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Acute necrotizing pancreatitis

MedGen UID:
75645
Concept ID:
C0267941
Disease or Syndrome
Synonyms: Acute Necrotizing Pancreatitis; Necrosis, Pancreatic; Necrotizing Pancreatitis, Acute; Pancreatic Necroses; Pancreatic Necrosis; Pancreatitis Necrotising; Pancreatitis Necrotisings; Pancreatitis Necrotizing; Pancreatitis Necrotizings; Pancreatitis, Acute Necrotizing
SNOMED CT: Acute necrotizing pancreatitis (7881005); Necrotizing pancreatitis (7881005)
 
Monarch Initiative: MONDO:0850420

Definition

An acute pancreatitis that is characterized by one or more areas of necrosis in the pancreas with varying degree of involvement of the surrounding tissues or organ systems. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute necrotizing pancreatitis

Professional guidelines

PubMed

Arvanitakis M, Ockenga J, Bezmarevic M, Gianotti L, Krznarić Ž, Lobo DN, Löser C, Madl C, Meier R, Phillips M, Rasmussen HH, Van Hooft JE, Bischoff SC
Clin Nutr 2020 Mar;39(3):612-631. Epub 2020 Jan 22 doi: 10.1016/j.clnu.2020.01.004. PMID: 32008871
Baron TH, DiMaio CJ, Wang AY, Morgan KA
Gastroenterology 2020 Jan;158(1):67-75.e1. Epub 2019 Aug 31 doi: 10.1053/j.gastro.2019.07.064. PMID: 31479658
Zerem E
World J Gastroenterol 2014 Oct 14;20(38):13879-92. doi: 10.3748/wjg.v20.i38.13879. PMID: 25320523Free PMC Article

Recent clinical studies

Etiology

Maatman TK, Zyromski NJ
Adv Surg 2022 Sep;56(1):13-35. doi: 10.1016/j.yasu.2022.02.010. PMID: 36096565
Valverde-López F, Martínez-Cara JG, Redondo-Cerezo E
Med Clin (Barc) 2022 Jun 10;158(11):556-563. Epub 2022 Mar 8 doi: 10.1016/j.medcli.2021.12.012. PMID: 35277268
Italian Association for the Study of the Pancreas (AISP), Pezzilli R, Zerbi A, Campra D, Capurso G, Golfieri R, Arcidiacono PG, Billi P, Butturini G, Calculli L, Cannizzaro R, Carrara S, Crippa S, De Gaudio R, De Rai P, Frulloni L, Mazza E, Mutignani M, Pagano N, Rabitti P, Balzano G
Dig Liver Dis 2015 Jul;47(7):532-43. Epub 2015 Apr 2 doi: 10.1016/j.dld.2015.03.022. PMID: 25921277
Zerem E
World J Gastroenterol 2014 Oct 14;20(38):13879-92. doi: 10.3748/wjg.v20.i38.13879. PMID: 25320523Free PMC Article
Besselink MG, van Santvoort HC, Nieuwenhuijs VB, Boermeester MA, Bollen TL, Buskens E, Dejong CH, van Eijck CH, van Goor H, Hofker SS, Lameris JS, van Leeuwen MS, Ploeg RJ, van Ramshorst B, Schaapherder AF, Cuesta MA, Consten EC, Gouma DJ, van der Harst E, Hesselink EJ, Houdijk LP, Karsten TM, van Laarhoven CJ, Pierie JP, Rosman C, Bilgen EJ, Timmer R, van der Tweel I, de Wit RJ, Witteman BJ, Gooszen HG; Dutch Acute Pancreatitis Study Group
BMC Surg 2006 Apr 11;6:6. doi: 10.1186/1471-2482-6-6. PMID: 16606471Free PMC Article

