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Recurrent Childhood Malignant Liver Neoplasm

MedGen UID:
75857
•Concept ID:
C0278700
•
Neoplastic Process
Synonyms: Recurrent Childhood Cancer of Liver; Recurrent Childhood Cancer of the Liver; Recurrent Childhood Liver Cancer; Recurrent Pediatric Cancer of Liver; Recurrent Pediatric Cancer of the Liver; Recurrent Pediatric Liver Cancer; Relapsed Childhood Cancer of Liver; Relapsed Childhood Cancer of the Liver; Relapsed Childhood Liver Cancer; Relapsed Pediatric Cancer of Liver; Relapsed Pediatric Cancer of the Liver; Relapsed Pediatric Liver Cancer

Definition

A malignant neoplasm of the liver that occurs during childhood and has recurred after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Malignant Liver Neoplasm

Professional guidelines

PubMed

Navigating relapsed hepatoblastoma: Predictive factors and surgical treatment strategy.
Espinoza AF, Patel KR, Shetty PB, Whitlock RS, Sumazin P, Yu X, Sarabia SF, Urbicain M, Heczey A, Masand P, Woodfield SE, López-Terrada DH, Vasudevan SA
Cancer Med 2023 Dec;12(23):21270-21278. Epub 2023 Nov 14 doi: 10.1002/cam4.6705. PMID: 37962078Free PMC Article
Treatment Strategies for Children With Relapsed Pancreatoblastoma: A Literature Review.
Reggiani G, Affinita MC, Dall'Igna P, Virgone C, Sorbara S, Bisogno G
J Pediatr Hematol Oncol 2021 Nov 1;43(8):288-293. doi: 10.1097/MPH.0000000000002033. PMID: 33323880
Management of hepatoblastoma: an update.
Kremer N, Walther AE, Tiao GM
Curr Opin Pediatr 2014 Jun;26(3):362-9. doi: 10.1097/MOP.0000000000000081. PMID: 24759227

Recent clinical studies

Etiology

Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.
Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Pediatric liver transplantation for hepatocellular cancer and rare liver malignancies: US multicenter and single-center experience (1981-2015).
Vinayak R, Cruz RJ Jr, Ranganathan S, Mohanka R, Mazariegos G, Soltys K, Bond G, Tadros S, Humar A, Marsh JW, Selby RR, Reyes J, Sun Q, Haberman K, Sindhi R
Liver Transpl 2017 Dec;23(12):1577-1588. doi: 10.1002/lt.24847. PMID: 28834194Free PMC Article
Liver Transplantation for Malignant Primary Pediatric Hepatic Tumors.
Khan AS, Brecklin B, Vachharajani N, Subramanian V, Nadler M, Stoll J, Turmelle Y, Lowell JA, Chapman WC, Doyle MM
J Am Coll Surg 2017 Jul;225(1):103-113. Epub 2017 Feb 20 doi: 10.1016/j.jamcollsurg.2017.02.006. PMID: 28232059
Management of hepatoblastoma: an update.
Kremer N, Walther AE, Tiao GM
Curr Opin Pediatr 2014 Jun;26(3):362-9. doi: 10.1097/MOP.0000000000000081. PMID: 24759227
Liver transplantation and chemotherapy for hepatoblastoma and hepatocellular cancer in childhood and adolescence.
Reyes JD, Carr B, Dvorchik I, Kocoshis S, Jaffe R, Gerber D, Mazariegos GV, Bueno J, Selby R
J Pediatr 2000 Jun;136(6):795-804. PMID: 10839879

Diagnosis

Hepatic hemangiomas in childhood: the spectrum of radiologic findings. A pictorial essay.
Esposito F, D'Auria D, Ferrara D, Esposito P, Gaglione G, Zeccolini M, Tomà P
J Ultrasound 2023 Mar;26(1):261-276. Epub 2022 Sep 7 doi: 10.1007/s40477-022-00714-y. PMID: 36071345Free PMC Article
Hepatocellular carcinoma: old friends and new tricks.
Kim E, Viatour P
Exp Mol Med 2020 Dec;52(12):1898-1907. Epub 2020 Dec 2 doi: 10.1038/s12276-020-00527-1. PMID: 33268834Free PMC Article
Management of hepatoblastoma: an update.
Kremer N, Walther AE, Tiao GM
Curr Opin Pediatr 2014 Jun;26(3):362-9. doi: 10.1097/MOP.0000000000000081. PMID: 24759227
Hepatic mesenchymal hamartoma.
Yen JB, Kong MS, Lin JN
J Paediatr Child Health 2003 Nov;39(8):632-4. doi: 10.1046/j.1440-1754.2003.00250.x. PMID: 14629534
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

