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Atypical lymphoproliferative disorder

MedGen UID:
75775
•Concept ID:
C0272217
•
Disease or Syndrome
Synonyms: Atypical lymphoid hyperplasia; Atypical Lymphoid Hyperplasia; atypical lymphoid hyperplasia; Atypical Lymphoproliferative Disorder; atypical lymphoproliferative disorder
SNOMED CT: Atypical lymphoproliferative disorder (20991001); Atypical lymphoid hyperplasia (30685006)
 
Monarch Initiative: MONDO:0044921

Definition

A lymphoproliferative disorder characterized by the presence of an atypical lymphocytic infiltrate. [from NCI]

Professional guidelines

PubMed

The clinicopathological behaviour and surgical treatment of abdominal Castleman's disease.
Han SL, Chen XX, Zheng XF, Yan JY, Shen X, Zhu GB
Singapore Med J 2010 Oct;51(10):813-6. PMID: 21103818

Recent clinical studies

Etiology

Renal involvement in Castleman disease.
El Karoui K, Vuiblet V, Dion D, Izzedine H, Guitard J, Frimat L, Delahousse M, Remy P, Boffa JJ, Pillebout E, Galicier L, Noël LH, Daugas E
Nephrol Dial Transplant 2011 Feb;26(2):599-609. Epub 2010 Jul 23 doi: 10.1093/ndt/gfq427. PMID: 20656751
Clinicopathologic study of Castleman's disease in Korea.
Kim JE, Kim CJ, Park IA, Kim WH, Seo JW, Jang JJ, Kim CW, Park SH, Lee HS, Chi JG, Kim YI, Ham EK
J Korean Med Sci 2000 Aug;15(4):393-8. doi: 10.3346/jkms.2000.15.4.393. PMID: 10983686Free PMC Article
Ornithine decarboxylase gene expression in Castleman's disease.
Malaguarnera L, Pilastro MR, Vicari L, Di Marco R, Malaguarnera M, Messina A
J Mol Med (Berl) 1999 Nov;77(11):798-803. doi: 10.1007/s001099900062. PMID: 10619440
Post-liver transplantation lymphoproliferative disorders with and without infusions of donor bone marrow cells.
Restrepo A, Albrecht F, Raez LE, Fernandez HF, Nassiri M, Byrne G Jr, Cassileth PA
Crit Rev Oncog 1999;10(3):239-45. PMID: 10468183
Molecular analysis of clonality in Castleman's disease.
Soulier J, Grollet L, Oksenhendler E, Micléa JM, Cacoub P, Baruchel A, Brice P, Clauvel JP, d'Agay MF, Raphael M
Blood 1995 Aug 1;86(3):1131-8. PMID: 7620166

Diagnosis

Hemosiderin deposition in lymph nodes of patients with plasma cell-type Castleman disease.
Han Y, Igawa T, Ogino K, Nishikori A, Gion Y, Yoshino T, Sato Y
J Clin Exp Hematop 2020 Mar 28;60(1):1-6. Epub 2020 Mar 8 doi: 10.3960/jslrt.19037. PMID: 32037354Free PMC Article
Atypical lymphoproliferative disorder-clinical and pathological features.
Wilmas K, Duvic M, Oki Y
Dermatol Online J 2016 Sep 15;22(9) PMID: 28329608
Wiskott-Aldrich syndrome complicated by an atypical lymphoproliferative disorder: a case report.
Ma YC, Shyur SD, Ho TY, Huang LH, Wu JY, Liang DC, Chien YH
J Microbiol Immunol Infect 2005 Aug;38(4):289-92. PMID: 16118678
Atypical lymphoproliferative disorders: Castleman's disease. Case report and review of the literature.
Martino G, Cariati S, Tintisona O, Veneroso S, De Villa F, Vergine M, Monti M
Tumori 2004 May-Jun;90(3):352-5. doi: 10.1177/030089160409000319. PMID: 15315321
Post-liver transplantation lymphoproliferative disorders with and without infusions of donor bone marrow cells.
Restrepo A, Albrecht F, Raez LE, Fernandez HF, Nassiri M, Byrne G Jr, Cassileth PA
Crit Rev Oncog 1999;10(3):239-45. PMID: 10468183

