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Immune thrombocytopenia

MedGen UID:
75778
•Concept ID:
C0272286
•
Disease or Syndrome
Synonyms: Immune Thrombocytopenia; ITP - immune thrombocytopenia; Thrombocytopenia due to immune destruction; Thrombocytopenia Due to Immune Destruction
SNOMED CT: Immune thrombocytopenia (2897005); ITP - immune thrombocytopenia (2897005); Thrombocytopenia due to immune destruction (2897005)

Definition

Thrombocytopenia that results from immune destruction of platelets. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmune thrombocytopenia

Professional guidelines

PubMed

Immune Thrombocytopenia Treatment.
Bolton-Maggs PHB, George JN
N Engl J Med 2021 Sep 2;385(10):948-950. doi: 10.1056/NEJMe2110953. PMID: 34469652
Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment.
Miltiadous O, Hou M, Bussel JB
Blood 2020 Feb 13;135(7):472-490. doi: 10.1182/blood.2019003599. PMID: 31756253Free PMC Article
Updated international consensus report on the investigation and management of primary immune thrombocytopenia.
Provan D, Arnold DM, Bussel JB, Chong BH, Cooper N, Gernsheimer T, Ghanima W, Godeau B, González-López TJ, Grainger J, Hou M, Kruse C, McDonald V, Michel M, Newland AC, Pavord S, Rodeghiero F, Scully M, Tomiyama Y, Wong RS, Zaja F, Kuter DJ
Blood Adv 2019 Nov 26;3(22):3780-3817. doi: 10.1182/bloodadvances.2019000812. PMID: 31770441Free PMC Article

Recent clinical studies

Etiology

Refractory primary immune thrombocytopenia (ITP): current clinical challenges and therapeutic perspectives.
Vianelli N, Auteri G, Buccisano F, Carrai V, Baldacci E, Clissa C, Bartoletti D, Giuffrida G, Magro D, Rivolti E, Esposito D, Podda GM, Palandri F
Ann Hematol 2022 May;101(5):963-978. Epub 2022 Feb 24 doi: 10.1007/s00277-022-04786-y. PMID: 35201417Free PMC Article
Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia.
Sun S, Urbanus RT, Ten Cate H, de Groot PG, de Laat B, Heemskerk JWM, Roest M
Cells 2021 Dec 1;10(12) doi: 10.3390/cells10123386. PMID: 34943895Free PMC Article
Immune thrombocytopenia.
Bussel J, Cooper N, Boccia R, Zaja F, Newland A
Expert Rev Hematol 2021 Nov;14(11):1013-1025. Epub 2021 Nov 18 doi: 10.1080/17474086.2021.1995347. PMID: 34720027
Thrombocytopenia in pregnancy: Diagnosis and approach to management.
Pishko AM, Levine LD, Cines DB
Blood Rev 2020 Mar;40:100638. Epub 2019 Nov 6 doi: 10.1016/j.blre.2019.100638. PMID: 31757523
Emerging Concepts in Immune Thrombocytopenia.
Swinkels M, Rijkers M, Voorberg J, Vidarsson G, Leebeek FWG, Jansen AJG
Front Immunol 2018;9:880. Epub 2018 Apr 30 doi: 10.3389/fimmu.2018.00880. PMID: 29760702Free PMC Article

Diagnosis

Thrombocytopenia in pregnancy.
Pishko AM, Marshall AL
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):303-311. doi: 10.1182/hematology.2022000375. PMID: 36485110Free PMC Article
Refractory primary immune thrombocytopenia (ITP): current clinical challenges and therapeutic perspectives.
Vianelli N, Auteri G, Buccisano F, Carrai V, Baldacci E, Clissa C, Bartoletti D, Giuffrida G, Magro D, Rivolti E, Esposito D, Podda GM, Palandri F
Ann Hematol 2022 May;101(5):963-978. Epub 2022 Feb 24 doi: 10.1007/s00277-022-04786-y. PMID: 35201417Free PMC Article
Neonatal thrombocytopenia: A review. I. Definitions, differential diagnosis, causes, immune thrombocytopenia.
Donato H
Arch Argent Pediatr 2021 Jun;119(3):e202-e214. doi: 10.5546/aap.2021.eng.e202. PMID: 34033425
Update on diagnosis and treatment of immune thrombocytopenia.
Sandal R, Mishra K, Jandial A, Sahu KK, Siddiqui AD
Expert Rev Clin Pharmacol 2021 May;14(5):553-568. Epub 2021 Mar 30 doi: 10.1080/17512433.2021.1903315. PMID: 33724124
How I approach new onset thrombocytopenia.
Swain F, Bird R
Platelets 2020;31(3):285-290. Epub 2019 Jul 3 doi: 10.1080/09537104.2019.1637835. PMID: 31269407