Diagnosis

Maatman TK, Zyromski NJ
Adv Surg 2022 Sep;56(1):13-35. doi: 10.1016/j.yasu.2022.02.010. PMID: 36096565
Oppenlander KE, Chadwick C, Carman K
Am Fam Physician 2022 Jul;106(1):44-50. PMID: 35839366
Valverde-López F, Martínez-Cara JG, Redondo-Cerezo E
Med Clin (Barc) 2022 Jun 10;158(11):556-563. Epub 2022 Mar 8 doi: 10.1016/j.medcli.2021.12.012. PMID: 35277268
Italian Association for the Study of the Pancreas (AISP), Pezzilli R, Zerbi A, Campra D, Capurso G, Golfieri R, Arcidiacono PG, Billi P, Butturini G, Calculli L, Cannizzaro R, Carrara S, Crippa S, De Gaudio R, De Rai P, Frulloni L, Mazza E, Mutignani M, Pagano N, Rabitti P, Balzano G
Dig Liver Dis 2015 Jul;47(7):532-43. Epub 2015 Apr 2 doi: 10.1016/j.dld.2015.03.022. PMID: 25921277
Zerem E
World J Gastroenterol 2014 Oct 14;20(38):13879-92. doi: 10.3748/wjg.v20.i38.13879. PMID: 25320523Free PMC Article

Therapy

Boxhoorn L, van Dijk SM, van Grinsven J, Verdonk RC, Boermeester MA, Bollen TL, Bouwense SAW, Bruno MJ, Cappendijk VC, Dejong CHC, van Duijvendijk P, van Eijck CHJ, Fockens P, Francken MFG, van Goor H, Hadithi M, Hallensleben NDL, Haveman JW, Jacobs MAJM, Jansen JM, Kop MPM, van Lienden KP, Manusama ER, Mieog JSD, Molenaar IQ, Nieuwenhuijs VB, Poen AC, Poley JW, van de Poll M, Quispel R, Römkens TEH, Schwartz MP, Seerden TC, Stommel MWJ, Straathof JWA, Timmerhuis HC, Venneman NG, Voermans RP, van de Vrie W, Witteman BJ, Dijkgraaf MGW, van Santvoort HC, Besselink MG; Dutch Pancreatitis Study Group
N Engl J Med 2021 Oct 7;385(15):1372-1381. doi: 10.1056/NEJMoa2100826. PMID: 34614330
Boxhoorn L, Voermans RP, Bouwense SA, Bruno MJ, Verdonk RC, Boermeester MA, van Santvoort HC, Besselink MG
Lancet 2020 Sep 5;396(10252):726-734. doi: 10.1016/S0140-6736(20)31310-6. PMID: 32891214
Baron TH, DiMaio CJ, Wang AY, Morgan KA
Gastroenterology 2020 Jan;158(1):67-75.e1. Epub 2019 Aug 31 doi: 10.1053/j.gastro.2019.07.064. PMID: 31479658
Italian Association for the Study of the Pancreas (AISP), Pezzilli R, Zerbi A, Campra D, Capurso G, Golfieri R, Arcidiacono PG, Billi P, Butturini G, Calculli L, Cannizzaro R, Carrara S, Crippa S, De Gaudio R, De Rai P, Frulloni L, Mazza E, Mutignani M, Pagano N, Rabitti P, Balzano G
Dig Liver Dis 2015 Jul;47(7):532-43. Epub 2015 Apr 2 doi: 10.1016/j.dld.2015.03.022. PMID: 25921277
Wang GJ, Gao CF, Wei D, Wang C, Ding SQ
World J Gastroenterol 2009 Mar 28;15(12):1427-30. doi: 10.3748/wjg.15.1427. PMID: 19322914Free PMC Article

Prognosis

Onnekink AM, Boxhoorn L, Timmerhuis HC, Bac ST, Besselink MG, Boermeester MA, Bollen TL, Bosscha K, Bouwense SAW, Bruno MJ, van Brunschot S, Cappendijk VC, Consten ECJ, Dejong CH, Dijkgraaf MGW, van Eijck CHJ, Erkelens WG, van Goor H, van Grinsven J, Haveman JW, van Hooft JE, Jansen JM, van Lienden KP, Meijssen MAC, Nieuwenhuijs VB, Poley JW, Quispel R, de Ridder RJ, Römkens TEH, van Santvoort HC, Scheepers JJ, Schwartz MP, Seerden T, Spanier MBW, Straathof JWA, Timmer R, Venneman NG, Verdonk RC, Vleggaar FP, van Wanrooij RL, Witteman BJM, Fockens P, Voermans RP; Dutch Pancreatitis Study Group
Gastroenterology 2022 Sep;163(3):712-722.e14. Epub 2022 May 14 doi: 10.1053/j.gastro.2022.05.015. PMID: 35580661
Gad MM, Simons-Linares CR
World J Gastroenterol 2020 Mar 14;26(10):1098-1106. doi: 10.3748/wjg.v26.i10.1098. PMID: 32206000Free PMC Article
Trikudanathan G, Wolbrink DRJ, van Santvoort HC, Mallery S, Freeman M, Besselink MG
Gastroenterology 2019 May;156(7):1994-2007.e3. Epub 2019 Feb 15 doi: 10.1053/j.gastro.2019.01.269. PMID: 30776347
Taj MA, Qureshi S, Ghazanfar S, Siddiqui AR, Niaz SK, Quraishy MS, Shahid M
J Coll Physicians Surg Pak 2016 Feb;26(2):96-9. PMID: 26876393
Zerem E
World J Gastroenterol 2014 Oct 14;20(38):13879-92. doi: 10.3748/wjg.v20.i38.13879. PMID: 25320523Free PMC Article