Therapy

Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma.
Abril-Fornaguera J, Torrens L, Andreu-Oller C, Carrillo-Reixach J, Rialdi A, Balaseviciute U, Pinyol R, Montironi C, Haber PK, Del Río-Álvarez Á, Domingo-Sàbat M, Royo L, Akers NK, Willoughby CE, Peix J, Torres-Martin M, Puigvehi M, Cairo S, Childs M, Maibach R, Alaggio R, Czauderna P, Morland B, Losic B, Mazzaferro V, Guccione E, Sia D, Armengol C, Llovet JM
Mol Cancer Ther 2023 Apr 3;22(4):485-498. doi: 10.1158/1535-7163.MCT-22-0335. PMID: 36780225Free PMC Article
Salvage Liver Transplant in the Treatment of a Child With Local Recurrence of Hepatoblastoma.
Gumus E, Hizarcioglu Gulsen H, Ozen H, Orhan D, Varan A, Dincer HA, Dogrul AB
Exp Clin Transplant 2022 May;20(Suppl 3):62-65. doi: 10.6002/ect.PediatricSymp2022.O21. PMID: 35570603
Treatment Strategies for Children With Relapsed Pancreatoblastoma: A Literature Review.
Reggiani G, Affinita MC, Dall'Igna P, Virgone C, Sorbara S, Bisogno G
J Pediatr Hematol Oncol 2021 Nov 1;43(8):288-293. doi: 10.1097/MPH.0000000000002033. PMID: 33323880
Current therapeutic strategies for childhood hepatic malignant tumors.
Hiyama E
Int J Clin Oncol 2013 Dec;18(6):943-5. Epub 2013 Sep 21 doi: 10.1007/s10147-013-0607-9. PMID: 24057320
Hepatic malignancies in childhood and adolescence (hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma).
Douglass EC
Cancer Treat Res 1997;92:201-12. doi: 10.1007/978-1-4615-5767-8_7. PMID: 9494762

Prognosis

Treatment Strategies for Children With Relapsed Pancreatoblastoma: A Literature Review.
Reggiani G, Affinita MC, Dall'Igna P, Virgone C, Sorbara S, Bisogno G
J Pediatr Hematol Oncol 2021 Nov 1;43(8):288-293. doi: 10.1097/MPH.0000000000002033. PMID: 33323880
Hepatocellular carcinoma: old friends and new tricks.
Kim E, Viatour P
Exp Mol Med 2020 Dec;52(12):1898-1907. Epub 2020 Dec 2 doi: 10.1038/s12276-020-00527-1. PMID: 33268834Free PMC Article
Management of hepatoblastoma: an update.
Kremer N, Walther AE, Tiao GM
Curr Opin Pediatr 2014 Jun;26(3):362-9. doi: 10.1097/MOP.0000000000000081. PMID: 24759227
Hepatic mesenchymal hamartoma.
Yen JB, Kong MS, Lin JN
J Paediatr Child Health 2003 Nov;39(8):632-4. doi: 10.1046/j.1440-1754.2003.00250.x. PMID: 14629534
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

Clinical prediction guides

Coexisting Infantile Hepatic Hemangioma and Hepatoblastoma in a Neonate: A Case Report.
Zhang SH, Chen GY, Wei L
Int J Surg Pathol 2023 Jun;31(4):485-490. Epub 2023 Apr 25 doi: 10.1177/10668969231171127. PMID: 37097887
Hepatic hemangiomas in childhood: the spectrum of radiologic findings. A pictorial essay.
Esposito F, D'Auria D, Ferrara D, Esposito P, Gaglione G, Zeccolini M, Tomà P
J Ultrasound 2023 Mar;26(1):261-276. Epub 2022 Sep 7 doi: 10.1007/s40477-022-00714-y. PMID: 36071345Free PMC Article
Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.
Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Pediatric liver transplantation for hepatocellular cancer and rare liver malignancies: US multicenter and single-center experience (1981-2015).
Vinayak R, Cruz RJ Jr, Ranganathan S, Mohanka R, Mazariegos G, Soltys K, Bond G, Tadros S, Humar A, Marsh JW, Selby RR, Reyes J, Sun Q, Haberman K, Sindhi R
Liver Transpl 2017 Dec;23(12):1577-1588. doi: 10.1002/lt.24847. PMID: 28834194Free PMC Article
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

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