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Recurrent Childhood Malignant Liver Neoplasm

MedGen UID:
75857
•Concept ID:
C0278700
•
Neoplastic Process
Synonyms: Recurrent Childhood Cancer of Liver; Recurrent Childhood Cancer of the Liver; Recurrent Childhood Liver Cancer; Recurrent Pediatric Cancer of Liver; Recurrent Pediatric Cancer of the Liver; Recurrent Pediatric Liver Cancer; Relapsed Childhood Cancer of Liver; Relapsed Childhood Cancer of the Liver; Relapsed Childhood Liver Cancer; Relapsed Pediatric Cancer of Liver; Relapsed Pediatric Cancer of the Liver; Relapsed Pediatric Liver Cancer

Definition

A malignant neoplasm of the liver that occurs during childhood and has recurred after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Malignant Liver Neoplasm

Professional guidelines

PubMed

Navigating relapsed hepatoblastoma: Predictive factors and surgical treatment strategy.
Espinoza AF, Patel KR, Shetty PB, Whitlock RS, Sumazin P, Yu X, Sarabia SF, Urbicain M, Heczey A, Masand P, Woodfield SE, López-Terrada DH, Vasudevan SA
Cancer Med 2023 Dec;12(23):21270-21278. Epub 2023 Nov 14 doi: 10.1002/cam4.6705. PMID: 37962078Free PMC Article
Treatment Strategies for Children With Relapsed Pancreatoblastoma: A Literature Review.
Reggiani G, Affinita MC, Dall'Igna P, Virgone C, Sorbara S, Bisogno G
J Pediatr Hematol Oncol 2021 Nov 1;43(8):288-293. doi: 10.1097/MPH.0000000000002033. PMID: 33323880
Management of hepatoblastoma: an update.
Kremer N, Walther AE, Tiao GM
Curr Opin Pediatr 2014 Jun;26(3):362-9. doi: 10.1097/MOP.0000000000000081. PMID: 24759227

Recent clinical studies

Etiology

Navigating relapsed hepatoblastoma: Predictive factors and surgical treatment strategy.
Espinoza AF, Patel KR, Shetty PB, Whitlock RS, Sumazin P, Yu X, Sarabia SF, Urbicain M, Heczey A, Masand P, Woodfield SE, López-Terrada DH, Vasudevan SA
Cancer Med 2023 Dec;12(23):21270-21278. Epub 2023 Nov 14 doi: 10.1002/cam4.6705. PMID: 37962078Free PMC Article
Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.
Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Management of hepatoblastoma: an update.
Kremer N, Walther AE, Tiao GM
Curr Opin Pediatr 2014 Jun;26(3):362-9. doi: 10.1097/MOP.0000000000000081. PMID: 24759227
Adult patient with Epstein-Barr virus (EBV)-associated lymphoproliferative disorder: chronic active EBV infection or de novo extranodal natural killer (NK)/T-cell lymphoma, nasal type?
Ohtsuka R, Abe Y, Sada E, Kiyasu J, Ashikari A, Shiratsuchi M, Nishimura J, Takayanagi R, Ohshima K
Intern Med 2009;48(6):471-4. Epub 2009 Mar 16 doi: 10.2169/internalmedicine.48.1346. PMID: 19293549
Surveillance of second cancer after previous childhood cancer treatment.
Ng SK, Mackay S, Seymour JF
Aust Fam Physician 2007 Aug;36(8):643-5. PMID: 17676190

Diagnosis

Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.
Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Hepatocellular carcinoma: old friends and new tricks.
Kim E, Viatour P
Exp Mol Med 2020 Dec;52(12):1898-1907. Epub 2020 Dec 2 doi: 10.1038/s12276-020-00527-1. PMID: 33268834Free PMC Article
Management of hepatoblastoma: an update.
Kremer N, Walther AE, Tiao GM
Curr Opin Pediatr 2014 Jun;26(3):362-9. doi: 10.1097/MOP.0000000000000081. PMID: 24759227
Childhood cancers: hepatoblastoma.
Herzog CE, Andrassy RJ, Eftekhari F
Oncologist 2000;5(6):445-53. doi: 10.1634/theoncologist.5-6-445. PMID: 11110595
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

