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Uremic neuropathy

MedGen UID:
75707
•Concept ID:
C0268708
•
Disease or Syndrome
Synonyms: Uremic Neuropathy; uremic neuropathy
SNOMED CT: Uremic neuropathy (11659006)
 
Monarch Initiative: MONDO:0003084

Definition

Neuropathy resulting from uremia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUremic neuropathy

Professional guidelines

PubMed

Chronic renal disease progression: treatment strategies and potassium intake.
Sinha AD, Agarwal R
Semin Nephrol 2013 May;33(3):290-9. doi: 10.1016/j.semnephrol.2013.04.009. PMID: 23953806
Preservation of peripheral nerve function in severe uremia during treatment with low protein high calorie diet and surplus of essential amino acids.
Bergström J, Lindblom U, Norée LO
Acta Neurol Scand 1975 Feb;51(2):99-109. doi: 10.1111/j.1600-0404.1975.tb01363.x. PMID: 1114881
Uremic neuropathy. III. Controlled study of restricted protein and fluid diet and infrequent hemodialysis versus conventional hemodialysis treatment.
Dyck PJ, Johnson WJ, Nelson RA, Lambert EH, O'Brien PC
Mayo Clin Proc 1975 Nov;50(11):641-9. PMID: 171524

Recent clinical studies

Etiology

The role of neuroimmune and inflammation in pediatric uremia-induced neuropathy.
Zhu L, Tong G, Yang F, Zhao Y, Chen G
Front Immunol 2022;13:1013562. Epub 2022 Sep 15 doi: 10.3389/fimmu.2022.1013562. PMID: 36189322Free PMC Article
The Bidirectional Relationship Between Obstructive Sleep Apnea and Chronic Kidney Disease.
Hui L, Benca R
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105652. Epub 2021 Feb 16 doi: 10.1016/j.jstrokecerebrovasdis.2021.105652. PMID: 33608118
Uremic neuropathy: an overview of the current literature.
Camargo CRS, Schoueri JHM, Alves BDCA, Veiga GRLD, Fonseca FLA, Bacci MR
Rev Assoc Med Bras (1992) 2019 Mar;65(3):469-474. Epub 2019 Apr 11 doi: 10.1590/1806-9282.65.3.469. PMID: 30994849
Chronic renal disease progression: treatment strategies and potassium intake.
Sinha AD, Agarwal R
Semin Nephrol 2013 May;33(3):290-9. doi: 10.1016/j.semnephrol.2013.04.009. PMID: 23953806
Heart rate variability.
van Ravenswaaij-Arts CM, Kollée LA, Hopman JC, Stoelinga GB, van Geijn HP
Ann Intern Med 1993 Mar 15;118(6):436-47. doi: 10.7326/0003-4819-118-6-199303150-00008. PMID: 8439119

Diagnosis

The role of neuroimmune and inflammation in pediatric uremia-induced neuropathy.
Zhu L, Tong G, Yang F, Zhao Y, Chen G
Front Immunol 2022;13:1013562. Epub 2022 Sep 15 doi: 10.3389/fimmu.2022.1013562. PMID: 36189322Free PMC Article
Genetic and Epigenomic Modifiers of Diabetic Neuropathy.
Jankovic M, Novakovic I, Nikolic D, Mitrovic Maksic J, Brankovic S, Petronic I, Cirovic D, Ducic S, Grajic M, Bogicevic D
Int J Mol Sci 2021 May 5;22(9) doi: 10.3390/ijms22094887. PMID: 34063061Free PMC Article
The Bidirectional Relationship Between Obstructive Sleep Apnea and Chronic Kidney Disease.
Hui L, Benca R
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105652. Epub 2021 Feb 16 doi: 10.1016/j.jstrokecerebrovasdis.2021.105652. PMID: 33608118
Uremic neuropathy: an overview of the current literature.
Camargo CRS, Schoueri JHM, Alves BDCA, Veiga GRLD, Fonseca FLA, Bacci MR
Rev Assoc Med Bras (1992) 2019 Mar;65(3):469-474. Epub 2019 Apr 11 doi: 10.1590/1806-9282.65.3.469. PMID: 30994849
Uremic neuropathy: an overview of the current literature.
Camargo CR, Schoueri JHM, Alves BDCA, Veiga GRLD, Fonseca FLA, Bacci MR
Rev Assoc Med Bras (1992) 2019 Feb;65(2):281-286. doi: 10.1590/1806-9282.65.2.281. PMID: 30892456

