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Recurrent Lung Small Cell Carcinoma

MedGen UID:
75863
Concept ID:
C0278727
Neoplastic Process
Synonyms: Recurrent Small Cell Carcinoma of Lung; Recurrent Small Cell Carcinoma of the Lung; Recurrent Small Cell Lung Cancer; Recurrent Small Cell Lung Carcinoma; Relapsed Small Cell Carcinoma of Lung; Relapsed Small Cell Carcinoma of the Lung; Relapsed Small Cell Lung Cancer; Relapsed Small Cell Lung Carcinoma

Definition

The reemergence of small cell carcinoma of the lung after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Lung Small Cell Carcinoma

Professional guidelines

PubMed

Niederle N, Schütte J, Schmidt CG, Seeber S
Cancer Treat Rep 1984 May;68(5):791-2. PMID: 6327037

Recent clinical studies

Etiology

Chang JY, Lin SH, Dong W, Liao Z, Gandhi SJ, Gay CM, Zhang J, Chun SG, Elamin YY, Fossella FV, Blumenschein G, Cascone T, Le X, Pozadzides JV, Tsao A, Verma V, Welsh JW, Chen AB, Altan M, Mehran RJ, Vaporciyan AA, Swisher SG, Balter PA, Fujimoto J, Wistuba II, Feng L, Lee JJ, Heymach JV
Lancet 2023 Sep 9;402(10405):871-881. Epub 2023 Jul 18 doi: 10.1016/S0140-6736(23)01384-3. PMID: 37478883Free PMC Article
Abbosh C, Frankell AM, Harrison T, Kisistok J, Garnett A, Johnson L, Veeriah S, Moreau M, Chesh A, Chaunzwa TL, Weiss J, Schroeder MR, Ward S, Grigoriadis K, Shahpurwalla A, Litchfield K, Puttick C, Biswas D, Karasaki T, Black JRM, Martínez-Ruiz C, Bakir MA, Pich O, Watkins TBK, Lim EL, Huebner A, Moore DA, Godin-Heymann N, L'Hernault A, Bye H, Odell A, Roberts P, Gomes F, Patel AJ, Manzano E, Hiley CT, Carey N, Riley J, Cook DE, Hodgson D, Stetson D, Barrett JC, Kortlever RM, Evan GI, Hackshaw A, Daber RD, Shaw JA, Aerts HJWL, Licon A, Stahl J, Jamal-Hanjani M; TRACERx Consortium, Birkbak NJ, McGranahan N, Swanton C
Nature 2023 Apr;616(7957):553-562. Epub 2023 Apr 13 doi: 10.1038/s41586-023-05776-4. PMID: 37055640Free PMC Article
Altorki N, Wang X, Kozono D, Watt C, Landrenau R, Wigle D, Port J, Jones DR, Conti M, Ashrafi AS, Liberman M, Yasufuku K, Yang S, Mitchell JD, Pass H, Keenan R, Bauer T, Miller D, Kohman LJ, Stinchcombe TE, Vokes E
N Engl J Med 2023 Feb 9;388(6):489-498. doi: 10.1056/NEJMoa2212083. PMID: 36780674Free PMC Article
Isaacs J, Stinchcombe TE
Drugs 2022 Jun;82(8):855-863. Epub 2022 May 21 doi: 10.1007/s40265-022-01721-3. PMID: 35596880
Trigo J, Subbiah V, Besse B, Moreno V, López R, Sala MA, Peters S, Ponce S, Fernández C, Alfaro V, Gómez J, Kahatt C, Zeaiter A, Zaman K, Boni V, Arrondeau J, Martínez M, Delord JP, Awada A, Kristeleit R, Olmedo ME, Wannesson L, Valdivia J, Rubio MJ, Anton A, Sarantopoulos J, Chawla SP, Mosquera-Martinez J, D'Arcangelo M, Santoro A, Villalobos VM, Sands J, Paz-Ares L
Lancet Oncol 2020 May;21(5):645-654. Epub 2020 Mar 27 doi: 10.1016/S1470-2045(20)30068-1. PMID: 32224306