Therapy

Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma.
Abril-Fornaguera J, Torrens L, Andreu-Oller C, Carrillo-Reixach J, Rialdi A, Balaseviciute U, Pinyol R, Montironi C, Haber PK, Del Río-Álvarez Á, Domingo-Sàbat M, Royo L, Akers NK, Willoughby CE, Peix J, Torres-Martin M, Puigvehi M, Cairo S, Childs M, Maibach R, Alaggio R, Czauderna P, Morland B, Losic B, Mazzaferro V, Guccione E, Sia D, Armengol C, Llovet JM
Mol Cancer Ther 2023 Apr 3;22(4):485-498. doi: 10.1158/1535-7163.MCT-22-0335. PMID: 36780225Free PMC Article
Treatment Strategies for Children With Relapsed Pancreatoblastoma: A Literature Review.
Reggiani G, Affinita MC, Dall'Igna P, Virgone C, Sorbara S, Bisogno G
J Pediatr Hematol Oncol 2021 Nov 1;43(8):288-293. doi: 10.1097/MPH.0000000000002033. PMID: 33323880
Solid pseudopapillary tumour (Frantz's tumour) of the pancreas in childhood: successful management of late liver metastases with sunitinib and chemoembolisation.
Escobar MA Jr, McClellan JM, Thomas W
BMJ Case Rep 2017 Dec 22;2017 doi: 10.1136/bcr-2017-221906. PMID: 29275383Free PMC Article
Hepatic malignancies in childhood and adolescence (hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma).
Douglass EC
Cancer Treat Res 1997;92:201-12. doi: 10.1007/978-1-4615-5767-8_7. PMID: 9494762
Primary chemotherapeutic management of unresectable and metastatic hepatoblastoma in children: report of four cases.
Siegel MM, Siegel SE, Isaacs H, Weitzman JJ, Hanson BA, Higgins GR, Shore NA
Med Pediatr Oncol 1978;4(4):297-304. doi: 10.1002/mpo.2950040404. PMID: 214690

Prognosis

Navigating relapsed hepatoblastoma: Predictive factors and surgical treatment strategy.
Espinoza AF, Patel KR, Shetty PB, Whitlock RS, Sumazin P, Yu X, Sarabia SF, Urbicain M, Heczey A, Masand P, Woodfield SE, López-Terrada DH, Vasudevan SA
Cancer Med 2023 Dec;12(23):21270-21278. Epub 2023 Nov 14 doi: 10.1002/cam4.6705. PMID: 37962078Free PMC Article
Hepatocellular carcinoma: old friends and new tricks.
Kim E, Viatour P
Exp Mol Med 2020 Dec;52(12):1898-1907. Epub 2020 Dec 2 doi: 10.1038/s12276-020-00527-1. PMID: 33268834Free PMC Article
Management of hepatoblastoma: an update.
Kremer N, Walther AE, Tiao GM
Curr Opin Pediatr 2014 Jun;26(3):362-9. doi: 10.1097/MOP.0000000000000081. PMID: 24759227
Childhood cancers: hepatoblastoma.
Herzog CE, Andrassy RJ, Eftekhari F
Oncologist 2000;5(6):445-53. doi: 10.1634/theoncologist.5-6-445. PMID: 11110595
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

Clinical prediction guides

Navigating relapsed hepatoblastoma: Predictive factors and surgical treatment strategy.
Espinoza AF, Patel KR, Shetty PB, Whitlock RS, Sumazin P, Yu X, Sarabia SF, Urbicain M, Heczey A, Masand P, Woodfield SE, López-Terrada DH, Vasudevan SA
Cancer Med 2023 Dec;12(23):21270-21278. Epub 2023 Nov 14 doi: 10.1002/cam4.6705. PMID: 37962078Free PMC Article
Hepatic hemangiomas in childhood: the spectrum of radiologic findings. A pictorial essay.
Esposito F, D'Auria D, Ferrara D, Esposito P, Gaglione G, Zeccolini M, Tomà P
J Ultrasound 2023 Mar;26(1):261-276. Epub 2022 Sep 7 doi: 10.1007/s40477-022-00714-y. PMID: 36071345Free PMC Article
Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.
Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Pediatric liver transplantation for hepatocellular cancer and rare liver malignancies: US multicenter and single-center experience (1981-2015).
Vinayak R, Cruz RJ Jr, Ranganathan S, Mohanka R, Mazariegos G, Soltys K, Bond G, Tadros S, Humar A, Marsh JW, Selby RR, Reyes J, Sun Q, Haberman K, Sindhi R
Liver Transpl 2017 Dec;23(12):1577-1588. doi: 10.1002/lt.24847. PMID: 28834194Free PMC Article
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

Recent systematic reviews

Reappraisal of liver resection as an alternative to transplantation in locally advanced hepatoblastoma: A systematic review and analysis of pooled individual patient data.
Fuchs J, Rabaux-Eygasier L, Ruping F, Kessler M, Günther P, Hoffmann K, Czigany Z, Michalski C, Hery G, Mehrabi A, Branchereau S
Pediatr Blood Cancer 2024 Dec;71(12):e31339. Epub 2024 Sep 27 doi: 10.1002/pbc.31339. PMID: 39334537

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