Therapy

Effect of Hemodiafiltration on the Progression of Neuropathy with Kidney Failure: A Randomized Controlled Trial.
Kang A, Arnold R, Gallagher M, Snelling P, Green J, Fernando M, Kiernan MC, Hand S, Grimley K, Burman J, Heath A, Rogers K, Bhattacharya A, Smyth B, Bradbury T, Hawley C, Perkovic V, Krishnan AV, Jardine MJ; FINESSE Steering Committee
Clin J Am Soc Nephrol 2021 Sep;16(9):1365-1375. Epub 2021 Jul 7 doi: 10.2215/CJN.17151120. PMID: 34233923Free PMC Article
Chronic renal disease progression: treatment strategies and potassium intake.
Sinha AD, Agarwal R
Semin Nephrol 2013 May;33(3):290-9. doi: 10.1016/j.semnephrol.2013.04.009. PMID: 23953806
Morbidity and mortality of CAPD and hemodialysis.
Maiorca R, Cancarini GC, Brunori G, Camerini C, Manili L
Kidney Int Suppl 1993 Feb;40:S4-15. PMID: 8445838
Nervous system complications in uremia.
Fraser CL, Arieff AI
Ann Intern Med 1988 Jul 15;109(2):143-53. doi: 10.7326/0003-4819-109-2-143. PMID: 2837930
Uremic neuropathy.
N Engl J Med 1967 Aug 17;277(7):371-2. doi: 10.1056/nejm196708172770710. PMID: 4378313

Prognosis

Etiopathogenesis of chronic kidney disease-associated pruritus: putting the pieces of the puzzle together.
Molina P, Ojeda R, Blanco A, Alcalde G, Prieto-Velasco M, Aresté N, Buades JM, Simó VE, Goicoechea M, Pérez-Morales RE, Sánchez-Álvarez E, Sánchez-Villanueva R, Montesa M, Arenas MD
Nefrologia (Engl Ed) 2023 Jan-Feb;43(1):48-62. Epub 2023 May 10 doi: 10.1016/j.nefroe.2023.03.015. PMID: 37173258
Genetic and Epigenomic Modifiers of Diabetic Neuropathy.
Jankovic M, Novakovic I, Nikolic D, Mitrovic Maksic J, Brankovic S, Petronic I, Cirovic D, Ducic S, Grajic M, Bogicevic D
Int J Mol Sci 2021 May 5;22(9) doi: 10.3390/ijms22094887. PMID: 34063061Free PMC Article
The Bidirectional Relationship Between Obstructive Sleep Apnea and Chronic Kidney Disease.
Hui L, Benca R
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105652. Epub 2021 Feb 16 doi: 10.1016/j.jstrokecerebrovasdis.2021.105652. PMID: 33608118
Renal-Cerebral Pathophysiology: The Interplay Between Chronic Kidney Disease and Cerebrovascular Disease.
Hanna RM, Ferrey A, Rhee CM, Kalantar-Zadeh K
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105461. Epub 2020 Nov 14 doi: 10.1016/j.jstrokecerebrovasdis.2020.105461. PMID: 33199089
Peripheral neuropathies associated with chronic renal failure.
Bolton CF
Can J Neurol Sci 1980 May;7(2):89-96. doi: 10.1017/s0317167100023453. PMID: 6250697

Clinical prediction guides

Etiopathogenesis of chronic kidney disease-associated pruritus: putting the pieces of the puzzle together.
Molina P, Ojeda R, Blanco A, Alcalde G, Prieto-Velasco M, Aresté N, Buades JM, Simó VE, Goicoechea M, Pérez-Morales RE, Sánchez-Álvarez E, Sánchez-Villanueva R, Montesa M, Arenas MD
Nefrologia (Engl Ed) 2023 Jan-Feb;43(1):48-62. Epub 2023 May 10 doi: 10.1016/j.nefroe.2023.03.015. PMID: 37173258
Effect of Hemodiafiltration on the Progression of Neuropathy with Kidney Failure: A Randomized Controlled Trial.
Kang A, Arnold R, Gallagher M, Snelling P, Green J, Fernando M, Kiernan MC, Hand S, Grimley K, Burman J, Heath A, Rogers K, Bhattacharya A, Smyth B, Bradbury T, Hawley C, Perkovic V, Krishnan AV, Jardine MJ; FINESSE Steering Committee
Clin J Am Soc Nephrol 2021 Sep;16(9):1365-1375. Epub 2021 Jul 7 doi: 10.2215/CJN.17151120. PMID: 34233923Free PMC Article
Relative contributions of diabetes and chronic kidney disease to neuropathy development in diabetic nephropathy patients.
Issar T, Arnold R, Kwai NCG, Walker S, Yan A, Borire AA, Poynten AM, Pussell BA, Endre ZH, Kiernan MC, Krishnan AV
Clin Neurophysiol 2019 Nov;130(11):2088-2095. Epub 2019 Aug 22 doi: 10.1016/j.clinph.2019.08.005. PMID: 31541986
Circadian blood pressure variations under different pathophysiological conditions.
Imai Y, Abe K, Munakata M, Sakuma H, Hashimoto J, Imai K, Sekino H, Yoshinaga K
J Hypertens Suppl 1990 Dec;8(7):S125-32. PMID: 2095380
Peripheral neuropathy in uremic patients and in renal transplant recipients.
Ahonen RE
Acta Neuropathol 1981;54(1):43-53. doi: 10.1007/BF00691331. PMID: 6263034

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