Diagnosis

Abbosh C, Frankell AM, Harrison T, Kisistok J, Garnett A, Johnson L, Veeriah S, Moreau M, Chesh A, Chaunzwa TL, Weiss J, Schroeder MR, Ward S, Grigoriadis K, Shahpurwalla A, Litchfield K, Puttick C, Biswas D, Karasaki T, Black JRM, Martínez-Ruiz C, Bakir MA, Pich O, Watkins TBK, Lim EL, Huebner A, Moore DA, Godin-Heymann N, L'Hernault A, Bye H, Odell A, Roberts P, Gomes F, Patel AJ, Manzano E, Hiley CT, Carey N, Riley J, Cook DE, Hodgson D, Stetson D, Barrett JC, Kortlever RM, Evan GI, Hackshaw A, Daber RD, Shaw JA, Aerts HJWL, Licon A, Stahl J, Jamal-Hanjani M; TRACERx Consortium, Birkbak NJ, McGranahan N, Swanton C
Nature 2023 Apr;616(7957):553-562. Epub 2023 Apr 13 doi: 10.1038/s41586-023-05776-4. PMID: 37055640Free PMC Article
Ganti AKP, Loo BW, Bassetti M, Blakely C, Chiang A, D'Amico TA, D'Avella C, Dowlati A, Downey RJ, Edelman M, Florsheim C, Gold KA, Goldman JW, Grecula JC, Hann C, Iams W, Iyengar P, Kelly K, Khalil M, Koczywas M, Merritt RE, Mohindra N, Molina J, Moran C, Pokharel S, Puri S, Qin A, Rusthoven C, Sands J, Santana-Davila R, Shafique M, Waqar SN, Gregory KM, Hughes M
J Natl Compr Canc Netw 2021 Dec;19(12):1441-1464. doi: 10.6004/jnccn.2021.0058. PMID: 34902832Free PMC Article
Trigo J, Subbiah V, Besse B, Moreno V, López R, Sala MA, Peters S, Ponce S, Fernández C, Alfaro V, Gómez J, Kahatt C, Zeaiter A, Zaman K, Boni V, Arrondeau J, Martínez M, Delord JP, Awada A, Kristeleit R, Olmedo ME, Wannesson L, Valdivia J, Rubio MJ, Anton A, Sarantopoulos J, Chawla SP, Mosquera-Martinez J, D'Arcangelo M, Santoro A, Villalobos VM, Sands J, Paz-Ares L
Lancet Oncol 2020 May;21(5):645-654. Epub 2020 Mar 27 doi: 10.1016/S1470-2045(20)30068-1. PMID: 32224306
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
van Meerbeeck JP, Fennell DA, De Ruysscher DK
Lancet 2011 Nov 12;378(9804):1741-55. Epub 2011 May 10 doi: 10.1016/S0140-6736(11)60165-7. PMID: 21565397

Therapy

Paz-Ares L, Champiat S, Lai WV, Izumi H, Govindan R, Boyer M, Hummel HD, Borghaei H, Johnson ML, Steeghs N, Blackhall F, Dowlati A, Reguart N, Yoshida T, He K, Gadgeel SM, Felip E, Zhang Y, Pati A, Minocha M, Mukherjee S, Goldrick A, Nagorsen D, Hashemi Sadraei N, Owonikoko TK
J Clin Oncol 2023 Jun 1;41(16):2893-2903. Epub 2023 Jan 23 doi: 10.1200/JCO.22.02823. PMID: 36689692Free PMC Article
Petty WJ, Paz-Ares L
JAMA Oncol 2023 Mar 1;9(3):419-429. doi: 10.1001/jamaoncol.2022.5631. PMID: 36520421
Zugazagoitia J, Paz-Ares L
J Clin Oncol 2022 Feb 20;40(6):671-680. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01881. PMID: 34985925
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
van Meerbeeck JP, Fennell DA, De Ruysscher DK
Lancet 2011 Nov 12;378(9804):1741-55. Epub 2011 May 10 doi: 10.1016/S0140-6736(11)60165-7. PMID: 21565397

