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Aplastic anemia due to drugs

MedGen UID:
75769
•Concept ID:
C0271909
•
Disease or Syndrome
Synonyms: Drug induced aplastic anemia; Drug-Induced Aplastic Anemia
SNOMED CT: Drug induced aplastic anemia (267527002); Aplastic anemia due to drugs (267527002)

Definition

A state of bone marrow suppression and failure that is caused by a cytotoxic or adverse immunologic response to a drug treatment, leading to a failure of production of red blood cells, white cells and platelets. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAplastic anemia due to drugs

Professional guidelines

PubMed

Diagnosis and Management of Acquired Aplastic Anemia: Consensus Statement of Indian Academy of Pediatrics.
Danewa A, Kalra M, Sachdeva A, Sachdeva P, Bansal D, Bhat S, Sachdeva D, Rani S, Yadav SP, Katewa S, Kumar A, Muniratnam D, Agarwal BR, Seth T, Mahajan A, Dua V, Kharya G, Misra R, Desai D, Gunasekaran V, Srivastava V
Indian Pediatr 2022 Jun 15;59(6):467-475. Epub 2022 Feb 1 PMID: 35105820
Recent Developments on the Use of Nanomaterials for the Treatment of Epilepsy.
Pedrero SG, Staedler D, Gerber-Lemaire S
Mini Rev Med Chem 2022;22(11):1460-1475. doi: 10.2174/1389557521666210805113647. PMID: 34353258
Herbal approach in the treatment of pancytopenia.
Bagwe SM, Kale PP, Bhatt LK, Prabhavalkar KS
J Complement Integr Med 2017 Mar 1;14(1) doi: 10.1515/jcim-2016-0053. PMID: 28195548

Recent clinical studies

Etiology

Inherited bone marrow failure in the pediatric patient.
Dokal I, Tummala H, Vulliamy T
Blood 2022 Aug 11;140(6):556-570. doi: 10.1182/blood.2020006481. PMID: 35605178Free PMC Article
Acquired aplastic anemia.
Keohane EM
Clin Lab Sci 2004 Summer;17(3):165-71. PMID: 15314891
Myelodysplastic syndromes.
Greenberg PL, Young NS, Gattermann N
Hematology Am Soc Hematol Educ Program 2002:136-61. doi: 10.1182/asheducation-2002.1.136. PMID: 12446422
Felbamate.
Pellock JM
Epilepsia 1999;40 Suppl 5:S57-62. doi: 10.1111/j.1528-1157.1999.tb00920.x. PMID: 10530695
Drug-induced agranulocytosis.
Drug Ther Bull 1997 Jul;35(7):49-52. doi: 10.1136/dtb.1997.35749. PMID: 9282424

Diagnosis

Inherited bone marrow failure in the pediatric patient.
Dokal I, Tummala H, Vulliamy T
Blood 2022 Aug 11;140(6):556-570. doi: 10.1182/blood.2020006481. PMID: 35605178Free PMC Article
Diamond-Blackfan anemia.
Da Costa L, Leblanc T, Mohandas N
Blood 2020 Sep 10;136(11):1262-1273. doi: 10.1182/blood.2019000947. PMID: 32702755Free PMC Article
Chromosome instability syndromes.
Taylor AMR, Rothblum-Oviatt C, Ellis NA, Hickson ID, Meyer S, Crawford TO, Smogorzewska A, Pietrucha B, Weemaes C, Stewart GS
Nat Rev Dis Primers 2019 Sep 19;5(1):64. doi: 10.1038/s41572-019-0113-0. PMID: 31537806Free PMC Article
Approach to pancytopenia: Diagnostic algorithm for clinical hematologists.
Gnanaraj J, Parnes A, Francis CW, Go RS, Takemoto CM, Hashmi SK
Blood Rev 2018 Sep;32(5):361-367. Epub 2018 Mar 5 doi: 10.1016/j.blre.2018.03.001. PMID: 29555368
Congenital Hemolytic Anemia.
Haley K
Med Clin North Am 2017 Mar;101(2):361-374. Epub 2016 Dec 8 doi: 10.1016/j.mcna.2016.09.008. PMID: 28189176