Clinical prediction guides

Oppenlander KE, Chadwick C, Carman K
Am Fam Physician 2022 Jul;106(1):44-50. PMID: 35839366
Lee DW, Cho CM
Medicina (Kaunas) 2022 Jun 11;58(6) doi: 10.3390/medicina58060787. PMID: 35744050Free PMC Article
Boxhoorn L, van Dijk SM, van Grinsven J, Verdonk RC, Boermeester MA, Bollen TL, Bouwense SAW, Bruno MJ, Cappendijk VC, Dejong CHC, van Duijvendijk P, van Eijck CHJ, Fockens P, Francken MFG, van Goor H, Hadithi M, Hallensleben NDL, Haveman JW, Jacobs MAJM, Jansen JM, Kop MPM, van Lienden KP, Manusama ER, Mieog JSD, Molenaar IQ, Nieuwenhuijs VB, Poen AC, Poley JW, van de Poll M, Quispel R, Römkens TEH, Schwartz MP, Seerden TC, Stommel MWJ, Straathof JWA, Timmerhuis HC, Venneman NG, Voermans RP, van de Vrie W, Witteman BJ, Dijkgraaf MGW, van Santvoort HC, Besselink MG; Dutch Pancreatitis Study Group
N Engl J Med 2021 Oct 7;385(15):1372-1381. doi: 10.1056/NEJMoa2100826. PMID: 34614330
Trikudanathan G, Wolbrink DRJ, van Santvoort HC, Mallery S, Freeman M, Besselink MG
Gastroenterology 2019 May;156(7):1994-2007.e3. Epub 2019 Feb 15 doi: 10.1053/j.gastro.2019.01.269. PMID: 30776347
Working Group IAP/APA Acute Pancreatitis Guidelines
Pancreatology 2013 Jul-Aug;13(4 Suppl 2):e1-15. doi: 10.1016/j.pan.2013.07.063. PMID: 24054878

Recent systematic reviews

Beyer G, Hoffmeister A, Lorenz P, Lynen P, Lerch MM, Mayerle J
Dtsch Arztebl Int 2022 Jul 25;119(29-30):495-501. doi: 10.3238/arztebl.m2022.0223. PMID: 35945698Free PMC Article
Imam Z, Hanna A, Jomaa D, Khasawneh M, Abonofal A, Murad MH
Pancreas 2021 Feb 1;50(2):206-213. doi: 10.1097/MPA.0000000000001741. PMID: 33565797
Hollemans RA, Hallensleben NDL, Mager DJ, Kelder JC, Besselink MG, Bruno MJ, Verdonk RC, van Santvoort HC; Dutch Pancreatitis Study Group
Pancreatology 2018 Apr;18(3):253-262. Epub 2018 Feb 20 doi: 10.1016/j.pan.2018.02.009. PMID: 29482892
Moggia E, Koti R, Belgaumkar AP, Fazio F, Pereira SP, Davidson BR, Gurusamy KS
Cochrane Database Syst Rev 2017 Apr 21;4(4):CD011384. doi: 10.1002/14651858.CD011384.pub2. PMID: 28431202Free PMC Article
Werge M, Novovic S, Schmidt PN, Gluud LL
Pancreatology 2016 Sep-Oct;16(5):698-707. Epub 2016 Jul 9 doi: 10.1016/j.pan.2016.07.004. PMID: 27449605

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