Prognosis

Rudin CM, Reck M, Johnson ML, Blackhall F, Hann CL, Yang JC, Bailis JM, Bebb G, Goldrick A, Umejiego J, Paz-Ares L
J Hematol Oncol 2023 Jun 24;16(1):66. doi: 10.1186/s13045-023-01464-y. PMID: 37355629Free PMC Article
Petty WJ, Paz-Ares L
JAMA Oncol 2023 Mar 1;9(3):419-429. doi: 10.1001/jamaoncol.2022.5631. PMID: 36520421
Niu X, Chen L, Li Y, Hu Z, He F
Semin Cancer Biol 2022 Nov;86(Pt 3):273-285. Epub 2022 Mar 12 doi: 10.1016/j.semcancer.2022.03.009. PMID: 35288298
Chan JM, Quintanal-Villalonga Á, Gao VR, Xie Y, Allaj V, Chaudhary O, Masilionis I, Egger J, Chow A, Walle T, Mattar M, Yarlagadda DVK, Wang JL, Uddin F, Offin M, Ciampricotti M, Qeriqi B, Bahr A, de Stanchina E, Bhanot UK, Lai WV, Bott MJ, Jones DR, Ruiz A, Baine MK, Li Y, Rekhtman N, Poirier JT, Nawy T, Sen T, Mazutis L, Hollmann TJ, Pe'er D, Rudin CM
Cancer Cell 2021 Nov 8;39(11):1479-1496.e18. Epub 2021 Oct 14 doi: 10.1016/j.ccell.2021.09.008. PMID: 34653364Free PMC Article
van Meerbeeck JP, Fennell DA, De Ruysscher DK
Lancet 2011 Nov 12;378(9804):1741-55. Epub 2011 May 10 doi: 10.1016/S0140-6736(11)60165-7. PMID: 21565397

Clinical prediction guides

Altorki N, Wang X, Kozono D, Watt C, Landrenau R, Wigle D, Port J, Jones DR, Conti M, Ashrafi AS, Liberman M, Yasufuku K, Yang S, Mitchell JD, Pass H, Keenan R, Bauer T, Miller D, Kohman LJ, Stinchcombe TE, Vokes E
N Engl J Med 2023 Feb 9;388(6):489-498. doi: 10.1056/NEJMoa2212083. PMID: 36780674Free PMC Article
Petty WJ, Paz-Ares L
JAMA Oncol 2023 Mar 1;9(3):419-429. doi: 10.1001/jamaoncol.2022.5631. PMID: 36520421
Pellini B, Chaudhuri AA
J Clin Oncol 2022 Feb 20;40(6):567-575. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01929. PMID: 34985936Free PMC Article
Zugazagoitia J, Paz-Ares L
J Clin Oncol 2022 Feb 20;40(6):671-680. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01881. PMID: 34985925
Chan JM, Quintanal-Villalonga Á, Gao VR, Xie Y, Allaj V, Chaudhary O, Masilionis I, Egger J, Chow A, Walle T, Mattar M, Yarlagadda DVK, Wang JL, Uddin F, Offin M, Ciampricotti M, Qeriqi B, Bahr A, de Stanchina E, Bhanot UK, Lai WV, Bott MJ, Jones DR, Ruiz A, Baine MK, Li Y, Rekhtman N, Poirier JT, Nawy T, Sen T, Mazutis L, Hollmann TJ, Pe'er D, Rudin CM
Cancer Cell 2021 Nov 8;39(11):1479-1496.e18. Epub 2021 Oct 14 doi: 10.1016/j.ccell.2021.09.008. PMID: 34653364Free PMC Article

Recent systematic reviews

Banna GL, Hassan MA, Signori A, Giunta EF, Maniam A, Anpalakhan S, Acharige S, Ghose A, Addeo A
JAMA Netw Open 2024 Apr 1;7(4):e246837. doi: 10.1001/jamanetworkopen.2024.6837. PMID: 38625698Free PMC Article
Bernabé-Caro R, Chen Y, Dowlati A, Eason P
Clin Lung Cancer 2023 May;24(3):185-208. Epub 2023 Feb 8 doi: 10.1016/j.cllc.2023.01.012. PMID: 36907793
Shen H, Jin Y, Zhao H, Wu M, Zhang K, Wei Z, Wang X, Wang Z, Li Y, Yang F, Wang J, Chen K
BMC Med 2022 Dec 14;20(1):480. doi: 10.1186/s12916-022-02681-x. PMID: 36514063Free PMC Article
Burdett S, Rydzewska L, Tierney J, Fisher D, Parmar MK, Arriagada R, Pignon JP, Le Pechoux C; PORT Meta‐analysis Trialists Group
Cochrane Database Syst Rev 2016 Oct 11;10(10):CD002142. doi: 10.1002/14651858.CD002142.pub4. PMID: 27727451Free PMC Article
NSCLC Meta-analysis Collaborative Group
Lancet 2014 May 3;383(9928):1561-71. Epub 2014 Feb 25 doi: 10.1016/S0140-6736(13)62159-5. PMID: 24576776Free PMC Article

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