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Metaplasia

MedGen UID:
7571
•Concept ID:
C0025568
•
Cell or Molecular Dysfunction
Synonym: Metaplastic Change
SNOMED CT: Metaplasia (17665002)

Definition

Transformation of a mature, normal cell or groups of mature cells to other forms of mature cells. The capacity for malignant transformation of metaplastic cells is a subject of controversy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetaplasia

Professional guidelines

PubMed

New Understanding of Diagnosis, Treatment and Prevention of Endometriosis.
Amro B, Ramirez Aristondo ME, Alsuwaidi S, Almaamari B, Hakim Z, Tahlak M, Wattiez A, Koninckx PR
Int J Environ Res Public Health 2022 May 31;19(11) doi: 10.3390/ijerph19116725. PMID: 35682310Free PMC Article
AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Endometriosis: pathogenesis and treatment.
Vercellini P, Viganò P, Somigliana E, Fedele L
Nat Rev Endocrinol 2014 May;10(5):261-75. Epub 2013 Dec 24 doi: 10.1038/nrendo.2013.255. PMID: 24366116

Recent clinical studies

Etiology

Mechanisms and pathophysiology of Barrett oesophagus.
Souza RF, Spechler SJ
Nat Rev Gastroenterol Hepatol 2022 Sep;19(9):605-620. Epub 2022 Jun 7 doi: 10.1038/s41575-022-00622-w. PMID: 35672395
Ductal metaplasia in pancreas.
Li S, Xie K
Biochim Biophys Acta Rev Cancer 2022 Mar;1877(2):188698. Epub 2022 Feb 15 doi: 10.1016/j.bbcan.2022.188698. PMID: 35176433
Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond.
Goldenring JR, Mills JC
Gastroenterology 2022 Feb;162(2):415-430. Epub 2021 Oct 30 doi: 10.1053/j.gastro.2021.10.036. PMID: 34728185Free PMC Article
AGA Clinical Practice Guidelines on Management of Gastric Intestinal Metaplasia.
Gupta S, Li D, El Serag HB, Davitkov P, Altayar O, Sultan S, Falck-Ytter Y, Mustafa RA
Gastroenterology 2020 Feb;158(3):693-702. Epub 2019 Dec 6 doi: 10.1053/j.gastro.2019.12.003. PMID: 31816298Free PMC Article
Injury, repair, inflammation and metaplasia in the stomach.
Meyer AR, Goldenring JR
J Physiol 2018 Sep;596(17):3861-3867. Epub 2018 Mar 24 doi: 10.1113/JP275512. PMID: 29427515Free PMC Article

Diagnosis

Claudin-18.
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond.
Goldenring JR, Mills JC
Gastroenterology 2022 Feb;162(2):415-430. Epub 2021 Oct 30 doi: 10.1053/j.gastro.2021.10.036. PMID: 34728185Free PMC Article
Helicobacter pylori: an evolutionary perspective.
Jessurun J
Histopathology 2021 Jan;78(1):39-47. doi: 10.1111/his.14245. PMID: 33382492
Pleomorphic adenoma: the great mimicker of malignancy.
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article

Therapy

Claudin-18.
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
Barrett Esophagus: A Review.
Sharma P
JAMA 2022 Aug 16;328(7):663-671. doi: 10.1001/jama.2022.13298. PMID: 35972481
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication.
Sung JJY, Coker OO, Chu E, Szeto CH, Luk STY, Lau HCH, Yu J
Gut 2020 Sep;69(9):1572-1580. Epub 2020 Jan 23 doi: 10.1136/gutjnl-2019-319826. PMID: 31974133Free PMC Article
Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.
Watari J, Chen N, Amenta PS, Fukui H, Oshima T, Tomita T, Miwa H, Lim KJ, Das KM
World J Gastroenterol 2014 May 14;20(18):5461-73. doi: 10.3748/wjg.v20.i18.5461. PMID: 24833876Free PMC Article

Prognosis

Controlling Gastric Cancer in a World of Heterogeneous Risk.
Huang RJ, Laszkowska M, In H, Hwang JH, Epplein M
Gastroenterology 2023 Apr;164(5):736-751. Epub 2023 Jan 24 doi: 10.1053/j.gastro.2023.01.018. PMID: 36706842Free PMC Article
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Barrett Esophagus.
Iyer PG, Kaul V
Mayo Clin Proc 2019 Sep;94(9):1888-1901. doi: 10.1016/j.mayocp.2019.01.032. PMID: 31486383
Barrett's esophagus.
Falk GW
Gastroenterology 2002 May;122(6):1569-91. doi: 10.1053/gast.2002.33427. PMID: 12016424

Clinical prediction guides

AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Endoscopic Kyoto classification of Helicobacter pylori infection and gastric cancer risk diagnosis.
Toyoshima O, Nishizawa T, Koike K
World J Gastroenterol 2020 Feb 7;26(5):466-477. doi: 10.3748/wjg.v26.i5.466. PMID: 32089624Free PMC Article
Non-malignant Helicobacter pylori-Associated Diseases.
Falkeis-Veits C, Vieth M
Adv Exp Med Biol 2019;1149:121-134. doi: 10.1007/5584_2019_362. PMID: 31016630
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent systematic reviews

Effect of Helicobacter pylori eradication on gastric precancerous lesions: A systematic review and meta-analysis.
Zhu F, Zhang X, Li P, Zhu Y
Helicobacter 2023 Dec;28(6):e13013. Epub 2023 Aug 21 doi: 10.1111/hel.13013. PMID: 37602719
Adenocarcinoma risk in gastric atrophy and intestinal metaplasia: a systematic review.
Spence AD, Cardwell CR, McMenamin ÚC, Hicks BM, Johnston BT, Murray LJ, Coleman HG
BMC Gastroenterol 2017 Dec 11;17(1):157. doi: 10.1186/s12876-017-0708-4. PMID: 29228909Free PMC Article
Oxidative Stress and Endometriosis: A Systematic Review of the Literature.
Scutiero G, Iannone P, Bernardi G, Bonaccorsi G, Spadaro S, Volta CA, Greco P, Nappi L
Oxid Med Cell Longev 2017;2017:7265238. Epub 2017 Sep 19 doi: 10.1155/2017/7265238. PMID: 29057034Free PMC Article
Tobacco smoking and intestinal metaplasia: Systematic review and meta-analysis.
Morais S, Rodrigues S, Amorim L, Peleteiro B, Lunet N
Dig Liver Dis 2014 Nov;46(11):1031-7. Epub 2014 Sep 5 doi: 10.1016/j.dld.2014.08.034. PMID: 25195087
Salt intake and risk of gastric intestinal metaplasia: systematic review and meta-analysis.
Dias-Neto M, Pintalhao M, Ferreira M, Lunet N
Nutr Cancer 2010;62(2):133-47. doi: 10.1080/01635580903305391. PMID: 20099187

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