Therapy

New-onset aplastic anemia after SARS-CoV-2 vaccination.
Chatzikalil E, Kattamis A, Diamantopoulos P, Solomou EE
Int J Hematol 2023 Dec;118(6):667-681. Epub 2023 Sep 28 doi: 10.1007/s12185-023-03666-z. PMID: 37768509
Hetrombopag: First Approval.
Syed YY
Drugs 2021 Sep;81(13):1581-1585. doi: 10.1007/s40265-021-01575-1. PMID: 34357499
Thrombopoietin Receptor Agonists (TPO-RAs): Drug Class Considerations for Pharmacists.
Gilreath J, Lo M, Bubalo J
Drugs 2021 Jul;81(11):1285-1305. Epub 2021 Jun 23 doi: 10.1007/s40265-021-01553-7. PMID: 34160821Free PMC Article
Diamond-Blackfan anemia.
Da Costa L, Leblanc T, Mohandas N
Blood 2020 Sep 10;136(11):1262-1273. doi: 10.1182/blood.2019000947. PMID: 32702755Free PMC Article
Felbamate.
Pellock JM
Epilepsia 1999;40 Suppl 5:S57-62. doi: 10.1111/j.1528-1157.1999.tb00920.x. PMID: 10530695

Prognosis

Activity of eltrombopag in severe aplastic anemia.
Scheinberg P
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):450-456. doi: 10.1182/asheducation-2018.1.450. PMID: 30504345Free PMC Article
Aplastic anaemia.
Brodsky RA, Jones RJ
Lancet 2005 May 7-13;365(9471):1647-56. doi: 10.1016/S0140-6736(05)66515-4. PMID: 15885298
Acquired aplastic anemia.
Keohane EM
Clin Lab Sci 2004 Summer;17(3):165-71. PMID: 15314891
Myelodysplastic syndromes.
Greenberg PL, Young NS, Gattermann N
Hematology Am Soc Hematol Educ Program 2002:136-61. doi: 10.1182/asheducation-2002.1.136. PMID: 12446422
Drug-induced anaemias.
Girdwood RH
Drugs 1976;11(5):394-404. doi: 10.2165/00003495-197611050-00003. PMID: 782836

Clinical prediction guides

New-onset aplastic anemia after SARS-CoV-2 vaccination.
Chatzikalil E, Kattamis A, Diamantopoulos P, Solomou EE
Int J Hematol 2023 Dec;118(6):667-681. Epub 2023 Sep 28 doi: 10.1007/s12185-023-03666-z. PMID: 37768509
Eltrombopag in Immune Thrombocytopenia, Aplastic Anemia, and Myelodysplastic Syndrome: From Megakaryopoiesis to Immunomodulation.
Fattizzo B, Levati G, Cassin R, Barcellini W
Drugs 2019 Aug;79(12):1305-1319. doi: 10.1007/s40265-019-01159-0. PMID: 31292909
Activity of eltrombopag in severe aplastic anemia.
Scheinberg P
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):450-456. doi: 10.1182/asheducation-2018.1.450. PMID: 30504345Free PMC Article
Herbal approach in the treatment of pancytopenia.
Bagwe SM, Kale PP, Bhatt LK, Prabhavalkar KS
J Complement Integr Med 2017 Mar 1;14(1) doi: 10.1515/jcim-2016-0053. PMID: 28195548
Aplastic anemia: what have we learned from animal models and from the clinic.
Scheinberg P, Chen J
Semin Hematol 2013 Apr;50(2):156-64. Epub 2013 Jun 11 doi: 10.1053/j.seminhematol.2013.03.028. PMID: 24216172

Recent systematic reviews

Pharmacological interventions for painful sickle cell vaso-occlusive crises in adults.
Cooper TE, Hambleton IR, Ballas SK, Johnston BA, Wiffen PJ
Cochrane Database Syst Rev 2019 Nov 14;2019(11) doi: 10.1002/14651858.CD012187.pub2. PMID: 31742673Free PMC Article
Temozolomide-related idiosyncratic and other uncommon toxicities: a systematic review.
Dixit S, Baker L, Walmsley V, Hingorani M
Anticancer Drugs 2012 Nov;23(10):1099-106. doi: 10.1097/CAD.0b013e328356f5b0. PMID: 22850321
ATG plus cyclosporine reduces all-cause mortality in patients with severe aplastic anemia--systematic review and meta-analysis.
Gafter-Gvili A, Ram R, Gurion R, Paul M, Yeshurun M, Raanani P, Shpilberg O
Acta Haematol 2008;120(4):237-43. Epub 2009 Feb 25 doi: 10.1159/000203403. PMID: 19246887
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Singh PC, Ballas SK
Cochrane Database Syst Rev 2007 Oct 17;(4):CD003426. doi: 10.1002/14651858.CD003426.pub2. PMID: 17943791
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Riddington C, De Franceschi L
Cochrane Database Syst Rev 2002;(4):CD003426. doi: 10.1002/14651858.CD003426. PMID: 12519597

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