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Childhood Craniopharyngioma

MedGen UID:
75847
•Concept ID:
C0278652
•
Neoplastic Process
Synonyms: Benign Childhood Neoplasm of Rathke's Pouch; Benign Childhood Rathke's Pouch Neoplasm; Benign Childhood Rathke's Pouch Tumor; Benign Childhood Tumor of Rathke's Pouch; Benign Pediatric Neoplasm of Rathke's Pouch; Benign Pediatric Rathke's Pouch Neoplasm; Benign Pediatric Rathke's Pouch Tumor; Benign Pediatric Tumor of Rathke's Pouch; Childhood Neoplasm of Rathke's Pouch; Childhood Rathke's Pouch Neoplasm; Childhood Rathke's Pouch Tumor; Childhood Tumor of Rathke's Pouch; Pediatric Craniopharyngioma; Pediatric Neoplasm of Rathke's Pouch; Pediatric Rathke's Pouch Neoplasm; Pediatric Rathke's Pouch Tumor; Pediatric Tumor of Rathke's Pouch

Definition

A craniopharyngioma that occurs during childhood. The vast majority of cases are adamantinomatous craniopharyngiomas. Clinical signs and symptoms include endocrine deficiencies and visual disturbances. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Craniopharyngioma

Professional guidelines

PubMed

Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma.
van Schaik J, Hoving EW, Müller HL, van Santen HM
Front Horm Res 2021;54:47-57. Epub 2021 May 7 doi: 10.1159/000515318. PMID: 33965963
Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up.
Bogusz A, Müller HL
Expert Rev Neurother 2018 Oct;18(10):793-806. Epub 2018 Oct 4 doi: 10.1080/14737175.2018.1528874. PMID: 30257123
Childhood craniopharyngioma - current status and recent perspectives in diagnostics and treatment.
Müller HL
J Pediatr Endocrinol Metab 2015 Jan;28(1-2):1-2. doi: 10.1515/jpem-2014-0416. PMID: 25503668

Recent clinical studies

Etiology

Treatment and outcome of the Dutch Childhood Craniopharyngioma Cohort study: First results after centralization of care.
Van Schaik J, Schouten-van Meeteren AYN, Vos-Kerkhof E, Janssens GO, Porro GL, Fiocco M, Bakker B, Tissing WJE, Hoving EW, van Santen HM
Neuro Oncol 2023 Dec 8;25(12):2250-2261. doi: 10.1093/neuonc/noad112. PMID: 37381692Free PMC Article
Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma.
van Schaik J, Hoving EW, Müller HL, van Santen HM
Front Horm Res 2021;54:47-57. Epub 2021 May 7 doi: 10.1159/000515318. PMID: 33965963
Periostin concentrations in childhood-onset craniopharyngioma patients.
Heinks K, De Schutter-Nüsse C, Boekhoff S, Bogusz A, Zhu J, Peng J, Müller HL
J Endocrinol Invest 2019 Jul;42(7):815-824. Epub 2018 Nov 24 doi: 10.1007/s40618-018-0987-9. PMID: 30474798
Craniopharyngioma in Children: Long-term Outcomes.
Steinbok P
Neurol Med Chir (Tokyo) 2015;55(9):722-6. Epub 2015 Sep 4 doi: 10.2176/nmc.ra.2015-0099. PMID: 26345668Free PMC Article
Childhood craniopharyngioma--current concepts in diagnosis, therapy and follow-up.
Müller HL
Nat Rev Endocrinol 2010 Nov;6(11):609-18. Epub 2010 Sep 28 doi: 10.1038/nrendo.2010.168. PMID: 20877295

Diagnosis

Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up.
Bogusz A, Müller HL
Expert Rev Neurother 2018 Oct;18(10):793-806. Epub 2018 Oct 4 doi: 10.1080/14737175.2018.1528874. PMID: 30257123
Childhood craniopharyngioma - current status and recent perspectives in diagnostics and treatment.
Müller HL
J Pediatr Endocrinol Metab 2015 Jan;28(1-2):1-2. doi: 10.1515/jpem-2014-0416. PMID: 25503668
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Childhood craniopharyngioma: treatment strategies and outcomes.
Müller HL
Expert Rev Neurother 2014 Feb;14(2):187-97. Epub 2014 Jan 13 doi: 10.1586/14737175.2014.875470. PMID: 24428758
Childhood craniopharyngioma.
Müller HL
Pituitary 2013 Mar;16(1):56-67. doi: 10.1007/s11102-012-0401-0. PMID: 22678820

