ryan T
Br J Dermatol 1975 Dec;93(6):701-6. doi: 10.1111/j.1365-2133.1975.tb05122.x. PMID: 1220816

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