Therapy

Systemic lupus erythematosus-complicating immune thrombocytopenia: From pathogenesis to treatment.
Jiang Y, Cheng Y, Ma S, Li T, Chen Z, Zuo X, Zhang X
J Autoimmun 2022 Oct;132:102887. Epub 2022 Aug 25 doi: 10.1016/j.jaut.2022.102887. PMID: 36030136
Recent advances in the mechanisms and treatment of immune thrombocytopenia.
Provan D, Semple JW
EBioMedicine 2022 Feb;76:103820. Epub 2022 Jan 21 doi: 10.1016/j.ebiom.2022.103820. PMID: 35074629Free PMC Article
Immune thrombocytopenia.
Bussel J, Cooper N, Boccia R, Zaja F, Newland A
Expert Rev Hematol 2021 Nov;14(11):1013-1025. Epub 2021 Nov 18 doi: 10.1080/17474086.2021.1995347. PMID: 34720027
Update on diagnosis and treatment of immune thrombocytopenia.
Sandal R, Mishra K, Jandial A, Sahu KK, Siddiqui AD
Expert Rev Clin Pharmacol 2021 May;14(5):553-568. Epub 2021 Mar 30 doi: 10.1080/17512433.2021.1903315. PMID: 33724124
Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment.
Miltiadous O, Hou M, Bussel JB
Blood 2020 Feb 13;135(7):472-490. doi: 10.1182/blood.2019003599. PMID: 31756253Free PMC Article

Prognosis

Systemic lupus erythematosus-complicating immune thrombocytopenia: From pathogenesis to treatment.
Jiang Y, Cheng Y, Ma S, Li T, Chen Z, Zuo X, Zhang X
J Autoimmun 2022 Oct;132:102887. Epub 2022 Aug 25 doi: 10.1016/j.jaut.2022.102887. PMID: 36030136
Pediatric Hematologic and Oncologic Emergencies.
Stephanos K, Dubbs SB
Emerg Med Clin North Am 2021 Aug;39(3):555-571. Epub 2021 Jun 9 doi: 10.1016/j.emc.2021.04.007. PMID: 34215402
Immune thrombocytopenia: A review of upfront treatment strategies.
Kochhar M, Neunert C
Blood Rev 2021 Sep;49:100822. Epub 2021 Mar 8 doi: 10.1016/j.blre.2021.100822. PMID: 33736875
Immune Thrombocytopenia (ITP): Current Limitations in Patient Management.
Terrell DR, Neunert CE, Cooper N, Heitink-Pollé KM, Kruse C, Imbach P, Kühne T, Ghanima W
Medicina (Kaunas) 2020 Nov 30;56(12) doi: 10.3390/medicina56120667. PMID: 33266286Free PMC Article
Epidemiology and Clinical Manifestations of Immune Thrombocytopenia.
Kohli R, Chaturvedi S
Hamostaseologie 2019 Aug;39(3):238-249. Epub 2019 Mar 13 doi: 10.1055/s-0039-1683416. PMID: 30868551

Clinical prediction guides

Adults with immune thrombocytopenia who switched to avatrombopag following prior treatment with eltrombopag or romiplostim: A multicentre US study.
Al-Samkari H, Jiang D, Gernsheimer T, Liebman H, Lee S, Wojdyla M, Vredenburg M, Cuker A
Br J Haematol 2022 May;197(3):359-366. Epub 2022 Feb 18 doi: 10.1111/bjh.18081. PMID: 35179784Free PMC Article
Immune thrombocytopenia: options and new perspectives.
Caserta S, Zaccuri AM, Innao V, Musolino C, Allegra A
Blood Coagul Fibrinolysis 2021 Oct 1;32(7):427-433. doi: 10.1097/MBC.0000000000001058. PMID: 34224465
Diagnosing Immune Thrombocytopenia.
Sachs UJ
Hamostaseologie 2019 Aug;39(3):250-258. Epub 2019 Feb 14 doi: 10.1055/s-0039-1678739. PMID: 30763966
Drug-associated thrombocytopenia.
Bakchoul T, Marini I
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):576-583. doi: 10.1182/asheducation-2018.1.576. PMID: 30504360Free PMC Article
Phenotyping bleeding.
James P, Coller BS
Curr Opin Hematol 2012 Sep;19(5):406-12. doi: 10.1097/MOH.0b013e32835673ab. PMID: 22759628Free PMC Article

Recent systematic reviews

COVID-19 associated with immune thrombocytopenia: a systematic review and meta-analysis.
Alharbi MG, Alanazi N, Yousef A, Alanazi N, Alotaibi B, Aljurf M, El Fakih R
Expert Rev Hematol 2022 Feb;15(2):157-166. Epub 2022 Feb 12 doi: 10.1080/17474086.2022.2029699. PMID: 35025706Free PMC Article
Systematic Review of Safety and Efficacy of Second- and Third-Generation CD20-Targeting Biologics in Treating Immune-Mediated Disorders.
Kaegi C, Wuest B, Crowley C, Boyman O
Front Immunol 2021;12:788830. Epub 2022 Feb 2 doi: 10.3389/fimmu.2021.788830. PMID: 35185862Free PMC Article
Systematic Review of Safety and Efficacy of Rituximab in Treating Immune-Mediated Disorders.
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Thrombopoietin-receptor agonists for children with immune thrombocytopenia: a systematic review.
Zhang J, Liang Y, Ai Y, Xie J, Li Y, Zheng W
Expert Opin Pharmacother 2017 Oct;18(15):1543-1551. Epub 2017 Sep 4 doi: 10.1080/14656566.2017.1373091. PMID: 28845713
Thromboembolism in adults with primary immune thrombocytopenia: a systematic literature review and meta-analysis.
Doobaree IU, Nandigam R, Bennett D, Newland A, Provan D
Eur J Haematol 2016 Oct;97(4):321-30. Epub 2016 Jun 20 doi: 10.1111/ejh.12777. PMID: 27199203

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