Therapy

Childhood craniopharyngioma - current status and recent perspectives in diagnostics and treatment.
Müller HL
J Pediatr Endocrinol Metab 2015 Jan;28(1-2):1-2. doi: 10.1515/jpem-2014-0416. PMID: 25503668
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Childhood craniopharyngioma: treatment strategies and outcomes.
Müller HL
Expert Rev Neurother 2014 Feb;14(2):187-97. Epub 2014 Jan 13 doi: 10.1586/14737175.2014.875470. PMID: 24428758
Childhood craniopharyngioma.
Müller HL
Pituitary 2013 Mar;16(1):56-67. doi: 10.1007/s11102-012-0401-0. PMID: 22678820
Childhood craniopharyngioma--current concepts in diagnosis, therapy and follow-up.
Müller HL
Nat Rev Endocrinol 2010 Nov;6(11):609-18. Epub 2010 Sep 28 doi: 10.1038/nrendo.2010.168. PMID: 20877295

Prognosis

Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma.
van Schaik J, Hoving EW, Müller HL, van Santen HM
Front Horm Res 2021;54:47-57. Epub 2021 May 7 doi: 10.1159/000515318. PMID: 33965963
Adamantinomatous craniopharyngioma in the molecular age and the potential of targeted therapies: a review.
Whelan R, Hengartner A, Folzenlogen Z, Prince E, Hankinson TC
Childs Nerv Syst 2020 Aug;36(8):1635-1642. Epub 2020 May 22 doi: 10.1007/s00381-020-04677-5. PMID: 32440897
Periostin concentrations in childhood-onset craniopharyngioma patients.
Heinks K, De Schutter-Nüsse C, Boekhoff S, Bogusz A, Zhu J, Peng J, Müller HL
J Endocrinol Invest 2019 Jul;42(7):815-824. Epub 2018 Nov 24 doi: 10.1007/s40618-018-0987-9. PMID: 30474798
Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up.
Bogusz A, Müller HL
Expert Rev Neurother 2018 Oct;18(10):793-806. Epub 2018 Oct 4 doi: 10.1080/14737175.2018.1528874. PMID: 30257123
Consequences of craniopharyngioma surgery in children.
Müller HL
J Clin Endocrinol Metab 2011 Jul;96(7):1981-91. Epub 2011 Apr 20 doi: 10.1210/jc.2011-0174. PMID: 21508127

Clinical prediction guides

Treatment and outcome of the Dutch Childhood Craniopharyngioma Cohort study: First results after centralization of care.
Van Schaik J, Schouten-van Meeteren AYN, Vos-Kerkhof E, Janssens GO, Porro GL, Fiocco M, Bakker B, Tissing WJE, Hoving EW, van Santen HM
Neuro Oncol 2023 Dec 8;25(12):2250-2261. doi: 10.1093/neuonc/noad112. PMID: 37381692Free PMC Article
Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up.
Bogusz A, Müller HL
Expert Rev Neurother 2018 Oct;18(10):793-806. Epub 2018 Oct 4 doi: 10.1080/14737175.2018.1528874. PMID: 30257123
Neuropsychological outcome in patients with childhood craniopharyngioma and hypothalamic involvement.
Özyurt J, Thiel CM, Lorenzen A, Gebhardt U, Calaminus G, Warmuth-Metz M, Müller HL
J Pediatr 2014 Apr;164(4):876-881.e4. Epub 2014 Feb 6 doi: 10.1016/j.jpeds.2013.12.010. PMID: 24507865
Childhood craniopharyngioma in Macedonia: incidence and outcome after subtotal resection and cranial irradiation.
Gucev ZS, Danilovski D, Tasic V, Ugrinovski J, Nastova V, Jancevska A, Krstevska-Konstantinova M, Pop-Jordanova N, Kirovski I
World J Pediatr 2011 Feb;7(1):74-8. Epub 2010 Dec 30 doi: 10.1007/s12519-011-0250-3. PMID: 21191780
Childhood craniopharyngioma--current concepts in diagnosis, therapy and follow-up.
Müller HL
Nat Rev Endocrinol 2010 Nov;6(11):609-18. Epub 2010 Sep 28 doi: 10.1038/nrendo.2010.168. PMID: 20877295

Recent systematic reviews

Visual functions in children with craniopharyngioma at diagnosis: A systematic review.
Nuijts MA, Veldhuis N, Stegeman I, van Santen HM, Porro GL, Imhof SM, Schouten-van Meeteren AYN
PLoS One 2020;15(10):e0240016. Epub 2020 Oct 1 doi: 10.1371/journal.pone.0240016. PMID: 33002047Free PMC Article
A systematic review of cognitive performance in patients with childhood craniopharyngioma.
Özyurt J, Müller HL, Thiel CM
J Neurooncol 2015 Oct;125(1):9-21. Epub 2015 Sep 14 doi: 10.1007/s11060-015-1885-z. PMID: 26369768
Prevalence of neurobehavioral, social, and emotional dysfunction in patients treated for childhood craniopharyngioma: a systematic literature review.
Zada G, Kintz N, Pulido M, Amezcua L
PLoS One 2013;8(11):e76562. Epub 2013 Nov 5 doi: 10.1371/journal.pone.0076562. PMID: 24223703Free PMC Article

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