Therapy

Atypical lymphoproliferative disorder-clinical and pathological features.
Wilmas K, Duvic M, Oki Y
Dermatol Online J 2016 Sep 15;22(9) PMID: 28329608
Concomitant Castleman's disease and sarcoidosis.
Rice BL, Farver CF, Pohlman B, Burkey BB, Parambil JG
Am J Med Sci 2011 Mar;341(3):257-9. doi: 10.1097/MAJ.0b013e31820376e3. PMID: 21326077
Siltuximab, a novel anti-interleukin-6 monoclonal antibody, for Castleman's disease.
van Rhee F, Fayad L, Voorhees P, Furman R, Lonial S, Borghaei H, Sokol L, Crawford J, Cornfeld M, Qi M, Qin X, Herring J, Casper C, Kurzrock R
J Clin Oncol 2010 Aug 10;28(23):3701-8. Epub 2010 Jul 12 doi: 10.1200/JCO.2009.27.2377. PMID: 20625121
Anti-interleukin-6 receptor antibody therapy in rheumatic diseases.
Nakahara H, Nishimoto N
Endocr Metab Immune Disord Drug Targets 2006 Dec;6(4):373-81. doi: 10.2174/187153006779025694. PMID: 17214583
Post-liver transplantation lymphoproliferative disorders with and without infusions of donor bone marrow cells.
Restrepo A, Albrecht F, Raez LE, Fernandez HF, Nassiri M, Byrne G Jr, Cassileth PA
Crit Rev Oncog 1999;10(3):239-45. PMID: 10468183

Prognosis

Atypical lymphoproliferative disorder-clinical and pathological features.
Wilmas K, Duvic M, Oki Y
Dermatol Online J 2016 Sep 15;22(9) PMID: 28329608
Atypical lymphoproliferative disorders: Castleman's disease. Case report and review of the literature.
Martino G, Cariati S, Tintisona O, Veneroso S, De Villa F, Vergine M, Monti M
Tumori 2004 May-Jun;90(3):352-5. doi: 10.1177/030089160409000319. PMID: 15315321
Castleman's disease and lymphoma: report of eight cases in HIV-negative patients and literature review.
Larroche C, Cacoub P, Soulier J, Oksenhendler E, Clauvel JP, Piette JC, Raphael M
Am J Hematol 2002 Feb;69(2):119-26. doi: 10.1002/ajh.10022. PMID: 11835348
Castleman's disease.
Palestro G, Turrini F, Pagano M, Chiusa L
Adv Clin Path 1999 Jan-Apr;3(1-2):11-22. PMID: 10655569
Ornithine decarboxylase gene expression in Castleman's disease.
Malaguarnera L, Pilastro MR, Vicari L, Di Marco R, Malaguarnera M, Messina A
J Mol Med (Berl) 1999 Nov;77(11):798-803. doi: 10.1007/s001099900062. PMID: 10619440

Clinical prediction guides

Hemosiderin deposition in lymph nodes of patients with plasma cell-type Castleman disease.
Han Y, Igawa T, Ogino K, Nishikori A, Gion Y, Yoshino T, Sato Y
J Clin Exp Hematop 2020 Mar 28;60(1):1-6. Epub 2020 Mar 8 doi: 10.3960/jslrt.19037. PMID: 32037354Free PMC Article
A diagnostic mystery solved by electron microscopy: a case of an "atypical" lymphoproliferative disorder.
Lee S, Graham LM, Chan G, Ruskova A
Ultrastruct Pathol 2012 Oct;36(5):362-5. doi: 10.3109/01913123.2012.691952. PMID: 23025654
Renal involvement in Castleman disease.
El Karoui K, Vuiblet V, Dion D, Izzedine H, Guitard J, Frimat L, Delahousse M, Remy P, Boffa JJ, Pillebout E, Galicier L, Noël LH, Daugas E
Nephrol Dial Transplant 2011 Feb;26(2):599-609. Epub 2010 Jul 23 doi: 10.1093/ndt/gfq427. PMID: 20656751
Ornithine decarboxylase gene expression in Castleman's disease.
Malaguarnera L, Pilastro MR, Vicari L, Di Marco R, Malaguarnera M, Messina A
J Mol Med (Berl) 1999 Nov;77(11):798-803. doi: 10.1007/s001099900062. PMID: 10619440

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